PROSITE entry PS51204

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51204
Entry name [info]	HSA
Accession [info]	PS51204
Entry type [info]	MATRIX
Date [info]	01-MAY-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51204
Associated ProRule [info]	PRU00549

Name and characterization of the entry

Description [info]

HSA domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=74;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=69;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6783061; R2=0.0056114; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=11842.0527344; R2=3.2533453; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1216; H_SCORE=15798; N_SCORE=9.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=682; H_SCORE=14061; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-46; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='Q';  M=-133, -17, -60, -41,   4, -72,-125,  25,  15,  38,  -4, -55,  48,  71,   4, -66,-130,-112,-141, -11;
/M: SY='K';  M= -79, -24, -25,  38, -29, -62,  12, -40,  64, -26,-127,-121,  46,  40,  19, -24, -46, -43,-157, -43;
/M: SY='R';  M= -10,-144,  -9,  -8, -10,-148, -18, -14,  38,  -3,  23, -19,  15,  20,  51, -44,   5, -20,-144,  -1;
/M: SY='E';  M=  -6,  23,   9,  58,  -3, -85, -31,   1, -25,  -9,  -2,-127,  32,  47, -67, -22, -19, -10,-150, -45;
/M: SY='Q';  M=  -2,-148, -13,  38, -58, -82,  26, -60, -12, -64, -46, -50,  42,  65,  31,   6, -78,  -6,   0,   9;
/M: SY='E';  M= -33,-155, -54,  82,-156, -14,-125,-133,   4,  -7, -25, -26,  29,  10,  17, -35, -15, -16,-166,-158;
/M: SY='P';  M= -10, -21, -53,  35,-150, -86,-127,-128,  10, -26,  24,  14,  69,   9,  41, -13,-123,   0,  27,-150;
/M: SY='P';  M= -21,-147, -26,  27, -59, -31, -35, -47,  34, -63,-131,   3,  49,  44,  36,  10,   0, -27,-155, -36;
/M: SY='R';  M= -52,-155, -26,  14,-156, -79,-116,   9,  18, -88,-128,  -6,   6,  40,  89, -14, -54, -49,-156,-151;
/M: SY='P';  M=-129,-157, -43,  16, -55,-149,  37, -56,  37, -44,-131,   9,  59,  48,  58, -29, -39, -48,-151, -13;
/M: SY='K';  M= -23,-149, -47,  -3, -35, -60,  24, -10,  72,-143,-129,  22, -31,  54,  19, -22, -56, -43,  43, -24;
/M: SY='T';  M=  -4,-130, -44,-122, -12, -85,-129, -42,  49, -63,-125, -55,-143, -43,  30,  47,  69,  -9,-154,-138;
/M: SY='H';  M=-139,-164,-125,  10,  12,-156, 133,-152,  -1, -44,-134,-110,-153,  48, -29,-127, -26,-150,-138,  12;
/M: SY='W';  M= -51, -40,-139,-123,-128, -74,  42, -45, -18, -27,-122,  -2,-155,  68,  57, -68,  -8, -55, 132,-109;
/M: SY='D';  M= -79,-163, 101,  37, -51, -26,-122,-158, -61, -88,-153,  28,-151,  22, -48, -60, -28, -57,-158,   3;
/M: SY='H';  M= -35,-144, -62, -19,  49, -76,  87, -37,   9, -11,-122, -46,-161,   4,-127, -64, -57,  -7,-108,  87;
/M: SY='L';  M=-137,-135,-156,  -9,  12,-170,   1,  -4, -40,  73,  48,-154,-164, -50,  -8,-144, -30,  20,-142,-124;
/M: SY='L';  M= -33,  -9, -59, -65, -31, -74,-142,  25,-143,  70,  -8,   9, -46,  23, -61, -23, -34,  -1,-149,-135;
/M: SY='Q';  M=  12,-146,   9,  62, -35, -80, -34,-154,  41, -84,-135,   1,-140,  69, -55,  24, -22,-142,-158,-145;
/M: SY='E';  M= -10,-148,-101,  87,-148, -53,  53,  40, -28,-132,-127, -57,-147,  19, -59,  -9, -55, -22,-164, -53;
/M: SY='M';  M=  10,  21,-159, -61, -48,  15,-151,  38,-145,   7, 110, -78,-156,-133, -64, -53, -59,   7,-139, -58;
