PROSITE entry PS51212

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PURL: https://purl.expasy.org/prosite/signature/PS51212

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General information about the entry

Entry name [info]	WSC
Accession [info]	PS51212
Entry type [info]	MATRIX
Date [info]	01-MAY-2006 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51212
Associated ProRule [info]	PRU00558

Name and characterization of the entry

Description [info]

WSC domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=93;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=93;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6489282; R2=0.0021189; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=2196; N_SCORE=7.3; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=1629; N_SCORE=6.1; MODE=1; TEXT='R?';
/DEFAULT: M0=-24; D=-100; I=-100; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='M';  M=  23, -50,  33, -34, -48,  23, -39,   4, -32, -37,  59, -32, -46,   4,  30,  -2,   2, -35, -57, -42;
/M: SY='W';  M=  29, -52,  13,   0,  31, -12, -38, -42, -40, -11, -38,  31,  31, -39, -45, -34, -38, -42,  71,  35;
/M: SY='T';  M= -34, -47, -29,  17, -45,  13, -35, -38,  -6, -44, -39,  49, -44,  23, -37, -25,  56,  12, -56,  12;
/M: SY='Y';  M= -45, -56, -43, -41,  41, -50, -22, -39, -34, -35, -32,  11, -56,  34,  12,   0, -39, -42, -18,  98;
/M: SY='V';  M= -39, -51, -51, -13, -29, -58, -44,  33,  -9,  34, -20, -47, -54, -39,  32,  -5, -35,  38, -50,  13;
/M: SY='G';  M=  24, -50, -42, -50, -57,  83, -48, -54, -45, -56, -48,   4, -47, -43, -52, -26, -41, -11, -53, -53;
/M: SY='C';  M= -78, 293,-118,-118, -98,-109,-118,-112,-110, -94, -94, -90,-140,-125,-122, -83, -78, -88,-158,-120;
/M: SY='Y';  M= -48, -53, -55, -54,  76, -56, -29, -28, -49,  12, -26, -51, -61, -48, -46,  -6, -41, -33, -16,  91;
/M: SY='S';  M= -32, -48, -40, -35, -44, -43, -39, -37,  24,  16, -34, -33,  10, -29,  39,  52,  20, -12, -56, -41;
/M: SY='D';  M=  15, -53,  81,  11, -55, -41, -35, -47, -31, -17, -45, -23, -45,  15,   0,  10, -33, -11, -66, -45;
/I:         I=-22; MD=-23;
/M: SY='N';  M= -17, -56,  43,   6, -62, -42,  31, -61,   7, -62, -53,  44,  31, -32, -38,  34, -33, -57, -70, -50; D=-22;
/I:         I=-22; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='N';  M=  -1, -58,  17,  15, -62, -46,  15, -59,   5, -27, -50,  41, -53,  23,  -5,  18, -38, -56, -69, -51; D=-22;
/I:         I=-22; DM=-23;
/M: SY='P';  M=   0, -59,  10,  -9, -63, -11, -45, -20, -11, -61, -54,  27,  44, -39, -15,  35, -36, -53, -68, -57; D=-22;
/I:         I=-22; DM=-23;
/M: SY='R';  M=   1, -53, -43, -38, -48,  16, -40,  -6, -24,  -4, -37, -36,  31, -31,  62,  24,   4, -40, -55, -44;
/M: SY='T';  M=  27, -46,  -2, -38, -51,  31, -44, -43, -36, -27, -41, -31,  15, -37,   7,  18,  51, -14, -58, -47;
/M: SY='L';  M= -41, -48,  -1, -48,   6,  -8,  24, -16, -51,  64, -15, -47, -57, -46, -50, -45,   2,  13, -52, -31;
/M: SY='T';  M=  44, -42, -42, -39, -43, -39, -44,  -8,  -8,   8, -33, -34, -44, -36,  -7,  24,  57, -28, -57, -43;
/M: SY='G';  M=   7, -52,   7,  30,   5,  42, -39, -45,  20,  10, -37,   4, -46, -33, -36, -33, -39, -44, -48,   4;
/M: SY='P';  M=   3, -55, -38,  11,  -6,   6,  25, -17,  21, -44, -38, -36,  44,  31,   8, -34, -10,   7, -51,  -2;
