PROSITE entry PS50968

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50968
Entry name [info]	BIOTINYL_LIPOYL
Accession [info]	PS50968
Entry type [info]	MATRIX
Date [info]	01-MAR-2004 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50968
Associated ProRule [info]	PRU01066

Name and characterization of the entry

Description [info]

Biotinyl/lipoyl domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=76;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=71;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0327859; R2=0.0085769; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=11098.9189453; R2=2.5826342; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1571; H_SCORE=15156; N_SCORE=15.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=521; H_SCORE=12444; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-40; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='I';  M=  -5,-104, -59, -18,  12, -29,  29,  35,   5, -18, -38, -93,  -1, -23, -15,   6,  23,  22,-107, -44;
/M: SY='A';  M=  36, -21, -39,  11, -26,   6, -11,  17, -27, -59, -34, -32, -57,  -2, -23, -36,  -3,  32, -14,  -4;
/M: SY='T';  M= -35,-104,  -3,  24, -36, -36, -34, -47,  10, -20, -91, -13, -27,  30, -13, -12,  60,   6,  26, -58;
/M: SY='I';  M= -14,-105, -28,  -3,  16,-114,-108,  70,-103,  -3,  -3,-105,-107, -45, -60, -59, -89,  53,-107, -88;
/M: SY='G';  M= -60,-108, -36, -20, -36,  71, -23, -70,  33, -38, -98,  -5, -16, -23, -25, -11, -20, -23,-107, -39;
/M: SY='M';  M=  -4,-102,  15,-100, -32, -67, -31,  60,-101,  11,  74, -50,-104, -97,-103,  -7, -11,  26,-108, -44;
/M: SY='P';  M= -25,-107, -94, -59,-109, -96, -99, -99, -91, -72, -97, -91, 104, -93, -60,  26,  66, -97,-113,-106;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='Y';  M=  -6,-109,  38, -28,  17, -12,  36, -63, -36, -59,  22,  -5, -33,   4, -97,  24,   2, -72,-104,  40; D=-25;
/I:         I=-25; DM=-63;
/M: SY='A';  M=  45,-104, -26, -40, -18, -56,  -9,   8, -53,  22,  31,-100, -23, -16,-102, -37,  -4,   8,  -3, -18; D=-25;
/I:         I=-25; DM=-63;
/M: SY='Q';  M=   3,-105, -21, -94, -98,  44, -99,  21, -95,  -5, -37, -91,  -9,  49, -55,  16, -41,  21,-108, -41; D=-25;
/I:         I=-25; DM=-63;
/M: SY='E';  M= -16, -35,  21,  59,-104, -27, -14, -19, -26, -35, -34,  -3,  19,  18,   3,   0,   6, -22,-111, -25; D=-25;
/I:         I=-25; DM=-63;
/M: SY='S';  M=  33,-101, -20, -10,  -3,  19, -30, -63, -22, -55, -40, -84, -98,  32, -30,  53,  26, -63,-107, -32; D=-25;
/I:         I=-25; DM=-63;
/M: SY='M';  M= -69,-106,-106, -23, -22,-110, -32,  28, -60,  47,  59, -49,  47, -47,-102, -27, -40,   4,-101,  22; D=-25;
/I:         I=-25; DM=-63;
/M: SY='M';  M=  15,-100,  -1, -17, -97,  43,  14, -58, -19, -25,  76, -33, -97, -19, -41,   2,  40, -41,-108, -46;