/M: SY='Q';  M=   6, -25,-120,  -4,-138,-142, -21,  -3,  48,  19,  24,  50,-148,  52, -28, -61,   6, -31,-155,-144;
/I:         I=-17; MD=-42;
/M: SY='W';  M= -54,-154,-136,   9, -52, -48,  11,-155,  -8,-159,-142,  26,-168,-130,-141,  10, -40, -30, 142,  -6; D=-17;
/I:         I=-17; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='M';  M= -74,-137,-152,-143,  55,-159,  94, -21,-141,   3, 106, -57,-158, -52, -62,   2, -50, -47,-124,  -9;
/M: SY='S';  M=  51, -31,-132,-121,-145,   4,-123, -20,   5,-143,-134,-119,-139,  30,  50,  58, -53, -70,-148, -11;
/M: SY='K';  M=  21,-141,  22,  26,-155, -60,-127,  -1,  64,-140,-130,  16,-144, -23,  16, -38,  25,  -8,-166,-151;
/M: SY='D';  M=-135, -16,  92,  38,-146, -51, -22,-136, -23,  18, -37,  -7,-152, -23,  -2, -12, -59, -76,-164, -36;
/M: SY='F';  M= -68,-133,-166,-160, 101,-168,  -7,  -4,-146,   2,  44,-153,-169, -50,  -2, -34, -37,   5,  -1,  20;
/M: SY='Q';  M=  11,-143, -12,  -2, -10,-146,  17, -11,  24, -30,  19, -29,-148,  56,  50, -12,-122, -19,-134,  35;
/M: SY='E';  M= -24,-154,  47,  74,-154,-141,-113, -63, -23,-156,-139,  35,-144,  68, -18, -20,  -2, -80,-156, -10;
/M: SY='E';  M= -12,-151, -28,  84,  15, -29, -27,-140, -10, -45,  -8, -13,-148, -39,  11,   2, -76, -45,-140,  34;
/M: SY='H';  M=  -9,-153, -59, -66,  -4, -86,  87, -55,  25, -58,-131, -61,-149,  20,  82, -24, -16, -47,-146, -41;
/M: SY='K';  M= -70,-151, -56,-115, -58, -52, -38, -69,  76, -36, -30,  -1,-147,   9,  71,  -6, -36, -15,  15,-142;
/M: SY='W';  M= -28,-143, -16, -30,   2, -78, -32, -80,   3, -59,-128,  12,-156,  28,  21,  20, -14, -17, 128,  34;
/M: SY='K';  M= -80,-158, -55,-110, -49, -52,  67, -39,  89,-147, -39,  11,-145,  30,  44,-123,-126, -48,-162,-132;
/M: SY='R';  M= -28,-141,-135, -37,-141,-148,  -5,  30,  45, -22,  38, -27,-149,  25,  66,   9, -23, -11,-154,-143;
/M: SY='A';  M=  51,-134,  17,   4, -48, -16,   7, -28,  20, -25,-129,  38,-143,   2, -27,  -9,   9, -70,  -7, -16;
/M: SY='R';  M=  32,   0,-134, -62,-146, -71,   4, -11,  43, -55,  19,  -4,-145,  32,  56, -25, -22,  18,-153,-144;
/M: SY='A';  M=  69,  63,-145, -56,   7,-132, -25,   5, -63,   0,  21,-135,-142, -26,   1,   5,   2,-110,-145,-130;
/M: SY='K';  M=  -9, -35,-130, -59, -36, -75,  16, -41,  78, -84,-128,-117,-144,  27,  56, -11,  13, -30,-152, -21;
/M: SY='K';  M= -29,-150,-125, -14, -49, -32, -36, -78,  74, -65,-128, -22,-145,  45,  60, -23,  -1, -11,-155, -44;
/M: SY='M';  M= -59,  23,-171,-165,  54,-172,-152,  44,-153,  51,  58, -49,-168,-147, -32, -86,-128,  32,-133,-109;
/M: SY='A';  M=  69,  37,-132,-132,-151,  27,-137,-132, -80,-142, -26,  10,-139,-127, -17,  45,  -5, -10,   2,-148;
/M: SY='H';  M= -22,-155, -26, -31, -61, -45,  66, -43,  41, -90,-132,  22,-148,  66,  63, -52, -52,-144,-142,  19;
/M: SY='M';  M=  57, -14, -57, -22,-128, -36,  18, -30, -21, -25,  71, -43,-143, -19,  17,  12, -46,-118,  70,   0;
/M: SY='C';  M=  -6,  91,-171,-161,-126, -83,-164,  57,-158, -26,  61,-157,-163,-150,-161, -58,-118,  65,-150,-143;
/M: SY='M';  M=  40,-131, -30,  17,-132, -73,-127,  17, -11,  -3,  61,  26,-146,  29, -13,  -7, -21, -17, -26, -19;
/M: SY='Q';  M=   8,-144,  27,  33,-157,-136,-116,-148,  29, -37,-131,  40,-143,  63,  22,  -1,  32,-138,-159,-151;
/M: SY='H';  M= -22,-143,-142, -20,  42, -59,  94, -58,-145, -12,-126, -43,-163, -35,-138, -27, -14, -48,  65,  91;
