PROSITE entry PS51215

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PURL: https://purl.expasy.org/prosite/signature/PS51215

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General information about the entry

Entry name [info]	AWS
Accession [info]	PS51215
Entry type [info]	MATRIX
Date [info]	01-JUN-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51215
Associated ProRule [info]	PRU00562

Name and characterization of the entry

Description [info]

AWS domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=51;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=46;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.2861123; R2=0.0114865; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3114.6025391; R2=3.0262697; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=454; H_SCORE=4489; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=280; H_SCORE=3962; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-22; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='D';  M=-13, 12,-51, 20,  4,-45,-26,-13,-45, -9,-47,-33,  5,-31, -4,-21, -2,-10,-36,-60,-39,  0;
/M: SY='D';  M=-21,  7,-58, 17, 17,-35,-31,-10,-52,-10,-51,-38, -5,-27, -3,-23,-11,-15,-40,-53,-31,  9;
/M:         M= -9,-27,-35,-30,-24,-16,-34,-26,-15,-23,-18,-12,-22,-36,-22,-26, -2,-10,-10,-46,-22,-24;
/M: SY='M';  M=-13,-34,-28,-38,-28,-16,-38,-26,-16,-27,-12,  4,-29,-28,-21,-32,-10,-13,-16,-42,-23,-26;
/M: SY='T';  M=-15,-29,-29,-36,-28,-28,-38,-33, -9, -7,-17,-10,-21,-38,-18,-21,-14,  3, -4,-51,-32,-27;
/M: SY='C';  M= -8,-55,116,-65,-65,-40,-56,-66,-21,-55,-30,-29,-45,-57,-46,-56,-14,-13,-19,-50,-48,-65;
/M: SY='N';  M=-15,  3,-45, -3,  2,-45,-26, -9,-39, -7,-39,-25, 12,-32, -2,-13,  4, -2,-26,-58,-37, -1;
/M: SY='C';  M= -6,-57,109,-65,-64,-41,-56,-66,-23,-55,-31,-30,-48,-44,-47,-56,-18,-20,-21,-51,-50,-64;
/M: SY='K';  M= -7,-12,-47,-16,  1,-47,-23,-19,-41, 18,-38,-25, -7,-19,  8, -5, -1,  2,-29,-56,-40,  2;
/I:         I=-7; MD=-15;
/M: SY='P';  M=-13,-14,-49,-13,  1,-41,-34,-13,-42, 10,-39,-30,-14, 13, -3,  1, -9,-13,-33,-48,-31,  0; D=-7;
/I:         I=-7; MI=0; MD=-15; IM=0; DM=-15;
/M:         M=-10,-15,-22,-15,-15,-18,-21,-16,-11, -9, -6, -6,-11, -7,-11, -7, -9, -5, -8,-27,-19,-13; D=-7;
/I:         I=-7; DM=-15;
/M: SY='D';  M= -6,  0,-22,  5, -6,-20,-12,-14,-18,-10,-16, -9, -3,-17, -6,-14, -1, -1,-15,-29,-21, -6; D=-7;
/I:         I=-7; DM=-15;
/M: SY='S';  M= -3,  4,-23,  5,  2,-26,-15,-10,-21, -6,-24,-16,  4,-16, -2,-12,  6,  3,-12,-34,-23,  0; D=-7;
/I:         I=-7; DM=-15;
/M: SY='S';  M= -5, -2,-28, -4,-10,-27,  0, -8,-28,-10,-29,-18,  2,-17, -9,-15,  3,  3,-22,-35,-22,-11; D=-7;
/I:         I=-7; DM=-15;
/M: SY='A';  M=  3,-13,-36,-14,-12,-39, -1,-25,-35,-13,-36,-23,-12,-10,-15,-20,  3, -5,-25,-48,-38,-13; D=-7;
/I:         I=-7; DM=-15;
/M: SY='C';  M= -4,-28, 18,-34,-30,-32,-38,-33,-13,-25,-24,-17,-23,-35,-23,-31, -2,  4,-10,-46,-32,-31; D=-7;
/I:         I=-7; DM=-15;
/M: SY='G';  M= -2,-19,-28,-29,-29,-50, 15,-33,-44,-10,-47,-33, -7,-40,-23,-25, -6, -7,-32,-57,-47,-29;
/M: SY='C';  M= -9,-39, 73,-46,-45,-44,-50,-53,-30,-44,-37,-33,-32,-38,-36,-47, -8,-16,-26,-55,-49,-47;
/M: SY='G';  M=-13,  2,-61,  5,-18,-54, 34,-28,-63,-21,-61,-47,  0,-43,-25,-32,-11,-25,-54,-62,-50,-21;
/M: SY='S';  M= -6,  5,-44,  6,  6,-43,-27,-10,-45, -4,-44,-30,  3,-27, -1,-13, 15,  5,-33,-56,-32,  2;
/M: SY='D';  M=-17, 24,-53, 31,  4,-49,-18,-15,-55, -7,-55,-41, 18,-32, -7,-17,  4, -2,-44,-65,-45, -1;
/M: SY='C';  M=-10,-60,130,-70,-70,-40,-60,-70,-20,-60,-30,-30,-50,-60,-50,-60,-20,-20,-20,-50,-50,-70;
