PROSITE entry PS51156

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51156
Entry name [info]	ELM2
Accession [info]	PS51156
Entry type [info]	MATRIX
Date [info]	01-OCT-2005 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51156
Associated ProRule [info]	PRU00512

Name and characterization of the entry

Description [info]

ELM2 domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=97;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=92;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4636354; R2=0.0065040; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=13380.1767578; R2=5.6353655; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=929; H_SCORE=18615; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=621; H_SCORE=16880; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-31; D=-90; I=-90; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='G';  M= -16, -82, -69,   1, -82,  55, -18, -82,  45, -53, -79,  21,  40, -72,  12,  -5, -37, -59, -77, -13;
/M: SY='E';  M= -28,  37, -68,  71, -84, -35,  18, -37,  45, -54, -19, -40, -32, -17,  19,   9, -23, -84, -80, -31;
/M: SY='I';  M= -40, -28, -85, -82, -70, -77, -75, 102, -45, -62,   8, -31, -84, -79, -80, -16,  -4, -14, -89, -74;
/M: SY='R';  M= -47, -77, -71, -72, -77, -59, -18, -81, -44, -46,  72,  71, -32, -62,  89, -29, -79, -80, -85, -73;
/M: SY='V';  M= -46, -78, -39, -50, -68, -49, -80,  24, -80,  -9, -73, -77, -88, -85, -39, -73, -25,  94, -91, -67;
/M: SY='G';  M= -74, -88,  -2, -44, -89, 102, -78, -47, -75, -82, -85, -68, -72, -81, -77, -64, -83, -88, -66, -88;
/M: SY='P';  M= -29, -17,  -9,  25, -83, -41,  24, -82, -33, -19, -85,  -1,  76, -71, -21,  49,  14, -83, -86, -25;
/I:         I=-20; MI=0; MD=-57; IM=0; DM=-57;
/M: SY='Q';  M= -17, -75,  28,  43, -83, -78, -31, -84,  36, -29,  30,   6, -73,  44,  39,   8, -29, -82,   3, -75;
/M: SY='Y';  M= -86, -20, -82, -53,  75, -88,  70, -49, -78, -60, -78, -82, -82, -31, -33, -74, -82,  -9, -56, 103;
/M: SY='Q';  M= -44, -79, -69, -58, -89, -82, -65, -84, -71, -79, -81, -74, -71, 131, -14, -31, -77, -90, -76,  -7;
/M: SY='A';  M=  95, -28, -20, -69, -79, -74, -76, -75, -30, -77, -72, -71, -76, -65, -71, -62, -32,  -6, -96, -30;
/M: SY='E';  M= -64, -75,  45,  51, -84, -47, -15, -28,  28, -42,  20, -70, -29,  34, -10, -20,  11,  21, -85, -75;
/M: SY='I';  M= -73, -22, -81, -81, -30, -80, -76,  81, -80,  23, -71, -10,  -6, -81, -79, -73, -44,  49, -88, -68;
/M: SY='P';  M= -55, -30, -16, -40, -90, -46, -62, -84, -33, -46, -94,  -5, 114, -18, -73, -42,   3, -18, -87, -80;
/M: SY='P';  M= -36, -75,  65,  51, -27, -45, -68, -59, -33, -30, -48, -23,  65, -13, -72,  -6, -35,  -8, -85, -77;
/M: SY='W';  M= -49,  23, -43, -75,  55,   2, -75, -18, -41,  37,  29, -39, -84, -26, -28, -74, -18, -48,  93,  33;
/M: SY='Q';  M= -11,  14, -23, -33,  10, -36,   7,  12,   3,  26,  -8,  12, -19,  35,  -3, -70,  15,  -3, -82,  -9;
/M: SY='P';  M= -41,  58,   5,  27,   0,  16, -70, -80,  15, -36, -84, -23,  67, -18, -50, -21, -45,  -3, -78,  -9;
/M: SY='R';  M= -23,   1,  10,  33, -16, -59, -28,   1, -14,  -3, -79,   6,  33,   0,  54,   2, -48, -61, -81, -17;
/M: SY='Y';  M=  -9,   4,  -7,   9, -77,  20, -69, -52, -34, -26, -82,  14,  27,   6,  -6,  35,   9, -60,   3,  50;
/M: SY='E';  M=  -3, -76,  24,  45, -40, -15,  10, -79,  19, -25, -79,   2,  25, -34,   2,   8, -24,  14, -84, -36;
