PROSITE entry PS51179

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51179
Entry name [info]	POU_3
Accession [info]	PS51179
Entry type [info]	MATRIX
Date [info]	01-JAN-2006 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00035
Associated ProRule [info]	PRU00530

Name and characterization of the entry

Description [info]

POU-specific (POUs) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=75;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=70;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2913959; R2=0.0090443; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=687; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=466; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-33; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='D';  M= -42, -74,  78,  70, -70, -52, -36, -56, -30, -50,  37, -13, -55, -10, -43,  -7, -34, -53, -78, -70;
/M: SY='D';  M= -39, -63,  75,  58, -62, -52, -38, -45, -33, -38,  55, -14, -55, -15, -45,   0,   3, -44, -70, -67;
/M: SY='D';  M=   7, -49,  49, -19, -66,  10, -39, -38,  11, -55, -45, -20,  11,   7,  21,  17,  13,   3, -69, -63;
/M: SY='P';  M=   5, -39, -49, -45, -54, -53, -51,   9, -46, -31,  33, -42,  79, -39, -52,   6,  55, -19, -63, -62;
/M: SY='D';  M= -33,  24,  77,  28, -63, -45, -39, -51, -39, -12, -45,  17, -57, -27, -49,  24,  25, -47, -78, -63;
/M: SY='P';  M= -32, -49, -40,  15, -41, -62, -44,  17, -40,  24,  41, -47,  67,  22, -47,  14, -28, -18, -61, -58;
/M: SY='R';  M= -35, -68,  35,  41, -76,  -6, -25, -75,  20, -72, -56,  30, -56, -11,  63,  12, -28, -64, -74, -64;
/M: SY='E';  M= -39, -87,  44,  92, -86, -59, -25, -78, -18, -78, -59, -22, -51,  36, -31, -28, -37, -62, -86, -73;
/M: SY='M';  M= -50, -41, -89, -77, -13, -82, -64,  10, -65,  73,  77, -77, -74, -47, -61, -64, -41,  -5, -49, -46;
/M: SY='E';  M= -38, -90,  15, 101, -89, -62, -27, -78, -18, -80, -63, -28, -50,   8, -32, -27, -37, -59, -95, -76;
/M: SY='Q';  M=  34, -47, -26,  23, -66,  -7, -20, -59,  23, -55, -34, -25, -44,  78, -16, -14,  15, -43, -57, -58;
/M: SY='F';  M= -64, -42, -84, -91, 113, -84, -44, -24, -75, -11, -19, -77, -90, -70, -77, -63, -56, -36,  -2,  36;
/M: SY='A';  M=  85, -20, -48, -36, -60, -19, -48, -45, -37, -48, -43, -45, -33, -32, -45,   4, -15, -21, -58, -56;
/M: SY='K';  M= -37, -69, -11,  45, -72, -50, -23, -71,  70, -68, -45,  33, -50,  38,  24, -27, -32, -61, -80, -62;
/M: SY='H';  M= -38, -61,  42,  44, -59, -57,  44, -48, -20, -10, -35, -19, -56,  37,  26, -21,  39, -44, -66, -48;
/M: SY='F';  M= -59, -42, -86, -87,  96, -84, -51,  -9, -74,  44,  -2, -79, -85, -65, -73, -64, -52, -23, -14,  22;
/M: SY='K';  M= -34, -68, -31, -12, -67, -49, -34, -68,  96, -65, -41, -18, -46,   3,  21, -30, -33, -59, -91, -62;
/M: SY='Q';  M= -34, -62, -32,  -2, -58, -60,  67, -38,  22, -47, -25, -21, -50,  96, -10, -31, -32,   5, -50, -37;
/M: SY='R';  M= -40, -76, -40, -18, -71, -56, -19, -70,  60, -62, -42, -23, -54,  36,  85, -34, -37, -63, -65, -60;
/M: SY='R';  M= -46, -84, -51, -30, -73, -60, -16, -72,  17, -63, -47, -28, -62, -10, 107, -38, -41, -66, -59, -60;
/M: SY='I';  M= -44, -30, -86, -76, -28, -96, -79,  86, -75,   7,   3, -79, -80, -72, -75, -60, -30,  50, -68, -44;
/M: SY='K';  M=   7, -48, -33, -18, -64, -42, -36, -57,  79, -59, -41, -19, -45,  -6,   8,  17,  30, -45, -79, -59;
