PROSITE entry PS51199

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51199
Entry name [info]	SF4_HELICASE
Accession [info]	PS51199
Entry type [info]	MATRIX
Date [info]	01-MAY-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51199
Associated ProRule [info]	PRU00596

Name and characterization of the entry

Description [info]

Superfamily 4 helicase domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=267;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=262;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2020674; R2=0.0088585; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=8994.6513672; R2=18.2528095; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=1784; H_SCORE=41558; N_SCORE=18.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=881; H_SCORE=25075; N_SCORE=10.0; MODE=1; TEXT='?';
/DEFAULT: M0=-25; D=-150; I=-150; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='S';  M=   3, -70,   6,  -4, -14,   4,  -1, -19,   2, -23, -25,  25,  13,   8,  23,  26,   8, -23, -89, -67;
/M: SY='D';  M= -30, -77,  30,  10, -78,  16,  24, -39,  28, -31, -65,  25,  20,  27, -17,  11,   0, -24, -90, -24;
/M: SY='G';  M= -12, -75,  14,  16, -81,  35,   8, -11,  20, -47, -65,  -5,  10,  14,   3,  17,  -3, -17, -91, -49;
/M: SY='P';  M=  -1, -70,   5,  15, -69,  25,  15,  -2, -16,  -1, -26,  -8,  31,   3, -62,   2, -17,  16, -86, -27;
/M: SY='I';  M=  -5, -66, -38, -11,  -4, -44,  21,  34,   0,   9, -43,  24,  18,  -7, -37, -23, -23,  25, -74,  14;
/M: SY='T';  M= -30,  -9,  -3, -30,  -3,  10,  14,  -6,  12, -34,   1, -15,  20,  -1, -16,   0,  48, -11,  30, -17;
/M: SY='G';  M= -40,  -6, -26, -74, -63,  82, -62, -11, -70, -32, -70,  11, -27, -27, -36, -37, -65, -14, -73,  33;
/M: SY='I';  M= -36, -64, -84, -75, -18, -28, -15,  42, -17,  35,  10, -76,  28, -25,  -5, -32, -21,  33, -74,   5;
/M: SY='P';  M=  -8, -68, -30, -12,  24, -70, -63, -65, -14, -57, -66, -54,  75, -56, -34,  48,  26, -26,  52, -16;
/M: SY='T';  M= -44, -38, -55, -12, -31, -33, -56, -57, -19, -27, -57,  -1, -73, -53, -37,  47,  81, -33,  47,  17;
/M: SY='G';  M= -48, -82, -43, -68, -37,  81, -33, -94,  -9, -90, -85,  -3,  41, -63,   3,  -6,  -3, -85, -87, -17;
/M: SY='F';  M= -75,  -6, -94, -94,  93, -50,  -4,  -9, -89,  11,  -9, -84, -11, -82, -87, -76, -12, -51,  60,  58;
/M: SY='W';  M= -16,  -5,  -5,  -4, -33, -21,  12, -35,  22, -46,   5, -39,  55, -21,  -3,   5,  26, -28,  56,  16;
/M: SY='D';  M= -33, -82,  65,  33, -46,  24, -14, -42,  12, -24, -69,  26, -29, -24, -14,   5, -43, -33, -98, -78;
/M: SY='L';  M= -71, -63, -30, -86,   4, -98, -80,  16, -43,  78, -15,  -8, -92, -74, -35, -77, -33,  -3, -74, -58;
/I:         I=-45; MD=-77;
/M: SY='D';  M= -38, -85,  93, -34, -89, -63, -53, -83, -55, -26, -78,  71, -80, -20, -28, -24,   1, -81,-112, -86; D=-45;
/I:         I=-45; MI=-77; IM=-77; DM=-77;
/M: SY='K';  M= -26, -83,  41,  26, -89, -27, -48, -41,  45, -48, -67,  29, -73,  37,  45,   3, -26, -73, -95, -80;
/M: SY='M';  M= -32,  -8, -79, -41,   6, -48, -63,  22,  16,  42,  77, -20, -29, -38, -23, -66, -15, -29, -64,  26;
/I:         I=-36; MD=-61;
/M: SY='T';  M= -54,  -1, -67, -29, -28, -80, -71,   8, -17,  25,  -1, -24, -78, -61, -66, -38,  88, -17,  15, -65; D=-36;
/I:         I=-36; MD=-61;
/M: SY='Y';  M= -12,   2, -11, -60,  -4,  39,  -8, -39,  16, -20, -13,  24, -82,  -2, -57,  24,  -4, -66, -65,  49; D=-36;
/I:         I=-36; MD=-61;
/M: SY='G';  M= -47, -86, -63, -38, -96,  97, -76,-101, -74, -61, -89, -52, -90, -29, -80, -30, -13, -91, -94,-100; D=-36;
/I:         I=-36; MI=-61; MD=-61; IM=-61; DM=-61;
/M: SY='F';  M= -42, -68, -93, -90,  73,  -3, -24,   6, -84,  48,   5, -85, -97, -27, -40, -77, -67,   6,  24,   1; D=-36;
/I:         I=-36; DM=-61;
/M: SY='R';  M= -22, -83, -58, -18, -34, -48,  54, -70,  29, -32, -21, -10, -38,  68,  69, -54, -59, -29, -80, -14;
/M: SY='P';  M= -35, -83,  19,  -3, -76,  -2, -29, -41,  32, -78, -25,  26,  71,  16,  14, -30,  -5, -73, -84,  12;
/I:         I=-45; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='G';  M= -16, -77, -41, -19, -93,  89,   9, -97, -66, -95, -87, -38, -34, -41, -52,  29, -20, -85, -93, -86;
/I:         I=-45; MD=-77;
/M: SY='E';  M= -63, -94,  68,  77, -96, -42,   5, -93, -17, -92, -77,   7, -74,  40, -33, -30, -20, -84, -15, -81; D=-45;
/I:         I=-45; MI=-77; IM=-77; DM=-77;
/M: SY='L';  M= -69, -61,-102, -94,  22,-103, -85,  20, -87,  75,  51, -94, -95, -77, -85, -59, -62,  12, -69, -52;
/M: SY='I';  M= -57, -10, -77, -79, -48, -41, -72,  67, -76, -12, -19,  -7, -87, -74, -79, -19,  54,  33,  25,  20;
/M: SY='I';  M= -27, -55, -91, -87, -51, -29, -90,  72, -84,  21,   2, -85, -90, -81, -85, -66,  17,  54, -82, -68;