/M: SY='D';  M=   6, -15,  28,  23,  -6,  -4,  -7, -56,   0, -32, -80, -21,   7,   8,  23,  24, -15, -35, -79,  24;
/M: SY='D';  M=  -3,  15,  50,  39, -82, -25, -23, -52, -53, -35,  12,  13, -22,  -3,  13,  15,   2, -51,   7,  23;
/M: SY='E';  M=   4, -15,  25,  41, -58, -17, -45, -35,  -6,  -9, -79,   4,   5,  33,  -9,  13, -20, -26, -80,  24;
/M: SY='D';  M= -26, -19,  58,  38, -85, -28, -18, -47,  48, -54, -24, -13, -18, -10,  21,   6, -28, -59, -83, -33;
/M: SY='D';  M= -14, -78,  34,  32,  -5, -78, -70, -44,  22, -46, -25,  17,  17,  23,   4,   1, -11,  -6, -80,  32;
/M: SY='D';  M=   0, -79,  45,  17, -79, -79,  44, -32,  14, -20, -20,  -2,   4,  35,  13, -39, -78, -39,  31,  41;
/I:         I=-4; MD=-10;
/M: SY='E';  M= -35, -78,  23,  58, -91,  -4, -74, -88,   3, -63, -85,  44,  -8,  15, -29, -15,   8, -62, -89, -42; D=-4;
/I:         I=-4; MD=-10;
/M: SY='N';  M= -72, -22,  17,  32, -93, -51,  14,  -3,   2, -36, -88,  36,   2,  -8, -55, -43,   4, -17, -98, -37; D=-4;
/I:         I=-4; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='R';  M= -24, -86, -11,   2, -86,  -9,  -7, -89, -14,  27,   3, -62, -52, -42,  36, -35,  10, -87,   5, -79; D=-4;
/I:         I=-4; DM=-10;
/M: SY='D';  M=  44, -76,  65,  58, -90,  24, -73, -85, -47, -78, -82, -69, -72, -69, -73,   2, -76, -52, -85, -85; D=-4;
/I:         I=-4; DM=-10;
/M: SY='Q';  M= -69, -74,   1,  54, -83, -80, -28,  -4, -24, -33,  56, -70, -74,  59, -34, -11,  50,  -1, -85, -75;
/M: SY='L';  M= -57, -25, -26, -69, -67, -80, -71,  -2,  17,  67,  -8, -76,   4,  17,  10, -15, -74, -12, -83, -62;
/M: SY='V';  M= -72,  -4, -77, -78, -66, -83, -28,  26, -48,  44,  40, -20, -87, -81, -22, -75, -71,  69, -15, -64;
/M: SY='W';  M= -94, -74,   8, -72, -14, -42, -83, -87, -32, -76, -87,-100, -37, -75, -67, -84, -96, -88, 166,  55;
/M: SY='S';  M= -39,  22,  32,  -2, -81, -76,  -3, -31, -10, -59, -17,  27,  18,   8,  19,  53,   9,  -7, -89, -78;
/M: SY='P';  M= -21,  -8, -71, -64, -45, -74, -62, -46, -67, -25, -95, -46, 115, -27, -39,  12, -48, -87, -86, -80;
/I:         I=-4; MD=-11;
/M: SY='W';  M= -57, -78,  33,  35, -69,  10,  -2, -37, -55, -36, -83,  27,  26,  -6, -14,   5,   0, -57,  59,  40; D=-4;
/I:         I=-4; MD=-11;
/M: SY='N';  M= -40,   6,   2,  24, -79, -34,  34,  -8, -33, -13,  11,  47, -25,  36, -71,  15, -38,  24, -88, -28; D=-4;
/I:         I=-4; MD=-11;
/M: SY='L';  M= -23, -43,   4,  31, -60, -48,  -6, -13, -74,  36, -17,  -2,  22,  12, -76,   4,  -7,  -6, -88, -35; D=-4;
/I:         I=-4; MD=-11;
/M: SY='L';  M= -64, -21,  10,  21, -84, -91, -82,   1,  -4,  37,  19,   8, -38, -49, -85, -55, -28, -28, -96, -43; D=-4;
/I:         I=-4; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='P';  M= -46,  15,  23,   6, -53, -56, -22, -82,   3, -58, -55,  15,  54, -19, -23,  24,  45, -12, -92, -81; D=-4;
/I:         I=-4; DM=-11;
/M: SY='D';  M= -71, -73,  79,  63, -40, -55, -30,  12, -12, -75, -83, -13, -24,  22, -30, -19, -78, -38, -85, -78;
/M: SY='K';  M=   5,   5,  -8,  48, -83, -28, -70, -84,  50, -55, -77,  11, -51,  31,  30,  19, -25, -83, -83, -79;
/M: SY='Q';  M= -13, -77,  31,  26, -40, -78, -70, -30,  51, -45, -54,  32, -12,  67,  17, -68, -77, -31, -84, -77;
/M: SY='I';  M= -49, -73, -15,  16, -68, -81, -75,  60, -76,  41, -71, -74, -83, -78, -22, -73, -20,  49, -86, -66;