/M: SY='S';  M= -29, -48,  18,  15,  -5,   9, -38, -34, -38, -42, -40,   1, -46, -33, -42,  58, -26,  30, -53,  18;
/M: SY='S';  M= -32, -49, -36,  25,  35, -13, -37, -39, -10, -40, -39, -33, -46,   9,   4,  47,  21,   3, -44,  24;
/M: SY='Y';  M= -10, -48, -44, -44,  27, -48, -34, -28, -12,   9, -29,   8,  -1, -40, -42,  11,  30,  11, -34,  67;
/M: SY='S';  M=  21, -47,  16,  -6, -42, -40, -38,  11, -10, -19, -35,  22, -46,  14, -39,  32,  18,  -1, -54,  13;
/M: SY='W';  M=   9, -53, -47, -44,  35,   6, -37,   0, -16, -14,  19,  11,  -3,  11, -42, -37,  -6, -36,  70,  55;
/I:         I=-19; MD=-19;
/M: SY='K';  M= -17, -71, -59, -50,   3, -19,  23, -64,  38, -26, -55, -52,  18, -49,  -7, -53, -20, -62, -67, -52; D=-19;
/I:         I=-19; MD=-19;
/M: SY='N';  M= -21, -73, -51,  -6, -81, -59, -57, -79,   3, -81, -72,  35, -69,  -4, -53,  28, -50, -74, -86, -72; D=-19;
/I:         I=-19; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='M';  M= -40, -51, -41, -34,  10, -49, -33, -26,   0,  23,  73,  37, -51,  65, -33, -37, -36,  -4, -51, -32;
/M: SY='T';  M= -26, -43,   5, -33, -51, -10, -39, -46, -34, -49, -44, -23, -40,  14, -40,  65,  70, -38, -62, -44;
/M: SY='P';  M= -36, -53, -46, -41, -42, -51, -48,  37,   6, -32, -30,   7,  61, -40,   4,   7, -31,  43, -58, -44;
/M: SY='Q';  M=  16, -50,   6,  42,  -9,  16, -35, -54, -30, -52, -45,  -2, -42,  49, -35,  44, -30, -48, -54, -43;
/M: SY='H';  M=  18, -49, -41, -36, -34, -46,  55, -40,  10, -23, -34, -34, -46,  16,  -3, -28,  50, -12,  54,  44;
/M: SY='C';  M= -78, 293,-118,-118, -98,-109,-118,-112,-110, -94, -94, -90,-140,-125,-122, -83, -78, -88,-158,-120;
/I:         I=-30; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='Q';  M= -34, -50, -34,  -2, -46, -43, -35,  19, -29,  -5, -32,  43, -48,  57,  13,  31,  -3,   5, -58, -41;
/M: SY='N';  M=  -5, -49,  35,  33, -56,  -3, -33, -55,  10, -56, -48,  50, -42, -26,  -2,  35,  14, -49, -63, -47;
/M: SY='F';  M=   2, -49, -40,   9,  56, -49,  14,  18, -40,  -3,   8,  36, -52,  21, -43, -38, -36,  13, -45, -24;
/M: SY='C';  M= -76, 289,-115,-115, -99,-106,-115,-112,-107, -94, -94, -87,-136,-120,-120, -17, -75, -88,-156,-118;
/M: SY='F';  M=  17, -50, -39,  16,  30,  -7, -38, -43,  -6, -10, -37, -37,  21, -33,  22,  25,   0, -40, -43,  26;
/I:         I=-26; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='Q';  M= -14, -59, -39,  25, -62, -16,  24, -59,   7, -56,   9, -37, -50,  38, -10,  34,   4, -55, -66, -50; D=-26;
/I:         I=-26; DM=-27;
/M: SY='Q';  M=  25, -58,   1, -34, -62, -49, -45, -56,  36, -27, -48, -38, -53,  37,  15,   1,   0, -51, -63, -52; D=-26;
/I:         I=-26; DM=-27;
/M: SY='G';  M= -29, -53, -33,  27, -59,  77, -41, -64, -35, -61, -51,  10, -44, -33,   5,  17, -39, -58, -55, -52;
/M: SY='Y';  M= -16, -56, -44, -41,  46, -51,  77,  -5, -40, -33, -29, -38, -54,  29, -38, -12, -41, -39, -26,  84;
/M: SY='P';  M=  24, -51, -42, -34, -48,  -5,  25, -39,   4,   4, -34, -37,  49,  31,   6,  -5,  15, -13, -56, -43;
/M: SY='Y';  M= -45, -52, -57, -55,  44, -60, -32,   3, -50,  37, -19, -55, -61, -47, -48, -48, -41,  18, -23,  86;
/M: SY='A';  M=  71, -43, -49, -43,  17,  14, -47, -33, -44, -38, -36, -42, -48, -42, -48, -25, -33,  19, -47,   3;
