PROSITE entry PS50853

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50853
Entry name [info]	FN3
Accession [info]	PS50853
Entry type [info]	MATRIX
Date [info]	01-DEC-2003 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50853
Associated ProRule [info]	PRU00316

Name and characterization of the entry

Description [info]

Fibronectin type-III domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=94;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=94;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9335736; R2=0.0078893; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=922; N_SCORE=9.2; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=516; N_SCORE=6.0; MODE=1; TEXT='R?';
/DEFAULT: M0=-18; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M=  36, -49, -63, -10, -56, -24, -26, -34, -13, -46, -38, -33,  82,  -8,  -9, -16, -20,  15, -91, -74;
/M: SY='P';  M= -75,-100, -62, -57, -87, -67, -48, -27, -53, -64, -68, -55, 122, -65, -74, -57, -43, -11, -92, -79;
/I:         I=-42; MD=-106;
/M: SY='Q';  M= -10, -78, -20,  23, -47,  12, -25, -68, -24, -33, -17, -45, -68,  44,  34,  38,  22, -24, -64, -37; D=-42;
/I:         I=-42; MD=-106;
/M: SY='N';  M= -10, -88,  41,  -2, -67, -23,   4, -46,   0, -71, -70,  68,  42,  -6,  -7,   1, -20, -61, -99, -64; D=-42;
/I:         I=-42; MI=-106; IM=-106; DM=-106;
/M: SY='P';  M= -64, -71, -85, -67,  -1, -92, -85,  26, -75,  45,  -6, -81,  71, -77, -41, -68, -58,  42, -47, -55;
/M: SY='Q';  M= -43, -28, -29,  13, -53, -45,  35, -21,  20, -55, -38, -13, -74,  55,  34,  14,  36,  -4,  -7, -50;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='V';  M=  17,  21, -76, -58,  11, -63, -49,  37, -61,  10, -28, -37, -25, -75, -64, -31, -33,  62,   7, -38;
/M: SY='T';  M= -26, -70,  -8,  20, -30, -39,  14,  -5,   9, -17, -13,  -7, -47,  14,   1,  30,  38,   6, -17, -16;
/M: SY='N';  M=  10, -33,  32,  19, -30, -19, -21, -40, -13, -29, -40,  36,   8,  -1,  -3,  16,   4,   3, -24, -29;
/M: SY='V';  M= -10, -52, -38,  -8, -44, -46, -17,  33, -31,   9,  -4,  -1, -23, -11,  -4,   0,  14,  43, -43, -14;
/I:         I=-36; MD=-90;
/M: SY='T';  M= -35, -51,  -1, -14, -46,   7,  -7, -83, -10, -66, -50,  38, -13,   0, -35,  51,  57, -64, -43, -36; D=-36;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='S';  M=   6, -54,  15,  17, -51, -23,  -5, -57,   5, -40, -24,  18,  40,  -6, -17,  44,  -1, -44, -11, -38; D=-36;
/I:         I=-36; DM=-90;
/M: SY='T';  M= -35, -59,  38, -11, -16,  -7,  16, -64, -13, -69, -43,  42, -39,   5,   9,  29,  54, -55, -93, -30;
/M: SY='S';  M=  -7, -19, -24,  -4, -35,  -8,  -5, -54, -12, -65, -35,   2, -73,  12,  -7,  71,  31, -42,   5, -14;
/M: SY='V';  M=  15,  12, -91, -81,  17, -68, -53,  41, -85,  34,  25, -45, -82, -71, -86, -46, -47,  50, -44, -13;
/M: SY='T';  M= -33, -40, -34,   3, -31, -55,  22,   3, -14,   6, -13,   8, -76,  14,  16,  15,  45,   8,  -5,  -1;
