PROSITE entry PS51198

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PURL: https://purl.expasy.org/prosite/signature/PS51198

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General information about the entry

Entry name [info]	UVRD_HELICASE_ATP_BIND
Accession [info]	PS51198
Entry type [info]	MATRIX
Date [info]	01-JUN-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51198
Associated ProRule [info]	PRU00560

Name and characterization of the entry

Description [info]

UvrD-like DNA helicase ATP-binding domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=290;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=285;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8038350; R2=0.0041334; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=75402.0000000; R2=0.0000000; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=3193; H_SCORE=75402; N_SCORE=15.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=1137; H_SCORE=75402; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-16; D=-50; I=-50; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='S';  M=   1, -55,   9,  18,   4, -16,   7, -11,   3, -11,  15,  -1,  16,   1, -14,  21,   5, -11, -46, -27;
/M: SY='P';  M=  -9, -56,   5,  -7, -17,   8,   6, -12,   0,  11,  10,  15,  19,  14,  -7,   5,   8, -32,  -1, -24;
/M: SY='L';  M= -23, -49,   6, -23,  -4, -28,  16, -26, -16,  50, -20,  -6,  26, -22, -27,  -6, -18, -30,  40, -13;
/M: SY='N';  M= -15, -53,  30, -11, -43, -38, -38, -33, -24, -13, -40,  69,  17, -11, -10,   3,  40, -23, -54, -44;
/M: SY='P';  M=   1, -27,  29,  33, -23, -31, -32, -35,   3, -35, -49,   2,  57,  18, -19,   2,  12, -44, -29, -51;
/M: SY='Q';  M=  14, -56,  10,  48, -31, -28, -16, -50,  -1, -41, -47, -16,  15,  66,  -1,   2, -33, -37, -59, -25;
/M: SY='Q';  M= -20, -64, -17,   7, -41, -34, -14, -30,  -5, -26, -30, -24, -43, 103,  25, -29, -29, -49, -38, -26;
/M: SY='Q';  M=   5, -45,  -7,   4, -24, -42, -26, -19,  23,  -9, -19, -17, -22,  54,  52, -18, -30, -32,  20, -19;
/M: SY='E';  M=  28, -39, -13,  40, -37, -33, -22,  -6,   5,  -1, -36, -12, -16,  29,  16, -12, -25,  -8, -42, -31;
/M: SY='A';  M=  60, -36, -27, -28, -23, -35, -46,  17, -34,  -6, -14, -45, -20, -20, -22, -17, -24,  31, -59, -38;
/M: SY='V';  M=  29, -22, -20, -24, -37, -48, -38,  35, -40, -13, -20,  -8, -44, -20, -11, -28,   3,  54, -62, -21;
/M: SY='T';  M=   2, -14,   4,  10,  -5, -31, -13, -10,  -4,   5, -26,  -4,   8,  -1,   2,  -2,  30,  -1,   0,  -6;
/M: SY='H';  M=  17, -17,  29,  -2, -29, -29,  58, -40, -22, -21, -38,   1,  22,  -7,  -3,   8,  15, -36,  20,   8;
/M: SY='P';  M= -21, -32,   4,   3, -13, -11,   2,  -5, -20,   6, -20,   3,  49,   5,   6,  -2,   6,  -6,  -5, -18;
/M: SY='D';  M=  -3, -37,  35,  21, -36,  14,  15, -43,  -5, -23, -43,  22,  -3,  10,   7,  17,   1, -42, -16, -34;
/M: SY='G';  M= -13, -27,   5, -11, -57,  71,  -9, -54,  -1, -43, -52,  -8, -21,   6,  -2,  -3,  -8, -42, -60, -43;
/M: SY='P';  M= -13, -27,  -8, -28, -43, -40,  52, -33, -13, -37, -31,  30,  75,  -9, -16,  21,   7, -28, -66, -37;
/M: SY='V';  M=   5,  13, -48, -53,   0, -52, -15,  17, -46,  36,  19,   3, -60, -22,  -9, -22, -13,  38, -35, -15;
/M: SY='L';  M= -14,   6, -54, -53,   1, -52, -44,   1, -32,  60,  12, -52, -63,  -3,   9, -39, -40,   7,  30, -13;
/M: SY='V';  M= -36, -34, -67, -62, -30, -69, -66,  56, -59,  13, -19, -61, -61, -59, -61, -52, -36,  75, -64, -36;
/M: SY='L';  M=  -5, -42, -36,  22, -23, -45, -35,  25, -21,  36, -12, -16, -40, -10, -31,  15,  -3,  13, -59, -24;
/M: SY='A';  M=  86, -46, -50, -45, -59,  22, -52, -51, -46, -52, -46, -43, -49, -43, -51, -15, -36, -38, -58, -55;
/M: SY='G';  M=   2,  27, -47, -53, -59,  74, -52, -44, -49, -51, -51,  -5,  -6, -46, -56,  33, -40,  -3, -61, -56;
/M: SY='A';  M=  76, -52, -50, -41, -62, -37, -52, -50, -37, -55, -47, -48,  74, -44, -52, -30, -37, -39, -60, -58;
/M: SY='G';  M= -64,-119, -94,-118,-132, 196,-108,-147,-105,-138,-116, -66,-102,-100,-120, -64,-102,-134,-113,-122;
/M: SY='S';  M=  13,  -9, -81, -83,-108, -66, -92, -99, -81,-107, -97, -59, -91, -75, -93, 150, 137, -79,-133, -86;
/M: SY='G';  M= -64,-119, -94,-118,-132, 196,-108,-147,-105,-138,-116, -66,-102,-100,-120, -64,-102,-134,-113,-122;
/M: SY='K';  M= -91,-120, -76, -48,-124,-105, -82,-124, 204,-122, -97, -62, -92, -45,  -1, -80, -80,-115,-110, -97;
/M: SY='T';  M= -68, -89, -80, -86,-102, -99,-100, -85, -80, -94, -87, -59, -84, -87, -97,  29, 209, -69,-141, -97;
/M: SY='R';  M=  -7, -55, -44,  -1,  21, -37,  19, -43,  12, -36, -43, -32, -52, -20,  54,  13,  41, -19,  10,   7;
/M: SY='V';  M=  -6, -30, -53, -42, -37, -43, -57,   0, -49,  -1,  -9, -32, -53, -51, -49, -14,  62,  63, -67, -45;
/M: SY='L';  M=  -7, -34, -66, -59, -21, -65, -54,  47, -59,  64,  45, -61, -62, -53, -58, -47, -41,  -7, -55, -38;
/M: SY='T';  M=  24, -21, -52, -27, -43, -50, -56,  19, -48,  -2, -13, -39, -52, -48, -45,  -6,  58,  47, -65, -46;
/M: SY='H';  M=  19, -20,  -7,  29, -32,   0,  73, -44, -21, -34, -25,  -9, -50,  23,   4,   4, -11, -36, -23,  15;
/M: SY='R';  M= -14, -61, -47, -36, -46, -50, -33, -24,  38,  -2, -41, -40, -56, -27,  90, -38, -30, -41, -33, -45;
/M: SY='I';  M=  22, -28, -63, -59,  -6, -60, -57,  62, -56,   6,  -6, -56, -58, -54, -58, -46, -18,  45, -53,  22;
/M: SY='A';  M=  58, -38, -45, -25, -37, -18, -25,   7, -18,  15, -21, -37, -39, -12, -21, -20, -25,  21, -59, -31;