/M: SY='W';  M= -65, -59,-102, -94,  -5,-104, -93,  56, -90,  48, -22, -98, -96, -84, -89, -82, -59,  55,  76, -52;
/M: SY='A';  M=  69, -54, -65, -61, -76,  36, -68, -28, -61, -30, -59, -24, -66, -22, -68,   4,  37, -28, -90, -77;
/M: SY='A';  M=  75, -58, -66, -65, -85,  67, -72, -76, -64, -79, -73, -59, -67, -65, -72, -17, -51, -59, -91, -84;
/M: SY='R';  M= -39, -83, -69, -60, -74,  26, -51,   1, -28, -68, -65, -24,  18, -43,  90, -26, -33, -11, -82,   1;
/M: SY='P';  M= -48, -72, -58, -61, -92, -72, -66, -79, -61, -80, -77,  19, 107, -61, -67,  26,  47, -70,-104, -89;
/M: SY='G';  M=  16, -67, -55, -64, -89,  76, -65, -89, -63, -89, -81,   2, -75, -62, -69,  63, -43, -77, -94, -86;
/M: SY='M';  M= -17, -58, -81, -70, -54, -84,  39,  14, -65,  -1, 102, -28, -85, -21,  -7,   5, -50,  44, -74, -59;
/M: SY='G';  M=  -4,  -9,  -6,  -8, -10,  10,  -8, -11,  -8, -10, -10,  -5,  -9,  -8,  -8,  -5,  -7, -10,  -9, -10;
/M: SY='K';  M=  -6,  -9,  -5,  -3, -10,  -7,  -5,  -8,  11,  -8,  -7,  -4,  -7,  -2,  -1,  -5,  -6,  -8, -10,  -8;
/I:         B1=0; BI=-105; BD=-105; E1=0; IE=-105; DE=-105;
/M: SY='T';  M=  -4,  -5,  -5,  -6,  -8,  -6,  -6,  -6,  -6,  -7,  -6,  -4,  -7,  -5,  -6,   6,  10,  -5,  -9,  -7;
/M: SY='T';  M=  50, -55, -26,   8, -34, -59, -61, -28, -55, -14, -53, -18, -67,  14, -62,  25,  63, -25, -88, -70;
/M: SY='F';  M= -75, -69, -98, -68,  93, -48, -69, -30, -92,  49,  15, -91,-102, -83, -89, -83, -70, -14,  45,   7;
/I:         I=-45; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='A';  M=  65,  34, -80, -70, -60, -46, -76,   0, -69,  26,  34, -74, -71, -66, -75, -14,  -7,  17, -83, -71;
/M: SY='L';  M= -60,  34, -10, -43, -53,  -1,  -9,   9, -60,  48,  38, -14, -86,   3,  19,   6,  -6, -34, -79, -20;
/M: SY='N';  M= -31,  -6,  10,  23, -58, -41,  48, -87, -18, -83, -23,  91, -77,  53, -47, -11, -27, -81, -97, -66;
/M: SY='I';  M= -41,  -6, -96, -86,   8,-101, -36,  62, -82,  45,  59, -88, -94, -16, -82, -76, -42,  21, -66,  13;
/M: SY='A';  M=  78,  -1, -75, -65, -65, -40, -73,   0, -64,   5,  24, -70, -66, -62, -72,   5, -44,   8, -85, -72;
/M: SY='L';  M= -17,  -6,  -6,   0,   5, -82, -54, -23, -10,  38, -22, -20, -31,  15,  21, -29,  15, -14, -14,  37;
/M: SY='N';  M= -23, -80,  40,   7, -42, -18,  68, -89, -49, -87, -75,  79, -78,  22, -11,   2, -15, -82,  13,  -8;
/M: SY='I';  M=  38,  -6, -81, -79,   5, -75, -70,  41, -76,  30,  -5,  -1, -82, -73, -80, -40, -31,  23,  41,  20;
/M: SY='A';  M=  63,  40, -51, -66, -28, -27, -72,  11, -51,   5,  38, -27, -71, -24, -71,   5, -36,  -5,  17, -66;
/I:         I=-15; MD=-26;
/M: SY='K';  M= -17, -69, -17,   3, -37, -74,  -7,  18,  33, -24,  13,  20, -77,  23,  25,   0,  27,   3, -88, -69; D=-15;
/I:         I=-15; MI=0; MD=-26; IM=0; DM=-26;
/M: SY='Q';  M= -36, -78,   9,  21, -14, -59,  47, -66,  12, -25, -40,  26,  -2,  74, -28, -15,  -7, -16, -80,  -8; D=-15;
/I:         I=-15; DM=-26;
/M: SY='G';  M= -52, -87,  30, -24, -96,  78,  -9,-100,  29, -96, -87,  21, -20,  -8, -19, -27, -47, -91, -96, -88;
/M: SY='W';  M=  -1, -27, -29,  24, -65,  -6,  24, -13,  36,   2,   1, -16, -13, -25,   1, -31, -14,  13,  42, -15;
/M: SY='P';  M=  14, -24, -26, -56, -82,   5,  22, -29,  12, -58, -69,  40,  62, -50,  33,   7, -16, -28, -95, -43;
/M: SY='V';  M= -20, -11, -85, -79,  -5, -88, -85,  20, -79, -12,  -1, -77, -84, -75, -81, -17,  34,  82, -78, -63;
/M: SY='C';  M=  45,  57, -80, -78, -28,  35, -26, -29, -75,  46, -37, -49, -80, -45, -79, -51, -57,  -5, -82, -70;
/M: SY='F';  M= -66, -63, -91, -43,  64, -99, -68,  46, -86,   2,  13, -87, -97, -79, -86, -73,   0,  44,  59,  38;
/M: SY='F';  M=  -7,  18, -87, -43,  95, -13,  -6,  29, -86, -18, -44, -82, -97, -39, -85, -71, -65,  -9, -47,  25;
/M: SY='S';  M= -12, -54, -50, -53, -11, -25, -57, -73, -54, -49, -68, -35, -20, -51, -60, 101, -23, -66, -92, -66;
/M: SY='L';  M= -47, -63, -98, -93,  36, -49, -73,   0, -86,  72,  37, -90, -30, -78, -84, -78, -34,  -1, -60,  21;
/M: SY='E';  M= -58,-103, -15, 111,-102, -78, -45, -92, -36, -93, -75, -48, -68, -15, -49, -50, -57, -80, -95, -88;
/M: SY='M';  M= -63, -61,  -9,  22, -53, -88, -64,  12, -64,  -8, 126,  -5, -88, -16, -68, -39, -29, -33, -69, -66;
/I:         I=-42; MD=-71;
/M: SY='S';  M= -21, -69, -16, -52, -88,   0, -60, -78,  25, -79, -17,  -1,  57,   6, -38,  58,  29, -70, -98, -82; D=-42;
/I:         I=-42; MI=-71; MD=-71; IM=-71; DM=-71;
/M: SY='P';  M=  29, -70, -33,   1, -55, -13, -58, -62,  35, -17,  -5,  34,  37,   0,  -1,  -9,  -1, -22, -92, -77; D=-42;
/I:         I=-42; DM=-71;
/M: SY='E';  M= -18, -76,  34,  60, -75, -43, -54, -20,   4, -36, -10, -21, -75,   7,  17,   8, -19,  21, -86, -20;
/M: SY='Q';  M= -13, -81,   5,  53, -89, -38, -42, -76,  10, -62, -60, -44, -71,  83,  38,  -9, -11, -31, -87, -79;