/M: SY='L';  M= -52, -42, -89, -81,  32, -84, -63,   8, -70,  76,  38, -81, -78, -56, -66, -65, -45,  -7, -46, -25;
/M: SY='G';  M= -26, -75, -43, -67, -87, 100, -68,-100, -59, -88, -78, -33, -71, -64, -66, -31, -53, -87, -80, -91;
/M: SY='Y';  M= -52, -43, -76, -77,  70, -87, -14, -10, -71, -23, -29, -64, -88, -63, -69, -57, -46,  28,   5, 100;
/M: SY='T';  M= -19, -27, -39, -39, -57, -50, -42, -32, -41, -45, -30, -20, -53, -36, -44,   8, 101, -19, -62, -56;
/M: SY='Q';  M= -32, -67, -25,  10, -66, -57,   0, -69,   0, -53, -22, -18, -45, 115,  -9, -27, -32, -60, -42, -53;
/M: SY='A';  M=  64, -31, -45, -43, -66,  54, -53, -53, -43, -56, -49, -37, -44, -40, -50,  -3,  23, -33, -64, -64;
/M: SY='D';  M= -55, -81, 107,   7, -86, -41, -37, -89, -39, -92, -86,  41, -61, -31, -53, -29, -38, -79, -91, -71;
/M: SY='V';  M= -28, -27, -80, -64, -36, -87, -74,  43, -68,  -4,  -5, -72, -73, -66, -71, -51, -21,  86, -59, -50;
/M: SY='G';  M= -26, -75, -43, -67, -87, 100, -68,-100, -59, -88, -78, -33, -71, -64, -66, -31, -53, -87, -80, -91;
/M: SY='Y';  M= -38, -49, -40,  18, -14, -67,  44, -10,  21,  31, -14, -40, -65, -25, -29,  -7, -33,  19, -36,  51;
/M: SY='A';  M=  81, -20, -48, -36, -60, -21, -48, -44, -38, -47, -42, -42, -35, -32, -45,   4,  19, -21, -58, -56;
/M: SY='L';  M= -51, -42, -90, -79, -12, -84, -66,  10, -69,  78,  53, -81, -76, -52, -64, -65, -43,  -5, -53, -45;
/M: SY='G';  M=  43, -48, -44, -54, -76,  84, -61, -73, -50, -70, -63, -37, -55, -50, -58, -16, -36, -53, -72, -76;
/M: SY='H';  M=   9, -38, -37, -35, -50, -51,  42,  17,  34, -30, -25,  31, -57, -25, -22, -21,  25,  37, -68, -43;
/M: SY='L';  M= -47, -43, -83, -70, -17, -82, -59,  10, -49,  72,  14, -72, -75, -50,  14, -60, -41,  21, -58, -46;
/M: SY='Y';  M= -53, -56, -56, -49,  50, -74,  56, -46,  33, -43, -45, -39, -75, -30, -25, -48, -49, -52,   2, 101;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='G';  M= -26, -75, -43, -67, -87, 100, -68,-100, -59, -88, -78, -33, -71, -64, -66, -31, -53, -87, -80, -91;
/M: SY='N';  M=   0, -41, -18, -23, -65, -35, -28, -60,  53, -64, -47,  56, -50, -14,  -8,  44,  25, -48, -75, -56;
/I:         I=-30; MD=-77;
/M: SY='M';  M= -51, -58,  48,  20, -55, -73, -60,   2, -54, -24,  60, -39, -72, -38, -63, -46,  -4,  21, -69, -70; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='F';  M= -61, -42, -85, -89, 103, -84, -48, -14, -74,  31,  -8, -78, -87, -67, -74, -64, -53, -27,  -9,  28;
/M: SY='S';  M=   3, -26, -26, -26, -60, -25, -33, -59, -34, -63, -54, -10, -43, -28, -38,  92,  11, -45, -66, -52;
/M: SY='Q';  M= -32, -67, -25,  10, -66, -57,   0, -69,   0, -53, -22, -18, -45, 115,  -9, -27, -32, -60, -42, -53;
/M: SY='T';  M= -14, -27, -35, -36, -57, -44, -40, -36, -39, -49, -34, -18, -51, -34, -43,  43,  92, -23, -63, -55;
/M: SY='T';  M= -19, -27, -39, -39, -57, -50, -42, -32, -41, -45, -30, -20, -53, -36, -44,   8, 101, -19, -62, -56;
/M: SY='I';  M= -50, -31, -88, -81, -25, -98, -80,  93, -76,   9,   5, -81, -82, -74, -76, -63, -33,  31, -71, -42;
/M: SY='C';  M= -22, 139, -68, -72, -53, -62, -72, -42, -68, -54, -48, -42, -73, -63, -76,  31, -21, -37, -66, -58;
/M: SY='R';  M= -46, -84, -51, -30, -73, -60, -16, -72,  17, -63, -47, -28, -62, -10, 107, -38, -41, -66, -59, -60;