/M: SY='W';  M= -17, -40, -12, -24, -13, -41,  52, -30,  -9, -44, -15,  -7, -57, -15,  51, -15, -35, -33,  75,  70;
/M: SY='L';  M= -21, -54, -53, -39, -21, -52,  -4,  10, -22,  70,  22, -51, -62, -23,  -4, -41, -40, -20, -54, -19;
/M: SY='I';  M= -11, -24, -65, -46, -20, -59, -46,  56, -47,  49,  15, -58, -61, -42, -51, -46, -40,  32, -57, -34;
/M: SY='A';  M=  26, -44,   1,  19, -32, -31,  -1, -11,  -1,  20, -31,   0, -52,  25,   3,  -4,   3, -20, -59, -22;
/I:         I=-6; MD=-30;
/M: SY='E';  M=  -4, -33,   6,  37, -54, -10,  17, -42,  -2, -50, -13,  31, -45,  32,  21,  12,   9, -15, -64, -35; D=-6;
/I:         I=-6; MD=-30;
/M: SY='G';  M= -25,  -1,  -9,   2, -51,  46,  29, -45,   6, -21, -24,  -7, -21,  -1,  12, -32, -40, -32, -21,   0; D=-6;
/I:         I=-6; MI=0; MD=-30; IM=0; DM=-30;
/M: SY='G';  M= -28,  -9,  -1,  -1, -41,  34,   3, -42,  -2, -19, -49,   9,   3,  16,  -3, -30, -40, -26, -53, -31; D=-6;
/I:         I=-6; DM=-30;
/M: SY='V';  M=  11, -34, -26, -25, -25, -36,  -2,  27, -28,   4, -24, -23, -13, -31, -36, -22,   2,  45, -19,   8; D=-6;
/I:         I=-6; DM=-30;
/M: SY='P';  M=   4, -48,  40,   7, -52, -28,   9, -49,   3, -28, -38,   8,  45,   5,   6,  21,  -1, -35, -42, -42; D=-6;
/I:         I=-6; DM=-30;
/M: SY='P';  M=  -3, -42, -27, -22, -41, -20,  -5,  -2, -22, -26, -37, -22,  95, -22, -22, -25, -22,  -8, -39, -34;
/M: SY='E';  M=  -9, -59,  31,  46, -39,  -2,   1, -56,  12, -43, -50,  -2, -16,  26,  19,  21, -31, -45,  11, -14;
/M: SY='Q';  M= -21, -32,   7,  31, -55, -21,  10, -55,  17, -57, -33,  28, -30,  51,  46,  14, -27, -38, -62, -40;
/M: SY='I';  M= -43, -20, -67, -62, -25, -70, -63,  81, -36,  20,  14, -59, -59, -45, -60, -54, -25,  36, -58, -40;
/M: SY='L';  M= -10, -18, -65, -58,  -3, -41, -43,  16, -57,  69,  15, -61, -50, -49, -37, -54, -32,   9, -30, -24;
/M: SY='A';  M=  47,  36, -59, -54, -10, -12, -56,  16, -53,  17,  17, -52, -57, -51, -47, -35, -27,  39, -59, -32;
/M: SY='V';  M= -34, -25, -63, -58, -15, -65, -59,  39, -57,  44,   1, -48, -60, -55, -58, -25,  13,  55, -61, -40;
/M: SY='T';  M=  -6, -29, -42, -44, -43, -37, -49, -41, -41, -34,  -3, -31, -44, -44, -49,  16,  98, -27, -68, -32;
/M: SY='F';  M= -43, -55, -66, -63, 107, -35, -19, -34, -58, -23, -34, -49, -39, -50, -56, -33, -49, -31, -25,  40;
/M: SY='T';  M= -29, -25, -39, -43, -52, -20, -47, -45, -25, -46, -17,  14, -27, -36, -41,  27,  94, -38, -69, -49;
/M: SY='N';  M= -30, -41,  -9,  11, -49, -41, -19, -55,  29, -59, -49,  76, -53, -20,  60, -23, -14, -32, -66, -50;
/M: SY='K';  M=  39, -54,   1, -19, -53, -39, -24, -44,  63, -28, -30,   1, -38, -11,  21,   1, -20, -41, -59, -34;
/M: SY='A';  M=  84, -38, -51, -44, -55, -17, -51, -32, -46, -14, -30, -37, -40, -36, -43,   0, -18, -35, -59, -52;
/M: SY='A';  M=  79, -20, -44, -43, -37, -29, -51, -41, -27, -48, -31, -43, -40, -32, -12,  -2,  12,  -4, -59, -36;
/M: SY='A';  M=  30, -50,   9,  22, -54,  -2,  -2, -36,  14, -37, -12,  21, -50,  26,  26,   8, -17, -28, -62, -47;
/M: SY='E';  M= -16, -40,  21,  90, -55, -41, -23, -56, -22, -48, -53,  15, -42,  -5, -25, -19, -22, -45, -64, -44;
/M: SY='M';  M= -28, -53, -55, -58,   8, -63, -45,  27, -53,  44, 102, -57, -59, -48, -33, -54, -39,  -8, -53, -10;
/M: SY='R';  M=  -5, -59, -30, -10, -33, -42, -16, -21,  54, -35, -44, -30, -52,  16,  68,  -4, -13, -30, -57, -30;
/M: SY='E';  M=  11, -57,  22,  56, -46,  -6,   8, -42,  -1, -38, -25,   2, -47,  17,   5,  15,  -3, -44, -52, -29;
/M: SY='R';  M= -28, -46, -27, -24, -58, -45, -36, -54,  17, -41, -33, -19, -56, -14, 100, -22, -41, -56, -59, -46;
/M: SY='I';  M= -17, -54, -65, -50,  -2, -66, -59,  57, -58,  42,  -2, -49, -60, -44, -59, -39, -24,  45, -57, -24;
/M: SY='R';  M=   7, -33, -12,  18, -18,   2,  -4, -22,   1,  -9, -14,   4, -52,  18,  40,   5,   1, -17, -58,  -9;
/M: SY='Q';  M=  23, -31,  15,  24, -53, -27, -12, -44,  30, -19, -18,   1, -23,  32,  10,  13,   1, -32, -51, -44;
/M: SY='R';  M=   1, -49, -46, -26, -12, -44, -14,   5,   2,  34,  13, -14, -57,  -2,  46, -15,  -9,  -9, -13,  -4;
/M: SY='L';  M= -16,  17, -30, -44,   6, -14, -46,  28, -41,  55,  -2, -41, -37, -43, -41, -29, -18,  14, -56, -29;
/M: SY='G';  M=   3, -36,  -5,  -1, -53,  41,   3, -18,   2, -32, -35,   1,  24,  10,   4,   2,  -7,  -8, -17, -36;
/M: SY='E';  M=  -9, -58,  22,  32, -31,   5,  -8, -32,  18, -21, -19,  13,  12,  23,  10,   3, -15, -25, -61, -29;
/I:         I=-3; MD=-13;
/M: SY='W';  M=  28, -32,   7,  12, -34, -10,  -5, -28,  -2,   0, -22,  -2, -15, -14,  -3,   7,   6, -17,  43, -30; D=-3;
/I:         I=-3; MD=-13;
/M: SY='A';  M=  24, -25, -17, -16, -25,   9, -11, -17,  -7,   6, -12, -13, -22,  -7,  -3,   1,  -3,  -3, -39, -14; D=-3;
/I:         I=-3; MD=-13;
/M: SY='A';  M=  14, -25, -17,   4, -37,   1, -16,  -6,  -8, -16,   0, -18, -25,   3,  11,   1,  -9, -15, -65, -20; D=-3;
/I:         I=-3; MD=-13;
/M: SY='K';  M=  -1, -43, -10, -16, -42, -17, -27, -42,   0, -17, -32,  -8, -17,  -9,  -4,  -7, -35, -45, -76, -27; D=-3;
/I:         I=-3; MD=-13;
/M: SY='D';  M= -28, -40,  -4, -27, -12, -39, -49, -38, -57, -25, -60, -26, -14, -18, -27, -24, -26, -57, -56, -59; D=-3;
/I:         I=-3; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='R';  M= -10, -50,  13,  28, -36,  28, -30, -35,   6, -21, -32,   5, -12,  12,  38,  -9,  -3, -43, -60, -28; D=-3;
