PROSITE entry PS51157

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51157
Entry name [info]	ZF_UBR
Accession [info]	PS51157
Entry type [info]	MATRIX
Date [info]	01-OCT-2005 CREATED; 13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51157
Associated ProRule [info]	PRU00508

Name and characterization of the entry

Description [info]

Zinc finger UBR-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=72;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=67;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5495398; R2=0.0027521; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=10196.3603516; R2=3.0561123; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1799; H_SCORE=15694; N_SCORE=7.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=1436; H_SCORE=14585; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-15; D=-40; I=-40; B1=-400; E1=-400; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='S';  M=  -1, -20,   8,   4, -15,  10,  -1, -18,  10, -11,  -9,  10,  -5,   7,  10,  14,   6, -15, -26,  -9;
/M: SY='V';  M=  -1,  -8, -11,   3,   2, -20,  -1,  10,   6,   4,   3,  -2,   3,   4,   0,  -5,  -3,  11, -23,  -7;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G';  M=   3, -17,  -6,  -8, -20,  30, -11, -15,  -5, -10, -10,  11, -14,   4,  -5,  13,  18, -10, -28, -16;
/I:         I=-6; MD=-17;
/M: SY='H';  M= -15, -26, -12,  -5,  25, -23,  37, -14,  12,  -5,  -4,  -4, -23,   0,  22,  -8, -10, -15,  -8,  27; D=-6;
/I:         I=-6; MD=-17;
/M: SY='V';  M=  -3, -22,  -9,  -3, -11, -12, -15,  13,   3,   2,   0,  -9,   8,   4,  -5,   1,   2,  13, -25,  -7; D=-6;
/I:         I=-6; MD=-17;
/M: SY='W';  M= -15,  35, -24, -12,  32, -12, -20,  -9,  -9,  -6,  -3, -14,  -7, -10, -13, -11, -12, -12,  81,  10; D=-6;
/I:         I=-6; MI=0; MD=-17; IM=0; DM=-17;
/M: SY='F';  M= -10, -23,  -6,   3,  16, -11,  11,  -8,  13,  -4,  -2,  -3,  -8,  13,  13,  -3,   0,  -6, -13,  12;
/M: SY='P';  M=  -2, -24,  -9,  -1, -15,  -7,   3,  -1,  14,  -7,   0,   3,  32,   7,   7,  -2,  -4,  -4, -24, -12;
/M: SY='G';  M=  -3, -23,   1,   0, -23,  28,   6, -21,   7, -19,  -8,  12,   4,   1,  17,   4,   0, -17, -27, -15;
/M: SY='E';  M=  -4, -27,  15,  36, -23, -17,  19, -24,   9, -20, -12,   1, -10,  35,   3,   4,  -2, -19, -27, -11;
/M: SY='W';  M=   3, -22,  -5, -10,  -3, -16,  14,   0, -11,  -3,  -4,  -7,  35, -11, -13,  -1,   8,   1,  47,  -1;
/M: SY='W';  M=   3, -18, -26, -22,  17, -16, -23,  21, -19,  14,   9, -19, -22, -18, -22,  -6,   4,  18,  51,   2;
/M: SY='Y';  M= -20, -27, -22, -24,  49, -27,  13,  -1, -17,   3,   2, -21, -32, -15, -14, -16, -14,  -6,  21,  67;
/M: SY='R';  M=   5, -21,  -7,   3,  -6, -15,  10, -20,  17, -17, -10,   0, -17,   5,  35,   6,   5, -14, -17,  10;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='K';  M= -12, -23,  -7,  -2,  12, -21,  11,  -2,  18,   6,   1,   4, -20,   6,  17,  -6,  -5,  -6, -14,  12;
/M: SY='T';  M=  -3, -14,  17,   9, -18, -15,  -9, -12,   0, -15, -11,  12,  -9,   2,  -9,  11,  38,  -6, -33,  -8;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-12; MD=-32;
/M: SY='G';  M=   8,  -1,  -3,   1, -26,  24, -12, -22,  -3, -23, -16,   7, -14,   4, -11,  16,  13, -14, -30, -19; D=-12;
/I:         I=-12; MI=-32; IM=-32; DM=-32;
/M: SY='P';  M=  -7,  10, -12,  -9,   9, -17, -12,   8,   0,  11,   9,  -6,  17,  -7, -10,  -8,   5,   5, -18,   5;
