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PROSITE entry PS50819


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50819
Entry name [info] INTEIN_ENDONUCLEASE
Accession [info] PS50819
Entry type [info] MATRIX
Date [info] 01-MAY-2002 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50819
Associated ProRule [info] PRU00273

Name and characterization of the entry

Description [info] Intein DOD-type homing endonuclease domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=129;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=124;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.6810000; R2=0.0213549; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=5322.7143555; R2=7.1428571; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=367; H_SCORE=7944; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=273; H_SCORE=7273; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 120 in 107 different sequences
Number of true positive hits 95 in 82 different sequences
Number of 'unknown' hits 25 in 25 different sequences
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 3
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] DOD-type homing endonuclease
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
82 sequences

AATA_PYRAB  (Q9UXU7), AATA_PYRFU  (Q8U4A6), AATA_PYRHO  (O57728), 
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UniProtKB/Swiss-Prot
'Unknown' sequences
25 sequences

WHIA_CLOAB  (Q97LP1), WHIA_CLOB1  (A7FYW9), WHIA_CLOB8  (A6M2Y1), 
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PDB
[Detailed view]
32 PDB

1B24; 1DFA; 1DQ3; 1EF0; 1JVA; 1LWS; 1LWT; 1MOW; 1UM2; 1VDE; 2CW7; 2CW8;
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