/M: SY='L';  M= -65, -61, -35, -37, -44, -94, -10,  34, -77,  63,  30, -20, -89, -23, -77, -39,  10,  17,  -8, -32;
/M: SY='A';  M=  41,  10, -79, -73, -58,   4,  13,  11, -71,  23,  40, -70, -78, -66, -75, -12,   7,  34, -80, -41;
/M: SY='M';  M= -18, -70,  20, -29, -63, -41,   2, -35,  36,  18,  65,   3, -78,  32,   8,  -9,   3, -35, -80, -28;
/M: SY='R';  M= -25, -90, -64, -24, -86, -24, -47, -77,  23, -49, -67, -28, -77, -32, 103, -55, -33, -36,  10, -75;
/M: SY='M';  M= -32, -61, -85, -79,   8, -58,   0,  34, -39,  46,  89, -17, -90, -63, -33, -23, -23, -11,   4, -53;
/M: SY='L';  M= -19, -60, -33, -35, -16, -57, -81,  47, -80,  59,  52, -31, -90, -71, -81, -68,  -1,  -3,   8, -60;
/M: SY='S';  M=  27,  56, -60, -56, -76, -16, -60, -22, -13, -32, -10, -24, -70,   3,  12,  67,   2, -27, -91, -75;
/M: SY='Q';  M=  25, -26, -32,   8, -48, -27,   5,  -7, -12, -32,  11,  15, -72,  64,  -5,  33, -22, -14, -85, -69;
/M: SY='E';  M=   0, -72, -23,  41,   9, -77,  22,   9,  14,   6,  -6, -56, -77,  39,  -3, -17,  -5, -18,  35, -16;
/M: SY='S';  M=  43,  16, -65, -64, -73,  36,  15, -34, -63, -20,  -9, -52, -71, -60, -69,  44,  32, -18,  15, -69;
/I:         I=-10; MD=-16;
/M: SY='G';  M=  -5,  33,   4,  17, -84,  48, -24, -38,  10, -27,  -2,   1, -80, -25,  24, -11, -26, -29, -93, -83; D=-10;
/I:         I=-10; MD=-16;
/M: SY='I';  M= -65, -67, -87, -42, -59, -49, -83,  62,  14,  -2,  -6, -82, -95, -10, -69, -38, -45,  45, -85, -24; D=-10;
/I:         I=-10; MD=-16;
/M: SY='D';  M= -30, -89,  46,   1,-103, -74, -34, -97,   7, -97, -89,  28,  46, -35,  11,  23, -27, -89,-113, -92; D=-10;
/I:         I=-10; MD=-16;
/M: SY='W';  M= -26, -86, -38, -80,   2, -21, -81, -40, -37,   0,   7, -20,  18,  -2, -83,  14, -70, -44,  20, -26; D=-10;
/I:         I=-10; MD=-16;
/M: SY='H';  M= -63,-104,  -1, -17,   8, -28,  26, -46, -63, -41, -86, -17,-110,   7, -63,  -8, -46, -92,  -9, -42; D=-10;
/I:         I=-10; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='D';  M= -50,-105,   6, -82, -57, -15,   3, -39, -26, -11, -30,  -5, -37, -19, -18, -38, -64, -87,-112, -35; D=-10;
/I:         I=-10; DM=-16;
/M: SY='Q';  M= -62, -96, -49,   1, -30, -34,  -6, -34,  -9,  -2, -36, -11,-102,  10, -34, -12, -19, -78, -94,   2; D=-10;
/I:         I=-10; DM=-16;
/M: SY='K';  M= -11, -89,   0,  -3, -43, -46,  14, -10,  29, -19, -35,   5, -30, -56,   9, -12, -68, -70, -94,  -5; D=-10;
/I:         I=-10; DM=-16;
/M: SY='I';  M= -47, -79,  21, -11, -67, -30, -74,  32,  14,  22,  -5,  -3, -52, -19,  -6, -51, -66, -10,   0, -46; D=-10;
/I:         I=-10; DM=-16;
/M: SY='R';  M= -32, -85,   0,   8, -30, -59,  14, -57,   1, -40, -12,  -2,   7,   2,  58,  -1, -14, -74,  11,  37; D=-10;
/I:         I=-10; DM=-16;
/M: SY='T';  M= -58, -72,   1, -10, -44, -15, -20,   1, -20,  -6, -25,  25, -18,  11,  17,  11,  47, -25, -15, -73; D=-10;
/I:         I=-10; DM=-16;
/M: SY='G';  M= -17, -81, -13,   8, -83,  62,  11, -13,  -5, -30, -69,  -6, -26, -11, -23, -36,  -2, -35,  29, -77; D=-10;
/I:         I=-10; DM=-16;
/M: SY='R';  M= -33, -80,  30,  -9,   2, -46, -13, -27,  15, -13, -29,  18, -18,  12,  38,  -3,  -9, -28,  -2,  -6; D=-10;
/I:         I=-10; DM=-16;
/M: SY='M';  M= -48, -27,   9,   0,  17, -90, -69,  20, -23,  33,  43, -23, -40, -10, -15, -39,  -1,   2, -76, -21; D=-10;
/I:         I=-10; DM=-16;
/M: SY='S';  M=  -8, -71,  37,   5, -76, -12,  -8,  -8, -33, -34, -65,  38, -22,   8, -17,  39,  18, -51, -92, -17; D=-10;
/I:         I=-10; DM=-16;
/M: SY='D';  M=   3, -76,  41,  13, -63, -30, -23,   4,  -8, -28, -61,  16, -21,  14,  16,  -5, -10, -28, -77,  30; D=-10;
/I:         I=-10; DM=-16;
/M: SY='E';  M= -21, -81,  34,  48,  17, -47,   9, -70,  -1, -38, -66, -11, -32,   8, -13, -23,  20, -43,  42,  19; D=-10;
/I:         I=-10; DM=-16;
/M: SY='E';  M=   5, -26,  50,  50, -31, -70, -53, -70,  -7, -45,  -1,  22, -27,  18, -57,  -3, -32, -29,  17,   2; D=-10;
/I:         I=-10; DM=-16;
/M: SY='W';  M= -15, -82,  21,  15,  12, -15, -67, -43,   8, -29,  -5, -63, -88,  -4, -12, -14, -66, -28, 124, -15; D=-10;
/I:         I=-10; DM=-16;
/M: SY='D';  M=  -3, -78,  34,  34, -43,  -7, -14, -24,  20, -19, -27,  -9, -16,  19, -13,  -1, -20, -23, -84,   2; D=-10;
/I:         I=-10; DM=-16;
/M: SY='K';  M=  -9, -76, -22,   2,  18, -75, -10, -19,  40,   1,   6,  16,  -4,  22,  35, -11, -29, -33,   0, -57; D=-10;
/I:         I=-10; DM=-16;
/M: SY='L';  M=  -6,  -9,  30,   1, -13, -17, -65,  16, -33,  46,   6,   2, -41, -25, -21, -19, -58, -19, -77,  -3;
/M: SY='W';  M=  11, -67, -19, -13,  -4,  -7,  18,   0, -10, -29,  18,  11, -79,  16,  -6,   8,   5,   5,  58,  26;
/M: SY='W';  M=  19, -67,   8,   3, -21, -53, -13,  -1,  12,  -1,   3,  -5,  18,   6, -14,  -3,   3,   0,  39,  -7;