/I:         I=-3; DM=-13;
/M: SY='P';  M=  19, -45, -59, -44,  -9, -49, -30,  24, -51,  28,  40, -46,  42, -45, -49, -28, -19,  33, -58, -28;
/M: SY='W';  M=  -1, -51,   4,  10,   4, -39,   4, -25,   3,  -6,  -5,   3, -17,  14,  -3,  -7,  22, -19,  81,   0;
/M: SY='I';  M=   4, -18, -63, -59,  -8, -46, -62,  67, -56,  -6,  -2, -44, -58, -33, -59, -16, -21,  54, -60, -41;
/M: SY='G';  M= -11,   3, -12, -26,   0,  44, -12, -38,  -9, -39, -14, -22, -52,  25,  24,  35,   0, -33, -42, -13;
/M: SY='T';  M= -35, -45, -40, -44, -50, -40, -37, -42, -37, -39, -32,  -2, -43, -44, -48, -15, 105, -32, -71, -48;
/M: SY='F';  M= -43, -37, -67, -63,  86, -58, -53,  47, -59,  11,   1, -53, -38, -62, -59, -45, -32,  -2,  -2,  18;
/M: SY='H';  M= -42, -63,  30, -25, -52, -52, 133, -68, -40, -50, -40, -10, -52, -19, -30, -37, -42, -67, -83, -13;
/M: SY='S';  M=  38, -50, -29, -25, -59,  33, -30, -57, -21, -54, -51, -21, -41, -15, -25,  69, -20, -48, -61, -37;
/M: SY='F';  M= -16, -55, -65, -54,  78, -54, -31,  11, -58,  35,   5, -56, -64, -55, -56, -49, -29,  -9,  49,  35;
/M: SY='C';  M=  45, 109, -56, -50,  -7,  20, -56, -46, -45, -37, -39, -45, -59, -53, -57, -12, -23, -21, -46, -33;
/M: SY='Q';  M=   2, -55, -41, -16,  16, -25,  24, -27, -21,  32,  -4,   6, -57,  32,  -2,  -1, -18,  -9,  -5,  25;
/M: SY='R';  M= -10, -60,  18,   6, -31, -25,   2, -55,  28, -37, -29,  -1, -52,  23,  64,   0, -12, -51,  -5,   0;
/M: SY='I';  M= -29, -26, -63, -57,  13, -65, -35,  54, -55,  38,  34, -33, -60,  10, -55, -49, -27,  25,  20,  -4;
/M: SY='L';  M= -21, -26, -66, -59, -16, -67, -54,  28, -59,  70, -11, -63, -64, -54, -58, -51, -30,  19, -23, -18;
/M: SY='R';  M= -16, -25, -13, -18, -45, -13,   7, -41,  26, -28, -41,  -3, -40,  26,  75,  -4, -11, -32, -60, -40;
/M: SY='R';  M=  -8, -36,   4,  36, -30, -37,  -9, -33,  22, -22, -12, -17, -37,  41,  46,   4, -10, -43, -57,  -7;
/M: SY='H';  M=  -2, -45,   2,  12,  32, -27,  74, -32, -30, -15, -16,   7,   5, -19, -29, -24, -24, -17, -32,  49;
/M: SY='W';  M=  25, -17, -30,  -9,   8,  33,  18,   3, -22, -36, -35, -19,  31, -30, -23, -13, -32, -26,  42,  22;
/M: SY='Y';  M=  -5, -29,  12,  11,  16, -15,   8, -14,  12,  -1, -31,  -5,  16,   9,   3, -13, -11, -18, -19,  25;
/M: SY='E';  M=   2, -38,   6,  34, -22, -29,  21, -21,   6,   7,  -9,   1, -12,   1,  26, -14, -14, -13,  -5, -16;
/I:         I=-5; MD=-23;
/M: SY='L';  M=  13, -39, -48, -37,  -9, -10, -21,  20, -50,  21, -25, -35, -53, -39, -26,  -2, -24,   5, -23,  -7; D=-5;
/I:         I=-5; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='G';  M= -18, -50,  24, -18, -70,  45, -25, -33, -23, -36, -53,  10,   6, -31, -16, -26, -45, -42, -57, -60; D=-5;
/I:         I=-5; DM=-23;
/M: SY='Y';  M= -22, -29, -42, -38,  13, -13, -18,  13, -43,  25, -19,  -9, -26, -30, -16, -19, -25,  -2,  11,  28; D=-5;
/I:         I=-5; DM=-23;
/M: SY='P';  M=  -5, -55,  29,  17, -43,  -6, -26, -39,   8, -42, -42,  10,  36, -12, -17,   5, -14, -28, -28, -52; D=-5;
/I:         I=-5; DM=-23;
/M: SY='P';  M=   3, -48, -12,   2, -18, -20, -13, -33,   2, -47, -33,  -9,  53,   3,  15,  19, -12, -44, -64, -27; D=-5;
/I:         I=-5; DM=-23;
/M: SY='N';  M= -22, -43,  27,   2, -55,  18,  11, -51,  -9, -33, -38,  39,   9,  17,   3,   2, -14, -42, -68, -27; D=-5;
/I:         I=-5; DM=-23;
/M: SY='F';  M= -16, -60, -50, -26,  78, -43, -34, -24, -30,  -1,   1, -33,  21, -37, -34, -35, -11, -17,  36,   6; D=-5;
/I:         I=-5; DM=-23;
/M: SY='R';  M= -13, -43,  -9,  11, -39, -20, -14, -20,  -2, -21, -37,  -2, -40,  20,  47,  22,  32, -11, -40, -23;
/M: SY='I';  M= -13, -56, -42, -30, -22, -55, -49,  58, -40,  35,  13, -55,  -5, -26, -21, -35, -15,  28, -57, -22;
/M: SY='L';  M=  -4, -21,   0, -22,   7, -40, -43,  30, -10,  35,  25, -33, -23, -29, -26, -33, -11,   5, -35,  24;
/M: SY='D';  M= -26, -58,  74,  23, -52, -15, -24, -27, -27, -22, -31,  -6, -12,  11, -22,  13,  18, -40, -26, -33;
/M: SY='D';  M=  -4, -37,  41,  39, -45,   1, -31, -34, -24, -32, -20,  -1,  19,   9,  -3,  28,  -3, -34, -65, -44;
/I:         I=-9; MD=-47;
/M: SY='D';  M=  17, -58,  30,  19, -48, -14,   5, -34,   9, -23, -37,   8, -14,  16,   4,   0,  13, -32,  15, -31; D=-9;
/I:         I=-9; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='D';  M=  -3, -52,  68,  41, -42, -29,  -6, -24, -17, -31, -35, -11, -32,   8,   3, -10, -21, -41, -38, -36; D=-9;
/I:         I=-9; DM=-47;
/M: SY='Q';  M=   9, -13,  -5,   1, -48, -20, -13, -18,   7, -13, -18, -13, -24,  68,  18,   4,   5, -24, -14, -17;
/M: SY='R';  M=   0, -57,  20,  15,   6, -27,  -4,  -8,   6,  10,  -5, -17, -42,  17,  20, -11,   2, -20,  16,   1;
/M: SY='R';  M=  22, -56,  -1,  -5, -17, -14,  -3, -17,   1,   0, -10,  -1, -18,  26,  32,   0,  -8,  -8,  -6, -24;
/M: SY='L';  M= -16, -41, -49, -22,  15, -56, -11,  41, -45,  48,  20, -45, -60, -30, -25, -30, -16,  14, -21,   0;
/M: SY='I';  M=  -2,  -9, -31, -11,  -9, -41, -34,  42, -18,  37,  21, -39, -32, -18, -16, -29, -23,  13,  -3, -12;
/M: SY='K';  M=  12, -46,   9,   7, -35, -17,   5, -39,  50, -36, -19,  -2, -48,  23,  32,   0, -24, -22, -21, -21;
/M: SY='E';  M= -13, -50,  34,  44, -38, -27,   7, -36,   0, -28, -22,  -4, -26,  33,  37,   3,  -7, -35, -29, -41;
/M: SY='W';  M=  18,   0, -14, -20,  -3, -46, -20,  35, -50,  22,   1, -32, -58, -21, -25, -29, -21,  30,  49,   1;
