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PROSITE entry PS50330


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PURL: https://purl.expasy.org/prosite/signature/PS50330

Direct ScanProsite submission
General information about the entry

Entry name [info] UIM
Accession [info] PS50330
Entry type [info] MATRIX
Date [info] 01-MAY-2003 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50330
Associated ProRule [info] PRU00213

Name and characterization of the entry

Description [info] Ubiquitin-interacting motif (UIM) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=20;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2009000; R2=0.0080229; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1468.8551025; R2=0.3444180; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=910; H_SCORE=1782; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=599; H_SCORE=1675; N_SCORE=6.0; MODE=1; TEXT='?';
/DEFAULT: B1=-128; E1=-128; MI=0; MD=0; IM=0; ID=0; DM=0; DI=0; M0=-15;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 214 in 131 different sequences
Number of true positive hits 210 in 127 different sequences
Number of 'unknown' hits 0
Number of false positive hits 4 in 4 different sequences
Number of false negative sequences 41
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.13 %
Recall (true positives / (true positives + false negatives)) 83.67 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] UIM
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
127 sequences

AKIB1_DANRE (Q1L8G6), AKIB1_HUMAN (Q9P2G1), AKIB1_MOUSE (Q6ZPS6), 
» more

UniProtKB/Swiss-Prot
False negative sequences
41 sequences

ASB2_BOVIN  (Q3SX45), ASB2_HUMAN  (Q96Q27), ASB2_RAT(Q5U2S6), 
» more

UniProtKB/Swiss-Prot
False positive sequences
4 sequences

MPH1_ASPNC  (A2Q8R2), MPH1_ASPTN  (Q0CWI2), MPH1_NEOFI  (A1D4V5), 
» more

PDB
[Detailed view]
136 PDB

1O06; 1P9C; 1P9D; 1Q0V; 1Q0W; 1UEL; 1YX4; 1YX5; 1YX6; 2D3G; 2KDE; 2KDF;
» more