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PROSITE entry PS50896


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50896
Entry name [info] LISH
Accession [info] PS50896
Entry type [info] MATRIX
Date [info] 01-FEB-2003 CREATED;
13-FEB-2019 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50896
Associated ProRule [info] PRU00126

Name and characterization of the entry

Description [info] LIS1 homology (LisH) motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=33;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=33;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=5.5517526; R2=0.0001392; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=124905.5937500; R2=0.2366895; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=13997; H_SCORE=128219; N_SCORE=7.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=6813; H_SCORE=126518; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: B0=*; B1=*; E0=*; E1=*; MM=*; II=*;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 267 in 267 different sequences
Number of true positive hits 267 in 267 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 12
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 95.70 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] LisH
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
267 sequences

ADN2_SCHPO  (O94619), ADN3_SCHPO  (O74522), ARMC9_BOVIN (Q2KI89), 
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UniProtKB/Swiss-Prot
False negative sequences
12 sequences

GID8_YEAST  (P40208), LIS11_PENRW (B6HP56), LIS11_UNCRE (C4JZS6), 
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PDB
[Detailed view]
89 PDB

1UUJ; 1VYH; 2D68; 2XTC; 2XTD; 2XTE; 4OYU; 4ZHE; 5C6Q; 5C6V; 5C7E; 5C7F;
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