/M: SY='A';  M=  39,   8,   0, -56,  -9, -25,  30, -11, -17, -64, -23,   0,  15, -12,  16,  13,  23, -20,  13, -16;
/M: SY='M';  M=   9, -28,  12,  -1, -20, -41, -35,  26, -14,  23,  27, -26,  -5, -10,  -4,   4,  -9, -10, -78,  -4;
/M: SY='N';  M= -17, -26,  26,  26,  17,  16,  12, -27,   1, -24, -60,  30, -81,   5, -14, -13, -19,  -8, -71,  28;
/M: SY='K';  M=  -3, -74,  26,  25,  12, -75,  12, -30,  30,   4,  24,   3, -12, -20,   9, -46,   1, -12, -77,  -5;
/M: SY='L';  M= -42, -65, -83, -43,  19, -33, -13,  22, -35,  52,  40, -35, -16, -68, -36, -13, -30,  -9,  16,  35;
/M: SY='S';  M=   7, -71,  24,   5, -26, -14,  11, -23,  21, -34, -12,   2, -74,  18,   0,  43, -47, -63,  30,  25;
/M: SY='E';  M=  -9, -76,  20,  36,  -3, -16,  -8, -33,   8, -28,   7,  32, -77,   5,  19,  -5,  -7, -16,  34,   2;
/M: SY='A';  M=  25, -30,  -9, -42,  -9,  -7,  -5,  -7,  24,  25,  24, -12, -13, -13, -23,  18, -37, -49,   4, -17;
/M: SY='P';  M=  -4, -76, -42, -35, -45,   7, -59, -16,  19, -32, -66,  34,  75,   0,  25, -13,  -5, -51, -95, -79;
/M: SY='I';  M= -63, -65, -41,   5,  23, -90,  -4,  51, -19,  46,  17, -36, -88, -23, -19,   4, -56,  -6, -76, -52;
/M: SY='W';  M= -35,  -7, -31, -44,  62, -27,  51, -24, -20, -18,   9, -44, -11, -27, -33, -42,   7, -27,  67,  63;
/M: SY='I';  M= -62, -61, -31, -21,  10, -52, -78,  70, -78,  25,  -1,  -7, -24, -25, -80, -22, -25,  31, -77, -32;
/M: SY='D';  M= -17, -22,  80, -20, -27, -19, -51, -28, -35, -17,   7,   9, -82,  11, -15, -13, -59, -37,  33,  44;
/M: SY='D';  M= -58, -99, 113,  19, -99, -35, -60, -97, -58, -98, -33, -22, -35, -19, -69, -53, -63, -92,-117, -94;
/M: SY='T';  M= -28, -63,   7, -18, -68, -24,   7, -23,  -4,  -4, -52, -22, -74,  18, -11,  40,  58,  -9,  42, -40;
/M: SY='P';  M=  -6, -70, -27, -16,  10, -13, -63, -21, -59, -19,   6,  -5,  74,  12, -11,  11,   5,   0, -13, -28;
/I:         I=-45; MD=-77;
/M: SY='G';  M=   5, -23, -29, -33, -65,  36,   5, -21,  -7, -11, -29,  33,  -1,  -9, -62,  15,  -9,   4,  15,   8; D=-45;
/I:         I=-45; MI=-77; IM=-77; DM=-77;
/M: SY='I';  M=  -8, -63, -16, -16,  -9, -36, -22,  42, -34,  28,  -4,  -5, -19,   3, -25,  13,  -2,   2,  10, -19;
/M: SY='T';  M=  -8, -63, -22, -28, -26, -67,  18,   4,  10, -41,  -3,  23, -51, -19,   3,  39,  52, -17,   6,   0;
/M: SY='I';  M= -21, -62,  -8,   2, -25, -86, -74,  52, -67,  20,  41, -11,   8, -62, -14, -14,  -2,  29, -83, -67;
/M: SY='M';  M= -16,  -6,  10,  12, -32, -21,  -9, -51,  -8,  -1,  36,   4, -15,  25,   7,  18,  15,  -6,  13,  -3;
/M: SY='D';  M=  -5, -20,  49,  46, -45, -52, -13, -17, -37, -30, -60,   0, -37,  30, -12,   0,   3,  -3, -77,  24;
/M: SY='M';  M= -32, -20, -34, -76, -27, -27,   7,  54, -29,  31,  62, -26, -40, -64,   1, -44, -14,   5, -74,  -3;
/M: SY='R';  M=   0, -76, -14,  -4, -69, -25, -23,  18,  -5, -18, -54, -23, -33,   0,  78, -39, -18, -10, -19, -10;
/I:         I=-12; MD=-20;
/M: SY='W';  M=  39, -61,  -9,  -5, -61, -51, -62,   3, -43,  -3, -52, -39, -40, -56,   0,  39,  18, -15,  48,   9; D=-12;
/I:         I=-12; MD=-20;
/M: SY='K';  M=  17, -75, -55,   3, -81, -23, -24, -23,  55, -47, -63,  -8, -39,  30,  40,  20, -51, -38, -89, -30; D=-12;
/I:         I=-12; MD=-20;
/M: SY='A';  M=  43,  40, -76, -24, -20, -71, -14,  12,   1,  14,  -4, -70, -77, -62, -66, -13,   2,  19, -74,  17; D=-12;
/I:         I=-12; MD=-20;
/M: SY='R';  M=  -6, -13,  13,  -8, -79, -44, -51, -21,  30, -68,  -7, -30, -78, -24,  83, -55, -45,  -8, -87, -17; D=-12;
/I:         I=-12; MD=-20;
/M: SY='R';  M= -17, -85,   1, -22, -80, -83, -58, -20,  32,  -1,  20, -57, -82,   9,  71, -60, -19, -63, -93, -80; D=-12;
/I:         I=-12; MD=-20;
/M: SY='L';  M= -13, -73, -37, -43, -16, -95, -67,   3, -16,  49,   5, -52, -94, -41,   7, -74, -50,   1, -68,  37; D=-12;
/I:         I=-12; MD=-20;
/M: SY='K';  M= -38,  -9, -55, -61, -29, -49,  -6, -58,  62,  12, -56, -62, -86, -24, -14, -15,  -9, -16, -78,  24; D=-12;
/I:         I=-12; MD=-20;
/M: SY='R';  M=   3, -85, -35, -50, -57, -10, -31, -25,  -4, -77,   3,  -9, -90,  11,  37,  -5, -18, -28,-101, -50; D=-12;
/I:         I=-12; MD=-20;
/M: SY='E';  M= -41,-107,   6,  25,-102, -98, -13, -57, -10, -98, -89, -15, -99,  24,  14, -57, -39, -31,-109, -28; D=-12;
/I:         I=-12; MI=0; MD=-20; IM=0; DM=-20;
/M: SY='G';  M= -53,-110,  21,   1,-117,  40, -31,-117,  11,-114,-102,   0,-100,  -3, -14, -71, -57,-108,-117,-106; D=-12;
/I:         I=-12; DM=-20;
/M: SY='I';  M= -45,  54, -96, -90, -49,-101, -21,  64, -60,  40, -26, -90,  -2, -81, -60, -75, -31,  38, -82, -41; D=-12;
/I:         I=-12; DM=-20;
/M: SY='D';  M= -24, -23,  54,   5, -92,  40, -57, -85,  38, -58, -76, -15,   3,  17,  23,  -5, -32, -63, -97, -86;
