PROSITE entry PS51044

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51044
Entry name [info]	ZF_SP_RING
Accession [info]	PS51044
Entry type [info]	MATRIX
Date [info]	01-DEC-2004 CREATED; 02-JUN-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51044
Associated ProRule [info]	PRU00452

Name and characterization of the entry

Description [info]

Zinc finger SP-RING-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=83;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=78;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2773535; R2=0.0080087; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1152; N_SCORE=11.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=528; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-35; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='P';  M= -58, -79,  49,  28, -80,  19, -64, -67, -60, -74, -11, -55,  59,   1, -67,  32, -56,  14, -85, -73;
/M: SY='D';  M= -10, -81, 102,  54, -88, -68, -56, -86, -53, -83, -81, -43, -66, -50, -62, -57, -60, -81, -96, -73;
/M: SY='D';  M= -21,  15,  70,  57, -80, -65, -59, -78, -55, -27, -73, -48, -66, -49, -62,  54, -53, -73, -89, -71;
/M: SY='D';  M= -65, -83,  93,  67, -88,   3, -56, -88, -52, -84, -81, -45, -64, -49, -62, -57, -61, -83, -93, -74;
/M: SY='I';  M= -63, -75, -87, -82, -51, -88, -80,  82, -78,   3,  61, -78, -77, -75, -79, -74, -59,  46, -78, -58;
/M: SY='I';  M=  43, -74, -65,  34, -67,  -6, -70,  48, -63, -53,  31, -66, -70,  28, -67, -57, -59,  18, -78, -66;
/M: SY='M';  M=   2, -70, -69,   5, -62, -76, -70,  12, -64,  -8,  54, -65, -71,  28, -68, -56,  49,  49, -82, -63;
/M: SY='T';  M= -57, -69,  -2,  27, -64,  -3, -65, -59, -60, -21, -60, -54, -65, -60, -67, -46,  89,   0, -80,  19;
/M: SY='S';  M=  25, -70, -60, -57, -78,  36, -63, -74, -56, -76, -67, -52,  39,  30,  -6,  64,   8, -68, -78, -70;
/M: SY='S';  M=  -6, -67,  11, -63, -62,   3, -67,  11, -64,  20, -53, -55, -68, -61, -69,  51,  50,   9, -81, -64;
/M: SY='Q';  M= -58, -75,  -8, -48, -13, -67, -55, -70,  38, -70, -62,   4, -68,  64,  57,  30,  25, -21, -76, -61;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='V';  M= -57, -69, -78, -72,  11, -80, -74,  45, -70,   8,  34, -70, -75,   7, -72, -12,  17,  66, -77, -55;
/M: SY='S';  M= -50, -68,  11,  12, -77, -12, -53, -77, -53, -80, -71,  77, -66, -48, -59,  80, -43, -72, -87, -69;
/M: SY='L';  M= -67, -69, -80, -76,  39, -82, -65, -36, -75,  80,  36,   9, -83, -70, -73, -74, -62, -43, -67, -47;
/M: SY='T';  M= -59, -72, -64, -56, -65, -72, -61,  26,  25,  -6,  33, -55, -67,  38,  45,   5,  59, -51, -77, -61;
/M: SY='C';  M= -62, 150,  16, -74, -72, -76, -78, -79, -75, -70, -70, -63, -89, -81, -81, -63, -61, -67,-101, -81;
/M: SY='P';  M= -66, -92, -67, -55, -86, -68, -70, -74, -63, -84, -70, -73, 128, -66, -75, -64, -59, -79, -79, -83;
/M: SY='I';  M= -65, -73, -81, -79, -46, -85, -73,  81, -76,  53,  39,  -1, -77, -71, -77, -73, -60, -29, -73, -55;
/M: SY='T';  M= -48,  24, -59, -62, -70,  10, -66, -62, -60, -67, -63, -48, -64, -59, -66,  66,  81,  -1, -85, -67;
/M: SY='C';  M= -62,  63, -65, -57,  34,  32, -60, -69,  56, -15, -60, -57, -73,  41,  12, -59, -63, -68, -65,  22;
/M: SY='M';  M= -56, -70, -60,   5, -66, -68, -58, -58,  40, -11,  80, -54, -65,  19,  18,  33,  45, -58, -77, -61;
/M: SY='R';  M= -66, -85, -56,  41, -79, -75, -55, -81, -32, -77, -67, -59,  61, -43,  96, -61, -63, -77, -77, -68;
/M: SY='M';  M= -63, -73, -83, -77, -45, -82, -64,  62, -72,  25, 104, -75, -75, -66, -72, -72, -60,   5, -68,  31;