/M: SY='D';  M=   7,-107,  61,  58,-109, -22, -88,-104, -20, -57, -99,   3,  47,  10, -89,   5, -30, -49,-112, -39;
/M: SY='G';  M=  12,  -1, -54,-101, -98,  72,-102,  30, -36, -48,  -8, -25,  -5, -97, -66, -55, -90,  32,-107, -99;
/M: SY='T';  M= -37, -99, -17,  19, -95, -66, -95, -31,  24, -13, -15,  23, -58, -30, -37,  -4,  56,  50,-113, -95;
/M: SY='V';  M= -93,-103,-110,-107,  54, -71, -10,  51,-104,  10, -30, -43,   7,-103,-104, -99, -89,  55, -91,  50;
/M: SY='V';  M=  -4, -43, -41, -58, -31, -17,-103,  40, -24,   4, -37, -10,-103, -35, -56, -16,   9,  60,  44, -45;
/M: SY='E';  M=  -3, -36,  11,  65, -53, -72, -87, -40,  58,-102, -96, -11, -93,  29,   3,   0, -37, -41, -10, -52;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='W';  M= -73,-122,-125,-115,   0,-119,-122,  -3, -26, -56, -97, -64,  12,-113, -64, -71, -68,  45, 121,   0; D=-28;
/I:         I=-28; DM=-70;
/M: SY='L';  M= -38,-102, -64, -10,  38,-107,  11,  -4,  14,  56,  17, -20, -26,  -5, -50, -43, -10, -20, -97,  -2;
/M: SY='V';  M= -48,-104,-101, -91, -56,-106,-102,   1,  52, -46, -82, -98,  66, -92, -43, -93, -53,  73,-109, -44;
/M: SY='K';  M=  10,-105,   0,  38,-109, -94,   9,-107,  78,-106, -97,  12,   8,  16, -36,   9, -36,-102,-108, -97;
/M: SY='E';  M=  -5,-104,  21,  54, -97,-103, -96,  15, -14, -18, -85, -12,  45, -46, -93, -59, -86,  53,-112, -97;
/M: SY='G';  M= -81,-107, -11,  -6,-112, 100, -19,-118, -95, -75,-104,   5, -98, -44,-103, -80, -96,-112,-106,-105;
/M: SY='D';  M=  -8,-106,  92,  37,-111, -40, -86,-108, -31, -72,-102, -17, -94,  17, -17,   2,  25,-103,-119, -99;
/M: SY='K';  M=  -8,-103, -53,   6, -33, -97,  31, -31,  55, -33,  -8, -18, -15,  55, -15,   8,  35, -44,-106, -24;
/M: SY='V';  M= -61, -17,-113,-108, -35,-115,-112,  59, -69,  12, -70,-108,-108,-106,-107, -99, -57,  84,-109, -38;
/M: SY='K';  M=   7,-102,   9,  41,-106, -63, -87, -56,  50,-101, -33,  38, -95,  20,  -4,  28,  -1, -10,-110, -97;
/M: SY='K';  M=  40, -35, -25,  35,-102, -96, -42, -28,  62, -51, -38, -37, -22,  27, -10, -58, -25,   5,-106, -38;
/M: SY='G';  M= -63,-107,  58,  15, -26,  82, -91,-115, -25,-111,-104,  13, -97, -26, -46, -82, -93,-111,-108, -41;
/M: SY='Q';  M= -90,-110,  69,  64,-113, -38, -83,-107, -37, -69, -98, -40, -21,  82, -52, -24,  -8, -59,-113, -98;
/M: SY='P';  M= -13, -37, -93,   8, -96, -35, -34,   2, -14,  -5, -85, -33,  69, -47, -96,  23,  31,  31,-110, -51;
/M: SY='L';  M= -29, -14,-113,-108,  47,-113,-102,  49,-106,  55, -68,-107,-110,-104,-106,-100, -28,  36, -96,   7;
/M: SY='C';  M=  49,  81,-105,-102, -13,  32,-103,   6,-101,  13,   6, -96,-105, -99,-104, -53, -88,  24,-107, -95;
/M: SY='E';  M= -52,-101,   4,  57, -94,-103, -97,  38, -89, -37, -83, -23, -97, -45, -95,  27,  24,  51,-113, -95;
