PROSITE entry PS50889

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PURL: https://purl.expasy.org/prosite/signature/PS50889

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General information about the entry

Entry name [info]	S4
Accession [info]	PS50889
Entry type [info]	MATRIX
Date [info]	01-NOV-2002 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50889
Associated ProRule [info]	PRU00182

Name and characterization of the entry

Description [info]

S4 RNA-binding domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=60;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=60;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=6.8325300; R2=0.0001254; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=319596.3750000; R2=0.8829120; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=13298; H_SCORE=331337; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=-2651; H_SCORE=317256; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: B0=*; B1=*; E0=*; E1=*; MM=*; II=*;

...

                A      C      D      E      F      G      H      I      K      L      M      N      P      Q      R      S      T      V      W      Y
/I:         B0=-8455; B1=-8455; BM=-6; BD=-7931;
/M: SY='M';  M= -1304, -1078, -2467,   122, -1636, -1208, -4919,   892,   478,  -176,  2801, -2128, -1982,  1287,   735,  -746, -1338,   879,  -612, -2582; M0=-639;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='R';  M= -2960, -6530, -1963, -2089, -6849, -1958, -4694, -3429,   445, -3263, -5619,  -559,  -224, -4235,  3681,  -867,   -76, -3639,    33, -6032; M0=-2210;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='L';  M= -1525, -7894,-10916,-10337, -1242,-10721, -9403,  1465,-10151,  2859,  -812,-10444, -9734, -8906, -9634,-10101, -8353,   622,  -526, -8132; M0=-5992;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='D';  M=  -698, -1164,  3306, -2473, -1099, -1764,  -840, -1382, -2329,  -530, -2354,  -182, -3265,   798, -2327,  -998, -2366,    38, -6586,  -813; M0=-1132;
/I:         MM=-19; MI=-13093; MD=-6255; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='K';  M=  -401, -1759,  1051,   -97, -1204, -3627, -2187,  -877,  2276, -2463, -1453,   598, -6111,   954,   236,  -638,  -178,   228, -6693,  -900; M0=-914;
/I:         MM=0; MI=-13074; MD=-14116; IM=-894; II=-1115; DM=-187; DD=-3039;
/M: SY='F';  M=    62, -1859, -7708, -2963,  2298, -2914, -5781,  1164, -3566,  1127, -1412, -6556, -6960, -6290, -1658, -3836, -2656,  1409,  2145,  1554; M0=-2171;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='L';  M= -3830,   296, -7877, -7247,   115, -7092, -5974,  1168, -6849,  2800,  -187, -6739, -3658, -6471, -6652, -2925, -3459,   748, -5828, -5488; M0=-3556;
/I:         MM=-6; MI=-13093; MD=-7877; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='A';  M=  1549,    97, -6584, -3608,   461, -2385,  -851, -2446,  1051,  -321, -1161, -1305, -3429, -1192,   107,   640, -1414,  1273,   652,   636; M0=-951;
/I:         MM=-49; MI=-4919; MD=-14129; IM=-23; II=-5954; DM=-1464; DD=-650;
/M: SY='R';  M=  -125, -6526,    80,  1220, -1259, -2789,   149, -1717,  1158, -1069, -1510,   518, -3383,   667,  1685,   236,  -409, -1080, -1709, -1302; M0=-612;
/I:         MM=0; MI=-13087; MD=-14129; IM=-894; II=-1115; DM=-371; DD=-2141;
/M: SY='M';  M=  1317,  -100, -6751,  -444, -2035, -6732,  -294,    72,  -188,  1323,  1330,  -550, -6792,   445,  -261,   116,  -324,  -477,  -685, -1755; M0=-1152;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='G';  M= -2809, -6416, -2048, -1600,   775,  2632,   186, -1752,   134,   578, -1521,   173, -3310, -2544,   -56, -1042, -1114, -2306, -1631,  -888; M0=-988;
/I:         MM=-556; MI=-13093; MD=-1646; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='F';  M= -1578, -4801, -3125, -1382,  2381, -6177, -4987,   776,  -147,  1616, -1828,  -432,  1355, -2523, -1898, -1829, -2020, -1072,  -145,   -70; M0=-1222;