/M: SY='L';  M= -54,  21, -95, -85, -16, -89, -87,  43, -88,  60,  -4, -90, -83, -78, -88, -79, -61,  55, -68, -67;
/M: SY='S';  M= -14, -44, -35,   5, -30, -46,  17, -56,   5, -51, -42,  -1, -55,  22,  15,  58,  47, -35, -26, -18;
/M: SY='W';  M= -86, -50, -97, -81, -21, -82,-111, -41, -80, -51, -82, -96, -59, -84, -87, -93, -96, -67, 177, -30;
/M: SY='E';  M= -25, -47,  29,  30, -41, -24, -19, -46,  25, -18, -28,  22, -14,  23,  -4,  18,  30, -34, -92, -57;
/I:         I=-26; MD=-67;
/M: SY='P';  M=  15, -38, -54,  -1, -72, -55, -35, -23,  -5, -26, -28, -40,  87, -26, -18, -10, -19, -14, -76, -27; D=-26;
/I:         I=-26; MD=-67;
/M: SY='P';  M= -38, -92, -83, -48, -84,  -4, -79, -44, -70, -28, -38, -35,  98, -59, -67, -23, -40,  -7, -31, -56; D=-26;
/I:         I=-26; MD=-67;
/M: SY='P';  M= -18, -84, -16,  18, -38, -66, -31, -46,   8,  -5, -39, -44,  18, -22,  -5,  -1, -16, -25,-102, -35; D=-26;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='D';  M= -50, -63,  54,  11, -38, -66,   2, -75, -24, -50, -67,  12, -67,   8, -30,   1, -20, -60, -45, -42; D=-26;
/I:         I=-26; DM=-67;
/M: SY='P';  M=  -1, -75, -47, -52, -69,  38,  -7, -41, -69, -43, -55, -28,  59,   2, -44,  -1,  -1, -58,  24, -63; D=-26;
/I:         I=-26; DM=-67;
/M: SY='N';  M= -45, -89,  -2, -15, -74,  33, -15, -84, -37, -69, -85,  77,  24, -59, -25,  23, -14, -86, -98, -23; D=-26;
/I:         I=-26; DM=-67;
/M: SY='G';  M=   4, -26, -16, -16, -43,  54, -14, -40, -32, -42, -42, -39,   1, -24, -15,  36,   6, -23, -38, -17; D=-26;
/I:         I=-26; DM=-67;
/M: SY='P';  M= -15, -53,  11,   9, -40, -18, -10,  -8,  10, -23, -25,  12,  56,  21,  10,  -3,  10, -17, -65, -54;
/M: SY='I';  M= -13, -24,   6, -27,  -8, -38, -31,  59, -48,   3, -38,   7,   5, -40, -69,  -7, -21,  35, -25, -33;
/M: SY='T';  M= -39, -41,  16,  -1,  -7, -54,  -5,   2, -14,  15,  -9, -32, -44,  20,   0,   2,  48,  10, -35, -13;
/M: SY='G';  M= -20, -49, -21,  -4, -31,  48,  33, -42,  12, -51, -32,  23, -60,  11,  -9,  20,  16, -44, -13,   1;
/M: SY='Y';  M= -63, -17, -78, -85,  47, -79, -19, -56, -68, -39, -61, -78, -81, -71, -65, -58, -52, -42,  -8, 125;
/M: SY='E';  M= -37, -51, -27,  31,  -7, -71,  18,  14,  12, -12, -44,   4, -69,  17,  24,   6,  25,   9, -24, -23;
/M: SY='V';  M= -46, -53, -88, -89, -40, -93, -71,  58, -88,  45, -15, -83, -90, -85, -84, -70, -64,  67, -89, -52;
/M: SY='E';  M= -15, -33, -27,  42,   8, -59,  10, -42,  -2, -16, -12, -24, -69,  41,  19,   4,   6, -11,  12,  35;
/M: SY='Y';  M= -37,  12, -86, -64,  19, -66, -30,   3, -13,   0,   7, -61, -84, -46,  -5, -38, -49,  14,  82,  91;
/I:         I=-29; MD=-75;
/M: SY='R';  M= -32,  13, -56, -20, -31, -38,  -8, -46,  28, -36, -26, -38, -86,  40,  59,   0,   3, -34,  43, -17; D=-29;
/I:         I=-29; MD=-75;