/M: SY='H';  M=-143, -17,-150,-143,  44, -43, 123,  -5,-149,  -6, -39,-126,-164,-118,-133, -55,-136, -18, 107, -22;
/M: SY='Q';  M=   9, -43,-121,  14, -32, -52,   9, -29,  40, -32,-124,   9,-145,  46,  29,  12,  31, -31,-149, -17;
/M: SY='N';  M= -17,-148,  15,  24, -59, -73,  55,-147,   1, -38,-136,  65,-151,  31,  35, -15, -12, -77,-140,  37;
/M: SY='K';  M= -72,-140, -11, -55,-137,  -1,-128,  12,  46,   8,  15, -43,-151,  25,  39, -17,  41, -16,-153, -36;
/M: SY='E';  M=  10,-153, -31,  82, -21,-142, -22,-150,  36, -87, -32,  23,  14,  29, -24, -57, -63, -65,-163,-145;
/M: SY='K';  M= -39,-153,-125,  15,-156,  12,-125, -24,  68, -56,-128,-121,   3,  14,  61, -70,  -8, -10,-163,-154;
/M: SY='E';  M=  11,  41,  21,  77,-156,-143, -16, -32,  11, -37,  -5,  -4,-145,  12,  12, -14, -60,-133,-165,-152;
/M: SY='E';  M= -41,  48,  12,  79,-159,-149,  25, -43,  28, -50,-136,-118,   7,  20,  24, -37, -59, -83,-167,-150;
/M: SY='Q';  M= -38, -35, -50,  60,-154,-146,-113, -11,  42, -41,-123, -14,-143,  86,   8,   0,-120, -27,-157,-150;
/M: SY='K';  M= -53, -31,  -2,  -7,-144,-146,-119, -62,  75, -36,  20, -15,-147,   8,  71,-122, -10, -75,-153, -11;
/I:         I=-18; MD=-45;
/M: SY='R';  M= -29,   2, -26,   9, -10,-161,   4, -34,  17, -10,-131,-134,-161,  12,  68, -76, -61, -65,  14,-140; D=-18;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='I';  M=   1,-138, -67,  22,-137, -24,-137,  50,  41,   5,  -6, -35,  14, -23,  17, -60, -48,   3,-161,-148;
/M: SY='E';  M=  21,-149, -12,  88, -50,-142, -36, -18,  20, -47, -25,-120, -66,  22, -31,  -1, -61, -78,-164,-149;
/M: SY='R';  M= -53,-158, -52,  18, -51, -75,  -4, -45,  63, -83,-133, -45, -48,  20,  83,   2,-123, -78,-158,-144;
/M: SY='E';  M= -45,-140, -41,  59, -69,-149,-125,  42,   5, -35,  20,  36, -30,  38, -56, -42,  35, -41,  -9,-144;
/M: SY='E';  M=  54,  11, -52,  76,-154, -74,-126, -24, -62, -18,-128,-127,   0,  32,  -9, -17,-119, -81,-160,-154;
/M: SY='K';  M= -40,-153, -19,  58,-160,-140, -55, -31,  81,-151, -33, -45, -23, -21,  22,  27,-118,-140,-171,-153;
/M: SY='Q';  M= -11, -32, -49,  56,-139,-144,-111,-136,  29, -34, -10,  21, -40,  83, -19, -14,-121, -17,-144,  16;
/M: SY='R';  M= -43,-161,  15, -28,-156,-147, -35, -68,  24, -43, -33,   9, -64, -33, 103,-126,-129, -40,   1,-147;
/M: SY='L';  M= -62,-134, -31,-149,-116, -35, -39,  58,   8,  65,  46, -24,-162,-135, -27, -46, -63, -63,-153,-139;
/M: SY='Q';  M= -25,-155,-120,  -1,-156,-144,   7,-148,  59, -49,-127,  15, -31,  82,  63, -56, -54, -53,-154,-146;
/M: SY='A';  M=  62,  -1, -34,-127,-138, -52,-131,   2,   8,  -6,  33, -26, -34,  -2,  42,  -3, -61, -37,-149, -45;
/M: SY='L';  M= -20, -13, -31,-146,  19,-162,   8,  14,  12,  68,  -4, -65,-161, -41,-136, -45,-128,   7,-140, -13;
/M: SY='W';  M=  39,-138,-130, -31,-139,-135,-127, -61,  68, -78,  41, -37, -27,   4,  25,  25,-116,-131,  79, -36;
/M: SY='S';  M=  43,-131, -13,  -9, -24, -29,-130,  10,  30,  -8, -44,   4,-142, -11,   8,  43, -26, -66,-155,-140;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	51 in 51 different sequences
Number of true positive hits	50 in 50 different sequences
Number of 'unknown' hits	0
Number of false positive hits	1
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	98.04 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	HSA
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

