PROSITE entry PS51140

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51140
Entry name [info]	CUE
Accession [info]	PS51140
Entry type [info]	MATRIX
Date [info]	01-JUL-2005 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51140
Associated ProRule [info]	PRU00468

Name and characterization of the entry

Description [info]

CUE domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=44;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=44;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0788274; R2=0.0083074; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=966; N_SCORE=10.1; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1;  SCORE=846; N_SCORE=9.1; MODE=1; TEXT='R?';
/DEFAULT: M0=-31; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E';  M= -23, -13,  24,  45, -87, -86, -13,  16, -18, -48,  28, -29, -84,  43,   1,  31, -30,  20, -99, -81;
/M: SY='H';  M= -49, -90,  -6, -17,  -3, -87,  41,  -5, -20,   9,  29,  39,  11,  -1,  22,  -6,  39, -18, -97, -75;
/M: SY='D';  M= -19, -92,  47,  41, -30, -82,  -8, -87,   9, -13,  16,  42,   9,  28, -30,  15,  -2, -85, -99, -82;
/M: SY='N';  M=  18, -19,   6,  36, -93, -23,  -2, -86, -17, -54,  15,  40,  24,  30, -17,  26,  -2, -28, -99, -85;
/M: SY='M';  M=  14,  -7,   6,  27, -82, -45,  29,  -6,  34,  11,  58, -24, -86,   1, -73, -75, -10,   9, -97, -78;
/M: SY='V';  M=   3, -86, -98, -92,  -1, -97, -90,  37, -90,  45,  22, -93, -95, -88, -44, -83, -10,  57, -90,   2;
/M: SY='H';  M= -27,  -7,  16,  49, -90, -85,  61, -41,  16, -21,  17, -26, -82,  39,  -7,  23,  18, -84,-100, -79;
/M: SY='Q';  M= -13,  -3,  10,  19, -33, -84,  -9, -19,  -3, -51, -10, -25, -84,  57, -15,  24,  50, -24, -92,  21;
/M: SY='L';  M= -80, -87,-102, -96,   0,-103, -91,  44, -94,  67,  23, -98, -98, -91, -94, -91, -77,  48, -91, -71;
/M: SY='Q';  M= -25, -93, -80, -68, -83, -88,  16,  -2,  58,   1,  53, -73, -86,  73,   3, -19, -11, -23, -91, -18;
/M: SY='E';  M= -23, -93,  47,  71, -97, -46, -72, -52,   4, -55, -86,  16, -80,  42, -70,  28,  -1, -88,-100, -86;
/M: SY='M';  M=   0, -87, -92,   1, -69, -93, -82,  16, -37,  46, 102, -89, -91, -79, -85, -16, -75,  14, -93, -74;
/M: SY='F';  M= -21, -88,-104, -99, 120, -98, -86, -38, -95,  -1, -66, -94,-102,-103, -93, -90, -84, -69, -61, -40;
/M: SY='P';  M= -84,-109, -84, -73,-104, -86, -87, -91, -80,-102, -88, -91, 131, -84, -93, -81, -76, -97, -97,-101;
/M: SY='D';  M= -28, -92,  63,   8, -32, -23,  40, -40, -32, -90, -19,  47, -84,  57, -74,  22,  15, -88,-103, -80;
/M: SY='V';  M= -24,  -7, -98, -92,  10, -98,  -8,  31, -88,  46,  46, -92, -95, -87, -15, -85, -12,  47,  40, -23;
/M: SY='D';  M= -40, -94,  72,  25, -98,  12,  24, -97, -73, -97, -90, -19,  50, -70, -31,  38,  12, -92,-105, -87;
/M: SY='P';  M= -14,  -7,  22,  30, -87, -86, -78, -36,  17, -21, -77,  10,  49,  16,  -1,   5, -31,  21, -96,  -6;
/M: SY='E';  M= -24, -92,  42,  53, -31,  12, -13, -89, -16, -57, -85,  -2, -28,   2, -32,  37,   3, -22,   8, -20;
/M: SY='Q';  M=  -2, -90, -12,  -1,  36, -92,  14,  33, -17,  14, -65, -29, -90,  47, -80, -77,   4,  29, -88, -24;
/M: SY='I';  M= -10, -90,-101, -96, -67,-102, -97,  84, -94,  38, -54, -95, -24, -91, -96, -88, -75,  37, -93, -75;