/M: SY='G';  M=  47, -48, -46, -49, -51,  68, -51,  15, -46, -44, -39, -36, -47, -44, -52, -27, -38,  -5, -53, -50;
/M: SY='L';  M= -41, -47, -62, -55, -22, -63, -50,  13, -55,  69,  19, -59, -60, -50, -53, -52, -38,  38, -52, -33;
/M: SY='E';  M=   9, -55, -27,  61,  14,  -4, -34, -17, -25, -45, -41, -35, -43,  40,  24,   0, -37, -44, -47,   8;
/I:         I=-30; MD=-32;
/M: SY='Y';  M=   6, -63, -48,  -7,  29,  -7, -44, -57, -52, -55, -53,  41, -65, -50, -56, -18, -49, -57, -48,  48; D=-30;
/I:         I=-30; MI=-32; IM=-32; DM=-32;
/M: SY='G';  M=  -8, -53, -38, -43, -58,  77,  17, -63, -37, -59, -48,  10, -46,  13,   4,  17, -39, -57, -55, -49;
/M: SY='W';  M=   2, -52,  -2,   0,  21,  11,  47, -46, -34, -22, -38,   8, -48,   4,   6,   9,  15, -45,  53,  26;
/M: SY='E';  M=  21, -55,  20,  73, -54, -15, -36, -53,   3, -48,  21, -34, -39,  16, -32, -32, -38, -48,  52, -44;
/M: SY='C';  M= -78, 293,-118,-118, -98,-109,-118,-112,-110, -94, -94, -90,-140,-125,-122, -83, -78, -88,-158,-120;
/M: SY='Y';  M= -50, -56, -56, -54,  69, -57,  24, -30, -49,  11, -27, -52, -61, -47, -46, -49, -46, -37,  80,  88;
/M: SY='C';  M= -78, 293,-118,-118, -98,-109,-118,-112,-110, -94, -94, -90,-140,-125,-122, -83, -78, -88,-158,-120;
/M: SY='G';  M=  14, -51,  -1, -46, -59,  83, -46, -62, -44, -60, -51, -28, -45, -41, -51,  22, -38, -54, -54, -53;
/M: SY='N';  M=  -7, -48,  36, -33,  17, -10,  18, -48, -34, -48, -43,  69, -48, -34, -40,  15,  23, -46, -52,  29;
/M: SY='D';  M=  -5, -50,  44,  -2, -55, -39, -36, -47,  12, -52, -46,  36,  32, -30,  -4,  34,  20, -10, -64, -47;
/M: SY='V';  M= -16, -47, -43,  -1,   2, -49, -44,  -1, -41,  23, -27,   0,  14,  12, -45,  15,  30,  32, -55, -37;
/M: SY='P';  M=  12, -55,  26,  24, -59, -42, -40, -51, -33, -54, -46, -34,  79,  27, -41,   8,  20, -48, -59, -51;
/M: SY='P';  M=  16, -50, -36, -35,  -6, -37, -34, -46, -31, -23, -40,  44,  52,   5,  21,  37, -29, -45, -50,  18;
/M: SY='W';  M=  13, -48,  -5, -38,  25,  20, -42, -39,   2,  -5, -36,  12, -47,  11, -11,   2,  32, -13,  32, -34;
/M: SY='N';  M=  23, -49, -31,  20,   6,  -8, -36, -49,   6, -49, -42,  38,   7,  32,  -2,  13,  24, -44, -54, -41;
/I:         I=-21; MD=-22;
/M: SY='V';  M=  -1, -51, -43,   8, -42,   5,   6,   2, -42,   4, -33, -40,  -1,  11, -46,  17,  19,  19, -57,  -2; D=-21;
/I:         I=-21; MD=-22;
/M: SY='S';  M= -36, -56, -45, -41, -51,  11,  21,   4,   2,  -8, -39, -37,   2,  12,  19,  45, -35, -15, -60, -45; D=-21;
/I:         I=-21; MD=-22;
/M: SY='D';  M=  -3, -69,  52,   1, -67, -64, -58, -61, -55,  -4, -58, -46, -64, -53, -62, -49,  21, -58, -84, -64; D=-21;
/I:         I=-21; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='S';  M=  -8, -48,  45,  42, -53, -37, -35, -46, -32, -24, -45,   5, -42, -26, -38,  62, -25,  -8, -63, -46;
/M: SY='S';  M=  18, -46, -37,  -7,   3,  22, -40, -45, -36, -47, -42, -29, -43,  33, -40,  59,  23, -15, -54, -41;
/M: SY='E';  M=  -6, -51,  33,  39, -48, -13, -36, -40,  -6,  14, -36,   1, -45,  35, -35,  26, -32,  -8, -58, -43;
/M: SY='C';  M= -78, 293,-118,-118, -98,-109,-118,-112,-110, -94, -94, -90,-140,-125,-122, -83, -78, -88,-158,-120;