/M: SY='P';  M= -31, -95,  -1,  34, -56, -57, -17, -40,  20, -26, -24, -14,  38,   3,   7,   3, -20, -24, -39, -17; D=-29;
/I:         I=-29; MD=-75;
/M: SY='A';  M=   5, -29, -21, -22, -32, -51, -53, -34,   3,  -8,  -8, -29, -51,   1, -41,  -3,   4,  -4, -85,  -5; D=-29;
/I:         I=-29; MD=-75;
/M: SY='D';  M= -55, -51,  24,   4, -73,  -4, -10, -62, -33, -52, -74,   8,  13, -20, -38,   9, -39, -76,  -9, -51; D=-29;
/I:         I=-29; MI=-75; MD=-75; IM=-75; DM=-75;
/M: SY='P';  M= -29, -67,  18,  11, -55,  20,  -2, -33,  -5, -60, -45,  18,  21,  -3, -18,   0,   5, -34, -24, -44; D=-29;
/I:         I=-29; DM=-75;
/M: SY='S';  M=  -8, -55,  19,  17, -58,  10, -15, -58, -28, -49, -50,  19,  14,  24,   9,  28,   7, -55, -62, -30; D=-29;
/I:         I=-29; DM=-75;
/M: SY='G';  M=  -8, -88,  23,  19, -74,  39,   8, -49, -14, -39, -51,   1,  -9,  10,  -8,  19,   8, -40,  13, -42; D=-29;
/I:         I=-29; DM=-75;
/M: SY='E';  M= -14, -86,  30,  35, -25,  -5,  -9, -30,   6, -31, -35,  11,  11,  24,  10,   7,  19, -29, -74, -49;
/M: SY='W';  M=  -5,   4, -40,   9, -11, -13, -21, -27, -24, -21,  -5,   3,  -1, -11, -17, -12,  -8, -12, 127, -24;
/M: SY='Q';  M= -28, -69, -25,  16, -18, -38,  10, -11,  25,  -9,   7, -29, -32,  38,  26,   0,  25,  -4,   5,  -5;
/M: SY='E';  M= -27,  -4, -18,  38, -54, -63,  19, -24,  18, -17, -12,   6,  13,  19,  -1,   8,  33, -13, -42,  -9;
/M: SY='V';  M= -10,  36, -34,  -3,   0, -64,  -4,  18,   2,   4,   7, -43, -60,  22,  -8, -21, -28,  43,  16,  -9;
/M: SY='N';  M= -27,  -7,   9,  28, -35, -19, -19,  -6,  -8, -29, -13,  33,   8,   8,   0,  14,  29, -22, -29,   3;
/I:         I=-31; MD=-79;
/M: SY='V';  M= -35, -41,  -7,   5, -11, -50, -61,  15,  -8,  -6, -15, -15, -28, -15,  -6,   5,   7,  42, -44,  11; D=-31;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='P';  M= -35,  16,  24, -13, -53, -21, -19, -27, -24, -42, -51,  20,  65, -26, -22,  21,  22, -16, -74, -57; D=-31;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='G';  M=   6, -34, -14, -25, -47,  37, -29, -11, -25, -19, -41,  -2,  30, -26, -18,  18,  21,  16, -27, -42;
/M: SY='T';  M= -21, -64,  21,   8, -61,   1,  -6, -54,   9, -36, -54,  34,  28,  14, -13,  24,  40, -39, -71, -32;
/M: SY='Q';  M=   6, -57,   9,  21, -50, -13, -15, -25,  -4, -28, -32,  11, -12,  31,   2,  11,  29,  12, -36, -35;
/M: SY='T';  M= -30,  13, -26, -24, -27, -36,   5, -44,  -7,  -6, -24,  28,  18,  13,  14,   4,  64, -48, -63, -21;
/M: SY='S';  M= -28, -46, -21,  26, -39, -31,  26, -46,  -2, -64, -22,  13, -45,  19,  16,  54,  27, -38,  39, -13;
/M: SY='Y';  M=  11,  60, -71, -54,  39, -52,  26,  -4, -52,   4,  -9, -79, -68, -51, -58, -48,   3,  21,  -6,  66;
/M: SY='T';  M= -42, -38,  -1,   3, -29, -71, -15,   3,   2,   6,  -5,  15, -22,  -4,   1,  -5,  55,  18, -91, -43;
/M: SY='L';  M= -28,  -4, -32, -79,  33, -93, -61,  46, -71,  48, -17, -73, -83, -32, -71, -64, -40,  47, -17, -48;