/M: SY='R';  M=   5, -92, -31,  28, -87, -88, -13, -40,  30,  -2, -15, -74, -86,  36,  58,  -2,   3,   1, -95, -81;
/M: SY='D';  M=  23,  30,  44,  19, -83, -24,  -7, -89,  -1, -52, -81, -71, -86,  38,  27,  -1, -12, -44,  15,  40;
/M: SY='C';  M= -12,  70,  48, -32, -79, -92,  32,  20, -85,  12, -68, -78, -92, -22, -88, -22, -31,  52,-104, -80;
/M: SY='L';  M= -45, -11,-101, -94, -21,-102, -87,   0, -94,  85,   0, -99,-100, -89, -92, -92, -79,   7, -88, -14;
/M: SY='R';  M=   3, -93, -30,  42,  -5, -88, -77,  25,   9,  -2, -72, -21, -86,  37,  42,   8, -75, -21, -91, -24;
/M: SY='E';  M=  43, -89,  -5,  43, -91, -80, -16, -19,  22, -55, -80,  19, -82,  34,   3,  14,   2, -80, -95, -26;
/I:         I=-13; MD=-27;
/M: SY='Y';  M=  -4,  21, -82, -85, -82, -88,  51, -98, -21, -96, -88,  53, -99,   2,  -8,  32, -80, -96, -92,  65; D=-13;
/I:         I=-13; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='N';  M= -78,  -2,  48,  10, -91,  -2,  33, -92, -13, -38, -84,  54, -86,  -6,  22, -20,  48, -88,-103, -16; D=-13;
/I:         I=-13; DM=-27;
/M: SY='G';  M= -77, -95,  -6, -40, -12,  66,  -3, -96, -16, -95, -88,  55, -91,  -4,   1, -18, -80, -45,  12,  27; D=-13;
/I:         I=-13; DM=-27;
/M: SY='N';  M= -19,   6,  71, -65, -30, -76, -71, -90, -15, -93, -14,  76, -87, -14, -14,  40, -30, -32,-106, -84;
/M: SY='V';  M= -27, -88, -94, -87,  -3, -96, -89,  37, -19,  34,  -8, -88, -35,  -1, -10,  -8, -35,  60, -92, -21;
/M: SY='E';  M= -11, -10,  70,  80,-101, -27, -72, -99, -66, -95, -90,   1, -79,  29, -74, -20, -12, -92,-103, -89;
/M: SY='Q';  M=  31, -89,  -9,   5, -85, -45, -10,  -5, -74,  22, -71,   2,  24,  51, -32,   8,  20, -39, -96, -82;
/M: SY='T';  M=  58,  59, -85, -82, -85, -81, -90, -14, -35, -76, -74, -76, -85, -82, -86, -27,  71,  31,-101, -85;
/M: SY='I';  M= -42,  49, -97, -94,  12, -98,  -6,  76, -91, -37,  29, -88, -93, -89, -93,  -4, -12,  41, -90,   7;
/M: SY='N';  M=  20, -89,  53,  44, -95, -42, -72, -89, -33, -51, -85,  66, -83,  30, -75,  11, -20, -23,-103, -87;
/M: SY='M';  M=  33, -87, -29,  -2, -83, -80, -12, -73,   1, -17,  59,  44, -25,  -2,  16,  21, -70,  13, -96, -18;
/M: SY='L';  M= -14,  17,-101, -95, -28,-101, -89,  53, -94,  74, -51, -97, -98, -89, -94, -90, -78, -11, -88,  -7;
/M: SY='L';  M= -48, -12, -95, -89,  19, -98, -12,   5,  -3,  72, -10, -31, -96, -84, -30, -38, -12,   6, -89, -70;
/I:         I=-15; MD=-32;
/M: SY='E';  M=   4,  -8,  23,  60, -40, -50, -73, -90,  13, -54,  -9,  30, -83,  35,   1,   6, -30, -46, -95,  -4; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='M';  M= -23, -92,  28,  12, -31,  39, -78,   0, -78,  31,  44,  -3, -89,   4,  -2, -35, -78, -39, -91,   0;
/M: SY='S';  M=  -3, -90, -13,  18, -34,   6, -77, -39,  10, -48, -81,  20, -26,  18,  28,  41,  20, -22,  13, -82;
/M: SY='H';  M= -10, -91,  39,  29, -29, -28,  46,   8, -13,  10,  15, -21, -30, -22, -79,   1,  14, -11, -96, -18;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	88 in 83 different sequences
Number of true positive hits	88 in 83 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	6
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	93.62 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	DOMAIN
Feature description [info]	CUE
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

