PROSITE entry PS51083

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PURL: https://purl.expasy.org/prosite/signature/PS51083

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General information about the entry

Entry name [info]	ZF_HIT
Accession [info]	PS51083
Entry type [info]	MATRIX
Date [info]	01-FEB-2005 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51083
Associated ProRule [info]	PRU00453

Name and characterization of the entry

Description [info]

Zinc finger HIT-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=31;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5706942; R2=0.0090412; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=833.5309448; R2=2.8289084; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=656; H_SCORE=2689; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=435; H_SCORE=2064; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-10; D=-30; I=-30; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M: SY='S';  M=  2, -8,-16, -7, -1,-19, -2,-11,-17, -6,-19,-12, -4,-16, -5,-12,  7, -6,-13,-25,-15, -2;
/M: SY='I';  M= -3,-28,-10,-28,-22, -4,-32,-27, 27,-23, 12,  8,-27,-24,-22,-26,-16, -3, 27,-27,-10,-22;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/I:         I=-8; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='G';  M= -4, -8,-25,-11, -8,-23,  8, -9,-24, -5,-21,-14,  0,-16, -5, -7,  0, -9,-19,-24,-18, -7;
/M: SY='K';  M= -4, -4,-23, -7,  1,-21, -8,-10,-18,  3,-18,-11,  1,-16,  0, -6,  1, -5,-12,-27,-16,  0;
/I:         I=-9; MD=-32;
/M: SY='N';  M= -9,  5,-21,  0,  5,-17, -9,  1,-19,  3,-18,-11, 13,-13,  5, -2,  3, -5,-16,-21, -7,  4; D=-9;
/I:         I=-9; MI=-32; IM=-32; DM=-32;
/M: SY='E';  M= -5, -5,-20, -1,  6,-23,-18,-13,-19, -1,-19,-12, -7, -1, -1, -9,  0, -3,-13,-29,-19,  4;
/M: SY='S';  M=  4,-10,-15,-11, -7,-14, -6, -6,-19, -6,-18,-12, -4,-11, -6, -9, 13, -1,-17,-20,-11, -7;
/M: SY='K';  M=-11, -6,-24,-13,  0,-23,-21,-10,-19, 21,-13, -7, -3,-14,  3,  7, -4,-10,-14,-27,-15,  1;
/I:         I=-9; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='Y';  M=-15,-27,-18,-27,-18, 23,-26, 16,-11,-28,-11,-10,-17,-27, -9,-19,-13,-16,-11, 13, 58,-18;
/M: SY='K';  M= -5, -2,-23,-10,  1,-26,-16, -8,-23, 18,-18,-11,  6,-13,  3, 14,  5,  5,-18,-29,-20,  1;
/M: SY='C';  M= -1,-30, 82,-30,-39,-14,-30,-29, -9,-30, -9, -9,-30,-31,-30,-30,-11,-11,-10,-18,-16,-30;
/M: SY='P';  M= -6,-19,-20,-13,-12,-31,-21,-21,-18,-11,-20,-13,-17, 38,-11,-19, -7,  2, -8,-34,-25,-11;
/M: SY='R';  M= -3, -9,-14,-16, -6,-22,-13, -9,-21,  9,-16,-10, -2,-18, -1, 12, -1, -6,-18,-27,-17, -5;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M: SY='G';  M= -8, -2,-26, -3, -3,-20,  5, -8,-25, -8,-23,-15,  4,-16, -4, -9,  2,-10,-21,-23,-15, -4;
/M: SY='V';  M=  1,-15,-14,-14, -9,-13,-21,-19,  1,-10, -1,  0,-14,-18,-10,-13, -5, -3,  3,-27,-15,-10;
/M: SY='R';  M=-11,-16,-22,-21, -8,-16,-25, -9,-16,  8, -8, -3,-10,-13,  0,  9,-10,-11,-15,-22, -8, -7;
/M: SY='Y';  M=-11,-24,-16,-24,-18, 15,-26,  1, -5,-18, -7, -7,-16,-25,-13,-19,-10, -1, -4,  1, 31,-18;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M: SY='S';  M=  8, -3, -3, -3, -4,-20, -2,-12,-19, -4,-19,-11,  6,-12, -4,-12, 33, 10,-18,-28,-20, -4;
/M: SY='L';  M= -7,-35, -8,-35,-27, -3,-36,-29, 23,-21, 27, 15,-29,-27,-31,-24,-18, -7, 19,-24,-10,-26;
/M: SY='K';  M=  3, -8,-22, -9,  4,-26,-12,-12,-19,  5,-19,-12, -7, -6,  0,  2,  0, -6,-12,-31,-20,  2;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M: SY='Y';  M=-12,-19,-18,-21,-15, 10,-22,  0, -8,-14, -8, -5,-10,-25, -9,-15, -7, -9, -9, -4, 22,-14;
/M: SY='K';  M=-10,  0,-29, -7,  7,-28,-16, -7,-27, 26,-20,-10,  4,-13, 10, 15, -1, -7,-20,-29,-19,  7;
/I:         I=-7; MI=0; MD=-23; IM=0; DM=-23; I=-7,-7,-7,-7,-7,-7,-7,-7,-7,-7,-7,-7,-7,-7,-7,-7,-7,-7,-7,-40,-7,-7;
/M: SY='K';  M= -7,-12,-19,-16, -6,-18,-24,-16, -5,  4, -3, -2, -7,-17, -4, -3, -3,  2, -2,-27,-16, -6;
/M: SY='H';  M=-20,  0,-30,-10,  0,-10,-20, 80,-30,-10,-30,-20, 10,-20,  0,  0,-10,-20,-30,-20, 20,  0;
/M: SY='K';  M=-10,  5,-27, -2,  8,-27,-14, -6,-25, 22,-21,-11, 10,-13,  9,  7,  4, -6,-19,-31,-19,  8;
/I:         I=-6; MD=-22;
/M: SY='E';  M= -6,  5,-26, 11, 18,-24,-17, -8,-21,  3,-22,-15, -1,-12,  6, -3,  2, -2,-16,-29,-19, 13; D=-6;
/I:         I=-6; MD=-22;
/M: SY='T';  M= -5, -4,-17, -4,  2,-19,-17,-11,-13, -1,-10, -5, -1,-12,  5, -2,  3,  8, -9,-21,-15,  2; D=-6;
/I:         I=-6; MD=-22;
/M: SY='R';  M= -6, -7,-19, -7,  0,-16,-16, -7,-15,  2,-11, -8, -4, -9,  0,  7, -4, -1,-12,-21,-13, -1; D=-6;
/I:         I=-6; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='C';  M=  0,-28, 79,-28,-36,-20,-28, 10,-11,-28,-11,-10,-27,-28,-28,-28, -9, -9,-10,-20,-18,-28;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	22 in 22 different sequences
Number of true positive hits	22 in 22 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	7
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	75.86 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	N_Hulo
Feature key [info]	ZN_FING
Feature description [info]	HIT-type
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