/M: SY='K';  M= -56, -72, -55,  13, -74, -30, -60, -67,  69, -70, -63, -50, -63,  31,   2,  10,  58,  -6, -78, -66;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='Y';  M=   0, -72,   8, -62, -52, -74,  32,  30,  25,  26, -46,   4, -73, -60, -60, -61,  -5,  26, -70,  40;
/M: SY='P';  M=  12, -87, -67, -56, -85, -65, -70, -73, -63, -82, -69, -72, 122, -66, -74, -60, -58, -75, -79, -82;
/M: SY='C';  M=  16,  77, -75, -73, -62,  16, -76,   4, -71,  -3, -51, -66, -76, -70, -75,  19, -53,  60, -83, -67;
/M: SY='R';  M= -65, -80, -63, -50, -71, -76, -57,   6,  67, -16, -58, -56, -71, -43,  89, -61, -62, -64, -74, -62;
/M: SY='S';  M=  20,  24, -58, -64,  32,  28, -61, -68, -61, -69, -65,  53, -70, -59, -66,  60,  -6, -29, -75, -60;
/M: SY='H';  M= -63, -75,  -7,  -9, -65, -74,  59,   1,  54,  12,  33, -55, -69,  28,  18, -59,   4,  -4, -78, -57;
/M: SY='D';  M=  -8, -72,  50, -53,  -9, -68, -63, -53,   9, -29,  12,  15,  38,   2, -61, -53,  41,  32, -83, -64;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='K';  M=  11, -72, -58, -57, -73,  32, -61, -12,  52, -70, -63,  44, -68, -52,  28, -16,  10,  -2, -78, -68;
/M: SY='H';  M= -69, -81, -53, -53, -68, -71, 149, -86, -58, -68, -54, -43, -70, -47, -52, -59, -68, -86,-103, -37;
/M: SY='M';  M= -61, -68, -78, -74,  12, -81, -71,  27, -72,  49,  57, -71, -75, -70, -73, -63,  44,  37, -74, -53;
/M: SY='Q';  M= -62, -82, -62, -50,  21,  15, -47, -68, -51, -63, -56, -57, -73, 102, -51, -55, -64, -71, -51,  84;
/M: SY='C';  M= -60, 130,  18,  61, -76, -74, -67, -81, -60, -73, -71, -59, -74, -59, -69, -15, -59, -70, -93, -78;
/M: SY='F';  M= -70, -74, -67,  27, 102, -79, -62, -59,  38, -51, -56, -66, -75, -62,  16, -67, -64, -61, -51, -32;
/M: SY='D';  M= -65, -80, 111,  28, -86, -64, -53, -85, -53, -83, -81, -37, -65, -51, -62,   2, -56, -81, -99, -70;
/M: SY='A';  M=  73, -65, -73, -67,  14,   4, -70, -50, -68,  34, -49, -67, -72, -65, -71, -52, -57,   0, -71, -60;
/M: SY='I';  M=  -7, -74, -12,  37, -56, -77, -72,  68, -65,  18, -45, -67, -70, -61, -70,   3, -15,   5,  38, -59;
/M: SY='W';  M=  -2, -71, -67,  -7,  15, -69, -66, -47, -63,  31, -50,  16, -73,  27, -66,  25,  -3,  30,  81, -52;
/M: SY='Y';  M= -68, -76, -67, -67,  70, -73,  36, -61, -55, -56, -55,  22, -79, -59,  45,  -2, -62, -64, -46,  89;
/M: SY='M';  M= -63, -70, -82, -76, -40, -83, -62,  -7, -73,  61,  74, -78, -80, -68, -71, -72, -60,  37, -64,  54;
/M: SY='Q';  M= -63, -78, -58,  35, -63, -76,  65,  49, -55,  15,  21,  -5, -69,  73, -57, -61, -61, -49, -77, -56;
/M: SY='M';  M= -59, -72, -62,  28, -58, -71, -57, -13, -58,  28,  92,  12, -70,  46, -60,  17, -56,  -1, -77, -58;
/I:         I=-21; MD=-53;
/M: SY='N';  M= -60, -72,   4, -56, -81,   5, -50, -80, -52, -84, -72, 102, -73,  38, -59,  27, -51, -80, -92, -73; D=-21;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='Q';  M= -69,  48, -60,  52, -84, -82, -67, -79,  29, -17,   7, -65, -75,  56, -57, -16, -15, -77, -88, -76; D=-21;
/I:         I=-21; DM=-53;
/M: SY='R';  M= -73, -91, -64,  13, -90, -83, -63, -90,  54, -85, -74, -62, -77,  50,  69, -67, -72, -86, -84, -74; D=-21;
/I:         I=-21; DM=-53;
/M: SY='K';  M= -62, -77, -60, -55, -67, -70, -58,  -2,  70, -70, -63,  30, -71, -50,  32,  22, -10, -20, -73,  30; D=-21;
/I:         I=-21; DM=-53;
/M: SY='P';  M= -63, -83, -63, -54, -81,   4, -65, -75,  39, -80, -68, -61, 102, -56,  29, -58,  14, -75, -78, -75;
/M: SY='T';  M= -55, -66, -55, -54, -71, -66, -62, -66,  52, -69, -63,  17, -62, -52,   1,  10,  92, -59, -83, -66;
/M: SY='W';  M=  31,  35, -88, -73, -50, -68, -86, -68, -64, -68, -68, -81, -77, -67,  13, -67, -73, -16, 158, -39;