83 sequences

AMFR_DANRE  (F1QB30), AMFR_HUMAN  (Q9UKV5), AMFR_MOUSE  (Q9R049),

ASCC2_DICDI (Q54VC4), ASCC2_HUMAN (Q9H1I8), ASCC2_MOUSE (Q91WR3), 
AUP1_CAEEL  (P34426), AUP1_DANRE  (Q6PBN5), AUP1_HUMAN  (Q9Y679), 
AUP1_MOUSE  (P70295), AUP1_RAT(A1L134), AUP1_XENLA  (B1H1N7), 
AUP1_XENTR  (A9ULG4), CID5_ARATH  (Q9LYE5), CID6_ARATH  (Q6NQH9), 
CUE1_CANAL  (Q59NY7), CUE1_CANGA  (Q6FS98), CUE1_DEBHA  (Q6BKU8), 
CUE1_EREGS  (Q756I2), CUE1_KLULA  (Q6CNN5), CUE1_YEAST  (P38428), 
CUE2_YEAST  (P36075), CUE3_SCHPO  (O74485), CUE3_YEAST  (P53137), 
CUE4_SCHPO  (P87238), CUE4_YEAST  (Q04201), CUE5_SCHPO  (O14319), 
CUE5_YEAST  (Q08412), CUED1_HUMAN (Q9NWM3), CUED1_MOUSE (Q8R3V6), 
CUED2_BOVIN (Q3ZBN4), CUED2_HUMAN (Q9H467), CUED2_MOUSE (Q9CXX9), 
CUED2_RAT   (A1L131), DEF1_CANAL  (Q5AMM4), DEF1_CANAW  (C4YHS3), 
DEF1_CANTT  (C5M2B8), DEF1_CLAL4  (C4Y1P0), DEF1_DEBHA  (Q6BRB3), 
DEF1_KLULA  (Q6CTH5), DEF1_LACTC  (C5DGU9), DEF1_LODEL  (A5E406), 
DEF1_SCHPO  (O43024), DEF1_YEAS2  (C7GP20), DEF1_YEAS7  (A6ZZR2), 
DEF1_YEAST  (P35732), DEF1_ZYGRC  (C5E4K0), DON1_YEAST  (Q05610), 
HRDL1_CAEBR (A8WWR3), HRDL1_CAEEL (P90859), N4BP2_HUMAN (Q86UW6), 
RIN2_ARATH  (Q8VYC8), RIN3_ARATH  (Q8W4Q5), SMRCD_BOVIN (E1B7X9), 
SMRCD_HUMAN (Q9H4L7), SMRCD_MOUSE (Q04692), SMRCD_RAT   (D3Z9Z9), 
SMRCD_XENTR (Q5FWR0), SMRDA_DANRE (B0R061), SMRDB_DANRE (E7F1C4), 
TAB2_DANRE  (Q5RFW2), TAB2_HUMAN  (Q9NYJ8), TAB2_MOUSE  (Q99K90), 
TAB2_RAT(Q5U303), TAB3_HUMAN  (Q8N5C8), TAB3_MOUSE  (Q571K4), 
TAB3_XENLA  (Q7ZXH3), TOIPA_ONCMY (Q4LBC8), TOIPA_XENLA (Q3B8H2), 
TOIPB_ONCMY (Q4LBC7), TOIPB_XENLA (Q6INE3), TOLIP_BOVIN (Q2LGB5), 
TOLIP_CHICK (Q5ZK05), TOLIP_DANRE (Q7ZV43), TOLIP_ESOLU (C1BZR1), 
TOLIP_HUMAN (Q9H0E2), TOLIP_MOUSE (Q9QZ06), TOLIP_RAT   (A2RUW1), 
TOLIP_SALSA (B5X370), TOLIP_XENTR (Q6DFR0), VPS91_SCHPO (O74396), 
VPS9_YEAST  (P54787), YR75_CAEEL  (Q09394)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

6 sequences

CID7_ARATH  (O64843), CUE2A_XENLA (Q6NU18), CUE2B_XENLA (Q68F60),

CUED2_DANRE (Q6TLH3), DEF1_CANGA  (Q6FIN4), DEF1_EREGS  (Q75DE9)

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PDB
[Detailed view]

18 PDB

1MN3; 1OTR; 1P3Q; 1WGL; 2DAE; 2DHY; 2DI0; 2EJS; 2EKF; 2LVN; 2LVO; 2LVP;
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