/M: SY='L';  M= -18,  -6, -43, -40,   1, -13,  28,  16, -39,  28,  14, -16, -45, -13, -38, -35, -15,   9, -38, -25;
/M: SY='I';  M= -15,  10, -49, -46,   4, -51, -47,  39, -44,   4,   1, -48, -47, -43, -45, -38, -27,  29, -39, -29;
/M: SY='V';  M= -25, -28, -49, -45,  12, -34, -43,  34, -44,  -3,  21, -46, -47, -41, -44, -38, -27,  34, -35,  -8;
/M: SY='I';  M= -31, -28, -50, -47, -17, -54, -48,  41, -45,  13, -11, -49, -48, -44, -45, -40, -27,  30, -40, -32;
/M: SY='D';  M= -38, -51,  60, -11, -51, -33, -31, -51, -30, -53, -52,  -9, -40, -27, -37, -27, -32, -49, -62, -48;
/M: SY='Y';  M= -34, -40, -33, -37,  -5, -41,  29, -35, -35, -34, -34,  17,   5, -31, -34,   5, -30, -37, -11,  58;
/M: SY='L';  M= -36, -31, -51, -48,  -7, -53, -42,  16, -44,  40,   5, -48, -12, -40, -43, -42, -33, -10,   9,  -8;
/M: SY='Q';  M= -27, -37, -25, -13, -40, -10,  -4, -35,  -7, -31,  22,   1, -36,  55, -18,   3,   8, -33, -39, -36;
/I:         I=-13; MD=-22;
/M: SY='L';  M= -14, -32, -44, -10,  10, -27, -40,  18, -11,  35,   8, -43, -46, -35, -19, -38, -32, -14, -37, -27; D=-13;
/I:         I=-13; MD=-22;
/M: SY='M';  M= -19,   8, -49, -43,  -9, -49, -40,  19, -40,  18,  52, -43, -46, -33, -40, -36,  -5,  11, -35, -31; D=-13;
/I:         I=-13; MD=-22;
/M: SY='Q';  M=   7, -69,   3,   3, -76, -68, -13, -33,  -4,  -7,  -7,  13, -37,  38,  29,  37,   0,  -8, -91, -74; D=-13;
/I:         I=-13; MD=-22;
/M: SY='G';  M=  -4, -31, -11, -33, -42,  50,  15, -38, -42, -25,  -9,  28,  10, -59, -18,  34, -10, -24, -93, -74; D=-13;
/I:         I=-13; MD=-22;
/M: SY='S';  M=   6, -71,  25,   1, -79,  10,  25, -46, -33, -41, -67, -10,  29,  14, -20,  32,  28, -39, -92, -25; D=-13;
/I:         I=-13; MD=-22;
/M: SY='G';  M= -25, -82,  10,  17, -81,  29,  -6, -58,   6, -29, -71,  16, -48,  11,  22,  10,  -1, -61, -92, -17; D=-13;
/I:         I=-13; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='R';  M= -61, -15, -11,  17,-106, -49, -71, -93,   9, -64, -19,   4, -54, -25,  37,  -8, -11, -67,-114,-100; D=-13;
/I:         I=-13; DM=-22;
/M: SY='Q';  M=  -1, -79,  31,  27, -56,  -6,   3, -74,   9, -54, -68,  19, -76,  45,  23,   8, -14, -26, -89, -23; D=-13;
/I:         I=-13; DM=-22;
/M: SY='N';  M= -28, -76,  10,  -3, -29,  -6, -53, -13,  25, -30, -65,  58,   2,  16, -14,  20,   2, -65, -91, -26; D=-13;
/I:         I=-13; DM=-22;
/M: SY='R';  M=   6, -79, -21,  21, -17,  -3, -51, -44, -14, -54,  17,   5, -77, -15,  73,   4, -34, -43, -83, -14; D=-13;
/I:         I=-13; DM=-22;
/M: SY='Q';  M=  -4, -65,   3,  -8, -23, -80,   5,  25, -37,   0, -43, -38, -27,  48, -36,  -2,  -1,  40, -81, -29; D=-13;
/I:         I=-13; DM=-22;
/M: SY='D';  M=   1, -76,  65,  28, -51, -14, -51, -77, -30, -38, -68,  35, -18,  47, -55,  18,   6, -57, -96, -79;
/M: SY='E';  M= -30, -91,  31,  80, -86, -74, -44, -51, -10, -82, -69, -15, -72,  45,  40, -26, -44, -47, -87, -18;
/M: SY='I';  M= -42,  -7, -87, -49,  24, -96,  -1,  67, -43,   1, -34, -80, -92, -75, -41, -32,   1,  39, -61,  43;
/M: SY='S';  M=  18,  -4, -28,  23, -77, -20,  12, -61, -15, -40,  34,   9, -70,  28, -54,  57,  15, -27, -89, -71;
/M: SY='E';  M=   4, -74, -24,  54, -27,   5, -51, -51,   1, -20, -15,   4, -74,  10,  26,  -7,  25, -40, -80,   3;
/M: SY='I';  M= -58, -65, -64,   1, -63, -40, -61,  68,  -1, -26,  -5, -27, -36,  64, -28, -15,  -5,  17, -84, -71;
/M: SY='S';  M= -11, -62,  18, -18, -66, -18, -63, -30,  14,  28,  -9, -22, -73, -52, -56,  64,  14, -35, -90, -73;
/I:         I=-45; MD=-77;
/M: SY='R';  M=   3, -82,  -7, -30, -81, -42, -48, -30,  42, -30, -62, -19, -74,  36,  80, -20, -42, -67, -88, -34; D=-45;
/I:         I=-45; MI=-77; IM=-77; DM=-77;
/M: SY='G';  M=  17, -66, -44, -11,  26,  40, -63,  11, -23, -16,   0,  -4, -79,  -4,   0,  21, -10, -17, -79, -58;
/M: SY='L';  M= -62, -59, -93, -87,   3, -96, -82,  25, -80,  66,  44, -84, -91, -73, -34,  -6, -24,  30, -73, -58;
/M: SY='K';  M=  30,  -3,   3,  12, -82, -25, -55, -69,  73, -73, -17, -48, -69, -12,  17, -27,  -9, -26, -88, -25;
/M: SY='K';  M=  21, -68,   8,   8, -71, -28, -55, -10,  43, -14,  28,  -1, -73,  24,   3,   8,  -6, -19, -84, -24;
/M: SY='L';  M= -46, -66, -46,  29,   4, -94, -71,  23, -64,  61,  37, -76, -87, -12,  -1, -38, -60,  -2, -75, -59;
/M: SY='A';  M=  59,  33, -72, -60, -38, -61, -12, -39,  17,  10, -50, -62, -70, -51,  39, -14,  -9, -22, -79,   0;
/M: SY='R';  M= -27, -84,  21,   4, -90,  10, -49, -60,  45, -59, -70,  36, -30,  26,  58,  -4, -27, -77, -95, -80;
/M: SY='E';  M= -65, -74,  -7,  65,  34, -91, -63,  35, -38,  18, -10, -68, -85, -46, -68, -67, -60,  18,  41, -10;
/M: SY='A';  M=  45,  12, -77, -68, -41, -68, -74,  -8,  -7,  44, -23, -69,  24, -63, -31,   6,   2,  -7, -85, -70;