/M: SY='F';  M= -64, -42, -84, -91, 113, -84, -44, -24, -75, -11, -19, -77, -90, -70, -77, -63, -56, -36,  -2,  36;
/M: SY='E';  M= -38, -90,  15, 101, -89, -62, -27, -78, -18, -80, -63, -28, -50,   8, -32, -27, -37, -59, -95, -76;
/M: SY='S';  M=  54, -25, -27, -30, -62, -23, -35, -54, -34, -58, -50,  33, -41, -29, -40,  64,  -1, -35, -64, -54;
/M: SY='L';  M= -52, -43, -90, -82, -11, -85, -67,  10, -72,  82,  20, -83, -78, -57, -66, -66, -45,  -5, -57, -44;
/M: SY='Q';  M= -31, -51, -18,  -4, -66, -48,  -8, -60, -11, -56, -30,  53, -51,  92, -19, -14,  42, -49, -52, -53;
/M: SY='L';  M= -52, -43, -90, -82, -11, -85, -67,  10, -72,  82,  20, -83, -78, -57, -66, -66, -45,  -5, -57, -44;
/M: SY='S';  M=   1, -26, -27, -27, -60, -27, -34, -56, -35, -61, -51, -11, -44, -29, -39,  88,  33, -42, -65, -53;
/M: SY='F';  M= -60, -48, -70, -68,  98, -79,  75, -26, -65,   7, -19, -52, -81, -44, -56, -56, -52, -37, -13,  28;
/M: SY='K';  M= -36, -63, -19, -15, -69, -44, -27, -70,  86, -68, -45,  53, -51,  -1,  14, -25, -29, -61, -88, -60;
/M: SY='N';  M= -47, -46,   9, -28, -75, -29,  -9, -78, -24, -82, -61, 113, -72, -21, -30, -12, -18, -69, -81, -52;
/M: SY='M';  M=   5, -35, -80, -60, -22, -63, -56,   3, -47,  16, 122, -60, -58, -26, -49, -43, -27,  -6, -32, -53;
/M: SY='C';  M= -34, 139, -92, -93, -46, -84, -90,  19, -82, -33, -31, -60, -85, -78, -90, -41, -34,  12, -66, -56;
/M: SY='K';  M=  27, -52, -33, -13, -66, -41, -31, -62,  81, -59, -39, -23, -43,  37,  10, -20, -28, -48, -74, -60;
/M: SY='L';  M= -52, -43, -90, -82, -11, -85, -67,  10, -72,  82,  20, -83, -78, -57, -66, -66, -45,  -5, -57, -44;
/M: SY='K';  M= -36, -71, -34, -15, -69, -51, -30, -68,  88, -64, -42, -20, -49,   1,  55, -31, -34, -60, -83, -62;
/M: SY='P';  M=  10, -62, -51, -45, -81, -55, -56, -70, -47, -69, -56, -65, 118, -42, -58, -32, -42, -58, -75, -83;
/M: SY='L';  M= -52, -38, -89, -82,  31, -89, -68,  55, -74,  63,  12, -82, -80, -63, -70, -65, -42,   9, -50, -24;
/M: SY='L';  M= -52, -43, -90, -82, -11, -85, -67,  10, -72,  82,  20, -83, -78, -57, -66, -66, -45,  -5, -57, -44;
/M: SY='E';  M= -32, -65,  -9,  61,  -8, -53,  45, -68,  20, -62, -44,   7, -51,  55,  10,  15, -27, -58, -62, -37;
/M: SY='K';  M=  13, -53, -25,  23, -68, -42, -28, -64,  64, -62, -43, -21, -46,  33,  33,  23, -22, -51, -72, -60;
/M: SY='W';  M= -68, -64, -96,-103,  -9, -84, -66, -75,-104, -63, -36, -89, -89, -52, -68, -75, -68, -63, 175,  16;
/M: SY='L';  M= -46, -39, -88, -77, -15, -85, -68,  15, -71,  74,  16, -81, -77, -58, -67, -63, -39,  34, -57, -45;
/M: SY='E';  M=   5, -62,  19,  76, -73,   8,  25, -42, -28, -60, -51,  11, -54,  -7, -38, -24, -32,   2, -80, -59;
/M: SY='E';  M= -41, -87,  58,  88, -86, -56, -30, -79,  14, -81, -64, -18, -52,   1, -27, -28, -38, -63, -94, -74;
/M: SY='A';  M=  76, -21, -52, -39, -55, -26, -51, -20, -41, -38, -34, -46, -38, -36, -48,  -1,   5,  24, -58, -55;
/M: SY='E';  M= -42, -89,  65,  90, -89, -56, -30, -80, -23, -83, -68, -17, -53,   0, -37, -28, -38, -64, -94, -75;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	101 in 101 different sequences
Number of true positive hits	101 in 101 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	POU-specific
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