/I:         I=-30; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='N';  M=   5, -46,  32, -33, -51,  12, -33, -48, -33, -18, -43,  73, -46, -33, -41,  23,  31, -45, -65, -47;
/M: SY='T';  M=  -2, -47, -41, -36, -39,  -5,  16, -13, -35, -35,  51, -32, -44,  45, -38,  22,  52, -10, -51,  25;
/M: SY='K';  M=  -4, -51,   6,  12, -44, -46, -38, -10,  43, -14, -37,   2,   9, -29,   7,   9,  21,  -2, -53,   6;
/M: SY='C';  M= -79, 288,-116,-114,-100,-108,-116,-112,-108, -95, -94, -91,   9,-123,-122, -83, -78, -89,-155,-120;
/M: SY='P';  M=   2, -49, -41,   0,  38, -44, -43, -38,   8,   6, -35, -38,  53, -37, -40,  35,  21, -38, -48, -34;
/M: SY='G';  M=  24, -51, -40, -49, -59,  86, -46, -62, -45, -60, -50,  14, -46, -42, -52, -25, -41, -54, -53, -54;
/I:         I=-26; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='W';  M=   0, -56,  12,  26, -34, -43,  20, -50, -29, -49, -42,  51,  10,  18,   4, -33, -37, -50,  66,  59;
/M: SY='P';  M=   9, -54, -38,  13, -52,  14,  30, -44,  14, -17, -40, -37,  66, -33,  -5,   9, -35,  -7, -57, -46;
/M: SY='Y';  M=  31, -49,  -6,  -9,   4,  18, -35, -41, -13, -39,  43, -35, -47,   8, -11,  15,   7, -39, -41,  45;
/M: SY='E';  M= -36, -58, -19,  78, -58, -49, -31, -54, -22, -19, -42, -33,  13,  65, -29,   9, -36, -51, -56, -46;
/M: SY='M';  M= -38, -49,   3, -42,  19, -51, -39,   7, -12, -10,  54,  -2,  14, -41, -43,  -5,  31,  23, -45,  38;
/M: SY='C';  M= -78, 288,-118,-119, -95,-111,-118, -11,-110, -86, -88, -91,-137,-124,-122, -85, -78, -77,-153,-116;
/M: SY='G';  M= -28, -55, -39,  -5, -60,  91, -46, -68, -41, -63, -52, -29, -46, -40,  -1, -28, -45, -61, -52, -54;
/I:         I=-30; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='G';  M=  24, -50, -43, -50, -56,  83, -49, -53, -46, -55, -47, -31, -46, -44, -52, -26,  -3, -11, -53, -53;
/M: SY='P';  M= -15, -53,  50,  -3,  36, -46, -40, -36, -41, -10, -38, -35,  54, -40, -46,  18, -33,   7, -48,  16;
/M: SY='N';  M= -35, -51,  31, -32, -47,  27, -33, -50,   1, -20, -43,  53,  13,  13, -37,  23,   4, -49, -54,  17;
/M: SY='R';  M=  33, -50,   4, -37, -34, -45, -35, -36, -26,   6, -32, -38, -51, -32,  56,  -8,   2,  -5, -44,  46;
/M: SY='M';  M= -44, -53, -57, -50,  10, -57,  25,   9, -49,  42,  57, -53,  34, -45, -49, -49, -40,   7,  51,  30;
/M: SY='S';  M= -33, -49,  20,   9,   6, -11, -38,  31, -36, -39, -37,  39, -46,  14, -41,  48, -27,  -3, -57, -39;
/M: SY='V';  M= -35, -50, -53, -46, -32, -10,  24,  39, -45,   0, -22, -46, -53,  35, -46, -42, -35,  62, -53,  15;
/M: SY='Y';  M= -48, -56,   2, -48,  44, -53, -21, -32, -43, -31, -30,   9, -60, -41, -42, -43, -41,  -6, -14, 108;
/M: SY='R';  M= -36, -51,   9,  19,   5, -50, -40,  14, -29, -11, -33, -35, -47,  30,  35,  25,   3,  21, -54, -37;
/M: SY='T';  M= -37, -47,  -4, -39, -34, -48,  30, -31, -36,  10, -31,  19,  10, -37,   1,  -9,  61,   5, -52,  34;
/M: SY='G';  M=  18,  30,  29,  -7, -49,  34, -41,  -6, -39,   6, -37,   2, -48,  27, -43,  16, -34, -39, -57, -46;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	43 in 31 different sequences
Number of true positive hits	43 in 31 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	3
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	DOMAIN
Feature description [info]	WSC
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