/M: SY='L';  M=  -4,   3,   2, -18,   3, -28, -40,  18, -27,  33,  17, -37, -41, -18,   6, -20, -10,  13,  11,   8;
/I:         I=-1; MD=-5;
/M: SY='R';  M=   5, -40,   5,  17, -20, -28,   3, -47,  29, -29, -19,  -5, -27,  11,  35,   5, -11, -40,  14,  -8; D=-1;
/I:         I=-1; MD=-5;
/M: SY='E';  M= -10, -64,  28,  38, -41,   0, -13, -47,  10, -36, -40,  -3, -26,  19,   8, -11, -17, -45,  28,  10; D=-1;
/I:         I=-1; MD=-5;
/M: SY='W';  M= -23,  -3,   3, -24,  -6, -30,  18, -13, -21,  27,  12, -30, -37,  -7, -13, -25, -27,  -3,  31,  20; D=-1;
/I:         I=-1; MD=-5;
/M: SY='W';  M=  -5, -27, -18,  -7,  -2,   0, -35, -30, -12,   1, -31,  16,  -2, -28,   8,  -3, -27, -23,  28, -31; D=-1;
/I:         I=-1; MD=-5;
/M: SY='E';  M= -22, -59, -11,  12, -28, -28,  -8, -47, -22, -12, -37,  -7, -36, -10,   1, -20, -36, -28,  -6, -20; D=-1;
/I:         I=-1; MD=-5;
/M: SY='D';  M= -19, -68,   6,   1, -53, -41, -22, -40, -24, -53, -60, -32, -13, -13,  -5, -16, -24, -35, -62, -23; D=-1;
/I:         I=-1; MD=-5;
/M: SY='H';  M= -23, -65, -36,  -3, -29, -20,   9, -42, -43, -24, -43, -29, -23, -39, -37, -35, -39, -31, -39, -18; D=-1;
/I:         I=-1; MI=0; MD=-5; IM=0; DM=-5;
/M: SY='R';  M= -18, -70,  -6, -24, -37, -23, -22, -48, -12, -38, -68, -23, -16,  -5,   1, -31, -42, -36, -45, -42; D=-1;
/I:         I=-1; DM=-5;
/M: SY='P';  M= -16, -35, -10,  -9, -26, -37, -39, -39, -17, -27, -56, -20,   5, -30, -21,  -6, -21, -23, -33, -24; D=-1;
/I:         I=-1; DM=-5;
/M: SY='L';  M=   4, -26, -14,  15,   7,  -4, -21,  11, -17,  21, -18, -23, -20, -14, -14,  -4,  -5,  -2,   3, -11; D=-1;
/I:         I=-1; DM=-5;
/M: SY='W';  M=  -8, -50,  38,   3, -14, -16,  -5, -16,   9,   7, -19,  10,  -5,   6,   0,  -6,  -9, -24,  46,  -7;
/M: SY='E';  M=   8, -35,  21,  28, -16, -11, -25, -12,  -9, -11, -28,   8,  13,  -5,  -7,   1,  21, -23,   6, -15;
/M: SY='D';  M=  -7, -30,  33,  12, -33, -17,  -3, -36,  32, -13, -24,  14, -11,   4,   3,   1,   8, -29,  14,   3;
/M: SY='R';  M=   1, -23,  13,  16, -19, -13, -21, -24,  30, -26, -22,  -5,  -1,  10,  31,  -6,   9,  -8, -47, -29;
/M: SY='W';  M=  -7, -47,  25,  22,  11,  -8, -38, -10,  12,  -9,  -6, -25,   2,   6, -22, -15,  -6,  -7,  43,  22;
/M: SY='P';  M=  -1, -57,  11,  15,  13, -32,   7, -19,   5,  13,  -1, -14,  19,  12,   4,  -3,  -6, -18,  -6, -17;
/M: SY='P';  M=   1, -10,  -5,  -2, -13, -33, -28,   5, -12,  14, -18, -12,  42,   0,   5, -24, -14,  12,  -9,   1;
/I:         I=-15; MD=-77;
/M: SY='R';  M=   3, -28,  17,  12, -16, -22,  -2, -31,  31, -30, -41,   0, -10,  19,  39,  -4,  -5, -27, -38, -23; D=-15;
/I:         I=-15; MI=-77; IM=-77; DM=-77;
/M: SY='Q';  M=   0, -52,  15,  21,  -5, -21, -20, -18,  11,   4,  -3,   0, -36,  31,  -5,  -4,  12, -13,  10, -12;
/M: SY='L';  M=  14, -38, -12, -16,  10, -33, -16,  28, -23,  30,  13, -24, -40, -24, -13, -26, -19,  22,   6, -18;
/M: SY='Q';  M=   6,  -8, -16,  -7,  -4, -27,   5,   2,   6,  17,   8, -11, -33,  29,  28, -16, -17, -10, -17,  -6;
/M: SY='W';  M=   8, -52,  10,  10, -17,  -1,  -4, -28,   8, -18, -33,  16, -18,  12,   6,  26,   3, -28,  33,  -7;
/M: SY='F';  M=   7, -30, -21,  15,  18, -23,  -8,   4,   1,   5,   2, -17, -28,  18,   9, -14,  -3,  -4,   8,  13;
/M: SY='I';  M=  -5, -29, -20, -15,  10, -38, -34,  61, -12,  15,   5, -34, -28, -25, -24, -23, -21,   9, -10, -10;
/M: SY='S';  M=  -1, -34,  21,  14, -19, -11, -22, -24,   4,  -7,  -8,  10, -21,   1,  -3,  48, -15, -28, -45, -24;
/M: SY='W';  M=  -5, -32,  13,  10,  -9, -12, -21, -30,  17, -13,  -8,  17, -28,   2,  31,  -2, -13, -22,  51,  13;
/M: SY='W';  M=  31,  15, -18, -27,  -5, -39, -33,  -5,  -5,  12,  -7, -27, -17,  22, -11, -11, -21,  -1,  78,  -8;
/M: SY='K';  M=  -2,  -9, -20,   5, -32, -23, -29, -23,  63, -16, -20,   0, -33,  -2,  19, -12, -14, -14, -12,  -3;
/M: SY='N';  M=  15, -48,  26,  25, -24, -10, -22, -25,  -6, -38, -32,  50, -29,   1,  -4,  18,  -7, -23, -15, -18;
/M: SY='E';  M= -14, -12,  23,  25, -25, -15,   1, -25,  15,  -4, -10,   2, -16,  25,  11,  17, -21, -25, -36,  -1;
/M: SY='M';  M=   4,  -8, -21, -22,   5,  30, -27, -16, -18,  30,  34,  -4, -31, -16,  -7, -25, -18, -14,   5,  -8;
/M: SY='L';  M= -13,  -7,  -1,  -8,  -6, -37, -22,  19,  -4,  26,  -6,  -7, -32, -16,  17, -13,  -8,  21, -18, -14;
/M: SY='P';  M=  -6, -20,  15,  -8, -34,  -4, -25, -23,  -1,  -6,   6,   9,  29, -14,  14,  18,  28, -24, -62, -29;
/M: SY='P';  M=  -4, -27,  -5,   2, -23, -25,  15, -24, -13, -22, -19,  -1,  78,  -4,  13, -11, -17, -26, -33, -14;
/M: SY='E';  M=  10, -23,  31,  36, -32,   2,   8, -35,  -2,  -9, -33,  12, -17,   9,   0,   0, -16, -22, -42, -16;
/M: SY='D';  M=  -6, -44,  37,  30, -20,  -2,   9, -26,   0, -15,  -9,  -5,   9,  21,  -3, -13,  -8, -17,  -4,  -3;
/M: SY='Y';  M=  16, -36,   3,  15,   0, -23, -23,   6, -14,  12, -13, -31, -15, -17, -23,  -3,  -8,  10, -43,  36;
/M: SY='Q';  M=   8, -57,  15,  11,  -7, -29, -13,  -2,  -3,   7, -20,  -9,  14,  30,  -6,  -9, -13,   2,  16, -11;
/M: SY='E';  M=  13, -27,  15,  18, -14,  -7, -21, -14,   8,   2, -17, -10,   9,   7,  17,   0,  -6, -26, -20, -21;
/M: SY='E';  M=   5, -16,  14,  20, -12,  -5,  15,  -9,   0,   3, -18,   0, -30,  -5,  14,  11, -12, -19,  -9, -10;
/M: SY='A';  M=  22, -21,   4,   5, -21,  -6, -10, -16,   0,   9,  -3,  -9,  -9,  21,   3,   1,  -5,  -6, -37, -19;