/M: SY='D';  M=   0, -20,  42,  12, -26,  -2,  -5, -17,   3, -23, -18,  21,  -5,  -1,  -8,   8,  10, -14, -37, -17;
/I:         I=-8; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='P';  M=  -6, -28,  25,  22, -25,   5,  -8, -25,   1, -27, -20,   5,  48,   0,  -6,   2,  -3, -22, -30, -21;
/I:         I=-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='C';  M=  -3,  27,  -8,  -5, -11, -11, -10,  -5,  -6,  -2,  -1,   7,  14,  -7,  -7,  12,  23,  -3, -28,  -5;
/M: SY='C';  M=   5,  72, -15, -15,  -3,  -9, -12,  -3, -12,  -5,   0,   2, -23, -12, -17,   7,   2,   0, -23,   6;
/M: SY='C';  M=  13,  48, -13,  -3, -15,  23, -18,  -2, -13, -11,  -8,  -9, -19, -11, -19,   3,  -2,   9, -26,  -8;
/M: SY='I';  M= -11,  16, -32, -27,   8, -34, -24,  35, -24,  27,  19, -25, -26, -18, -25, -20,  -7,  27, -22,   0;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='Y';  M=   4,   0,  -5,   4,  -3, -11,  -9,   6,  -8,   4,   2,  -8, -18,  -5,  -6,   8,   6,   8, -17,  13;
/M: SY='D';  M=   2, -21,  20,  19, -17,   2,   8, -15,   3, -12, -12,  11,   2,   3,  -4,   6,   1, -10, -29, -11;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='F';  M=   1,  -4, -25, -22,  58, -18, -13,   2, -19,   5,   1, -16, -26, -21, -19,   1,  -6,   0,   2,  25;
/M: SY='D';  M= -12, -23,  19,   9,   0, -18,   2,  -2,  11,   2,  -1,  16, -18,  10,   8,  -5,  -6,  -7, -22,   0;
/M: SY='P';  M=   3, -21,   7,  12, -25,  -4,   2, -17,  11, -21, -13,  20,  25,   8,   0,   7,   3, -11, -30, -17;
/M: SY='C';  M=  -1,  79,   1,   1, -23,  16, -14, -26,  -7, -23, -18,   5, -19,  -8, -15,  14,   5, -17, -35, -22;
/I:         I=-12; MD=-32;
/M: SY='D';  M= -27, -23,  19,  -5, -40, -24, -20, -28,  -6, -38, -33,   8, -34, -12, -19, -19, -21, -31, -50, -27; D=-12;
/I:         I=-12; MI=-32; IM=-32; DM=-32;
/M: SY='H';  M= -87, -99, -71, -71, -85, -89, 153,-104, -76, -86, -71, -60, -87, -65, -70, -76, -85,-103,-121, -54;
/I:         I=-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='E';  M=   2, -21,   9,  17, -18, -15, -10,  -1,  12,  -7,  -6,  -2, -14,   7,  13,   2,   3,   5, -28, -14;
/M: SY='G';  M=   0, -22,  10, -11, -23,  54,  -9, -32,  -8, -31, -21,  22, -17,  -5, -16,   9,  -7, -28, -25, -15;
/M: SY='H';  M= -87, -99, -71, -71, -85, -89, 153,-104, -76, -86, -71, -60, -87, -65, -70, -76, -85,-103,-121, -54;
/I:         I=-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='D';  M=  -4, -11,  32,  23, -23, -14,  -4, -14,   7, -15, -11,   9, -13,  12,   7,   7,   2, -11, -32, -15;
/M: SY='Y';  M= -12,   1, -24, -24,  34, -28,  -3,  14, -19,  12,   7, -21, -28, -17, -18, -14,  -3,  14,   6,  48;
/M: SY='H';  M=   0, -19,  -4,   6,  -7, -12,  12,  -2,   5,  -6,  -2,   1, -16,   5,  10,   6,   9,   4, -23,   3;
/M: SY='M';  M=  -4,   0,  -8,   4,   6, -23, -11,  15,  -6,  17,  20, -14, -20,  -6,  -4,  -7,  -6,  10, -19,   2;
/I:         I=-8; MD=-22;
/M: SY='Y';  M= -14,  -3, -19, -12,  18, -16,  12,  -4,  -4,   3,  -3, -13, -26,  -6,   0,  -7,  -6,  -7, -10,  24; D=-8;
/I:         I=-8; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='W';  M= -13, -29, -17,  -4,   0, -24, -18, -23,  -8, -20, -15, -11, -19,  -3,  -8,   4,   4, -21,  14,  -5; D=-8;
/I:         I=-8; DM=-22;
/M: SY='T';  M=  -2, -20,  -5,  -1, -18,  -7,  -3, -21,   4, -22, -16,   6,  -6,  -2,  15,  14,  17, -14, -32, -13; D=-8;