/M: SY='Q';  M= -61,  37,  17, -50, -66, -71, -54, -26,  -3, -61,  40,  15, -71,  75,  40, -55,   8,   8, -74,  22;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='P';  M= -66, -92, -67, -55, -86, -68, -70, -74, -63, -84, -70, -73, 128, -66, -75, -64, -59, -79, -79, -83;
/I:         I=-28; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='V';  M=   2, -71, -73, -74, -62,  53,  36,  35, -71, -51, -51, -63, -73, -70, -74, -58, -58,  65, -81, -63;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='S';  M= -20, -71,  45,   4, -71, -61, -55, -64, -52,   5, -61,  48, -69,  38,   8,  52, -50, -14, -84, -65;
/M: SY='H';  M=  -8, -76, -57, -48, -75,  -4,  84,  -3,  68, -70, -60, -49, -66,  53, -41,  10, -58, -68, -78, -57;
/I:         I=-22; MD=-57;
/M: SY='T';  M= -83, -98,   5, -83, -98, -94, -92, -81, -28, -92, -89,  -3,  25, -87, -91, -13,  34,  10,-115, -96; D=-22;
/I:         I=-22; MI=0; MD=-57; IM=0; DM=-57;
/M: SY='D';  M= -62, -77,  77,  29, -81, -16,  16, -81,  28, -80, -73,  38,   9, -48,   7, -14,  -9, -78, -88, -68;
/M: SY='M';  M=  15, -72, -71, -67,  22, -73,   9,  19, -63,  28,  55,  12, -76,  16,  -6, -62, -59,   3, -64,  46;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='Q';  M= -16,  41, -64,  -7, -65, -71, -58, -60, -48,  37, -51, -60,  -4,  66,  51,  21, -58, -61, -76, -62;
/M: SY='Y';  M=  -8, -73,  16, -62,  -3, -73, -58,  31,  18,  10,  33,  14, -74, -59,   5, -61, -19,   6, -64,  56;
/M: SY='S';  M= -54, -73,  26,  42, -71, -65, -63,  38, -58, -63, -61, -54,  38, -53, -65,  63,  -8, -12, -82, -67;
/M: SY='D';  M= -59, -75,  81, -44, -74, -19,  12,   6,   3, -17, -65,  -1, -68,  21, -59,  45, -52, -65, -87, -65;
/M: SY='L';  M= -62, -72,  -6,  18, -49,   0, -65,  21, -69,  59,  43, -71, -75, -63, -71, -68, -61,  15, -72,  10;
/M: SY='I';  M= -65, -76, -70,  24,  30, -83, -67,  69,  -1,   1,  47, -69, -73, -61,   9, -69, -60,  -3, -66,  11;
/M: SY='V';  M= -62,  38, -74,   0,  19, -81, -71,  40, -68,  34, -43, -73,  25,  32, -70, -67, -59,  41, -74, -56;
/M: SY='D';  M= -65, -79, 107, -37, -81, -16, -55, -78, -53, -28,   4, -40, -68, -54,  14,  -7, -57, -76, -95, -68;
/M: SY='E';  M=  -6,  47,  29,  54, -80,  18, -60, -15, -26, -73, -67,  -1,  38,  40, -60, -53,  -3, -69, -82, -72;
/M: SY='Y';  M=  28, -72, -72, -68,  -2, -72, -61,  51,  22,  14,  54,  -9, -73, -61, -62, -62, -59, -42, -61,  56;
/M: SY='L';  M= -67, -71, -85, -79,  52, -85, -69,  38, -77,  68,  56, -79, -81, -72, -75, -75, -63, -38, -64, -45;
/M: SY='Q';  M=  25, -75, -56,   4, -69, -64, -54, -71,  39, -68,  32,  37, -68,  50,  43, -11, -57, -68,  41,   9;
/M: SY='R';  M= -64, -78, -55,  24,  10, -22,  16, -15,  48, -69, -62,  32, -70, -45,  73, -58, -61, -70, -71,  -2;
/M: SY='C';  M=  17,  74, -71,   2, -61, -75, -71,  64, -62, -48,  42, -66, -72,   6,   3, -59,  12,  -6, -79, -63;
/M: SY='I';  M= -63, -72,  -4, -30, -56, -75, -65,  50,   9,  42, -44,  23, -14,  19, -63, -59,  37, -43, -77, -60;
/M: SY='E';  M= -22, -75,  28,  75, -80, -65, -54, -80,  32, -78, -71,  22, -61, -41,   8,  37, -53, -74, -82, -70;
/M: SY='N';  M=  -8,  11,  47,  27, -72, -61, -56, -11, -14,  -7, -63,  52, -68, -50,   5,  46, -51, -64, -85, -67;
/M: SY='H';  M=  -8,  49,   0, -62, -57, -74,  62,  -9, -64,   3,  50, -61, -74,  27, -65, -59,  15,  44, -80,  10;
/M: SY='E';  M= -59, -77, -43,  70, -81, -23, -53, -79,   5, -77, -68,  47,  -3,  49,  28,   3,  -5, -75, -80, -69;
/M: SY='Q';  M= -59, -77,  12,  42, -78, -37,  55, -10,  40, -72, -63,   6, -64,  61,  -6,  28, -56, -70, -80, -62;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	32 in 32 different sequences
Number of true positive hits	32 in 32 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	SP-RING-type
Version [info]	7