/M: SY='L';  M=-19,-47,-33,-49,-34,-13,-54,-28,  1,-29,  7,  3,-40,-42,-22,-32,-23,-14,  1,-32,-15,-29;
/M: SY='N';  M=-25, 22,-19, -2,-23,-52,-23, -9,-46,-12,-46,-32, 53,-43,-11,-20,  3,  1,-38,-64,-40,-22;
/M: SY='R';  M=-21,-20,-55,-27, -7,-48,-32, -7,-45, 18,-39,-29,-13,-30,  4, 59,-14,-17,-32,-52,-41, -1;
/M: SY='M';  M= -1,-38,-32,-41,-20,-21,-40,-29, -9,-14,  1, 19,-33,-32, -8,-25,-14,-12, -4,-41,-29,-16;
/M: SY='M';  M=-12,-44,-16,-49,-38,-20,-49,-39,  3,-26,  9, 15,-33,-40,-21,-31,-16, -4,  6,-45,-30,-32;
/M:         M=-21,-28,-25,-38,-32,  0,-42, -5,-26,-23,-20, -7,-16,-43,-16,-24, -8,-15,-25,-32,  0,-28;
/M: SY='I';  M=-19,-33,-30,-42,-37,-15,-48,-30,  7,-27, -8, -3,-23,-42,-25,-27,-15, -2,  4,-44,-19,-35;
/M: SY='E';  M=-18,  0,-60,  5, 52,-43,-40, -5,-49,  2,-49,-32,-13,-25, 22,-14, -6,-17,-34,-54,-39, 39;
/M: SY='C';  M= -4,-58,120,-67,-66,-40,-56,-67,-21,-56,-30,-29,-49,-56,-48,-58,-17,-19,-19,-50,-49,-66;
/M: SY='S';  M= -9,  2,-29, -8,-18,-39,-26,-12,-36,-16,-40,-29, 15,-29,-14,-23, 19,  9,-26,-55,-26,-18;
/M: SY='P';  M= -1,-12,-46,-11, -6,-46,-31,-13,-43,  3,-42,-31,-10,  8, -5,-13,  6,-10,-32,-60,-38, -6;
/M: SY='S';  M=-10, -4,-49, -8, -3,-48,-10,-18,-46,  0,-44,-32,  0,-32, -4, -7,  4, -8,-34,-59,-42, -4;
/I:         I=-15; MD=-32;
/M: SY='T';  M=-13, -7,-30,-12, -5,-21,-27, -4,-20, -6,-23,-16, -2,-25, -5,-10, -3,  1,-14,-31,-10, -6; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='C';  M=-10,-60,130,-70,-70,-40,-60,-70,-20,-60,-30,-30,-50,-60,-50,-60,-20,-20,-20,-50,-50,-70;
/M: SY='P';  M=-13,-20,-40,-26,-20,-49,-26,-26,-44, -6,-39,-30,-10,  8,-17,-11, -7,-14,-35,-60,-46,-19;
/I:         I=-10; MD=-21;
/M: SY='C';  M= -3,-47, 30,-53,-46,-29,-45,-45,-15,-34,-11,-13,-38,-42,-33,-33,-14,-16,-10,-40,-35,-43; D=-10;
/I:         I=-10; MD=-21;
/M: SY='G';  M=  0,-16,-48,-21,-26,-49, 45,-31,-53,-21,-52,-35,-11,-24,-25,-30, -6,-22,-45,-52,-48,-25; D=-10;
/I:         I=-10; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='E';  M= -4, -3,-49, -2, 18,-49,-30,-15,-45, 11,-45,-33, -6,-13,  4, -7,  9, -6,-31,-61,-42, 12;
/M: SY='H';  M=-22,-12,-52,-21,-11,-32,-31,  4,-44,  1,-36,-27,  2,-29,  3, -9,-10,-16,-37,-42,-10, -6;
/M: SY='C';  M=-10,-60,130,-70,-70,-40,-60,-70,-20,-60,-30,-30,-50,-60,-50,-60,-20,-20,-20,-50,-50,-70;
/M: SY='S';  M= -7, -9,-41,-16, -3,-42,-11,-13,-46, -3,-44,-26, -1,-33,  2,-14,  3, -4,-35,-53,-36, -3;
/M: SY='N';  M=-29, 46,-51, 18, -9,-59,-11,  9,-59,  5,-59,-39, 85,-39,  1, -8,  9, -1,-49,-69,-40, -9;
/M: SY='R';  M=-24,-17,-55,-23,  6,-48,-40,  1,-45, 28,-38,-20, -7,-30, 40, 47,-16,-15,-37,-47,-36, 18;
/M: SY='R';  M=-18,-26,-38,-28,-20,-39,-39,-21,-39, -4,-36,-25,-21, -9,-10, 17,-14,-19,-33,-52,-39,-16;
/M: SY='F';  M=-38,-61,-36,-62,-60, 76,-62,-28,  4,-49,  8,  6,-60,-58,-49,-49,-40,-36, -9,-11, 25,-59;
/M: SY='Q';  M=-16,-18,-47,-22,  2,-42,-34, -4,-40,  3,-33,-18, -9,-33, 27,  6, -9,-10,-29,-40,-30, 11;
/M: SY='K';  M=-17,-10,-56,-18,  4,-48,-34, -7,-47, 44,-38,-23, -2,-26, 19, 36,-10,-12,-38,-55,-39,  9;
/M: SY='R';  M=-21,-17,-55,-24, -6,-37,-32, -1,-46, 11,-37,-28, -9,-24,  3, 22,-12,-19,-38,-50,-30, -3;
/M: SY='Q';  M=-17,-12,-52,-14, 10,-41,-38,  0,-45, 21,-35,-19, -4,-24, 36,  3,-11,-11,-36,-48,-30, 18;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	38 in 38 different sequences
Number of true positive hits	38 in 38 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	AWS
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

