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PROSITE entry PS50845


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PURL: https://purl.expasy.org/prosite/signature/PS50845

Direct ScanProsite submission
General information about the entry

Entry name [info] RETICULON
Accession [info] PS50845
Entry type [info] MATRIX
Date [info] 01-JAN-2002 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50845
Associated ProRule [info] PRU00170

Name and characterization of the entry

Description [info] Reticulon domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=193;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=188;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.5152000; R2=0.0149632; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=9790.8427734; R2=15.4684896; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=634; H_SCORE=19598; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=400; H_SCORE=15978; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 47 in 47 different sequences
Number of true positive hits 47 in 47 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 2
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 95.92 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] Reticulon
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
47 sequences

HSDD2_ARATH (Q67ZE1), HSDD3_ARATH (A9X4U2), RTN1A_XENLA (Q6IFY7), 
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UniProtKB/Swiss-Prot
False negative sequences
2 sequences

RTNLT_ARATH (Q8GWH5), RTNLU_ARATH (P0C941)

		
UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

HSDD1_ARATH (Q9FX01)

		
PDB
[Detailed view]
3 PDB

2G31; 2JV5; 2KO2