/I:         MM=-27; MI=-5779; MD=-13579; IM=-479; II=-1823; DM=-52; DD=-4833;
/M: SY='C';  M=  1270,  1404,   110,  -178,   420,   175,  -818,   248,  -662,  -941, -5421,   879, -6181, -1401, -1541,  -991, -1360,  1165, -1676,   218; M0=-604;
/I:         MM=0; MI=-13079; MD=-14122; IM=-894; II=-1115; DM=-863; DD=-1151;
/M: SY='C';  M=  -334,  1247,  -788,  -605,  -434,   367,  -347,   549,   852,  -121, -2356, -1786,   786,  -430,  -265,   214,     6,  -363,  -626,   373; M0=-146;
/I:         MM=0; MI=-13086; MD=-14128; IM=-894; II=-1115; DM=-1505; DD=-627;
/M: SY='S';  M= -5319, -6807, -3109, -2440, -7126, -2927, -2055, -6881, -1577, -4360, -5904,  -354,  -220, -4472, -1539,  3238,  1504, -6430, -6986, -6293; M0=-3082;
/I:         MM=0; MI=-13086; MD=-14128; IM=-894; II=-1115; DM=-359; DD=-2182;
/M: SY='R';  M= -2072, -6116, -5205, -2566, -1686,  -115,  -647,   646,   766, -1815, -1034,  -711, -3283, -2633,  3392, -1634, -1125, -1861, -1415, -5841; M0=-1535;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='S';  M=   -81, -6532, -3044, -1017,  -808,   549, -1392, -2243,   431, -2732, -5622,   672, -1983,  -529,  1721,  1834,   147, -1356, -6716,  -329; M0=-902;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='Q';  M=   188, -6524,  -806,  2019,  -680, -3539,   291,  -948,   794,  -498,  -270, -2210, -6130,  2186,   151, -1749, -2617, -1312, -6710,   482; M0=-1073;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='A';  M=  2814,   739, -7711, -7075, -1526, -1451, -5784,  1291, -6669,  -768,  -448, -6559, -6962, -6292, -6469,  -798, -3420,   854, -5649,  -487; M0=-2839;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='R';  M=  -476, -6531, -1096,   668, -2235, -3687, -1239, -2068,  1884, -1997,  -813, -1060, -6128,  1761,  2344, -2774,  -735, -1056, -6715,    30; M0=-1299;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='Q';  M=     1, -1778,   357,   688, -1697,  -863, -1335, -1132,  1728, -1743,  -856,  -575, -6128,  2071,  1480,  -949, -2001, -2957,   -63, -1286; M0=-858;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='W';  M=   443, -5201, -2075, -3717,   778, -3713,    -5,     1, -1748,  2198,  1603, -6503, -6944, -1670, -1972, -2261, -1351,  -896,  2615,    61; M0=-1554;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='I';  M= -1295,   588,-10081, -9736,  -912, -9921, -9741,  3452, -9686,   363,  -769, -9578, -9577, -9448, -9759, -9293, -7394,  1318, -8909, -8579; M0=-5720;
/I:         MM=-6; MI=-8024; MD=-14135; IM=-985; II=-1015; DM=-701; DD=-1378;
/M: SY='K';  M=   190, -6531,  -239,   919,  -703, -2944, -4693, -1442,  1524,  -262,    75,   622, -3443,  1161,  1339,    93, -1148, -1689, -6715, -2869; M0=-772;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='H';  M=   248, -1778,   337,  1114, -6855,   382,  2320, -6605,   417, -2092,  -836,   714, -6127,  1723,  -760,   511,  -821, -3739, -6717, -1802; M0=-1329;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='G';  M= -3665, -6539, -2365, -2011, -6860,  3339,  -332, -6611,   727, -6555, -5628,   382, -6132, -1123,  -422, -1688, -2482, -3826, -6722, -2608; M0=-2813;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='H';  M=   310,  -457,  -319,  -711, -1292,   662,  1980, -3749,  1284,    93, -2430,   -56, -6129,   456,  1699, -1193, -2125, -3738,   316,  -909; M0=-872;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='V';  M= -2508, -1717,-10036, -9734, -1803, -9924,-10076,  1991, -9729,  -417, -6187, -9576, -9633, -9714, -9932, -9324, -7324,  3367, -9369, -8829; M0=-6080;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='K';  M= -2971, -1196, -5838, -1576,   999, -3844,   -51, -1460,  1627,   799,  -200, -1917, -6530,   159,  1452,   -66,   843, -2660,  -583,  1304; M0=-1217;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='V';  M= -3732,  -784, -7950, -7327, -2229, -7176, -6070,  2073, -6934,   458, -2272, -2308, -7215, -6564, -3619, -6269, -5530,  3146, -5925, -1977; M0=-3816;