31 sequences

GLTX_GLYTI  (A0A1U9VX91), KREM1_HUMAN (Q96MU8), KREM1_MOUSE (Q99N43),

KREM1_RAT   (Q924S4), KREM1_XENLA (Q90Y90), KREM2_HUMAN (Q8NCW0), 
KREM2_MOUSE (Q8K1S7), PFM_CHAGB   (P84675), PK1L_ACRMI  (B8UU59), 
PKD1_HUMAN  (P98161), PKD1_MOUSE  (O08852), SLG1_YEAST  (P54867), 
WSC1_SCHPO  (P87179), WSC2_YEAST  (P53832), WSC3_YEAST  (Q12215), 
WSC4_YEAST  (P38739), WSCD1_ARTBC (D4AUF1), WSCD1_HUMAN (Q658N2), 
WSCD1_MOUSE (Q80XH4), WSCD1_RAT   (Q505J3), WSCD1_XENTR (Q0IIY2), 
WSCD2_ARTBC (D4AUF4), WSCD2_DANRE (A2BGL3), WSCD2_HUMAN (Q2TBF2), 
WSCD2_MOUSE (D4PHA7), WSCK_DROME  (P83097), XYLT_CAEBR  (Q5QQ52), 
XYLT_CAEEL  (Q965Q8), XYLT_DROME  (Q7KVA1), XYLT_DROPS  (Q5QQ53), 
YLU2_PICAN  (P34735)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

8 PDB

5FWS; 5FWT; 5FWU; 5FWV; 5FWW; 7BZT; 7BZU; 7PZ2