/M: SY='D';  M= -44, -74,  74,  49, -37, -54, -72,  -7,   9, -18, -27,  19, -73, -21, -12, -43,  -2, -52, -84,  -2;
/M: SY='E';  M=  -9, -71,  21,  74, -87, -79, -66, -59, -35, -75,  28,  17, -72,  64,  -9, -10, -27, -42, -81, -12;
/M: SY='Y';  M= -86, -85, -39, -81,  81, -86, -72, -73, -77,  21, -78, -26, -86, -80, -68, -41, -51, -52,   4, 100;
/M: SY='L';  M=   4, -26, -74,  -1, -66, -80, -70,  32, -39,  66,  56, -75, -83, -75, -76, -18, -73, -30,  -2, -63;
/M: SY='S';  M=   2, -76,  -6,   0, -74, -77, -73,   4,  14,   3, -26,  20, -78, -73,  10,  36,  13,  30, -88, -25;
/M: SY='V';  M=   3, -11,  27,  26,   3, -81, -73,  -7,  11,   4,  13, -74, -79, -37,  -5, -28, -49,  39, -80,  28;
/M: SY='A';  M=  76, -22, -68, -32, -77, -45, -76,  36, -73, -73, -73,  -1, -78, -70, -74,  -6,  12,  10, -95, -85;
/M: SY='R';  M= -31,  47, -71, -27, -78, -79, -26, -82,  53, -48, -76, -73, -74,  31,  67,  30, -15,  -9,  -2, -73;
/I:         I=-5; MD=-13;
/M: SY='S';  M=   7,  14, -29,  28, -87, -23, -79, -89, -20, -12, -18, -81, -84, -79,   1,  60, -81, -88, -93, -30; D=-5;
/I:         I=-5; MD=-13;
/M: SY='M';  M= -49,  31, -95, -92, -89,-100, -30, -18, -90,   2,  47, -95, -46, -90,  37, -45, -95,  21,   4, -14; D=-5;
/I:         I=-5; MD=-13;
/M: SY='A';  M=  34, -30, -54, -94,-101,  26, -96, -22, -91, -97, -97, -90, -94, -88,  24, -40,  20, -93,-102,-102; D=-5;
/I:         I=-5; MD=-13;
/M: SY='T';  M=  -4, -48, -51, -90,-102,  15, -98, -99,  28, -42, -97, -50, -39, -95, -94, -85,  43, -58,   3,-100; D=-5;
/I:         I=-5; MD=-13;
/M: SY='F';  M= -35, -98,   6, -23,  56, -58, -47, -52, -28, -64,-101,  27,-101,  19, -89, -23, -48, -97, -99, -38; D=-5;
/I:         I=-5; MD=-13;
/M: SY='W';  M=  27, -94, -90,  26, -99, -32,  21,-101, -59, -24, -38, -96, -37,   1, -90, -89, -18, -99,  81, -89; D=-5;
/I:         I=-5; MD=-13;
/M: SY='R';  M= -45,-101, -20, -22,-101,   8, -93,-105,  36, -51,   4, -93, -93, -85,  56, -88,-103,-102, -97, -94; D=-5;
/I:         I=-5; MD=-13;
/M: SY='A';  M=  32,-104, -95, -95,-103, -28, -95, -57, -96, -25,  30, -97,-104,  27, -58,   8, -96, -39,-113,-104; D=-5;
/I:         I=-5; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='C';  M=  26,  46,  -2, -88, -98, -62, -93,  16, -91, -55, -97,   6, -16, -10, -30,   8, -91, -54,-108,-102; D=-5;
/I:         I=-5; DM=-13;
/M: SY='P';  M=  37, -94, -47, -26, -95, -64, -21, -54, -57, -40, -32, -11,  43,  -5, -86,   1, -51,   0,-104, -39; D=-5;
/I:         I=-5; DM=-13;
/M: SY='A';  M=  47,  19,   0,  13, -10, -61, -80, -86, -79,   5, -13, -83,  35, -15, -52, -29, -83, -38, -95, -87; D=-5;
/I:         I=-5; DM=-13;
/M: SY='G';  M=  42, -30, -42,  43, -20,  50, -71, -82,  -7, -53, -81, -72,  42, -13, -45, -23, -48, -82, -78, -44;
/M: SY='W';  M= -33,  15, -42,   2, -75,  -2,  -3, -55,  15, -41, -27, -21, -75, -32,  26,  60,   1, -26,  74,   8;
/M: SY='H';  M=  -6, -83, -74, -21, -40,   1,  93, -78, -72, -22, -75, -33, -74, -69,  54,  24, -79,   5, -78,  37;
/M: SY='D';  M= -45, -81,  67, -70, -85,  36,  17,   0, -43, -24, -82, -37,  27, -32, -74,   4,  21,   7, -85, -77;
/M: SY='I';  M= -34, -80,  -3, -74,  33, -80, -23,  44,  24, -21, -75,   9, -79, -72,  44, -26,  11, -35, -76,  43;
