PROSITE entry PS51203

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51203
Entry name [info]	CS
Accession [info]	PS51203
Entry type [info]	MATRIX
Date [info]	01-MAY-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51203
Associated ProRule [info]	PRU00547

Name and characterization of the entry

Description [info]

CS domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=92;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=87;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.6717743; R2=0.0056106; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=12781.6074219; R2=3.5854430; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1396; H_SCORE=17787; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=1039; H_SCORE=16507; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-19; D=-100; I=-100; B1=-1000; E1=-1000; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='M';  M= 12,-33,-13,-24,-46,  2, -2,-18,  3,-17, 36,  5,  9,  6, -4, 10, 13, 16,-13,-16;
/M: SY='V';  M= -8,-31,-10,  0,-60,-13, -7, 11, -2, -5,-20, -5, 22, 25, -1, 17,  2, 25,-69,-57;
/M: SY='T';  M=-14,-34,-13,  7,  0,-16, 21,  0, 10,-18,-60,  1, 23, 12,-13,-15, 40, -3,-65,  7;
/M: SY='P';  M= -6, 31,-12,  9, -9,-44,-31,-23, 16,-14,-36,-27, 81,-55,-54,-24,  2,-11,-65, -7;
/M: SY='R';  M=-11,-61,-12, 17,-22,-27,  5,-37, 38,-42,-60,  7, 22, -3, 52,  9, -7,-42, -6,-28;
/M: SY='Y';  M=-39,-32,-50,-47, 48,-55, 34,  1,-60, -7,  6,-29,-66,-61,-52,-56, -8, 22, 24, 89;
/M: SY='D';  M=-14,-33, 52, 24,-20,-52,-28,-40,  9, -3,-38,-34,-56,  1,-10, 31, 29,-30,-67,  2;
/M: SY='W';  M=-77,-54,-71,-41, 31,-49,-19,-46,-62,-28,-69,-84,-66,-59,-51,-47,-80,-53,166, -7;
/M: SY='Y';  M= 33,-12,  9, -7, 14,-24, 17,-46,-23,-54,-61,-19,-58,-11, -9, 25, 34,-56,-59, 54;
/M: SY='Q';  M=-49,-58,  8, 23,-75,-64,-48,-68,-51,-52,-64,-43,-53,122,-34,-42,-60,-74,-61,-58;
/M: SY='T';  M=-52,  3, 21,-24,-64,-18,-31,-63,-31,-58,-64,  2,-56,-38, 43, 45, 72,-58,-72,-59;
/I:         I=-22; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='P';  M=-18,-59, 29, 29,-49,  0, 12,-18, 12,  5,-36, 12, 41,-40,-36, 15,-19,-39,-67,-28;
/M: SY='D';  M=-32,-58, 58, 42,-52, -4,-15,-67, 20,-60,-64, 33,-54,  6,-26, 21, 14,-65,-69,-44;
/M: SY='E';  M=-29,  0, 41, 45, 24,-62, 13,-35,  4,-41,-62, 14,-56, 14,-43, -1, 19,-31, -8, 19;
/I:         I=-18; MI=0; MD=-18; IM=0; DM=-18;
