PROSITE entry PS50305

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50305
Entry name [info]	SIRTUIN
Accession [info]	PS50305
Entry type [info]	MATRIX
Date [info]	01-APR-2002 CREATED; 12-OCT-2022 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50305
Associated ProRule [info]	PRU00236

Name and characterization of the entry

Description [info]

Sirtuin catalytic domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=259;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=254;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2089150; R2=0.0058253; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1767; N_SCORE=11.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=909; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-32; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='M';  M= -16, -92, -80, -36, -83, -84, -77, -78,  -9, -51,  54,  -2,  49, -71,  22, -72,  15, -79,  45, -78;
/M: SY='P';  M= -13, -87, -12,  26, -28, -36,   5, -45, -66, -20, -11, -27,  35, -16,   1, -37,  21, -46, -92, -77;
/M: SY='D';  M= -73, -29,  23,  19, -38, -82,   5, -14,   9,   6, -67,   2, -29, -20, -17,  -7,   7, -42, -92, -73;
/M: SY='M';  M= -72,  -2,  27,  -3, -36, -55, -69, -29,  -1,  15,  38,  29,  -2, -14, -17, -70, -36,  -3, -89, -71;
/M: SY='E';  M= -44, -84,   9,  53, -28, -45, -65, -23,  -3, -28,  -8,   2,  15,   0,   1,  11, -26, -74, -87, -74;
/M: SY='E';  M= -44, -80,  -2,  25, -14, -52, -10, -13, -30,   7,   9,  15, -77,  14,  17, -13,  -7,   4, -85, -67;
/I:         I=-42; MD=-106;
/M: SY='K';  M= -26, -82,   3, -18,  -4, -39, -71, -74,  33, -23,   4, -21, -78,  18, -63,  16,  28, -39, -88, -72; D=-42;
/I:         I=-42; MI=-106; MD=-106; IM=-106; DM=-106;
/M: SY='I';  M=  -4, -83, -22, -85, -64, -45, -86,  50, -85,  19,  31, -84, -35, -82, -87, -78, -69,  31, -89, -71; D=-42;
/I:         I=-42; DM=-106;
/M: SY='W';  M=  24, -82,  -3,  42, -35, -29,  11, -82,  47, -79, -72, -60, -70,  11,  10, -24, -65, -77,  53, -67;
/I:         I=-31; MD=-79;
/M: SY='E';  M= -40, -90,  40,  59, -20, -27,  18, -88,  10, -49, -78, -30, -16,  28, -62, -66, -70, -85, -90, -74; D=-31;
/I:         I=-31; MD=-79;
/M: SY='F';  M=  19, -75, -88, -81,  58, -83, -77,   9, -80,  45, -47, -82, -86, -79, -39, -73, -67,   9, -70, -51; D=-31;
/I:         I=-31; MD=-79;
/M: SY='A';  M=  49, -74, -73, -30, -70, -70, -13, -10, -29,   1, -59, -68, -76,  19,   3,   0,   0,  10, -82, -23; D=-31;
/I:         I=-31; MD=-79;
/M: SY='K';  M=  -2, -83,  -9,  20, -80, -26,  -2, -81,  49, -78,   8, -59, -32,  27,  32,   7, -64, -77, -80,  -6; D=-31;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='W';  M=  18, -25, -76,  -1,  27, -79,   1,  -8,  -4,  32,  -8, -74, -79,   0, -69, -67, -24,  -8,  42,   2; D=-31;
/I:         I=-31; DM=-79;
/M: SY='I';  M= -25, -74, -86, -80,   0, -84, -77,  48, -78,  40,  43, -79, -81, -74, -78,  -9, -61,  38,  17, -57;
/M: SY='W';  M=  18, -78, -29, -15, -74, -35,  33, -72,  30, -28,  29,  15, -28,  26,  33, -21, -15, -70,  53, -63;
/M: SY='E';  M= -15, -77, -54,  51, -72, -39, -60, -71,  30,  -6, -11,  -3,  -5,  23,   7,   1,  18, -68, -78,  -6;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='C';  M=  44,  78, -70, -67, -32, -63,  -4, -38, -25, -71,  -3,  -8, -76, -15, -69,  50, -55, -33, -85, -22; D=-38;
/I:         I=-38; DM=-97;
/M: SY='K';  M= -24, -30,  29,  22, -78, -35, -56, -76,  60, -73,  20, -20, -12,  16,  48,  16, -56, -72, -78, -66;
/M: SY='H';  M= -19, -76, -54, -53, -68, -66,  72, -75,  41, -32, -61,  54, -20, -46,  64, -11, -58, -73, -77,  15;
/M: SY='V';  M=  17, -68, -81, -75, -52, -79, -77,  51, -74,  33,  11, -75, -76, -71, -75, -64, -11,  62, -78, -59;