/M: SY='N';  M= -60, -73,  17,   6, -73, -12, -30,  24,   3, -11, -52,  50, -80,  26,  32, -18,  11,   1, -92, -75;
/M: SY='I';  M= -21,  38,   0,  23,  10, -85, -10,  45, -23, -17,   2, -33, -84,  24, -34, -59,   2,  33, -76, -15;
/M: SY='P';  M=   4, -28, -66, -66,   8, -76,  13, -14,  -1,   8,  -8,  25,  80, -60, -35, -29, -19, -12, -77,   9;
/M: SY='V';  M= -58, -64, -17,  -1, -25, -26, -68,  48, -17,  -1, -38,  38, -86,  -1, -32, -23, -51,  56, -85, -68;
/M: SY='C';  M=   1,  60, -80, -77, -19, -79, -80,  53, -76,  -2,   4, -70, -83, -72, -80,  38,  -6,  44, -83, -66;
/I:         I=-42; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='H';  M=  51,  27, -63, -49, -72, -63, 102, -69, -55, -46, -28, -25,  29,  42, -54, -43, -30, -33, -89, -44;
/M: SY='L';  M= -55, -60,-102, -95, -15,-104, -91,  42, -89,  68, -17, -97, -95, -82, -88, -82, -60,  41,  48, -57;
/M: SY='S';  M=   2, -23, -52, -57, -71, -60,  40, -13, -29, -33, -59,  33, -72, -51, -10,  68,  34, -11,  41, -60;
/M: SY='Q';  M= -16, -74, -63, -40, -29, -24, -47, -14, -17,  19,  10, -21, -27,  88,  43, -55, -30, -21, -79, -70;
/M: SY='L';  M=  -9, -62, -13, -76, -52, -36, -81,   7, -33,  57, -27, -75,  19, -71, -28, -11, -55,  41, -82, -71;
/I:         I=-45; MD=-77;
/M: SY='S';  M=  14, -13, -20, -52, -45, -60,  -7,  -8, -13, -65, -60,  54, -73,  25, -56,  59,  -4,  12, -93, -70; D=-45;
/I:         I=-45; MI=-77; IM=-77; DM=-77;
/M: SY='H';  M= -41, -86, -53,  18, -77,   0,  82, -85, -14, -57, -69,  -2, -77,  14,  76, -17,   0, -79, -87, -15;
/I:         I=-25; MD=-42;
/M: SY='P';  M=  11, -73, -13,  -9, -25,  28, -58, -73, -24, -14, -18,  38,  53,  24, -19,  24, -51, -69, -92, -76; D=-25;
/I:         I=-25; MD=-42;
/M: SY='R';  M= -30, -28, -65, -57, -74, -79, -58, -30,  27,  -9, -51,  20,  -6, -12,  69, -33, -21,  44, -89, -76; D=-25;
/I:         I=-25; MD=-42;
/M: SY='E';  M= -22, -88, -36,  72, -95, -27, -51, -82,  50, -85, -72, -13,  -4,  -5,  25, -27,   2, -49, -96, -84; D=-25;
/I:         I=-25; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='H';  M=   1, -74,  13,  12, -82,  -3,  49, -45,   2, -64, -68,  25, -25,  45, -12,  33,   0, -49, -93, -41; D=-25;
/I:         I=-25; DM=-42;
/M: SY='R';  M= -32, -86,  26,  37, -77, -17, -48, -50, -32, -82, -74, -19, -36,   2,  74,  16, -18, -76,  13,   5; D=-25;
/I:         I=-25; DM=-42;
/M: SY='E';  M= -15, -82,  48,  57, -74,  -4, -49, -21,  -6, -52, -68,  21,   7,  35, -53, -29,   7, -67, -83,  10;
/M: SY='D';  M= -47, -87,  80,  11, -87,  50, -57, -65, -44, -95, -89,  41, -81, -53, -35,   7, -57, -87,   5, -23;
/I:         I=-38; MD=-65;
/M: SY='K';  M= -20, -85,   8, -20, -89,   9,  13, -51,  77, -50, -68,  -4, -24,  15,  32, -40, -30, -75, -95, -75; D=-38;
/I:         I=-38; MD=-65;
/M: SY='R';  M= -14, -82,  12,  20, -84, -76,  -4, -64,   1, -29, -31, -51,  21, -11,  79, -17, -12,  -6, -93, -77; D=-38;
/I:         I=-38; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='P';  M= -56, -73, -78, -73, -78, -51, -82,  22, -73, -15, -56, -79, 110, -73, -78, -65, -32,  24, -97, -87;
/I:         I=-45; MD=-77;
/M: SY='M';  M= -39, -66,  -6, -15, -69,   4, -59,  19,   1, -30,  67,  22, -28,  34, -26,  17,  20,  -3, -85, -74; D=-45;
/I:         I=-45; MI=-77; IM=-77; DM=-77;
/M: SY='L';  M= -44, -62, -81, -17, -22, -49, -78,  28,   3,  63,  56, -54, -88, -63, -68, -33, -17,   4, -76, -63;
/M: SY='S';  M=  17, -59, -48,  11, -37, -34, -22, -71, -27, -48, -16, -16, -67,  25, -27,  80,   0, -63, -81,   3;
/I:         I=-45; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='D';  M= -15, -86, 107, -27, -91, -63,  43, -91, -58, -92, -23, -23, -77, -17, -66,  17, -55, -85,-112, -75;
/M: SY='L';  M= -28, -60, -96, -94,  32, -99, -85,  46, -88,  68, -17, -36, -94, -82, -86, -78, -61,  16, -71, -49;
/M: SY='R';  M= -21, -88, -62, -21, -10, -42, -46, -82,  45, -77, -69, -49, -75, -31,  96, -14, -29, -77, -84, -23;
/M: SY='E';  M= -53, -95,  34,  81,-100,  65, -57,-100, -50, -98, -86, -44, -77, -35, -62, -37, -62, -88, -96, -94;
/M: SY='S';  M=  -5, -53, -48, -51, -81, -30, -56, -75, -53, -79, -70, -33, -64, -49, -58, 102,   9, -65, -97, -73;
/M: SY='G';  M=  15, -78, -64, -74, -86,  93, -70, -92, -64, -92, -86, -52, -83, -70,   1, -15, -63, -54, -86, -23;
/I:         B1=0; BI=-105; BD=-105; E1=0; IE=-105; DE=-105;
/M: SY='S';  M=  56, -58, -26, -13, -82,  -7,  -8, -70,  10, -75, -66,  -5, -64,  11, -15,  60, -37, -35, -93, -73;
/M: SY='I';  M= -35, -57, -99, -95, -17,-105, -90,  94, -89,  20,   4, -95, -97, -87, -90, -50, -57,   6,  16, -14;
/M: SY='E';  M= -54, -84, -28,  91, -32,  -2, -51, -18, -42, -47, -65, -49, -72,  -4,  -7,   2,  14, -38, -90, -78;
