PROSITE entry PS51256

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS51256

Direct ScanProsite submission

General information about the entry

Entry name [info]	GS
Accession [info]	PS51256
Entry type [info]	MATRIX
Date [info]	01-OCT-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51256
Associated ProRule [info]	PRU00585

Name and characterization of the entry

Description [info]

GS domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=30;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=27;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6356133; R2=0.0071500; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2852.9260254; R2=0.4629630; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=961; H_SCORE=3298; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=681; H_SCORE=3168; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-36; D=-20; I=-20; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='P';  M=-54,-72,-53, -3,-75, 13,-59,-73, 30,-77,-68, 41, 51,-30,-40, 45, 42,-69,-79,-21;
/M: SY='T';  M=-34,-46,-53, 27,-13, -7, 23,-24,-23,-47,  1, 29,-41,-24,-29,  7, 74,-59,-78,  5;
/M: SY='M';  M=-61,-72,-80,-75,-46,-35,-26, 43,-73, 47, 68,-73,-77,-67,-72, -4,-40, 23, 42, 19;
/M: SY='Q';  M=-31,-76, 31, 33,-40,  0, 31,-70, 31,-68, 42,-20,-15, 50, -5, 16,-57,-31,-79,-63;
/M: SY='D';  M=-33,-80, 87, 49,-85,-22,-56,-81,-11,-80,-75,-38, 35, 11,-58, -8,-19,-78,-88,-71;
/M: SY='M';  M=-21,-71,-37,-69,  1,-73,-61, 33,-16, 44, 68, -5,-75,-62,-66, 25,-56,-43,-66, 33;
/M: SY='I';  M= -1,-73,-75,-69, 15,-75,-69, 50, -5, 26, 25,-68, 10,-64,  1, -2, -2, -6, 41,-14;
/M: SY='D';  M= -7,-76, 66, 42,-37,-59,-44,-65,-18,-44, 25,-31,  3, 13,-59,  6,-56, -6,-73, 42;
/M: SY='M';  M=-38,-74, 55, 27,-64,-14, 39,-41,-59, 16, 78,-55,-69,  2,-63,  1,-58,  1,-82,-59;
/M: SY='M';  M= -9,-69, 20,-63, 21,-69,-14,-12,-41, 30, 45,-59,-71,-61,-67, 35, 34,-15,-70, 23;
/I:         I=-5; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='C';  M= -9, 64,  0, 36,-72,-68,-64, 14,-56,-63,-60,-54,-16, 43,-62, 26, 51,-11,-83,-68;
/M: SY='T';  M=-33,-12, 33,-56,-72, 16,-63,-69,-58,-72,-67,-45,-63,-57,-65, 61, 78,-62,-85,-37;
/M: SY='S';  M=-44,  3,-58,-60,-75, 30,-62,-74,-59,-77,-70,-46,-64,-53,-64, 95, 24,-67,-82,-68;
/M: SY='G';  M=-47,-74,-63,-72,-81, 95,-69,-87,-67,-84,-74,-49,-67,-63,-74, 39,-60,-80,-75,-75;
/M: SY='S';  M=-42, 10,-57,-59,-75, 17,-60,-75,-59,-78,-71,-45,-65,-51,-63,102,-39,-68,-82,-68;
/M: SY='G';  M=-48,-74,-63,-73,-81, 96,-69,-86,-67,-84,-74,-49,-67,-64,-74, 21, -5,-80,-75,-76;
/M: SY='S';  M= 17,-64,-58,-58,-72,-52,-60,-68,-58,-69, 32,-47,-64,-51,-62, 96, 21,-61,-81,-65;
/M: SY='G';  M=-49,-77,-64,-76,-83,103,-71,-91,-70,-86,-75,-50,-68,-67,-77,-49,-68,-84,-74,-78;
/M: SY='L';  M=-66,-73,-73,-64, -5,-78,-63,-43, 19, 69, 31, -4, 34, 21,-61,-68,-61,-49,-71,-56;
/M: SY='P';  M= 20,-83,-66,-56,-83,-65,-70,-71,-62,-80,-68,-69,118,-65,-73,-57,  7,-72,-79,-80;
/M: SY='L';  M= -6,-68,-76,-72, 41,-77,-64,-41,-72, 67,-39,-71,-78,-69,-71,-19, 33,-46,-62, 34;
/M: SY='L';  M=-67,-69,-85,-77,  2,-86,-68,-33,-78, 88, 23,-83,-84,-71,-74,-77,-63,-40,-69,-51;
/M: SY='V';  M=-54,-68,-75,-73,-56,-79, 33, 23,-71,-19,-44, -9,-76,-71,-73,-13,  1, 87,-87,-59;
/M: SY='Q';  M=-59,-83,-54,-35,-87,-67,-16,-76, 26,-72,-59,-49,-66,123,-38, -9,-60,-77,-73,-61;
/M: SY='R';  M=-46,-82,-64,-51,-73,-76,-53,-76,-27,-15,-60,-57,-75, 25,110,-61,-65,-72,-75,-62;
/M: SY='T';  M=-50,-62,-57,-60,-69,-64,-66,-61,-57,-66,-62,-46,-60,-59,-65, 43,106,-53,-87,-66;
/M: SY='I';  M=-61,-73,-85,-81,  7,-87,-82, 87,-77,-14, 26,-77,-76,-75,-79,-71,-57, 53,-74,-54;
/M: SY='A';  M= 88,-64,-66,-60,-76,  0,-67,-68,-58,-69,-63,-59,-67,-57, 11, 14,-52,-56,-76,-71;
/M: SY='R';  M=-20,-80,-60,-49,-78, -5,-53,-81, 30,-75,-64,  3,-72, 39, 97,-56,-63,-75,-75,-64;
/M: SY='Q';  M=-60,-79, 40,-38,-84,-66, -8,-75,-43,-72,-62,  5,-66,110,  4,-31, 31,-74,-79,-63;
/I:         E1=0; IE=-105; DE=-105;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	28 in 28 different sequences
Number of true positive hits	28 in 28 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	GS
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

28 sequences

ACV1B_HUMAN (P36896), ACV1B_MOUSE (Q61271), ACV1B_RAT   (P80202),

ACV1C_HUMAN (Q8NER5), ACV1C_MOUSE (Q8K348), ACV1C_RAT   (P70539), 
ACVL1_HUMAN (P37023), ACVL1_MOUSE (Q61288), ACVL1_PONAB (Q5RAN0), 
ACVL1_RAT   (P80203), ACVR1_BOVIN (Q28041), ACVR1_CHICK (Q90ZK6), 
ACVR1_HUMAN (Q04771), ACVR1_MOUSE (P37172), ACVR1_RAT   (P80201), 
BMR1A_HUMAN (P36894), BMR1A_MOUSE (P36895), BMR1A_RAT   (Q78EA7), 
BMR1B_CHICK (Q05438), BMR1B_HUMAN (O00238), BMR1B_MOUSE (P36898), 
DAF1_CAEEL  (P20792), SMA6_CAEEL  (Q09488), TGFR1_BOVIN (O46680), 
TGFR1_HUMAN (P36897), TGFR1_MOUSE (Q64729), TGFR1_PIG   (Q5CD18), 
TGFR1_RAT   (P80204)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

16 PDB

1B6C; 1IAS; 1PY5; 2X7O; 3FAA; 3H9R; 3KCF; 3MDY; 4C02; 6EIX; 6I1S; 8POD;
» more