/M: SY='V';  M=-30,-32,-61,-64,-48,-65,-60, 50,-63, 27, -7,-58,-70,-66,-59,-56,-52, 75,-72,-48;
/M: SY='Y';  M=-58,  0, -8, 19, 32,-54, -2,-13, -7,-23,-38, 22,-60,-38,-38,-37, 52,  5,-57, 56;
/M: SY='I';  M=-23,-30,-62,-62, -5,-64,-58, 57,-61, 42, 24,-57,-70,-64,-60,-57,-54, 51,-69,-47;
/M: SY='T';  M=-13, -3,-19, -2,-13,-61,-15,-48, -3,-24,-16, 25,-38, -3, 12, 28, 54,-18,-65, 32;
/M: SY='I';  M=-37,-58,-66,-66, 41,-64,-60, 73,-63, 17,-54,-56,-70,-65,-60,-55,-41, 45,-66,-33;
/M: SY='Y';  M=-47,  0, 17, -1, 22,-62, 10,-63, 16,-18,-44,  6, 45,-26, 18, -2, -4,-38,-56, 54;
/I:         I=-28; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='V';  M=  5,-11,-59,-60, -8,-54,-36, 30,-50, 40,  7,-58,-68,-62,-26,-34, -3, 50,-69,-17;
/I:         I=-11; MD=-12;
/M: SY='P';  M=-27,-65,-21,  5,-30,-29, -4,-57, 46,-64,-66,-11, 77, -5,-13, 16, -3,-49,-68,-41; D=-11;
/I:         I=-11; MD=-12;
/M: SY='N';  M=-25,-71, 19,  5,-55, 20,-38,-38, 11,-43,-19, 31,  6,-14,-29, -5,-67,-51,-70, 16; D=-11;
/I:         I=-11; MD=-12;
/M: SY='G';  M=-37,-86,-11,-22,-85,  8,-81,  1,-22,-27,-85,-24,-33,-81,-19,-18,-38,-48,-19,-35; D=-11;
/I:         I=-11; MI=0; MD=-12; IM=0; DM=-12;
/M: SY='V';  M=  1,-36,-52,-23,-11,-56,-27, 14,-42,  5, 10,-65,-37,-21,-28,-40, 15, 37,-78,-29; D=-11;
/I:         I=-11; DM=-12;
/M: SY='D';  M=-47,-41, 51,-40,-66,-60,-14,-39, 40,-35,-63, 36, -4,  0, 13, 22, 19,-30,-22,-61; D=-11;
/I:         I=-11; DM=-12;
/M: SY='P';  M= 25, 21,-32,  4,-63,-16, -3, -4, 36,-35,-38,-55, 39,-12, -3, 18, -9, -7,-68,-44;
/M: SY='K';  M=-27,-60, 32, 37,-44,-12,-54,-56, 55,-60,-60, -9,-40,-36, 13, 35,  0,-40,-66,-38;
/M: SY='D';  M=-32, -4, 77, 18,-39,-23,-26,-67,  7,-44,-44, 43,-57, -3,-35, 17,-14,-42,-71,-25;
/M: SY='V';  M=-13,-21,-58,-12, -6,-63,-56, 40,-58, 26, -8,-43, 16,-29,-46,-19,-24, 51,-67, -4;
/M: SY='K';  M=-33,-59, 33, 20,-24,-60,-16,-15, 43,-38,-59, 30,-56, 39,  3,  8, -3, -4,-25,-58;
/M: SY='V';  M=-15, 23,-43,-64, -6,-53,-61, 57,-62, -5,-37,-57,-69,-45,-58,-36,-32, 68,-68, -6;
/M: SY='D';  M=-45,-58, 47, 43,-33,-49,-14,-12, 29,-32,-11, 28,-56,-11,  0,-11, 10, -8,-67, -9;
/M: SY='F';  M=-24,-17,-66,-64, 66,-35,-60, 60,-47, 15,-10,-55,-49,-42,-58,-35,-25, 23,-61,-45;
/M: SY='T';  M=-26,-59, 11, 26,-45,-15,-55,-50, 31,-36,-60, 16,-54, 27,-15, 15, 59,-30,-70,-60;
/M: SY='P';  M=-22,-25, 34, 38,-51,-11,-31,-52, 25,-50,-17, 24, 41, -5,-25, 21, -7,-29,-68,-63;