22 sequences

BCD1_HUMAN  (Q9NWK9), BCD1_MOUSE  (Q3UFB2), BCD1_PONAB  (Q5RF97),

BCD1_SCHPO  (O74906), BCD1_YEAST  (P38772), HIT1_YEAST  (P46973), 
SWC6_ARATH  (Q9FHW2), VPS71_SCHPO (O59669), VPS71_YEAST (Q03433), 
YEKJ_SCHPO  (O36031), ZNHI1_BOVIN (Q24JY4), ZNHI1_DICDI (Q54NW0), 
ZNHI1_HUMAN (O43257), ZNHI1_MOUSE (Q8R331), ZNHI2_BOVIN (Q2TBW5), 
ZNHI2_HUMAN (Q9UHR6), ZNHI2_MOUSE (Q9QY66), ZNHI3_BOVIN (Q2KIH1), 
ZNHI3_HUMAN (Q15649), ZNHI3_MACMU (Q6UIM1), ZNHI3_MOUSE (Q9CQK1), 
ZNHI3_PANTR (Q6UIM2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

7 sequences

DDX59_HUMAN (Q5T1V6), DDX59_MOUSE (Q9DBN9), DDX59_RAT   (Q66HG7),

IN80B_HUMAN (Q9C086), IN80B_MOUSE (Q99PT3), RH41_ARATH  (Q3EBD3), 
RH41_ORYSJ  (Q0E2Z7)

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PDB
[Detailed view]

16 PDB

1X4S; 2N94; 2N95; 2YQQ; 6GEJ; 6GEN; 8QKU; 8QKV; 8QYV; 8QZ0; 8X15; 8X19;
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