/I:         I=-8; DM=-22;
/M: SY='K';  M=  -4, -24,  -3,  -1,  -5,  10, -11, -18,  13, -19, -14,   3,   9,   4,   1,   6,   2, -15, -23,  -8; D=-8;
/I:         I=-8; DM=-22;
/M: SY='R';  M=  -2, -22,   6,   8, -11,  15,   0, -19,   4, -18, -13,  13,  -4,   4,  19,   9,   1, -17, -24,  -6;
/M: SY='G';  M=   3, -11,  -1, -10, -25,  41,   5, -25,   0, -26, -17,  22, -16,  -4,   0,  12,   3, -19, -29, -18;
/M: SY='G';  M=  -1, -22, -13, -19,  36,  42, -15, -16,  -6, -10,  -8,  -6, -21, -16,  -7,  -5, -13, -15,  -8,   5;
/M: SY='C';  M=  -5,  53, -23, -19,  23, -25, -16,  12,  -8,   3,   1, -15, -26, -16,   6,  -8,   0,  12, -14,  13;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='D';  M= -16, -29,  69,  20, -34, -13,  24, -34,  -3, -31, -28,  17, -15,  -1, -10,  -4,  -6, -31, -51, -14;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G';  M=   3, -25, -13, -24, -29,  69, -19, -38, -18, -34, -23,   1, -16, -15, -25,   2, -16, -32,  14, -23;
/I:         I=-7; MD=-18;
/M: SY='D';  M= -12, -27,  48,   8, -35,  -9,  -5, -32,  -6, -34, -28,  28, -20,  -3, -14,   0,   1, -29, -49, -23; D=-7;
/I:         I=-7; MD=-18;
/M: SY='P';  M= -16, -40, -13,   3, -32, -31, -27, -24, -12, -31, -26, -22,  38, -13, -23, -12,  -9, -22, -42, -32; D=-7;
/I:         I=-7; MI=0; MD=-18; IM=0; DM=-18;
/M: SY='E';  M= -17, -36,   6,  18, -25, -30, -18, -26,  -9, -23, -18,  -8, -25,  -3, -15, -10, -10, -23, -42, -26; D=-7;
/I:         I=-7; DM=-18;
/M: SY='A';  M=  23, -21, -13, -10, -29,  -7, -22, -13,  -8, -21, -16, -13, -22,  -9, -12,   7,  -4,  -6, -34, -24; D=-7;
/I:         I=-7; DM=-18;
/M: SY='W';  M= -24, -40, -37, -29,  16, -12, -33, -12, -19, -12,  -8, -21,   0, -24, -22, -25, -23, -21, 104,   6; D=-7;
/I:         I=-7; DM=-18;
/M: SY='K';  M=  -7, -22,   0,   3, -20,  -3,  -6, -15,  29, -21, -12,  18,  -5,   6,  18,   1,   6, -12, -27, -15; D=-7;
/I:         I=-7; DM=-18;
/M: SY='K';  M=  -6, -24,   2,  10,  -2, -11,   3,  -7,  14,  -6,  -7,   3,   7,   4,  10,  -1,  -4,  -6, -23,  -7; D=-7;
/I:         I=-7; DM=-18;
/M: SY='D';  M=   1, -22,  22,  18,  -7,   6,  -6, -23,  -1, -22, -17,  10,  20,   6,  -6,  11,   2, -19, -26, -10;
/M: SY='G';  M=  -1,   1, -10, -15,   0,  42, -13, -10, -12,  -3,  -6,   0,  -4, -10, -14,   2,  -9, -10, -18,  -1;
/M: SY='F';  M=  -8,  15,  -3,  -7,  36,  -3,  19, -11,  -6,  -6,  -7,  11,  -5,  -4, -11,   1,  -4, -11, -11,  14;
/I:         I=-10; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='K';  M=   1, -22,  -3,   9, -23, -13,   2, -20,  30, -21, -11,   7,  -6,  18,  22,   9,   4, -15, -23,  -8;
/M: SY='C';  M=   0,  21,  -6,  -4,  -4, -13,   6,   4,   0,  12,   3,   9, -21,  -5,  -2,  -1,  -2,   0, -21,   5;
/M: SY='H';  M=  -6, -10,  -6,   4,  -4, -18,  68, -16,  -2,  -1,   4,   0, -19,  12,   7,  -4, -11, -17, -27,  14;
/M: SY='P';  M=  -1, -21,  -7,   6, -16,   8, -12,  -1,   7,  -2,  -5,  -1,  14,  -2,   7,   4,   2,  -3, -25, -14;
/M: SY='D';  M=  -5, -24,  21,   9, -21,   4,  14,  -7,   7, -14,  -9,  17,  12,   3,   1,   0,  -3,  -9, -31, -14;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	36 in 36 different sequences
Number of true positive hits	36 in 36 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	N_Hulo
Feature key [info]	ZN_FING
Feature description [info]	UBR-type
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