101 sequences

BRN3_CHICK  (Q91998), CF1A_DROME  (P16241), HM06_CAEEL  (P20268),

HM18_CAEEL  (P41934), HM19_XENLA  (P20913), IPOU_DROME  (P24350), 
P2F3L_XENLA (P20912), P2F3S_XENLA (A0A1L8FFY5), P3F1A_XENLA (P31363), 
P3F1B_XENLA (Q561L5), P3F2A_XENLA (P31365), P3F2B_XENLA (P70030), 
P3F3A_DANRE (P56224), P3F3B_DANRE (P79745), P3F4A_XENLA (P31364), 
P3F4B_XENLA (Q6DJN3), P5F11_XENLA (Q7T103), P5F11_XENTR (B3DM25), 
P5F12_XENLA (B7ZQA9), P5F13_XENLA (Q91989), P5F13_XENTR (B3DM23), 
P5F1B_HUMAN (Q06416), PDM1_DROME  (P31368), PDM2A_DROME (P31369), 
PDM2B_DROME (Q9VK71), PDM2_DROVI  (Q24705), PIT1_BOVIN  (P10036), 
PIT1_CANLF  (Q9TTI7), PIT1_CHICK  (Q9YGL7), PIT1_HUMAN  (P28069), 
PIT1_MACMU  (Q28503), PIT1_MELGA  (Q05749), PIT1_MOUSE  (Q00286), 
PIT1_ONCKE  (Q91169), PIT1_ONCMY  (Q08478), PIT1_PIG(Q04788), 
PIT1_RAT(P10037), PIT1_SHEEP  (P79364), PO2F1_CHICK (P15143), 
PO2F1_HUMAN (P14859), PO2F1_MOUSE (P25425), PO2F1_PIG   (Q29076), 
PO2F1_RAT   (P31503), PO2F1_XENLA (P16143), PO2F1_XENTR (Q28BL7), 
PO2F2_HUMAN (P09086), PO2F2_MOUSE (Q00196), PO2F2_PIG   (Q29013), 
PO2F3_HUMAN (Q9UKI9), PO2F3_MOUSE (P31362), PO2F3_RAT   (P42571), 
PO3F1_DANRE (Q90482), PO3F1_HUMAN (Q03052), PO3F1_MOUSE (P21952), 
PO3F1_RAT   (P20267), PO3F1_XENTR (Q4QQQ7), PO3F2_DANRE (P79746), 
PO3F2_HUMAN (P20265), PO3F2_MOUSE (P31360), PO3F2_RAT   (P56222), 
PO3F3_HUMAN (P20264), PO3F3_MOUSE (P31361), PO3F3_PIG   (Q29087), 
PO3F3_RAT   (Q63262), PO3F3_XENLA (P20914), PO3F4_HUMAN (P49335), 
PO3F4_MESAU (Q812B1), PO3F4_MOUSE (P62515), PO3F4_RAT   (P62516), 
PO3F4_XENTR (A1L0Z1), PO4F1_CHICK (P55968), PO4F1_HUMAN (Q01851), 
PO4F1_MOUSE (P17208), PO4F1_RAT   (P20266), PO4F2_HUMAN (Q12837), 
PO4F2_MOUSE (Q63934), PO4F2_RAT   (G3V7L5), PO4F3_DANRE (Q90435), 
PO4F3_HUMAN (Q15319), PO4F3_MOUSE (Q63955), PO4F3_RAT   (D3ZTL1), 
PO5F1_BOVIN (O97552), PO5F1_DANRE (Q90270), PO5F1_HUMAN (Q01860), 
PO5F1_MACMU (Q5TM49), PO5F1_MOUSE (P20263), PO5F1_PANTR (Q7YR49), 
PO5F1_PIG   (Q9TSV5), PO5F2_HUMAN (Q8N7G0), PO5F2_MOUSE (Q9DAC9), 
PO5F2_RAT   (P56225), PO5F3_CHICK (A7Y7W2), PO6F1_DANRE (P31367), 
PO6F1_HUMAN (Q14863), PO6F1_MOUSE (Q07916), PO6F1_RAT   (P56223), 
PO6F2_HUMAN (P78424), PO6F2_MOUSE (Q8BJI4), POU1_DUGJA  (P31370), 
SGF3_BOMMO  (Q17237), UNC86_CAEEL (P13528)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

29 PDB

1AU7; 1CQT; 1E3O; 1GT0; 1HF0; 1O4X; 1OCT; 1POU; 2XSD; 3D1N; 3L1P; 5WC9;
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