38 sequences

ASH1L_HUMAN (Q9NR48), ASH1L_MOUSE (Q99MY8), ASH1_DROME  (Q9VW15),

ASHH1_ARATH (Q84WW6), ASHH2_ARATH (Q2LAE1), ASHH3_ARATH (Q945S8), 
ASHH4_ARATH (Q9M1X9), ASHR3_ARATH (Q949T8), LIN59_CAEEL (O44757), 
NSD1_HUMAN  (Q96L73), NSD1_MOUSE  (O88491), NSD2_HUMAN  (O96028), 
NSD2_MOUSE  (Q8BVE8), NSD3_HUMAN  (Q9BZ95), NSD3_MOUSE  (Q6P2L6), 
NSD_DROME   (Q8MT36), SET2_ASPFU  (Q4WTT2), SET2_ASPOR  (Q2UTN6), 
SET2_CANAL  (Q59XV0), SET2_CANGA  (Q6FX50), SET2_CHAGB  (Q2H988), 
SET2_COCIM  (Q1DU03), SET2_CRYNB  (P0CO29), SET2_CRYNJ  (P0CO28), 
SET2_DEBHA  (Q6BM04), SET2_DROME  (Q9VYD1), SET2_EMENI  (Q5ASA5), 
SET2_EREGS  (Q757Y8), SET2_GIBZE  (Q4IB50), SET2_KLULA  (Q6CXP5), 
SET2_MYCMD  (Q4PBL3), SET2_NEUCR  (Q7RZU4), SET2_SCHPO  (O14026), 
SET2_YARLI  (Q6C5G5), SET2_YEAST  (P46995), SETD2_HUMAN (Q9BYW2), 
SETD2_MOUSE (E9Q5F9), SETVS_PLAF7 (Q8IE95)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

52 PDB

3OOI; 3OPE; 4FMU; 4H12; 4YNM; 4YNP; 4YPA; 4YPE; 4YPU; 5JJY; 5JLB; 5JLE;
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