/M: SY='D';  M= -44, -77,  65, -39, -39, -75, -72, -79, -71, -14, -82,  59,  16, -73, -76,  21,  64, -77, -97, -78;
/M: SY='N';  M= -73, -75,  -3,  -1, -15, -39, -21,  -1,  -1,  25,  43,  48,  33,  31, -71, -11,   7, -41, -87, -72;
/M: SY='E';  M= -75, -67,  32,  94,  44, -81, -69, -29, -24, -26, -81, -72, -70, -31, -72, -70, -45, -83,  10, -72;
/M: SY='Q';  M= -50, -80, -15, -13,  13, -83,  73, -78, -21, -12, -76,   3, -74,  88, -11, -46, -13, -10, -78,  33;
/M: SY='A';  M=  98, -79, -64, -70, -80, -73, -76, -29, -71, -78, -72, -71, -76, -64, -33, -31, -47, -30, -98, -92;
/M: SY='L';  M= -49, -72, -75, -73,   3, -82, -19, -16, -75,  75,  69, -77, -47, -77, -40, -29, -73, -66, -78,  25;
/M: SY='H';  M= -23,  11,  49, -37,  -4,  15,  67, -32,  24, -72, -77,   8, -74,  15, -42, -70, -53, -80, -72,  66;
/M: SY='M';  M= -29,  31, -73,  41, -76, -81, -19,  33, -71,  22,  64, -71, -78, -13, -75, -43,  51, -26,   6, -46;
/M: SY='L';  M= -80, -68, -72, -71, -59, -83, -71, -64, -30,  93, -63, -78, -85, -78, -78, -77, -72, -64, -83, -54;
/M: SY='H';  M= -79, -84, -80, -73,  48, -85, 108, -45, -46,   0,  32, -36, -77,   3, -21, -72, -18,  16, -79,  35;
/M: SY='W';  M= -63, -78, -17,  24, -15, -77,  -1, -32,  62, -77, -76,  -3, -72,  28,  46, -25, -83, -83,  91,  13;
/M: SY='C';  M=  16,  89, -70, -31, -81, -79,  84, -78, -45, -59, -77,  62, -78, -31, -73,  29, -29, -26, -92, -41;
/M: SY='N';  M= -72, -79,  21, -25, -81,  39, -32, -35,  55, -80, -76,  77, -74, -20, -18,  -8, -56, -75, -86, -84;
/M: SY='Y';  M= -86, -91, -79, -78,  60,  17,  77, -77, -78, -46, -78, -21, -79, -78, -68, -72, -16, -75, -56, 102;
/M: SY='D';  M= -70, -76,  94, -36, -89, -73, -73, -49, -27, -78, -85,  84, -78, -73, -34,   7, -72, -83, -99, -83;
/M: SY='I';  M=  -2, -78, -77, -77,  21, -79, -74,  61, -39,   8, -42, -73,  40, -78, -76,  -5,  20,  26, -85, -28;
/M: SY='E';  M=  -9, -73,  24,  72, -86,  -3,  25, -85,  35, -38,  -6,  -2, -16, -35, -44,   4, -58, -55, -83, -80;
/M: SY='K';  M=  -5, -74,   0,  60, -82, -78, -70, -85,  62, -26, -74, -71, -69,  11,  37,   5, -54, -49, -81, -76;
/M: SY='A';  M=  91, -79, -64, -70, -79, -72, -74, -76, -70, -79, -75, -70, -75, -66, -71,  41,  -7, -39, -98, -91;
/M: SY='L';  M= -76, -25, -76, -74, -64, -81, -16,  45,  -3,  67,  41, -75, -85, -79, -76, -39, -73,   9, -83, -11;
/M: SY='E';  M=  18, -32, -18,  54, -81, -77, -28, -47,  10, -48, -18, -12, -72,  33,  36,  42, -48, -50, -83, -23;
/M: SY='R';  M=   4, -78,  45,   1, -78, -79, -71, -19,  -8, -22,  11, -72, -76,   7,  60,  20,  -1, -27, -81,  19;
/M: SY='L';  M= -52, -23, -75, -73,   5, -83, -27, -11, -29,  79,  42, -77, -86, -78, -75, -77, -74, -46, -78,  24;
/M: SY='P';  M=   8,  37, -17, -38, -76, -79, -16, -73,  17,   3,  11,  19,  42, -72,  34, -25, -74,  38, -87, -74;
/M: SY='P';  M= -35,  36, -31, -21,  40, -77, -70, -47,  18, -15, -26,  43,  54,   7,  -4,  27, -27, -49, -83, -74;
/M: SY='N';  M= -53,  10, -49, -71,  47, -77, -27, -54,   2, -39, -80,  68,   1,  31,  21,  34, -21, -18, -84, -38;
/M: SY='T';  M= -38, -79,  30,   3, -82,  28,  11, -52, -10, -23, -21,  17,  28, -33, -29, -22,  40,  23, -86, -77;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	46 in 46 different sequences
Number of true positive hits	46 in 46 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	ELM2
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