/M: SY='D';  M=   8, -30,  20,   0, -21, -14,  -3,   2,  -6,  -3, -15,  12, -10,  11,  15,   3,   4, -15, -12, -11;
/I:         I=-1; MD=-6;
/M: SY='N';  M=  18, -49,  12,  15, -19,  -7,  -6, -17,  -5, -16, -23,  19,  -4,   7,   9,   1,   3, -13, -14,   0; D=-1;
/I:         I=-1; MD=-6;
/M: SY='Q';  M=   5, -18,   9,   9,  -5,  -7,  11, -10,  -4, -11, -23,   2,   7,  14,   7,   5,  -7, -15,  -4,  10; D=-1;
/I:         I=-1; MD=-6;
/M: SY='R';  M=   6, -44,   0,  11,  -3,   1,   5, -13,   0,   9, -31,  -8,  -2,   7,  26, -16, -25, -27, -19,   0; D=-1;
/I:         I=-1; MD=-6;
/M: SY='R';  M= -11, -10,  10,  17, -25, -23, -31, -19, -12,  -3, -25, -23,  -8,   4,  23, -16, -30, -14, -33, -24; D=-1;
/I:         I=-1; MD=-6;
/M: SY='E';  M= -30, -44,   8,  30, -46, -40,  -2, -54,  -2, -45, -30, -14,   1,  13,  14, -21, -22, -42, -12, -28; D=-1;
/I:         I=-1; MD=-6;
/M: SY='E';  M= -30, -66,  -6,   1,  -2, -33, -11, -30, -32, -12, -18, -15, -10, -31, -16, -28, -28, -30,  -4, -21; D=-1;
/I:         I=-1; MD=-6;
/M: SY='W';  M=   3, -44, -35, -25, -39, -47, -12, -11, -30, -35, -35, -42,  -4, -24, -34, -44, -40, -21,  34, -44; D=-1;
/I:         I=-1; MI=0; MD=-6; IM=0; DM=-6;
/M: SY='H';  M= -14, -58, -12,   7, -56, -44,   8, -42, -17, -52, -54, -28, -38,   4,   6, -39, -30, -37, -36, -30; D=-1;
/I:         I=-1; DM=-6;
/M: SY='A';  M=  16, -59, -22, -15,  -9, -54, -64,  -3, -18,   6, -11, -47, -52, -22, -34, -33,  -5, -24, -11, -40; D=-1;
/I:         I=-1; DM=-6;
/M: SY='L';  M=  17, -20, -50, -49,   9, -29, -62,  13, -44,  22,   5, -46, -53, -40, -36, -43, -19,  15,  -9, -17; D=-1;
/I:         I=-1; DM=-6;
/M: SY='W';  M=  31, -22, -20, -13, -19, -16, -10, -10,  -8,   0, -34, -20, -38,  -4,  -7, -19, -27,  -9,  46, -20; D=-1;
/I:         I=-1; DM=-6;
/M: SY='P';  M=   1, -64,  19,  21, -42, -16,  13, -37,   2, -31, -43, -12,  22,   9,  18, -15,  -2, -40,  21,  -2; D=-1;
/I:         I=-1; DM=-6;
/M: SY='V';  M=  -1,  26, -48, -24,  33, -38, -39,  30, -47,  33,  -6, -39, -49, -49, -27, -36, -24,  36, -22,  -3;
/M: SY='Y';  M=   0, -25, -42, -32,  26, -37,  -6,   4, -30,  15, -10, -29, -55, -30,  -9, -19, -36,   0,  10,  83;
/M: SY='E';  M=  18, -47,   2,  44, -46, -25,  -9, -38,  19, -30, -33,  -9, -18,  29,  24,  -5,  -7, -16, -14, -13;
/M: SY='R';  M=  28, -17,   0,  31, -32, -16,   3, -16,  -2,  -3, -15, -18, -51,  15,  31,  -1, -13, -29, -28, -26;
/M: SY='Y';  M= -31, -60, -49, -36,  41, -53, -21, -27, -42,   7, -18, -50, -64, -38, -37, -46, -37,  -8,  34, 105;
/M: SY='Q';  M=   4, -20,   8,  47, -51, -37,   5, -27,   5, -15, -20,  -9, -30,  59,  17, -23, -15, -28,  -9, -31;
/M: SY='Q';  M=  20, -32,  20,  35, -47, -32, -10, -39,  23, -33, -26,  19, -32,  37,  20, -10,  -7, -33, -61, -30;
/M: SY='R';  M=   8, -39, -27,  19,  -5, -35,  15, -11,  -1,   3,  14, -18, -29,  15,  34, -18,  -9,  -2, -11,  19;
/M: SY='K';  M= -40,  13, -39, -30, -18, -40, -32, -22,  53,  50,  10, -26, -57, -15,  11, -33, -28, -27, -19, -33;
/M: SY='R';  M=   8, -41,  15,   7, -43, -15, -11, -23,  35, -17, -37,  -6, -37,  27,  50, -12, -22, -33, -28, -30;
/M: SY='E';  M=  11, -47,  14,  37, -33, -30, -15, -39,  23, -16, -17,   0, -43,  29,  30,   7,   0, -37, -61, -46;
/M: SY='R';  M=   8, -31,  -2,  14, -30, -29,  26, -43,  12, -10, -25,  26, -47,  26,  42,  -3, -21, -37,  -8,  12;
/M: SY='N';  M=  -7, -23,  -7, -10, -41,  48,   6, -54,   4, -47, -24,  65, -23,   4,   2,  -1, -37, -56, -30, -40;
/M: SY='A';  M=  30,   1, -46,  -8,  -9, -34, -16,   2,  -9,  26, -11, -35, -41,   3, -11,  -9, -24,  12,  29,  11;
/M: SY='L';  M= -20, -19, -49, -46,   2, -64, -34,  37, -40,  43,  36, -51, -51, -24, -13, -37, -25,  33,  -2,   5;
/M: SY='D';  M= -33, -44,  95,   3, -38,  -7, -16, -42, -34, -44, -43, -15, -39, -29, -46,   8,  12, -56, -76, -51;
/M: SY='F';  M= -32, -41, -43, -56,  97, -58, -17, -19, -46, -12,  -6, -56, -15, -46, -38, -42, -34, -26, -12,  57;
/M: SY='D';  M=   8, -57,  76,  18, -55,   3, -24, -51, -37, -56, -56,  29, -15, -10, -30,  21, -18, -53, -70, -31;
/M: SY='D';  M= -23, -61,  96,  21, -56, -19, -23, -54, -38, -26, -14, -11, -37, -17, -33, -16, -24, -54, -74, -28;
/M: SY='L';  M= -15, -34, -33, -38, -22, -49, -49,  19, -41,  60,  55, -56, -39,  10, -49, -31, -43,   4, -24, -26;
/M: SY='I';  M= -13, -44, -44,   5, -13, -38, -52,  48, -46,  46,  12, -37, -28,   4, -32, -30, -39,   6, -29, -26;
/M: SY='H';  M=  -6, -45, -23, -15,  -9, -29,  37,   6, -25,  27,  11, -15, -37,  -2,  12,  -1,   8,  -3,  19,  18;
/M: SY='R';  M=  -5, -38,  -6,  10,   5, -38,   5,  -3,  10,  28, -15,  -5, -55,   4,  29, -21, -17, -27,   5,  14;
/M: SY='A';  M=  50,  40, -42, -31, -24, -37, -52, -36, -40,  10, -14, -36,  24, -46, -35,  -5,  36,  -8,  -4, -33;
/M: SY='V';  M=  10,  -5,  -8, -25, -15, -50,   7,   8, -20,  24, -26, -11, -37, -32,  -3, -22,  -5,  33, -10,  33;
/M: SY='R';  M=   7, -38,  13,  32, -32, -34,   2, -27,   9,  -5, -14,   4, -15,  28,  34,  -7,  -9, -25, -19, -29;
/M: SY='L';  M=  20, -27, -49, -30, -19, -36, -31,  19, -41,  56,  19, -40, -51, -30, -21, -42, -23,   3, -36,  -8;
/I:         I=-6; MD=-28;
/M: SY='L';  M= -15, -38, -58, -50,  33, -50, -31,  10, -33,  63,  21, -49, -47, -24, -28, -42, -43,  -5,  -8, -29; D=-6;
/I:         I=-6; MI=0; MD=-28; IM=0; DM=-28;
/M: SY='E';  M=  -9, -37,  -3,  22, -63, -28, -34, -43,  -2, -24, -45, -15, -27,  11,  22, -10, -15, -26, -44, -39; D=-6;