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

32 sequences

GEI17_CAEEL (Q94361), NSE2_ARATH  (Q8GYH7), NSE2_BOVIN  (Q32KY9),

NSE2_HUMAN  (Q96MF7), NSE2_MOUSE  (Q91VT1), NSE2_RAT(Q4V8A0), 
NSE2_SCHPO  (Q4PIR3), NSE2_XENLA  (Q7ZXH2), NSE2_YEAST  (P38632), 
PIAL1_ARATH (A0A0A7EPL0), PIAL2_ARATH (F4JYG0), PIAS1_HUMAN (O75925), 
PIAS1_MOUSE (O88907), PIAS2_HUMAN (O75928), PIAS2_MOUSE (Q8C5D8), 
PIAS2_RAT   (Q6AZ28), PIAS3_HUMAN (Q9Y6X2), PIAS3_MOUSE (O54714), 
PIAS3_RAT   (O70260), PIAS4_HUMAN (Q8N2W9), PIAS4_MOUSE (Q9JM05), 
PIS4A_DANRE (F1R4C4), PLI1_SCHPO  (O94451), SIZ1_ARATH  (Q680Q4), 
SIZ1_ORYSJ  (Q6L4L4), SIZ1_YEAST  (Q04195), SIZ2_ORYSJ  (Q6ASW7), 
SIZ2_YEAST  (Q12216), ZMIZ1_HUMAN (Q9ULJ6), ZMIZ1_MOUSE (Q6P1E1), 
ZMIZ2_HUMAN (Q8NF64), ZMIZ2_MOUSE (Q8CIE2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

17 PDB

2YU4; 3HTK; 3I2D; 4FO9; 4MVT; 5JNE; 6U75; 7P47; 7QCD; 7YLM; 7YQH; 8I21;
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