/M: SY='V';  M= -90,-100,-113,-108, -79,-115,-108,  66,-106,  37,  32, -54,-108,-104,-107,-101, -86,  71,-108, -87;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='E';  M= -89,-109, -19, 109,-111,-103, -84, -64, -73,-104,  -9, -85, -87,  10, -82,  -2, -32,-103,-110,-101;
/M: SY='S';  M=  52, -93, -90, -89,-102, -31, -95, -93, -36, -98, -93, -47, -94, -86, -94,  71,  64, -12,-112, -97;
/M: SY='M';  M= -26,-102,  72, -14, -94, -35, -90, -30, -92, -58, 104, -34, -99, -48, -96, -41,  -3,  35,-115, -91;
/M: SY='K';  M= -54,-106, -84, -29,-109, -99, -88,-109, 113,-108, -96, -78, -93, -70, -55, -32, -86,-104,-103, -96;
/M: SY='M';  M=  49, -97, -28, -37, -91, -95, -95, -13, -93, -35,  95, -92, -99, -90, -51,  14,  28,  22,  34, -89;
/M: SY='E';  M=  32, -21, -19,  51, -98, -66, -92, -14, -54, -67,  40,   6, -96,  28, -91,  -8,  30,  28,-110, -38;
/M: SY='M';  M=  -7, -99, -93, -17, -24, -32,  29,  36, -92, -33,  78,  40,-100, -42, -96,  38,  -4,  15,-109, -88;
/M: SY='E';  M= -39,-107,  63,  69,-108, -16, -38, -99, -33, -50, -97, -53,  35,   5, -89, -39,  20,   0,-115,-100;
/M: SY='I';  M= -91,-101,-115,-110,  20,-117,-109,  71,-107,  37, -27,-109,-109,-106,-108,-102, -87,  64,-103, -83;
/M: SY='Y';  M= -66,-107, -35,  31, -13,-100, -12, -93,   1, -17, -17,  24,  62,  -8,   3, -12,   4, -31, -94,  65;
/M: SY='S';  M=  67,   0, -93, -90,-101, -82, -94, -71, -90, -51,   2, -84, -96, -38, -95,  80,  -8, -35,-108, -43;
/M: SY='P';  M= -68,-117,   0,   6, -55, -38, -32,-103, -58, -54, -98, -95, 116,  20, -28, -29, -89, -75,-109,-105;
/M: SY='V';  M=   1,   1,  12,  18,  13,-104,  15,  28,  -9,  -2,   6, -93,-102, -30, -57,  -8, -61,  48,-104,   2;
/M: SY='S';  M=  28, -99,  55,  11,-106, -23, -89, -63, -22,-103, -12,   7, -95, -81, -13,  65,  22, -95,-114, -98;
/M: SY='G';  M= -39, -25, -93,-105,-112, 104,-100,-118, -99, -77,-104,  -7, -99, -96,-106, -79, -97,-112,-105,-107;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='T';  M= -88,-102, -88,  41, -92,-105, -94,  34,  39, -86, -84, -87, -95,  -7,  -2, -52,  62,  29,-105,  18;
/M: SY='V';  M= -55,-100,-114,-108, -80,-115,-112,  63,-106,  20, -20,-108,-108,-105,-107, -99, -84,  84,-110, -89;
/M: SY='K';  M=   1,-101, -91,  13, -95, -68,  -2,  19,  40,  -3, -82, -18, -98,  12, -16,  12,  24,  35,-109, -93;
/M: SY='E';  M=  28,-104,  20,  66, -49, -35, -26, -65,  48, -29, -94, -49, -93, -18, -43,  13, -86, -41,-107, -36;
/M: SY='I';  M= -90,-102,-112,-108, -33,-116,-109,  76, -57,  31, -67, -59,-107, -49, -67,-100, -40,  64,-107, -87;
/M: SY='N';  M= -29, -31, -85, -57,  -4, -36,  33, -30,   3,  31,  -1,  88, -49, -87, -44, -56, -85,   3,-108, -13;
/I:         I=-29; MD=-75;
/M: SY='V';  M=   7, -35, -15,  36, -57, -23,  12,   8,   6, -89, -87, -17, -32,  -4, -42, -49,  -3,  53,-111, -17; D=-29;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='K';  M=  -4,-105,  48,  30,-109, -70, -36, -66,  57, -72, -97,  29,  -5,  22,  -6,   7, -22, -42,-112, -98; D=-29;