/I:         I=-6; DM=-28;
/M: SY='Q';  M=  -6, -45,   7,  25, -54, -20,  -5, -48,  -2, -43, -25,  19, -54,  29,   7,  -8,  -4, -18, -72, -46; D=-6;
/I:         I=-6; DM=-28;
/M: SY='N';  M= -20, -33,  31, -18,  -6, -12,  30, -47, -30, -48, -50,  49,  -1,  -5,  -5,  -6, -29, -39, -69,  -2; D=-6;
/I:         I=-6; DM=-28;
/M: SY='P';  M=  -1, -52,  -3,  20, -59, -26, -11, -32, -19, -62, -47, -21,  73,  -4, -10,   0, -10, -44, -69, -61; D=-6;
/I:         I=-6; DM=-28;
/M: SY='W';  M=   2, -27,  33,  41, -38, -26,   5, -34,  -8, -26, -37,  -3,   3,  13,  -1, -15, -27, -40,  51, -45; D=-6;
/I:         I=-6; DM=-28;
/M: SY='V';  M=  -8, -42, -34, -18,  -4, -48, -49,  36, -25,  28, -13, -21, -46, -33, -32, -21, -16,  48, -18, -14; D=-6;
/I:         I=-6; DM=-28;
/M: SY='R';  M=  24, -14, -28, -23, -18, -11,  -4, -16,   0,  29, -29, -27, -52,   9,  43, -20, -25, -15, -57, -20; D=-6;
/I:         I=-6; DM=-28;
/M: SY='E';  M=  24, -44,  14,  26, -26,  -8,   3, -28,  16, -27, -29,  11,  -6,  19,  13,  -5,  -9, -32, -58,   0;
/M: SY='K';  M=  13, -57,  -5,  14,  -7, -33,  25, -25,  32, -17, -11, -15, -36,  22,  31,  -1,  -4, -29, -21,  -1;
/M: SY='W';  M= -21,  -2, -45,  -4,  11, -43, -16,  16, -44,  28,  -6, -45,  -8,  -8, -35, -47, -29,  10,  72,  58;
/M: SY='Q';  M=  -4, -45,  10, -14, -41, -19,  14, -34,  -5, -29, -43, -18, -10,  61,  59,   0, -14, -26, -19, -25;
/M: SY='Q';  M=   4, -48,  16,  21, -47,  -7,  -5, -45,  10, -25, -33,  30, -13,  37,  21,  20, -17, -35, -61, -14;
/M: SY='R';  M= -34, -29, -27, -15, -31, -17,   7, -35,  27, -18, -37,   2,   5,  30,  71, -14, -18, -44,  -3, -20;
/M: SY='Y';  M= -31, -32, -63, -60,  72, -42, -20,  19, -55,   0, -12, -58, -37, -56, -52, -52, -30,  -1,  62,  74;
/M: SY='R';  M= -26, -34,  38,   4, -36, -33,   6, -60,  35, -51, -49, -15,  24,  28,  51,  -5,   1, -52, -61, -23;
/M: SY='H';  M=  -4, -31, -35,   3,   9, -51,  91, -21, -42,  -9, -30, -35, -57, -37, -37, -27, -30,  11,   2,  69;
/M: SY='I';  M=  -4, -45, -51, -50,  -6, -65, -48,  61, -43,  24,   0, -59, -59, -55, -47, -51, -39,  55, -45, -40;
/M: SY='L';  M= -43, -22, -65, -44,  27, -65, -27,  15, -57,  61,  57, -49, -47, -34, -56, -45, -37,  13, -34, -16;
/M: SY='V';  M= -36,  -3, -63, -22, -32, -53, -65,  50, -57,  -4, -13, -59, -45, -45, -59, -44, -34,  77, -65, -43;
/M: SY='D';  M= -90,-127, 222, -30,-107, -83, -73,-135, -64,-132,-130, -38, -79, -75, -66, -77, -81,-111,-168,-105;
/M: SY='E';  M= -77,-127,  21, 202,-128,-116, -73,-130, -51,-105,-110, -58, -79, -37, -59, -66, -73,-100,-126, -67;
/M: SY='Y';  M=  22, -24, -46, -56,  75, -40, -17, -22, -52, -25, -17, -43, -62, -52, -51, -21, -40, -22, -26,  83;
/M: SY='Q';  M= -33, -67, -37,  -5, -72, -50, -20, -58, -23, -54, -41, -33, -49, 121, -24, -23, -37, -60, -55, -44;
/M: SY='D';  M= -50, -64, 109,  -1, -68, -48, -11, -66, -37, -58, -63, -11, -50, -14, -37, -39, -40, -49, -83, -40;
/M: SY='T';  M= -25,  -2, -47, -48, -31, -53, -24,  19, -45,   4,  -3, -10, -49, -34, -51,   5,  83,   2, -65, -26;
/M: SY='N';  M= -33, -52,  50, -29, -59, -16, -10, -51, -31, -51, -53,  82, -51, -30, -35,  43,  10, -55, -74, -43;
/M: SY='P';  M=  -3, -48, -26,  16, -29, -31,  33, -22,  -6, -11, -25, -19,  73,   3,   2, -13,  -6, -21, -39, -10;
/M: SY='L';  M=  24, -12, -26, -30, -31, -49, -33,  28, -31,  29,   1, -41, -28,  22, -27,  -6,   0,  25, -45, -43;
/M: SY='Q';  M= -10, -65, -30,  -7, -68, -43,  -1, -55, -21, -41, -15, -31, -31, 114,  -5, -27, -38, -44, -41, -44;
/M: SY='W';  M=  -8, -60, -38,  13,  27, -45,   3, -16, -29,   9,   1, -31, -58,   1, -23, -29, -29, -28,  84,  75;
/M: SY='R';  M=   9, -58,  13,  39, -44, -31, -10, -45,  12, -20, -25, -11, -33,  25,  48,  -6,  -5, -18, -29, -41;
/M: SY='W';  M= -30, -36, -67, -52,   8, -58, -57,  55, -59,  54,  25, -62, -62, -44, -59, -56, -31,   5,  56, -33;
/M: SY='L';  M= -24, -49, -45, -59,  22, -66, -56,  43, -42,  54,   7, -60, -62, -41, -57, -52, -25,  34, -54, -30;
/M: SY='R';  M=  -1, -41,   6,  25, -27, -39, -11, -49,  39, -34, -22,  -5, -30,  24,  50,   4,  -7, -40, -14, -27;
/M: SY='L';  M=  22, -22, -40,  -9, -19, -37, -11, -14,   2,  38,  10, -33, -45,  -6,  17,   4,  -8,  -5, -19, -22;
/M: SY='L';  M= -23, -54, -53, -59,   1, -54, -10,  40, -58,  64,   7, -61, -63, -53, -39, -46, -44,   4,  27, -24;
/M: SY='A';  M=  47,  30, -46, -32,  24, -26, -22, -12, -31, -14, -24, -19, -43, -45, -27,  16,  17,   3, -17,  16;
/M: SY='G';  M=  15, -45,  -9,  12, -50,  37, -12, -46,  14, -26, -29,   3,   2,  15,  12,  11,  -2, -37, -60, -30;
/M: SY='E';  M=   0, -21,  24,  27, -53,  26,   3, -38,  16, -36, -36,  13,  20,  -5,  -3,   2,  -6, -27, -63, -44;
/M: SY='H';  M=  -1, -28,   1,   1,   0,  25,  53, -52,   2, -45, -39,  23, -24,   0,  21,   7,   2, -40, -16, -12;
/I:         I=-3; MD=-14;
/M: SY='N';  M=   0, -17,  16,   1,  -9,   8,  17, -33,   2, -44, -40,  27,  12,  11,   6,   7,   6, -25, -63, -27; D=-3;
/I:         I=-3; MD=-14;
/M: SY='N';  M=   0, -44,   9,  -4, -38, -14,   0, -37,  -7, -37, -27,  52,  -4,  13,   3,   6,   6, -43, -67, -12; D=-3;
/I:         I=-3; MI=0; MD=-14; IM=0; DM=-14;
/M: SY='L';  M= -25, -34, -65, -50,  11, -67, -56,  38, -58,  58,   9, -61, -63, -50, -45, -45, -14,  28, -56, -32; D=-3;
/I:         I=-3; DM=-14;