/I:         I=-26; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='N';  M=-43,-59, 42, -5,-45,-36, 19,-41, 19,-28,-60, 54,-57, 24, 18,  9, 33,-45,-73,-60;
/M: SY='H';  M=-24,-14,-10,-11, -1,-41, 59,-33, 16,-40,  8,  5,-36,-18, -2, 52, 19,-26,-67,  4;
/M: SY='L';  M=-48,-11,-63,-62, 50,-65,-58, 44,-62, 54,-16,-58,-70,-65,-59,-42,-56, 28,-63,-42;
/M: SY='S';  M=-54, -1, -6, 15,-18,-60, 29,-27, 38,-31,-59,  4,-56,-16, 14, 44, 28,-19,-67, -5;
/M: SY='F';  M=-15,-60,-65,-65, 61,-41,-60, 42,-61, 17,  2,-57,-71,-66,-41,-55,-56, 55,-62,-28;
/M: SY='S';  M=-26,-15,-10,  2, -7,-17,  8,-31, 26,-41,-35,  9,-36,  1,  1, 56,  2,-14,-65,  6;
/I:         I=-6; MD=-7;
/M: SY='I';  M= 24, 22,-61,-60, 32, -3,  5, 39,-60, 13,  8,-27,-31,-45,-42,-30,-58, 11,-63,  7; D=-6;
/I:         I=-6; MD=-7;
/M: SY='K';  M=-42,-69,-40,-18,-45,-55, 11,-15, 50,-11,-22,-25, 19, -7,  3,-14, -1,  2,-73,-21; D=-6;
/I:         I=-6; MD=-7;
/M: SY='N';  M=-36,-81,-25,-52,-25,  6,-39,-22,-76,-18,-38, 16,-37, -3,-59, 11,-14,-23,-88,-79; D=-6;
/I:         I=-6; MI=0; MD=-7; IM=0; DM=-7;
/M: SY='P';  M=-21,-87, 11,-34,-44, -7,  8,-45, -7,-70,-87, -2, 12,-27,-58,-12,-42,-53,-92,-86; D=-6;
/I:         I=-6; DM=-7;
/M: SY='D';  M=-34,-79, 25, -1,-85, 25, -6,-82,-16,-59,-44, 21, -8,-47,-36,-27,-16,-68,-82,-42; D=-6;
/I:         I=-6; DM=-7;
/M: SY='N';  M=-54,-69,  1, 13,-74, 32,-10,-72, 15,-45,-70, 34, 12,  7,-11, -8,-27,-49,-71,-29; D=-6;
/I:         I=-6; MI=0; MD=-7; IM=0; DM=-7;
/M: SY='N';  M=-24,-59, 16, 26,-49, -2, 19,-43, 31,-35,-21, 42, 13, -2,  6, 10,-11,-20,-68,-42;
/M: SY='Y';  M=-30,-61,  6, 31,-24,-21, 16,-31, 21,-36,-35,-27, 29, 19, 11,  1,  4, -6,-60, 35;
/M: SY='Y';  M=-39,-35,-59,-58, 34,-65, -3,  8,-15,-10,-60,-36, 11, -4,  6, -7,-12, 15,-18, 82;
/M: SY='Y';  M=-35, -9,-26, 21, 28,-56, 18, 30, -1, 22,-37,-23,-61, 14,-37, -9,-46,  2,-58, 36;
/M: SY='F';  M=-26, 16,-16,-58, 50,-55,-58, 18,-16, 41,-34, -2,-46,-44,-10,-24,-42,  8, 42, -6;
/M: SY='D';  M=-46,-58, 44, 33,-64,-27, 24,-24,  9,-18,-61, 25,-56, 14,-26, 17, 19,  0,-69,-14;
/M: SY='G';  M=-13,-29, -3,-33,  0, 38,-14, 16, -5, 30,-10,-10,-21,-40, -5,-53,-45, -4, 19,-16;
/M: SY='E';  M=-40,-29, 43, 44, -7,-51, 13,-67, 34,-49,-11, 11,  7, 21,  8,-21, 10,-36,-67,-59;
/M: SY='L';  M=-48,-53,-59,-57, 55,-66,-56,-38,-61, 76,-50,-59,-24,-63,-59,-57,-20,-48,-60,-22;
/M: SY='Y';  M=-18,  7,-61,-39, 64,-51, 15,-59,-35, -5,-63,-17,  6,-38,-14,  9,-32,-57, 56, 75;