/I:         I=-29; DM=-75;
/M: SY='E';  M=  10,-103,  20,  64,-103, -93, -87, -41, -26, -61, -95,  50,  17, -21, -88,  26, -18,  -1,-111, -14;
/M: SY='G';  M= -59,-111, -10, -44,-113,  86, -98,-114, -94,-114,-103, -26,  79, -21, -69, -83, -94,-111,-106, -57;
/M: SY='D';  M=  -8,-105,  69,  56,-111,  -6, -86, -67, -25,-105, -29,  -9, -93,  47, -86,  20,  15,-101,-114, -99;
/M: SY='T';  M= -19,-101, -96, -19, -30,-103, -95,  27,  27,  17,  10, -11,   1,  -6, -29,  -7,  43,  24,-105, -13;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='V';  M= -19, -33,-113,-108, -81,-113,-111,  61,-105,  11,  15,-107,-107,-104,-107, -98, -84,  82,-111, -89;
/M: SY='N';  M= -35,-102,   2,  32,-107, -47, -35,-101,  -2, -62, -96,  81,  17,  34, -27,  28,   8, -32,-115, -99;
/M: SY='V';  M=  18, -34,  10,  27, -13, -23, -23,  -8, -26, -56, -88, -18,   6,  -1, -53,  19,  18,  40,-109, -41;
/M: SY='G';  M= -57,-106,  62, -29,-112,  78, -30,-115,  -2,-113,-105,  -2, -97, -39, -57,  23, -59,-110,-111,-102;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='D';  M=  12, -23,  46,  18,-109,  41, -32, -47, -20,-104, -98,   0, -45,  42, -90,  18,  30, -67,-112, -99;
/M: SY='W';  M=  -9,-109, -38, -20, -82, -57,-106,   6, -30,  20, -27, -57,  33, -50,-100, -95,   8,  15, 132, -21;
/M: SY='I';  M= -62,-101,-114,-108,   7,-115,-102,  65,-106,  65,  51,-108,-108,-102,-106,-103, -32,  -1,-101, -82;
/M: SY='C';  M=  43,  48,-108,-103,  47,  -7,-103,  20,-102,  -4,  35,-100,-106,-101,-104, -89, -32,  44,-100, -43;
/M: SY='K';  M= -53,-104, -40,  24, -53,-104, -91,  12,  68, -31, -41, -26, -98, -44,  37, -58,  12,  25,-104,  -9;
/M: SY='I';  M= -67, -26,-114,-110,  14,-116,-107,  80,-107,  41,  22,-107,-108,-104,-108,-102, -47,  37,-102, -83;
/M: SY='E';  M=   3,-105,   9,  63,-106, -16, -89, -27,  54,-100, -95,  -8, -94,  -7,   6, -15, -14,  -1,-109, -98;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	696 in 677 different sequences
Number of true positive hits	696 in 677 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	4

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.86 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	3
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Biotinyl/lipoyl
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	677 sequences 2OCL_HYDTT (D3DJ41), ACACA_BOVIN (Q9TTS3), ACACA_HUMAN (Q13085), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	1 sequence GCVHL_STRPG (P0DN69)
UniProtKB/Swiss-Prot 'Partial' sequences	4 sequences ODO2_DELAC (P83708), ODO2_MESAU (P86219), ODO2_SOLTU (P81896), ODPX_MESAU (P86238) » more
PDB [Detailed view]	123 PDB 1A6X; 1BDO; 1DCZ; 1DD2; 1DXM; 1FYC; 1GHJ; 1GHK; 1HPC; 1HTP; 1IYU; 1IYV; » more