/M: SY='F';  M= -40,  60, -59, -57,  73, -60, -51,  -1, -53,  -6,  31, -32, -59, -39, -55, -25,  43,   4,   4,   1;
/M: SY='V';  M=  24,  26, -62, -48,  -6, -50, -56,  27, -45,  12,  46, -55, -47, -51, -15, -42, -35,  54, -39, -30;
/M: SY='V';  M=  -1, -26, -64, -59, -22, -51, -65,  32, -57, -15, -15, -58, -60, -58, -59, -39, -18,  83, -66, -44;
/M: SY='G';  M= -14, -59, -36, -44, -39,  95, -53, -71, -52, -67, -57, -33, -51, -49, -59, -27, -31, -64, -56, -59;
/M: SY='D';  M= -38, -63, 111, -15, -70, -41, -37, -67, -28, -66, -65, -19, -50, -37, -46, -27, -32, -57, -85, -53;
/M: SY='P';  M=  -8, -63,  55,   3, -33, -31, -46, -28, -23, -50, -50, -17,  81, -42, -34, -12, -18,  -1, -45, -20;
/M: SY='D';  M= -23, -33,  74, -17, -45, -42,  24, -49,  48, -54, -12,  39, -50, -32,  -9, -20, -33, -54,  24, -43;
/M: SY='Q';  M= -37, -66, -30, -11, -71, -50, -31, -57, -23, -53, -27, -33, -49, 121, -19, -23, -28, -53, -55, -44;
/M: SY='S';  M=  39,  17, -37, -25, -56, -20, -45, -47, -34, -44, -31, -24, -49, -23,   7,  72,  11, -31, -64, -50;
/M: SY='I';  M= -38, -60, -68, -66, -32, -72, -47,  97, -61,  -4, -19, -58, -57, -58, -64, -49, -30,  11, -57, -40;
/I:         I=-15; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='Y';  M= -47, -46, -45, -55,  24, -51, -16, -29, -41, -27,  -6, -29, -47, -26, -46, -44, -41, -38, -14, 119;
/M: SY='G';  M=  17, -55, -18,   3, -50,  47, -27, -61, -12, -51, -49, -21, -31,   6,  32,  42, -15, -54, -36, -51;
/I:         I=-15; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='W';  M= -47, -53, -67, -38,  93, -55, -24, -30, -54, -32, -40, -24, -43, -59, -29, -30, -35, -40, 118,   5;
/M: SY='R';  M= -15, -62, -45, -30, -30, -43, -32, -51,  -7, -38, -36,   2, -36,  18,  94, -21,  -9, -44, -19, -37;
/M: SY='G';  M= -25, -55, -17, -42, -37,  84, -21, -54, -43, -31, -35,  -7, -27,   0, -38,  -8, -29, -34, -58, -40;
/M: SY='A';  M=  80, -30, -44, -44, -29,   4, -52, -46, -46, -38, -44, -35, -42, -43, -51,  15, -14, -15, -59, -52;
/M: SY='D';  M= -14, -58,  68,  17, -29, -44,  -7, -39,   3, -15, -34,  15, -50,  -2,  11,  11,   4, -33, -14, -31;
/M: SY='P';  M=  -1, -59, -28, -32, -17, -11, -36,  28, -49,  -9, -12, -42,  72, -37, -36,  -8, -19,  28, -58,  -9;
/M: SY='E';  M=  -3, -50,  25,  31, -13,  -3,  13, -34,   1, -33,  -8,   3, -25,  21,  22,  14,  -2, -30, -37,  -8;
/M: SY='N';  M=  -5,  -5, -10, -26,   9, -17,  -5,   1, -35,   9, -11,  62, -43, -33, -16,  -3,  16, -10, -57,  15;
/M: SY='F';  M= -25, -40, -62, -51,  60, -13, -26,  44, -45,  25,  24, -40, -61, -49, -44, -43, -16, -12, -40,  41;
/M: SY='L';  M=  -9, -54,   1,   2,   5, -17, -12,  10, -22,  39,  18,  -9, -47,   2,  -8,  -8,  -1,  -7, -33, -34;
/M: SY='N';  M=  -2, -58,  27,  30, -50,  -7,   8, -39,  11, -34, -27,  36, -50,  30,  36,  -4, -17, -31, -64, -39;
/I:         I=-15; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='F';  M=  17, -54, -43, -25,  76, -49, -30,  -4,   4,  13,  18, -30, -43, -30, -19, -40, -39, -18,  14,   0;
/M: SY='R';  M=   4, -19,  -3,  24,  16, -15,  -7,  -9,  11, -23, -40, -11,   9,   9,  35,  -9, -23, -24, -41,  11;
/M: SY='E';  M=  -3, -12,  21,  30, -27,  -5,  19, -40,  25, -34, -32,  10, -21,  27,  19,   7,  -3, -39, -47, -33;
/M: SY='D';  M=  -4, -59,  58,  22, -37, -22,   9, -30,   4, -22, -14, -15, -24,   9,  35,  -5,  -9, -39, -63, -12;
/M: SY='F';  M=  -7,  13, -24, -31,  75, -39,   0, -11, -37, -15, -20, -33, -28, -22, -25, -16,  -6, -13,   1,  53;
/I:         I=-5; MD=-27;
/M: SY='P';  M=  -2, -20,   4,   6,  -6,   7,  -7, -42,  -3, -46, -49,   2,  66,  11, -10,   6, -18, -26, -61, -32; D=-5;
/I:         I=-5; MD=-27;
/M: SY='D';  M=  -3, -13,  26,  -3, -52,  15,  -2, -33,   0, -39, -43,  26,   8,  11,   8,  -7, -12, -22, -47, -52; D=-5;
/I:         I=-5; MD=-27;
/M: SY='A';  M=  25, -20,  -6, -24, -47, -22, -18, -37, -23,   0, -31, -13, -11,  -7,  -9,  -5,  11, -26, -55, -35; D=-5;
/I:         I=-5; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='K';  M=   0, -33,  -4,  14, -46, -36,  18, -23,  38, -30, -31,   7, -15,  19,  34,   6,  19, -32, -61, -33;
/M: SY='V';  M= -23, -16, -21,   2, -26, -48,  11,  15,   0,  -3,  -8, -26, -19,   8,  25,  -6,  22,  33, -60,  -7;
/M: SY='I';  M= -26, -17, -33, -37,  21, -45,  11,  49, -26,   8, -12, -31, -42, -31, -13, -40, -16,  31, -32,  46;
/M: SY='T';  M= -13, -55,  -8,   8, -20, -48,  18, -18,  25, -13, -12,  -4,  -9,   0,  28,   8,  31,  -2, -50,   2;
/M: SY='L';  M= -43, -26, -65, -58, -10, -67, -51,   0, -58,  79,  22, -63, -51, -41, -40, -38, -22, -22, -54, -36;
/M: SY='E';  M=  -3, -37,  24,  47, -56, -13, -29, -32, -13, -32, -48,  23,  -7,  -4, -10,  18,  31, -23, -29, -22;
/M: SY='Q';  M= -24, -27,  -4,  30, -38, -30,   0, -17,  13, -38, -37, -16, -37,  52,  30, -21,  40,  -9, -29, -14;
/M: SY='N';  M= -14,   6,   4, -39, -58, -34, -30, -43, -34, -52, -51, 101, -40, -19, -35,  23,   6, -48, -75, -53;
/M: SY='Y';  M= -38, -62, -57, -49,  61, -33,  15, -24, -48, -30, -35, -53, -58, -28,  -7, -37, -46, -39,  64, 100;
/M: SY='R';  M= -31, -65, -46, -28, -39, -53, -26, -57,  -5, -53, -46, -40, -58, -24, 107, -44, -48, -58, -30, -44;
/M: SY='S';  M= -23,  22, -33, -29,  -1, -34, -34, -47, -26, -36, -43,   5, -49, -22, -42,  87,  -4, -42,  -6, -17;
/M: SY='T';  M=   4, -16, -13, -31, -39,  -1,  -4, -33, -31, -33, -32,   8,  -7,  -8,   9,  34,  62, -15, -36, -41;
/I:         E1=0; IE=-255; DE=-255;