36 sequences

BIG_ARATH   (Q9SRU2), BIG_ORYSJ   (B9G2A8), DRE1_CAEEL  (Q94251),

FBX11_HUMAN (Q86XK2), FBX11_MOUSE (Q7TPD1), FBX11_RAT   (Q7TSL3), 
HYD_DROME   (P51592), MLO2_SCHPO  (Q09329), POE_DROME   (Q9VLT5), 
POE_DROPS   (Q29L39), PRT6_ARATH  (F4KCC2), UBR11_SCHPO (O13731), 
UBR1_CAEEL  (P91133), UBR1_DROME  (Q9VX91), UBR1_HUMAN  (Q8IWV7), 
UBR1_KLULA  (O60014), UBR1_MOUSE  (O70481), UBR1_SCHPO  (O60152), 
UBR1_YEAST  (P19812), UBR2_HUMAN  (Q8IWV8), UBR2_MOUSE  (Q6WKZ8), 
UBR2_YEAST  (Q07963), UBR3_DANRE  (F1QJX5), UBR3_DROME  (Q9W3M3), 
UBR3_HUMAN  (Q6ZT12), UBR3_MOUSE  (Q5U430), UBR4_HUMAN  (Q5T4S7), 
UBR4_MOUSE  (A2AN08), UBR4_RAT(Q2TL32), UBR5_HUMAN  (O95071), 
UBR5_MOUSE  (Q80TP3), UBR5_RAT(Q62671), UBR7_DICDI  (Q54DV0), 
UBR7_HUMAN  (Q8N806), UBR7_MOUSE  (Q8BU04), Y3893_DICDI (Q54QG5)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

41 PDB

3NIH; 3NII; 3NIJ; 3NIK; 3NIL; 3NIM; 3NIN; 3NIS; 3NIT; 3NY1; 3NY2; 3NY3;
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