/M: SY='T';  M= -38, -31,  10,  18, -53, -23,  -1, -48,   6, -45, -28,   6,  18,  19,   3,  36,  47, -22, -25, -33;
/I:         I=-42; MD=-106;
/M: SY='N';  M= -39,  -5,  38,   4, -64,  48,  17, -62, -17, -55, -38,  51, -26,  -9, -21,   0, -28, -67, -30, -34; D=-42;
/I:         I=-42; MI=-106; MD=-106; IM=-106; DM=-106;
/M: SY='L';  M= -39, -59, -55, -69, -23, -80, -81,  -9, -72,  83, -18, -67, -35, -57, -73, -52, -36, -15, -30, -52; D=-42;
/I:         I=-42; DM=-106;
/M: SY='Q';  M= -30, -57,   1,  28, -48, -63,   2, -11,  32,  -1, -19,  11, -12,  36,  14,   4,  11, -10, -40, -29;
/M: SY='P';  M=   0, -33, -46,   9, -53, -46, -42, -42,   1, -50, -40, -51, 101, -27, -26,   6, -22, -43,  -4, -38;
/M: SY='G';  M= -18, -35,  19, -12,  20,  53,  26, -81, -28, -47, -62,  29, -18,  -8, -17,   7, -30, -76,  17,  23;
/M: SY='T';  M= -13, -16, -10, -14, -59, -14,  -4, -23,  -2, -53, -12, -19, -71,   4,  -1,  20,  76,   4, -59, -69;
/M: SY='E';  M= -17, -31,  12,  33, -47, -47, -15, -28,  10,   5, -27,  19,  12,   9,   6,   1,  31, -19, -29, -39;
/M: SY='Y';  M= -51, -39, -81, -63,  -8, -84,  -5, -43, -69, -42, -49, -37, -85, -54, -74, -69, -49, -42, -28, 130;
/M: SY='E';  M= -20, -10, -10,  33, -15, -66,  14, -19,  11, -16, -28,  23, -71,  27,  15,   9,  24,  -8, -25,   2;
/M: SY='F';  M= -13, -27, -86, -88,  75, -70, -68,  40, -41,   8, -22, -66, -77, -80, -80, -79, -42,  52, -73,   0;
/M: SY='R';  M= -25,   4, -40,  -4, -51, -41, -23, -65,  15, -51, -43, -25, -81,  39,  74,  17,  21, -43,  38, -17;
/M: SY='V';  M= -33, -56, -81, -74, -43, -95, -81,  46, -82,  18,   3, -88, -89, -86, -88, -69, -34,  84, -92, -64;
/M: SY='R';  M=  -2,   4, -58, -13, -11, -55, -23, -14,  -7, -19, -10, -43, -48,  38,  53,  15,  21,   3,  -3,  10;
/M: SY='A';  M=  76,  30, -74, -57, -68, -15, -80, -55, -71, -46, -12, -53,  10, -65, -68,  10,  17,  -5, -50, -28;
/M: SY='V';  M= -16,  20, -60,  11,   3, -61,  -5,  17,   0,  -3,   1, -32, -84,   7,  14,  -9,   4,  33, -15,  25;
/M: SY='N';  M= -46, -26, -11, -37, -25, -15, -17, -52, -23, -31, -51,  84, -26, -33, -20,  27,  40, -29, -45,  10;
/M: SY='P';  M=   7,   1,  17,  16, -55,  17, -11, -34,   3, -28, -25,  11,  24,  15,   5,  21, -17, -27, -38, -44;
/I:         I=-26; MD=-67;
/M: SY='A';  M=  22, -11,   7,  -6,  -9,  14,   1, -26,   8, -21, -23,  10, -25, -11, -15,  12, -15,   6, -21,  -1; D=-26;
/I:         I=-26; MD=-67;
/M: SY='G';  M= -46, -77, -45, -30, -37,  80, -18, -47, -23, -39, -30, -15, -55, -17, -25,  -1, -30, -48, -87,  -7; D=-26;
/I:         I=-26; MD=-67;
/M: SY='E';  M= -26,  15,   0,  35, -30, -41, -17,  -9,   2, -20, -19,   1,  10,   1,   1, -14,   0, -22,  -4,  15; D=-26;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='S';  M= -26, -54, -73, -43, -81,  65, -82, -96, -50, -71, -88, -22, -72, -52, -51,  66, -40, -68, -64, -70; D=-26;