» more

Post-processing [info]

PROMOTED_BY

PS51217

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	261 in 261 different sequences
Number of true positive hits	261 in 261 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	9
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	96.67 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Feature key [info]	DOMAIN
Feature description [info]	UvrD-like helicase ATP-binding
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

261 sequences

ADDA_ACET2  (A3DH19), ADDA_ALKMQ  (A6TVN2), ADDA_ALKOO  (A8MJ41),

ADDA_ANOFW  (B7GM51), ADDA_BACAH  (A0RAX7), ADDA_BACAN  (Q81TW1), 
ADDA_BACC0  (B7JDU4), ADDA_BACC1  (Q73C23), ADDA_BACC2  (B7IL84), 
ADDA_BACC4  (B7HGP9), ADDA_BACC7  (B7HZR5), ADDA_BACCN  (A7GM37), 
ADDA_BACCQ  (B9ITE9), ADDA_BACCR  (Q81GP9), ADDA_BACCZ  (Q63EM2), 
ADDA_BACHK  (Q6HM43), ADDA_BACLD  (Q65LJ9), ADDA_BACMK  (A9VJ02), 
ADDA_BACP2  (A8FBR1), ADDA_BACSU  (P23478), ADDA_BACVZ  (A7Z368), 
ADDA_CALS4  (Q8RCZ0), ADDA_CARHZ  (Q3AA35), ADDA_CLOAB  (Q97GV3), 
ADDA_CLOB1  (A7FPG0), ADDA_CLOB6  (C3L047), ADDA_CLOB8  (A6LPC4), 
ADDA_CLOBA  (B2UX57), ADDA_CLOBB  (B2THC8), ADDA_CLOBH  (A5HYY0), 
ADDA_CLOBJ  (C1FSA8), ADDA_CLOBK  (B1IEN0), ADDA_CLOBL  (A7GAJ8), 
ADDA_CLOBM  (B1KUZ8), ADDA_CLOD6  (Q18AN9), ADDA_CLOK1  (B9DZK4), 
ADDA_CLOK5  (A5N628), ADDA_CLONN  (A0PY67), ADDA_CLOP1  (Q0TV46), 
ADDA_CLOPE  (Q8XPE2), ADDA_CLOPS  (Q0SWW4), ADDA_DESAP  (B1I493), 
ADDA_DESHD  (B8FXD7), ADDA_DESHY  (Q24WW8), ADDA_DESRM  (A4J4E3), 
ADDA_ENTFA  (Q836J8), ADDA_EXIS2  (B1YKM8), ADDA_GEOKA  (Q5L263), 
ADDA_GEOTN  (A4IKW7), ADDA_HELMI  (B0TDI0), ADDA_LACAC  (Q5FJX0), 
ADDA_LACCB  (B3WEJ1), ADDA_LACDA  (Q1GAA9), ADDA_LACDB  (Q04AN7), 
ADDA_LACGA  (Q043G6), ADDA_LACH4  (A8YVK0), ADDA_LACJO  (Q74JA6), 
ADDA_LACLA  (Q9CJI9), ADDA_LACLM  (A2RH77), ADDA_LACLS  (Q033I1), 
ADDA_LACP3  (Q038V7), ADDA_LACP7  (A9KTE6), ADDA_LACPL  (Q88U41), 
ADDA_LATSS  (Q38X69), ADDA_LEUCK  (B1MZM2), ADDA_LEUMM  (Q03W49), 
ADDA_LEVBA  (Q03NA7), ADDA_LIGS1  (Q1WRS0), ADDA_LIMF3  (B2GEY4), 
ADDA_LIMRD  (A5VHK2), ADDA_LIMRJ  (B2G532), ADDA_LISIN  (Q929A9), 
ADDA_LISMF  (Q71X99), ADDA_LISMH  (B8DF44), ADDA_LISMO  (Q8Y511), 
ADDA_LISW6  (A0AL18), ADDA_LYSSC  (B1HN90), ADDA_MOOTA  (Q2RL77), 
ADDA_NATTJ  (B2A610), ADDA_OCEIH  (Q8ERW5), ADDA_OENOB  (Q04GY7), 
ADDA_PEDPA  (Q03D71), ADDA_PELTS  (A5D1P3), ADDA_RUMCH  (B8I2Y2), 
ADDA_STAA1  (A7X0I2), ADDA_STAA2  (A6U074), ADDA_STAA3  (Q2FIA8), 
ADDA_STAA8  (Q2FZT5), ADDA_STAA9  (A5IRE5), ADDA_STAAB  (Q2YWW4), 
ADDA_STAAC  (Q5HHB7), ADDA_STAAE  (A6QFH8), ADDA_STAAM  (Q99VC3), 
ADDA_STAAN  (Q7A6H4), ADDA_STAAR  (Q6GIC1), ADDA_STAAS  (Q6GAV9), 
ADDA_STAAT  (A8Z073), ADDA_STAAW  (Q8NXE9), ADDA_STACT  (B9DIS2), 
ADDA_STAEQ  (Q5HQJ4), ADDA_STAES  (Q8CPT9), ADDA_STAHJ  (Q4L4Y3), 
ADDA_STAS1  (Q49WA6), ADDA_STRA1  (Q3K1I4), ADDA_STRA3  (Q8E5T9), 
ADDA_STRA5  (Q8E061), ADDA_STREM  (B4U2H1), ADDA_STRGC  (A8AY33), 
ADDA_STRMU  (Q8DT76), ADDA_STRP1  (Q9A0H3), ADDA_STRP2  (Q04KF8), 
ADDA_STRP3  (P0CZ52), ADDA_STRP4  (B5E4P5), ADDA_STRP6  (Q5XCW6), 
ADDA_STRP8  (Q8P1J2), ADDA_STRPB  (Q1JCJ8), ADDA_STRPC  (Q1JMH5), 
ADDA_STRPD  (Q1JHM1), ADDA_STRPF  (Q1J7E4), ADDA_STRPG  (A2RFA8), 
ADDA_STRPI  (B1IBR6), ADDA_STRPJ  (B8ZQ32), ADDA_STRPM  (Q48UB8), 
ADDA_STRPN  (Q97QP9), ADDA_STRPQ  (P0CZ53), ADDA_STRPS  (B2IPX3), 
ADDA_STRPZ  (B5XKR4), ADDA_STRR6  (Q8DPR6), ADDA_STRS2  (A4W0M7), 
ADDA_STRS7  (C0MGY6), ADDA_STRSV  (A3CNT9), ADDA_STRSY  (A4VUD2), 
ADDA_STRT1  (Q5LY80), ADDA_STRT2  (Q5M2T7), ADDA_STRTD  (Q03IZ8), 
ADDA_STRU0  (B9DRV0), ADDA_SYMTH  (Q67MD5), ADDA_SYNWW  (Q0AXU8), 
ADDA_THEP3  (B0KDB7), ADDA_THEPX  (B0K213), ADDB_ACET2  (A3DH20), 
ADDB_ALKMQ  (A6TVN9), ADDB_ALKOO  (A8MJ51), ADDB_ANOFW  (B7GM52), 
ADDB_BACAH  (A0RAX6), ADDB_BACAN  (Q81TW2), ADDB_BACC0  (B7JDU3), 
ADDB_BACC1  (Q73C24), ADDB_BACC2  (B7IL83), ADDB_BACC4  (B7HGP8), 
ADDB_BACC7  (B7HZR4), ADDB_BACCN  (A7GM36), ADDB_BACCQ  (B9ITE8), 
ADDB_BACCR  (Q81GQ0), ADDB_BACCZ  (Q63EM3), ADDB_BACHK  (Q6HM44), 
ADDB_BACLD  (Q65LK0), ADDB_BACMK  (A9VJ01), ADDB_BACP2  (A8FBR0), 
ADDB_BACSU  (P23477), ADDB_BACVZ  (A7Z367), ADDB_CLOB8  (A6LPC3), 
ADDB_CLOBA  (B2UX56), ADDB_CLOBB  (B2THC7), ADDB_DESAP  (B1I494), 
ADDB_DESHD  (B8FXD8), ADDB_DESHY  (Q24WW7), ADDB_DESRM  (A4J4E2), 
ADDB_EXIS2  (B1YKM7), ADDB_GEOKA  (Q5L264), ADDB_GEOTN  (A4IKW6), 
ADDB_HELMI  (B0TDI1), ADDB_LISIN  (Q929A8), ADDB_LISMF  (Q71X98), 
ADDB_LISMH  (B8DF43), ADDB_LISMO  (Q8Y510), ADDB_LISW6  (A0AL19), 
ADDB_LYSSC  (B1HN89), ADDB_MOOTA  (Q2RL78), ADDB_NATTJ  (B2A611), 
ADDB_OCEIH  (Q8ERW6), ADDB_PELTS  (A5D1P4), ADDB_STAA1  (A7X0I1), 
ADDB_STAA2  (A6U073), ADDB_STAA3  (Q2FIA9), ADDB_STAA8  (Q2FZT6), 
ADDB_STAA9  (A5IRE4), ADDB_STAAB  (Q2YWU2), ADDB_STAAC  (Q5HHB8), 
ADDB_STAAE  (A6QFH7), ADDB_STAAM  (Q99VC4), ADDB_STAAN  (Q7A6H5), 
ADDB_STAAR  (Q6GIC2), ADDB_STAAS  (Q6GAW0), ADDB_STAAT  (A8Z072), 
ADDB_STAAW  (Q8NXF0), ADDB_STACT  (B9DIT7), ADDB_STAEQ  (Q5HQJ5), 
ADDB_STAES  (Q8CPU0), ADDB_STAHJ  (Q4L4Y2), ADDB_STAS1  (Q49WA5), 
ADDB_SYMTH  (Q67MD4), GAJB_BACC5  (P0DW48), GAJB_BACC6  (J8HQ06), 
HELD_BACSU  (O32215), HELD_ECOLI  (P15038), HMI1_YEAST  (Q12039), 
PCRA_BACSU  (O34580), PCRA_GEOSE  (P56255), PCRA_LEUCI  (Q9S3Q0), 
PCRA_STAA8  (Q53727), PCRA_STAAC  (Q5HEL7), PCRA_STAAM  (P64318), 
PCRA_STAAN  (P64319), PCRA_STAAR  (Q6GFF2), PCRA_STAAS  (Q6G828), 
PCRA_STAAW  (Q8NVT1), PCRA_STAEQ  (Q5HN29), PCRA_STAES  (Q8CRT9), 
RECB_BORBU  (O51578), RECB_BUCAI  (P57529), RECB_BUCAP  (Q8K9A9), 
RECB_BUCBP  (Q89AB3), RECB_CHLMU  (Q9PLT8), RECB_CHLPN  (Q9Z7G7), 
RECB_CHLTR  (O84645), RECB_ECOLI  (P08394), RECB_HAEIN  (P45157), 
RECB_MYCS2  (A0QS29), RECB_MYCTO  (P9WMQ2), RECB_MYCTU  (P9WMQ3), 
REP_BUCAI   (P57654), REP_BUCAP   (O51889), REP_BUCBP   (Q89A21), 
REP_ECOLI   (P09980), REP_HAEIN   (P44804), REP_SALTY   (Q9L6S1), 
SRS2L_ARATH (D1KF50), SRS2_SCHPO  (Q10213), SRS2_YEAST  (P12954), 
UVRD1_MYCBO (P0A5A4), UVRD1_MYCLE (Q9CD72), UVRD1_MYCTO (P9WMQ0), 
UVRD1_MYCTU (P9WMQ1), UVRD2_MYCBO (P64321), UVRD2_MYCLE (P53528), 
UVRD2_MYCTO (P9WMP8), UVRD2_MYCTU (P9WMP9), UVRD_ECOLI  (P03018), 
UVRD_HAEIN  (Q02322), UVRD_MYCCT  (P45612), UVRD_MYCGE  (P47486), 
UVRD_MYCPN  (P75437), UVRD_RICBR  (Q1RIP8), UVRD_RICCN  (Q92HZ6), 
UVRD_RICFE  (Q4ULN5), UVRD_RICPR  (Q9ZD95), UVRD_RICTY  (Q68WT1), 
UVRD_SALTY  (Q05311), Y340_MYCPN  (P75438), YJCD_BACSU  (O31626)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

9 sequences

FBH1_CHICK  (F1ND48), FBH1_HUMAN  (Q8NFZ0), FBH1_MOUSE  (Q8K2I9),

HELZ2_HUMAN (Q9BYK8), HELZ2_MOUSE (E9QAM5), JHS1_ARATH  (A0A1P8ASY1), 
MAA3_ARATH  (B6SFA4), YR568_MIMIV (Q5UR49), ZNFX1_CAEEL (E9P860)

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PDB
[Detailed view]

47 PDB

1PJR; 1QHG; 1QHH; 1UAA; 1W36; 2IS1; 2IS2; 2IS4; 2IS6; 2PJR; 3K70; 3LFU;
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