/I:         MM=-7; MI=-7804; MD=-14135; IM=-150; II=-3339; DM=-701; DD=-1378;
/M: SY='N';  M= -2645, -9463,  1915, -5508, -9819,  -666, -6804, -9831, -3608, -9663, -9123,  3995, -7898, -2133, -8336, -4012, -3745, -9210, -9869, -8713; M0=-5334;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='G';  M= -3441, -6534,   792, -1202, -6855,  3097,   664, -6605,  -648, -4057, -5623,   920, -3211,  -865, -1948, -1402, -3291, -6156,   932,  -314; M0=-2328;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='K';  M=  -738, -1854, -1307,  1663, -2136, -2025, -1236,  -562,  2240, -2427, -1496, -1729, -6128,  1469,   827, -1103,  -451,  -198, -6714, -6032; M0=-1140;
/I:         MM=-12; MI=-6939; MD=-14135; IM=-2254; II=-339; DM=-701; DD=-1378;
/M: SY='V';  M= -1143,  -375, -3386, -1457, -1648, -6194, -1344,  1054,  1399,  -316, -2504, -2857,  1022, -1118,  1265, -1557,   444,  1597, -6391, -5830; M0=-1139;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='V';  M=  1011,  1108, -2729,   182, -2938, -6670, -5466,  1046, -2151, -1375,  -713, -1688, -3409,  -613, -1633, -2025, -2459,  2774, -5820, -1799; M0=-1540;
/I:         MM=-386; MI=-13093; MD=-2091; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='T';  M=  -876, -6154,   810,   484, -2817, -2519, -4318,  -521,  1206, -1076, -1732,  1274, -5753,  -731,   725,   105,  1805, -2519, -6338,  -497; M0=-947;
/I:         MM=-18; MI=-6327; MD=-13749; IM=-2127; II=-375; DM=-14; DD=-6698;
/M: SY='D';  M= -5060, -1846,  2210,    69, -2074, -2001,  -370,  -232,  1957, -2383, -5622,   149, -3198,   315,   809,    28,  -597, -1633, -6716, -1275; M0=-1134;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='P';  M=   902, -6514, -3120,  -120, -1256,  -839, -1254, -1784,   234,   -85, -2314,  -385,  2630, -1206,  -119,  -399, -1128,  -504, -6703,  -597; M0=-675;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='S';  M=   282, -6534,   360, -1021, -3351,  1459,  -139, -6605,   640, -6550, -5623,  1654, -6127,  -383,  -179,  1827, -1326, -6156, -6717, -2867; M0=-2033;
/I:         MM=-6; MI=-7870; MD=-14135; IM=-1893; II=-452; DM=-701; DD=-1378;
/M: SY='Y';  M=  -576,  -409,  -254, -1558,  1713, -3839,   565, -1134,   685, -1043,   663, -5270, -6458,   640,   144, -1064,   717, -1184,  -565,  2713; M0=-1006;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='K';  M= -1292, -6517, -1242,  -143, -2231, -6039,   386,   978,  1953,   -14,  -471,  -520,  -232,   830,  1239, -1707,    67,  -482, -6705, -2766; M0=-880;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='V';  M= -2050,   493, -7816, -7185,  -203, -7028, -5907,  1538, -6785,  1649, -1299, -3110, -2544, -6409, -6587, -6115, -5405,  2727, -5767, -2751; M0=-3427;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='K';  M=  -569,    -9,   979,   616, -1617, -1224,  -122, -3709,  1869,  -929, -5622,   189, -1446,   672,   931,   138,  -304, -1589, -6716,  -722; M0=-632;
/I:         MM=-332; MI=-2283; MD=-14135; IM=-1450; II=-657; DM=-701; DD=-1378;
/M: SY='E';  M=  -314, -1959,   638,  1236,    52,   -54, -1472,  -387,   184, -1297,  -440,   668,  1232,   390, -3213,   -62,  -576,    -4, -6706, -2924; M0=-397;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='G';  M= -2411,  -926,   664,   482, -1608,  2569, -1471, -3715,  -261, -2304,    65,  1298, -2383,   219,  -828, -1246,  -619, -2443, -6715, -2608; M0=-1042;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='D';  M=  -687, -6533,  3533,    64, -1692, -1010, -1300, -6604, -2430, -2703,  -253,  -389, -3387,  -412, -1490, -1000, -1052, -2252, -6716, -1902; M0=-1623;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='V';  M=  -673, -1043, -3296,   618, -1202, -6349,  -158,  1225,   328,   115,  -507,  -947, -6429,   469,  1069, -1437,   224,  1316, -1488,   -41; M0=-914;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='I';  M= -7342,  -902, -9999, -3875, -1139, -9805, -9555,  2979, -9579,   815, -5908, -9457, -9505, -9376, -9654, -9156, -7323,  2417, -8841, -2921; M0=-5639;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='E';  M=  -873,  -995,  -807,  1731,  -247, -3893,  -394,  -301,    36,  -767, -5596, -2049, -6136,   231,   393,  1018,  1317,  -435, -1460,  -349; M0=-794;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='V';  M= -2000, -5189, -7708, -7072,  1378,  -582,  -261,  2008, -6667,  1114, -4392, -6556, -6960,    74, -1648, -5995, -3509,  2034, -1354,   318; M0=-2596;
/I:         MM=-49; MI=-13093; MD=-4902; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='R';  M=  -689, -1910,  1191,   344, -1252, -1889,   650, -2105,  1023, -1785, -5573,   854,   522,    95,  1256,  -401,  -545,   -45,  -389,    -3; M0=-459;
/I:         MM=-13; MI=-13044; MD=-6805; IM=-894; II=-1115; DM=-1709; DD=-527;
/M: SY='G';  M=  -301, -6440,    88,   506,  -231,  2077, -2178,  -903,   -82,  -248, -1434,   -64,   766,  -383, -2383, -1829, -1971,  -248,  -579,  -293; M0=-507;
/I:         MM=-2073; MI=-437; MD=-5387; IM=-2554; II=-269; DM=-454; DD=-1888;
/M: SY='K';  M= -1060, -1720,  -518,  1527, -6810,   -72, -4647, -6560,  2651, -3427, -5577, -1656,  1411,  -162,  -421, -2076, -1138, -3653, -6672,  -391; M0=-1681;
/I:         MM=0; MI=-13047; MD=-14089; IM=-894; II=-1115; DM=-1218; DD=-810;
/M: SY='K';  M= -5038, -6470, -3193,   269, -1596, -6018,   483,  -804,  1873,  1063, -1471,  -570,  -948,   321,  1824,  -601, -2047,  -505, -6663,  -555; M0=-1240;
/I:         MM=0; MI=-13065; MD=-14107; IM=-894; II=-1115; DM=-2758; DD=-231;
/M: SY='Y';  M=  -932, -1954,   439,   105,   710, -6016,   188,  -940,  1714, -1679, -5569,   604,  1006, -1125, -1028, -1974,   166,  -315,  -536,  1853; M0=-815;
/I:         MM=0; MI=-13065; MD=-14107; IM=-894; II=-1115; DM=-1157; DD=-859;
/M: SY='F';  M= -5226, -5540, -2524,  -262,  2047, -6504, -2234,  1709,   496,   288,  -826,  -485, -6576,  -869,  -711, -1047,  -544,   217,   324,  1828; M0=-1364;
/I:         MM=0; MI=-13076; MD=-14118; IM=-894; II=-1115; DM=-1231; DD=-801;
/M: SY='V';  M=  -112, -5313,  -297,  -309,   508, -3965, -1237,  1329, -2795,   843,  1092, -6064, -3244, -1296, -1220, -2118,  -208,  1877, -5751,   501; M0=-1046;
/I:         MM=0; MI=-13081; MD=-14124; IM=-894; II=-1115; DM=-266; DD=-2570;
/M: SY='Y';  M=  -171, -5899, -1044, -1764,   486, -2989, -2347,   977,   559,  1232,   185, -1394, -3453, -1584,   168,   406, -5101,   515, -1397,  1425; M0=-799;
/I:         MM=0; MI=-13093; MD=-14135; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='R';  M= -2324,  -943,  -775,  1586,  -109, -6053,  1253,  -627,   861,   284, -5568,   764, -2394,  -625,  1729, -2798, -5007,   -14,    32,    68; M0=-1120;
/I:         MM=-8257; MI=-5; MD=-14135; IM=-1; II=-10830; DM=-701; DD=-1378;
/M: SY='V';  M=   189, -1976,  -394,   404,  -884,  -193, -1384,  1036,   962,   179,  -546,   667,   954, -1511, -3289, -5168, -5079,  1095, -6327, -1350; M0=-844;
/I:         E0=-1000; E1=-1000;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	1'871 in 1'869 different sequences
Number of true positive hits	1'871 in 1'869 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	28
Number of 'partial' sequences	1

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	98.53 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	S4 RNA-binding
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	1869 sequences HLYA_BRAHO (Q06803), HSLR_AERSA (Q44264), HSLR_ECO57 (P0ACH0), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	28 sequences MRES1_HUMAN (Q9P0P8), MRES1_MOUSE (Q9CQF4), PUS3_ARATH (Q5XET6), » more
UniProtKB/Swiss-Prot 'Partial' sequences	1 sequence RS9_PIG (Q29197)
PDB [Detailed view]	1529 PDB 1C05; 1C06; 1DM9; 1EG0; 1FJG; 1FKA; 1H3E; 1H3F; 1HNW; 1HNX; 1HNZ; 1HR0; » more