50 sequences

BRM_DROME   (P25439), DOM_DROME   (Q9NDJ2), EAF11_MYCMD (Q4P209),

EAF1A_ARATH (F4J7T3), EAF1B_ARATH (F4J7T2), EAF1_ASPFU  (Q4WP03), 
EAF1_CANAL  (Q5A119), EAF1_CRYNB  (P0CO99), EAF1_CRYNJ  (P0CO98), 
EAF1_DEBHA  (Q6BI82), EAF1_EMENI  (Q5B4Q8), EAF1_EREGS  (Q756L0), 
EAF1_GIBZE  (Q4IB96), EAF1_KLULA  (Q6CMB8), EAF1_NEUCR  (Q7SBU6), 
EAF1_YARLI  (Q6C7K8), EAF1_YEAST  (Q06337), EAF_SCHPO   (O59773), 
EP400_HUMAN (Q96L91), EP400_MOUSE (Q8CHI8), HEPF1_PLAF7 (C0H4W3), 
PIE1_ARATH  (Q7X9V2), SMCA2_HUMAN (P51531), SMCA2_MOUSE (Q6DIC0), 
SMCA4_BOVIN (A7Z019), SMCA4_HUMAN (P51532), SMCA4_MOUSE (Q3TKT4), 
SMCA4_RAT   (Q8K1P7), SNF21_SCHPO (Q9UTN6), SNF22_SCHPO (O94421), 
SNF2_YEAST  (P22082), SRCAP_HUMAN (Q6ZRS2), SSL1_CAEEL  (Q9NEL2), 
STH1_YEAST  (P32597), SWR1_ASPFU  (Q4WAS9), SWR1_CANAL  (Q59U81), 
SWR1_CANGA  (Q6FK48), SWR1_CRYNJ  (P0CO18), SWR1_DEBHA  (Q6BKC2), 
SWR1_EMENI  (Q5ARK3), SWR1_EREGS  (Q759G7), SWR1_GIBZE  (Q4IAK7), 
SWR1_KLULA  (Q6CJ38), SWR1_MYCMD  (Q4P328), SWR1_NEUCR  (Q7S133), 
SWR1_SCHPO  (O13682), SWR1_YARLI  (Q6CA87), SWR1_YEAST  (Q05471), 
SWSN4_CAEEL (G5EF53), SYD_ARATH   (F4IHS2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False positive sequences

1 sequence

YPF17_PLAF7 (Q8ILR9)

PDB
[Detailed view]

47 PDB

4I6M; 5I9E; 5Y81; 6GEJ; 6GEN; 6IGM; 6K15; 6KW3; 6KW4; 6KW5; 6LTH; 6LTJ;
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