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PROSITE entry PS50975


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50975
Entry name [info] ATP_GRASP
Accession [info] PS50975
Entry type [info] MATRIX
Date [info] 01-APR-2004 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50975
Associated ProRule [info] PRU00409

Name and characterization of the entry

Description [info] ATP-grasp fold profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=195;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=190;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=15.4682245; R2=0.0368132; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=9789.0283203; R2=11.3829412; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=-186; H_SCORE=7672; N_SCORE=8.6; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=-243; H_SCORE=7023; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-50; I=-50; B0=-400; B1=-400; E0=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Post-processing [info]

COMPETES_HIT_WITH PS51221

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 2'410 in 2'148 different sequences
Number of true positive hits 2'409 in 2'147 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 73
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 99.96 %
Recall (true positives / (true positives + false negatives)) 97.06 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] N_Hulo
Feature key [info] DOMAIN
Feature description [info] ATP-grasp
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
2147 sequences

2OCS_HYDTT  (D3DJ42), ACACA_BOVIN (Q9TTS3), ACACA_HUMAN (Q13085), 
» more

UniProtKB/Swiss-Prot
False negative sequences
73 sequences

ACLY_BOVIN  (Q32PF2), ACLY_HUMAN  (P53396), ACLY_MOUSE  (Q91V92), 
» more

UniProtKB/Swiss-Prot
'Partial' sequences
3 sequences

ACCC_POPEU  (P84546), SUCB1_CANLF (P99507), SUCB1_MESAU (P86226)

		
UniProtKB/Swiss-Prot
False positive sequences
1 sequence

SYN_HELPO   (Q6QM28)

		
PDB
[Detailed view]
273 PDB

1A9X; 1B6R; 1B6S; 1BNC; 1BXR; 1C30; 1C3O; 1CE8; 1CQI; 1CQJ; 1CS0; 1DV1;
» more