/M: SY='H';  M= 24,-62, 32,  0,-48, 31, 48,-65, 29,-52,-60, 29,-55,-23,-27, 16,-44,-64,  2,-64;
/M: SY='P';  M= -9,-34,  5, 46,-66,-59,-29,-29, 21,-19,-64,  3, 61,-18,  8, 14,-21,-33,-68,-61;
/M: SY='I';  M=-54,-59,-43,-67,-51,-62,-61, 88,-64,-26,-54,-55,-69,-65,-62,-55,-42, 57,-72,-52;
/M: SY='D';  M=-30,-14, 70,-10,-65,-49,-31, -4, 29,-23,-61, 48,-59,-14,-53,-10,-34, 17,-74,-60;
/M: SY='P';  M=-10, -1, 20,  9,-33,-38, -4,-38,-10,-35,-68,-47, 78,-56,-55, 19,  3, 18,-70,-60;
/M: SY='E';  M=  1,-54, 55, 69,-55,-38,-27,-68, -4,-59,-64, 26,-53, -7,-42, 18,-26,-42,-69,-64;
/M: SY='E';  M= -2, 15, 48, 48,-35,-12,-54,-65, 16,-24,-62,  6,-40,  7,-14,  9, -7,-23,-67,-61;
/M: SY='S';  M=  5, 56,-18,-31,-43,-44,-54,-59,-53,-41,-68,-53,-44,-41,-39, 85, -2, -6,-71,-18;
/I:         I=-20; MD=-21;
/M: SY='T';  M=-25,-38,-55,-10, -9,-62,-17,-25, 37,-34, -9,-40,-58,-13,  7, 40, 45,  0,-13,  3; D=-20;
/I:         I=-20; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='W';  M=-16, -9,-30,-57, 17,-58, 25,  0,-25,-46,-62,-51,-64,-28,-30,-37,-18, 18,129, 58;
/M: SY='T';  M=-39, -7,-21,-39,-19,-51,  2,-41, 44,-45,-36, 31,-36, 15, 15, 11, 53,  3,-70,-28;
/M: SY='I';  M=-22,-36,-45,-41,  8,-52, -5, 54,-59, 16, 26,-20,-45,-61,-16,-55, -2, 44,-26,  2;
/M: SY='E';  M=-16,-58, 26, 41,-19,-25, -3,-33, 17,-11, -8, -7,-55, -9, -5, 15, 34,-36,-65,  5;
/I:         I=-7; MI=0; MD=-8; IM=0; DM=-8;
/M: SY='G';  M=-24,-28, 35,  8,-69, 41,-55,-64,  5,-47,-35,-11, 30,  9,-45, 30, -6,-14,-65,-64; D=-7;
/I:         I=-7; DM=-8;
/M: SY='R';  M=-48,-62, 11,-15,-26, 16,-18,-64, 39,-33,-15, 33,-44,-22, 46,  9, 26,-50,-65,-31;
/M: SY='K';  M=-38, 43,-29,  6,-13,-20,-14, -7, 46,-11,  1, -2,-57, 19, 17,  1,  7,-17,-63,-10;
/M: SY='I';  M=-42,-57,-62,-41, -2,-64,-58, 61,-62, 41,-30,-40,-54,-63,-33,-56,-54, 49,-67,-10;
/M: SY='E';  M=-34,-36, -1, 60, -4,-63, 39, -6,-28,-30,-60,  7,-56, 10,-23,  0, 14, 19,-65, -5;
/M: SY='I';  M=-42,  7,-64,-63, 28,-64,-59, 70,-62, 34,-14,-56,-69,-64,-33,-47,-56, 32,-65,-26;
/M: SY='T';  M=-42, 14,-21,-13,-28,-61, 17,  5, 33,-25,-35,  8,-58, -7, -3, 19, 47, 19,-70,-23;
/M: SY='L';  M=-50,-12,-58,-57,-22,-65,-54, 18,-60, 74, 37,-59,-69,-61,-33,-59,-55,  6,-65,-28;
/I:         I=-28; MD=-29;
/M: SY='R';  M= -4,-61,-18, 20,-18,-63,-31,-17, 25,-49,-19,-57, 25, 37, 44, -9,  5,  4,-65,-31; D=-28;
