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PROSITE entry PS50878


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PURL: https://purl.expasy.org/prosite/signature/PS50878

Direct ScanProsite submission
General information about the entry

Entry name [info] RT_POL
Accession [info] PS50878
Entry type [info] MATRIX
Date [info] 01-OCT-2004 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50878
Associated ProRule [info] PRU00405

Name and characterization of the entry

Description [info] Reverse transcriptase (RT) catalytic domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=178;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=173;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0494502; R2=0.0204990; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=315; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=218; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-400; E1=-400; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 288 in 288 different sequences
Number of true positive hits 287 in 287 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.65 %
Recall (true positives / (true positives + false negatives)) 97.95 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] N_Hulo
Feature key [info] DOMAIN
Feature description [info] Reverse transcriptase
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
287 sequences

AI1M_YEAST  (P03875), AI2M_YEAST  (P03876), DPOL_ASHV   (Q64898), 
» more

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

NMAT1_ARATH (Q9C8R8), NMAT2_ARATH (Q9FJR9), PO11_POPJA  (Q03276), 
» more

UniProtKB/Swiss-Prot
False positive sequences
1 sequence

RLR78_PLAVT (P0CV25)

		
PDB
[Detailed view]
521 PDB

1BQM; 1BQN; 1C0T; 1C0U; 1C1B; 1C1C; 1D0E; 1D1U; 1DLO; 1DTQ; 1DTT; 1EET;
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