/M: SY='Q';  M= -40, -82,  18,  -6, -12, -73,   5, -83, -33, -75, -54,  17, -74, 113, -14, -48, -28, -76, -69,  12;
/M: SY='D';  M= -21, -85,  94,  14, -79, -36, -62, -26, -14,  -6, -67,   4, -79, -17, -65,  -7, -59, -70,  54, -75;
/M: SY='A';  M=  84,  38, -67, -59, -77, -46, -69, -57, -59, -66, -61, -60, -60, -59, -68,  36, -19, -12, -91, -75;
/M: SY='D';  M= -74, -97, 113,  -6, -38, -67, -58, -93, -59, -92, -17,   7, -80, -17, -70, -32, -62, -90,-106, -27;
/M: SY='N';  M= -22, -61, -61, -72,  -4, -55, -65,  54, -69,   6,  29,  58, -87,  -7, -72, -57,   1,  38, -79, -21;
/M: SY='V';  M= -19,  -4, -90, -85, -26, -26, -89,  54, -84,  -9,  38, -30, -90, -78, -85, -69, -51,  76, -79, -66;
/M: SY='M';  M= -18,  -5, -97, -65,  25, -68, -82,  60, -84,  44,  82, -90, -94, -73, -84, -75, -60, -20,  18, -49;
/M: SY='F';  M=   4, -64, -87, -85,  83,   4, -70,  11, -80,  19,  36, -77, -90, -75, -42, -34,  -1,  -8, -56, -24;
/M: SY='L';  M= -66, -59,-101, -94, -16,-106, -90,  57, -88,  64,  31, -96, -45, -81, -87, -82, -59,  35, -76, -61;
/M: SY='Y';  M= -67, -82, -56,  27,  -9, -81,  74, -74, -58, -58, -10,   6, -87,  38, -58,   1, -62, -75,  87,  88;
/M: SY='R';  M= -65, -92, -36,  -9, -39, -78, -44, -79, -11, -52, -68, -27, -34,  -3, 105,  -8, -60, -48,   3, -36;
/M: SY='D';  M= -15, -86,  73,  37, -36, -28, -19, -58,   5, -60, -78,  57,  16, -19, -12, -31, -42, -79,-102, -78;
/M: SY='D';  M= -16, -84,  56,  55, -85, -29, -10, -50,  26, -51, -68, -27, -73,  38,  17, -18,   6, -72, -92, -38;
/I:         I=-12; MD=-20;
/M: SY='Y';  M= -21, -81,  17, -49, -27, -88,   9, -28,  -7, -34, -31, -64, -31,  20, -17, -12, -46,   9, -52,  78; D=-12;
/I:         I=-12; MD=-20;
/M: SY='Y';  M= -18,-100,   5, -22, -25, -54,  -5, -87, -21, -58, -85, -44, -43, -19, -18, -78, -53, -66, -58,  75; D=-12;
/I:         I=-12; MI=0; MD=-20; IM=0; DM=-20;
/M: SY='Y';  M= -40,-105,   6,  15, -48, -61, -66, -93,   4, -72, -88, -47, -35,  21, -40, -55, -28, -52, -84,  36; D=-12;
/I:         I=-12; DM=-20;
/M: SY='D';  M= -26, -94,  29,  24, -11, -30, -37, -89,  -2, -73, -87,  21, -49, -25, -52,   7, -38, -49, -98, -10; D=-12;
/I:         I=-12; DM=-20;
/M: SY='P';  M=   1, -44,  41,  29, -89, -78, -64, -37,  12, -54, -35, -54,  45,   4,  -5,  -7, -34, -74, -99, -24; D=-12;
/I:         I=-12; DM=-20;
/M: SY='D';  M= -25, -81,  60,  15, -79,   8, -16, -27,  13, -37,   1,  25,  -8,  22, -18,   6, -23, -51, -92, -22; D=-12;
/I:         I=-12; DM=-20;
/M: SY='P';  M= -39, -43,  24,  22, -75,  -8, -22, -30, -13,  -4, -25,  33,  35,   5, -22,  18,  20, -23, -91, -32; D=-12;
/I:         I=-12; DM=-20;
/M: SY='D';  M= -23, -80,  46,  44, -26, -20,   3, -12,  -2,  -8, -30,   0,  31,   8, -17, -23, -27, -14, -92, -72; D=-12;
/I:         I=-12; DM=-20;
/M: SY='D';  M= -19, -80,  39,  29, -39, -25, -16, -39,  33, -62, -14,  34, -20,   8,  -3,  -2, -20,  -6, -14, -75; D=-12;
/I:         I=-12; DM=-20;
/M: SY='P';  M= -10, -83, -44,  13, -55, -43,  -8, -74,  44, -37,   7, -16,  46,   1,  41,  -3, -35, -45, -95, -78; D=-12;
/I:         I=-12; DM=-20;
/M: SY='G';  M= -31, -81,  12, -31, -25,  54,   3, -12, -15, -66, -75,  43,  31, -11,   2,  -7, -32, -52, -93, -46; D=-12;
/I:         I=-12; DM=-20;
/M: SY='I';  M=  -8, -70,  22,  31, -11, -78,   7,  35,   8,   2, -13, -37,  -8,   9, -12, -16,   4,  -6, -81, -16;
/M: SY='T';  M=  42,  -4, -67, -21, -36, -24, -68,   6, -17, -32, -50, -59, -71,  -7, -16,   9,  50,  30,  12, -68;
/M: SY='E';  M= -61, -84,  18,  73, -12, -44, -48, -19,   6,  -6, -56, -51, -44,  13,  12, -41, -14, -19, -72,  27;
/M: SY='I';  M= -39, -35, -37, -33,  15, -99, -85,  55, -63,  46,  26, -48, -93, -76, -83, -76, -58,  44,  12, -54;
/M: SY='I';  M= -64,  -7, -22, -43, -55, -88,  35,  69,  12, -26,  -7,  -6, -87,   9,  35, -29, -56,   6, -79,   7;
/I:         I=-42; MD=-71;
/M: SY='I';  M= -63,  33, -89, -24, -50,-104, -89,  75, -84,  27,   2, -55, -94, -25, -85, -76, -40,  45, -83, -68; D=-42;
/I:         I=-42; MI=-71; MD=-71; IM=-71; DM=-71;
/M: SY='A';  M=  49, -64,  18,  13, -71,   6,  -8, -13,  -5,  13, -50, -37, -72, -16, -20,  -7, -23, -10, -90, -74; D=-42;
/I:         I=-42; DM=-71;
/M: SY='K';  M= -57, -91, -53, -34, -95, -71, -53, -85, 108, -83, -69, -42, -69, -25,   0, -51, -55, -80, -95, -76;
/M: SY='N';  M= -41,  20,   9, -31, -32, -49,  66, -28, -47, -56, -61,  79, -80,  72, -48, -24, -53, -14, -88, -31;
/M: SY='R';  M= -53, -98, -67, -49, -88, -79, -41, -88,   8, -81, -71, -49, -77, -16, 113, -58, -64, -82, -89, -40;
/M: SY='N';  M= -41, -77,   6, -56,  31, -11,  38, -52, -38, -70, -18,  88, -84,  -2, -25,  -1, -18, -46, -69,  37;
/M: SY='G';  M= -39, -80,  -8, -33, -78,  85,   6, -64, -21, -67, -80, -26, -85, -26, -30, -11,   9, -60, -10,  -1;
/I:         I=-13; MD=-22;