/I:         I=-28; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='K';  M=-55,-67,-49,-34,-60,-58,-58,-68,107,-63,-47,-49,-47,-54,-39,-28,-62,-67,-64,-60;
/I:         I=-18; MI=0; MD=-18; IM=0; DM=-18;
/M: SY='K';  M= 21,-66,-42,-10,-64,-54,-60, -5, 55,-21, -8,-14,-32, 29,-10, -4,-48, -8,-11,-63; D=-18;
/I:         I=-18; DM=-18;
/M: SY='E';  M=-24,-37, 27, 56,-68,-21,  6,-49, 23,-45,-60, 27,-43, 16,-13, -6, 24,-13,-68,-61;
/M: SY='P';  M=-20,-27,-16, 40,-46,-34, -6,-39, 26,-26,-64,  1, 65, 27,-12, 19,-30,-67,-65,-32;
/I:         I=-17; MD=-18;
/M: SY='G';  M= -7,-33,-15,  8, -9, 50,-34, -7,  7,-39, 35, 22,-18,  0,-42,-14, -5,-46,-62,-40; D=-17;
/I:         I=-17; MD=-18;
/M: SY='E';  M=-61,-72, -5, 44,-84,-80, -2,-46,-33,-24,-78,-16, -4, 29,-69,-38,-17, -2,-85,-75; D=-17;
/I:         I=-17; MI=0; MD=-18; IM=0; DM=-18;
/M: SY='W';  M=-36, -1,-58,-21,-13,-38, 24,-10, 16,-34,  5,-15,-28,  0, 19, 10, -1,-19,107, 38;
/M: SY='W';  M=-79,-53,-72,-55, 11,-38,-71,-70,-62,-62,-72,-90,-65,-59,-50,-42,-84,-75,172,-21;
/M: SY='P';  M=-12,-61, 14, 24,-68,-25,-48,-66, 18,-31,-33,  6, 80,-26,-53, 24, -7,-43,-69,-63;
/M: SY='R';  M=-21, 48, 14,-30,-33,-28, 14,-64, -2,-45,-63,  3,-58, 23, 53, 35, 22,-33,-65,-18;
/M: SY='L';  M=-35,-13,-56,-56,-30,-65,-56, -3,-62, 76,-49,-60,-28,-62,-60,-59,-54, 28,-23,-18;
/M: SY='T';  M=-56,-14, 10, 38, 29,-36,  0, 13,-17, 14,-58,  5,-59,-40,-33,-29, 39,  7,-66,-52;
/I:         E1=0; IE=-105; DE=-105;

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Post-processing [info]

COMPETES_HIT_WITH

PS01031

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	111 in 108 different sequences
Number of true positive hits	110 in 107 different sequences
Number of 'unknown' hits	0
Number of false positive hits	1
Number of false negative sequences	6
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	99.10 %
Recall (true positives / (true positives + false negatives))	94.83 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	CS
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	107 sequences BOB1_ARATH (Q9LV09), BOB2_ARATH (Q9STN7), CHRD1_BOVIN (Q29RL2), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	6 sequences DAA11_BOVIN (Q1RMR5), DAA11_DANRE (B3DH20), DAA11_MOUSE (O88978), » more
UniProtKB/Swiss-Prot False positive sequences	1 sequence SKL2_ARATH (O82290)
PDB [Detailed view]	27 PDB 1EJF; 1RL1; 1WFI; 1WGV; 1WH0; 1X5M; 2CG9; 2CR0; 2JKI; 2K8Q; 2KMW; 2MNW; » more