/I:         I=-26; DM=-67;
/M: SY='P';  M=   1, -58,  11,  21, -58, -30,   5, -46,   1, -35, -35, -12,  68,   9, -18,   2,  -5, -18, -93, -44; D=-26;
/I:         I=-26; DM=-67;
/M: SY='W';  M=   1, -44, -28,   5,  17, -61, -23, -37, -28, -32, -31, -39,  67, -32, -11,  -4, -27, -25,  96,  14; D=-26;
/I:         I=-26; DM=-67;
/M: SY='S';  M=   4,  -1, -65, -47, -58,  -8, -50, -34, -60, -28, -66, -35, -25, -36, -22,  82,  27,   1, -68, -42;
/M: SY='E';  M=  -7, -76,  21,  49, -40, -51,  -9, -24,  -9, -23, -35,   7,  24,  29,  -3,   9,  18, -30, -35, -25;
/M: SY='W';  M=  -7, -16, -36,   6, -35, -23, -49,   9, -19, -16, -26, -27,  56, -10, -32,  23,  13,  13,  60, -47;
/M: SY='V';  M=   0, -11, -34,  -1,  -6, -45, -11,   6,   0,   1, -16, -31, -35,   3, -10,  32,  16,  32, -87, -15;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='T';  M= -28,   5, -33,  13, -10, -47,   3,   0, -31, -15, -24,   4,  43,  -7, -24,  14,  43,   2,  20, -11;
/M: SY='F';  M=   8,  -5, -82, -43,  55, -16, -10,  30, -40,  -1,  -9, -55, -38, -33, -15, -32,  -4,  40, -55, -22;
/M: SY='T';  M= -35, -31, -18,  11, -64, -50,  11, -28,  16, -30, -19, -18, -42,  34,  27,  14,  57, -29, -23,  15;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='T';  M=   0,   6, -52, -60, -31, -68, -66,   0, -68,  -8, -19, -63, -32, -66, -77,  13,  89,  16, -57, -71;
/M: SY='P';  M=   6, -16,  -3,   9, -61, -13,  -2, -58,  24,  -5, -17, -19,  58,  16,  -1,  -6, -24, -21, -20, -24;
/M: SY='P';  M= -10, -80,  22,  42, -66, -24, -28, -50, -11, -28, -29, -10,  69,  21,   1,   3, -50, -40, -58, -46;
/M: SY='P';  M=  18, -33,  37,   6, -28,  11, -42, -24, -18, -28, -53,  -5,  38, -18, -19,  13,  10, -24, -57, -35;
/I:         E1=0; IE=-380; DE=-380;

» more

Post-processing [info]

COMPETES_HIT_WITH

PS50835(15)

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	2'883 in 806 different sequences
Number of true positive hits	2'882 in 805 different sequences
Number of 'unknown' hits	0
Number of false positive hits	1
Number of false negative sequences	41
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	99.97 %
Recall (true positives / (true positives + false negatives))	98.60 %

Comments [info]

Taxonomic range [info]	Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	132
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Fibronectin type-III
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	805 sequences 7LESS_DROME (P13368), 7LESS_DROVI (P20806), AAMY_NIACI (A0P8X0), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	41 sequences 45KD_TAEOV (P19617), ASTN1_HUMAN (O14525), ASTN1_MOUSE (Q61137), » more
UniProtKB/Swiss-Prot False positive sequences	1 sequence BP07_BPT4 (P19061)
PDB [Detailed view]	550 PDB 1A21; 1A22; 1AXI; 1BJ8; 1BP3; 1BPV; 1BQU; 1C8P; 1CD9; 1CFB; 1CN4; 1CTO; » more