46 sequences

ARID1_ARATH (Q84JT7), ARID2_ARATH (Q9LDD4), EGL27_CAEEL (Q09228),

MDEAS_HUMAN (Q6PJG2), MIER1_CHICK (Q5ZKT9), MIER1_HUMAN (Q8N108), 
MIER1_MOUSE (Q5UAK0), MIER1_PONAB (Q5REE1), MIER1_XENLA (Q7T105), 
MIER2_BOVIN (A5PJX4), MIER2_HUMAN (Q8N344), MIER2_MOUSE (Q3U3N0), 
MIER3_HUMAN (Q7Z3K6), MIER3_MACFA (Q4R3R9), MIER3_MOUSE (Q3UHF3), 
MTA1_HUMAN  (Q13330), MTA1_MOUSE  (Q8K4B0), MTA1_RAT(Q62599), 
MTA2_HUMAN  (O94776), MTA2_MOUSE  (Q9R190), MTA3_BOVIN  (A6QL72), 
MTA3_HUMAN  (Q9BTC8), MTA3_MOUSE  (Q924K8), RCOR1_HUMAN (Q9UKL0), 
RCOR1_MOUSE (Q8CFE3), RCOR1_XENLA (Q90WN5), RCOR2_DANRE (Q6P116), 
RCOR2_HUMAN (Q8IZ40), RCOR2_MOUSE (Q8C796), RCOR2_RAT   (Q5FWT8), 
RCOR2_XENLA (Q6NRZ0), RCOR3_CHICK (Q5ZJ40), RCOR3_HUMAN (Q9P2K3), 
RCOR3_MOUSE (Q6PGA0), RCORA_CAEEL (Q95Y41), RCORB_CAEEL (Q18919), 
RCOR_DROME  (Q59E36), RERE_HUMAN  (Q9P2R6), RERE_MOUSE  (Q80TZ9), 
RERE_RAT(Q62901), SAEG1_CAEEL (Q20733), TREF1_HUMAN (Q96PN7), 
TREF1_MOUSE (Q8BXJ2), ZN541_HUMAN (Q9H0D2), ZN541_MACFA (Q4R2Z8), 
ZN541_MOUSE (Q0GGX2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

40 PDB

2XAF; 2XAG; 2XAH; 2XAJ; 2XAQ; 2XAS; 3ZMS; 3ZMT; 3ZMU; 3ZMV; 3ZMZ; 3ZN0;
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