/M: SY='G';  M= -39,-106,   4,  17, -71,  42, -88, -71, -15,-109,-103, -71, -27, -73, -84, -24, -57, -54,-118,-110; D=-13;
/I:         I=-13; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='P';  M=  -8, -77,  15,  24, -34, -50,  -1, -58, -54, -67, -71, -20,  75,  26, -18,  18,   9, -71,  64, -22; D=-13;
/I:         I=-13; DM=-22;
/M: SY='T';  M= -40, -27, -63,   5, -61, -28, -67,  32, -21,  -1,   0, -39, -78, -19, -51, -23,  78,   9, -83, -18; D=-13;
/I:         I=-13; DM=-22;
/M: SY='G';  M= -48, -42,  -5, -70, -66,  96, -71, -96, -14, -96, -90, -16, -88, -38, -19, -54, -69, -46, -92, -95;
/M: SY='T';  M= -15,  -9,  -1,  -6, -72, -42,   1,   2,  22, -25,  14,   2, -48,  19,   9,  -4,  55,   7, -89, -71;
/M: SY='V';  M=  21, -18, -84, -79,  26, -65, -81,  40, -29,   8,  -4, -25, -84, -73, -77, -59,  -5,  62, -75, -54;
/M: SY='P';  M=  -3,  -4,  15,  11,   2,   6, -20, -39,  29, -51, -26,   6,  48,   7,   8, -19, -13, -42, -80,   5;
/M: SY='L';  M= -68, -63, -92, -84,  30, -98,  19,   9, -51,  65,  50, -81, -93, -28, -76, -39, -20,  -1, -61,  22;
/M: SY='W';  M=   0,   5, -48, -14,  14, -59,   5,   4,   8,  20,  -5,  -7, -82,   6,  14, -27,   8,   4,  56,   5;
/M: SY='F';  M= -48, -75, -41, -11, 101, -91, -15, -46, -19, -16,  -2, -44, -98, -69, -35, -39, -68, -23,  48,  43;
/M: SY='D';  M= -43, -82,  55,  24, -19, -43,  45, -20, -30,  -8, -36,  42, -82,  21,   3, -25, -59, -45, -68,  46;
/M: SY='P';  M=  -1, -77,  -1,  -5, -76,  21, -22, -34,  44, -41, -14,   5,  51, -30,  15,   6, -41, -43, -86,  -3;
/M: SY='E';  M= -31, -75,  17,  52, -84, -69,   0, -68,   8, -50,  15,  13,   0,  42,   7,  33,   6, -24, -91, -75;
/M: SY='F';  M= -36, -70,   6, -30,  55, -76,  33, -15, -20, -35, -57,   7, -31, -11,   9,  10,  45, -44, -58,  47;
/M: SY='T';  M=  -9, -12, -57, -26, -24,  11, -10, -36, -39,  -1,  17,  19, -76,   8, -40,  25,  64, -20, -78,   0;
/M: SY='R';  M= -26,  16, -59, -48, -77,   5, -22, -48,  44, -58, -63, -16, -74,  34,  58,  18,  24, -23, -85, -15;
/M: SY='F';  M= -78, -78, -30, -24, 101, -95,   7, -21, -42, -28, -51, -77, -36, -71,  -1, -78, -72, -59,  58,  54;
/M: SY='S';  M= -23, -66, -33,   8,  10, -35, -15,   8,   5,  16,   8, -44, -78,  13,  14,  27,  14,  10, -77, -27;
/M: SY='D';  M= -21, -11,  62,  51, -89, -21, -53, -26, -12, -77, -19,  42,  -7,  -2, -25,  11, -14, -35,-100, -84;
/M: SY='P';  M= -15, -12,   1,  -9, -23, -56, -25, -20,   8,  18,  29, -12,  36, -21,   0,  17, -18,  -3, -70,  30;
/M: SY='E';  M=  31, -70,  31,  38, -78,  -6,  -9, -43,   2, -63, -70,  -5,  31, -20, -41,  22,  10, -48, -89, -11;
/M: SY='E';  M= -58,-103, -15, 111,-102, -78, -45, -92, -36, -93, -75, -48, -68, -15, -49, -50, -57, -80, -95, -88;
/M: SY='Q';  M= -59, -82, -47, -14, -89, -76, -28, -87, -26, -75, -48, -40, -71, 129, -26, -48, -56, -77, -74, -75;
/M: SY='A';  M=  97, -45, -70, -57, -78, -41, -70, -62, -57, -67, -61, -68, -56, -58, -67, -24, -42, -44, -90, -74;
/I:         E1=0; IE=-255; DE=-255;

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Post-processing [info]

COMPETES_SEQ_WITH

PS50162

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	59 in 49 different sequences
Number of true positive hits	59 in 49 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Bacteriophages, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Feature key [info]	DOMAIN
Feature description [info]	SF4 helicase
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

49 sequences

DNAB_BUCAI  (P57611), DNAB_BUCAP  (Q8K932), DNAB_BUCBP  (Q89A52),

DNAB_ECO57  (Q8X5V3), DNAB_ECOL6  (Q8FB22), DNAB_ECOLI  (P0ACB0), 
DNAB_GEOSE  (Q9X4C9), DNAB_GUITH  (O78411), DNAB_HAEIN  (P45256), 
DNAB_HELPJ  (Q9ZJM5), DNAB_HELPY  (O25916), DNAB_LEIXX  (Q6ABX1), 
DNAB_MYCBO  (P59966), DNAB_MYCGE  (P47340), DNAB_MYCIT  (Q9F5P4), 
DNAB_MYCLE  (P46394), DNAB_MYCPN  (P75539), DNAB_MYCTO  (P9WMR2), 
DNAB_MYCTU  (P9WMR3), DNAB_NEOYE  (Q1XDF3), DNAB_NOSS1  (Q8YZA1), 
DNAB_PASMU  (Q9CNL6), DNAB_PORPU  (P51333), DNAB_RHOMR  (O30477), 
DNAB_RICBR  (Q1RI04), DNAB_RICCN  (Q92HG8), DNAB_RICFE  (Q4UL62), 
DNAB_RICPR  (Q9ZD08), DNAB_RICTY  (Q68WJ2), DNAB_SALTI  (P0A1Q5), 
DNAB_SALTY  (P0A1Q4), DNAB_SHIFL  (P0ACB1), DNAB_SYNY3  (Q55418), 
DNAB_TREPA  (O83097), DNAB_TRICV  (P49519), DNAC_BACSU  (P37469), 
GP1D_CHLMU  (Q46437), GP1D_CHLPS  (Q46259), GP1D_CHLT2  (B0BCM3), 
GP1D_CHLTH  (P0CE16), HELIC_BPT3  (P20315), HELIC_BPT4  (P04530), 
HELIC_BPT7  (P03692), PEO1_CHICK  (Q5ZIW1), PEO1_DROME  (Q9VL76), 
PEO1_HUMAN  (Q96RR1), PEO1_MOUSE  (Q8CIW5), TWIH_ARATH  (B5X582), 
VG12_BPP22  (P03006)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

43 PDB

1CR0; 1CR1; 1CR2; 1CR4; 1E0J; 1E0K; 1Q57; 2R6A; 2R6C; 2R6D; 2R6E; 4A1F;
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