/M: SY='V';  M=  21,   0, -79, -36,  -4, -77, -76,  25, -72,  22,  19, -74, -76, -71, -74, -63, -22,  70, -78, -58;
/M: SY='V';  M=  -2,  31, -82, -77,  38, -81, -81,  46, -75, -41, -44, -75, -78, -77, -77, -65, -27,  77, -75, -53;
/M: SY='M';  M= -65, -71, -81, -76,  44, -21,  27,   8, -74,  58,  66, -74, -79, -69, -72, -71, -62,   8, -65,   9;
/M: SY='T';  M=  10, -63, -61, -62, -66, -65, -69,  -9, -60, -60, -57, -51, -63, -62, -67,  30,  94,  20, -85, -65;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/M: SY='A';  M=  98, -61, -67, -60, -76, -49, -69, -65, -62, -67, -61, -62, -66, -59, -67, -17, -52, -52, -76, -71;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/M: SY='I';  M= -62, -73, -84, -80, -49, -87, -80,  85, -76,  17,  36, -76, -75, -73, -78, -71, -21,  44, -76, -57;
/M: SY='S';  M= -41, -64, -56, -57, -74, -49, -59, -74, -57, -77, -71, -44, -64, -48, -61, 109, -35, -66, -82, -66;
/M: SY='T';  M=  60,   6, -64, -62, -69, -61, -69, -55, -34, -60,  19, -56, -64, -61, -66, -41,  81,   4, -82, -67;
/M: SY='E';  M=  39, -34,  24,  72, -80, -62, -59, -76, -52, -76, -70, -54,  37, -46, -60,  37, -53, -68, -81, -72;
/M: SY='S';  M=  23,  35,  -3, -58, -72, -53, -62, -67, -59, -43, -66, -49, -66, -53, -46,  92, -41, -15, -83, -67;
/M: SY='G';  M= -49, -76, -34, -73, -82, 100, -69, -90, -68, -86, -75, -13, -68, -66, -75, -10, -65, -83, -75, -77;
/M: SY='I';  M= -65, -76, -85, -83,  24, -88, -79,  94, -78,  -2, -37, -77, -76, -76, -80, -73, -59,  20, -67,  11;
/I:         I=-45; MD=-115;
/M: SY='P';  M= -66, -89, -68, -28, -83, -40, -71, -68, -26, -79, -68, -72, 115, -23,  -7, -65, -61,   3, -81, -80; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='D';  M= -59, -71,  94, -42, -78, -64, -58, -73, -55, -75, -72,   4, -64, -56, -64,   7,  71, -68, -96, -68;
/M: SY='F';  M= -74, -76, -83, -80, 102, -81, -58, -52, -74, -46, -52, -77, -85, -78, -72, -72, -68, -31,  75,  82;
/I:         I=-6; MD=-16;
/M: SY='R';  M= -19, -84, -65, -53, -78, -77, -55, -84,   1, -77, -66, -58, -76, -43, 111, -62, -67, -77, -78, -65; D=-6;
/I:         I=-6; MD=-16;
/M: SY='S';  M= -36, -76,  18, -64, -85,  51, -68, -86, -11, -87, -79, -52, -72, -60, -69,  74, -54, -79, -87, -76; D=-6;
/I:         I=-6; MD=-16;
/M: SY='P';  M= -27, -94,  -3,   7, -90, -82, -79, -83, -19,  -9, -78, -76,  74, -71, -29,  15, -70, -84, -95, -87; D=-6;
/I:         I=-6; MD=-16;
/M: SY='H';  M= -12, -82,  -1,  21, -79,  10,  26, -76,  24,   6, -68,  10, -22, -59, -26,   2, -18, -75, -88, -73; D=-6;
/I:         I=-6; MD=-16;
/M: SY='T';  M= -72, -88,  15, -12, -91,  17, -80, -80,  -2, -87, -82,  17, -83, -74, -77, -18,  38,   3,-102, -86; D=-6;
/I:         I=-6; MD=-16;
/M: SY='G';  M= -57, -83, -68, -17, -88,  87, -75, -48, -71, -89, -79, -58,   2, -69, -31,  -9, -71, -86, -81, -83; D=-6;
/I:         I=-6; MD=-16;
/M: SY='L';  M=  -6, -78,   4, -76, -19, -86, -76,  37, -79,  51, -45, -79, -85, -22, -80, -75, -66,  18, -78,  -4; D=-6;
/I:         I=-6; MD=-16;
/M: SY='W';  M=   4, -89, -83, -77,  11, -20, -67, -71, -19, -69, -68, -22, -85,  -3, -72, -71, -75, -40, 118,  79; D=-6;
/I:         I=-6; MD=-16;
/M: SY='D';  M=  20, -78,  48, -56, -85, -67,   9, -81, -17, -82, -75, -28,   1,   7, -16,  41,  27, -74, -93, -74; D=-6;
/I:         I=-6; MD=-16;
/M: SY='R';  M= -69, -84, -62,  12, -82,   7, -63, -80,  18, -32,  23,  44, -77, -15,  52, -26,  -9, -78, -88, -75; D=-6;
/I:         I=-6; MD=-16;
/M: SY='L';  M= -74, -80, -83,  -8,   7, -92, -77,   5, -80,  53, -48, -27, -87, -77, -82, -76,  15,   2, -79,  -3; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='W';  M= -23,-101, -79,  12, -97, -35,  -8, -95,  -4, -95, -87, -44, -25,  22,  20, -77,   1, -43,  44, -85; D=-6;
/I:         I=-6; DM=-16;
/M: SY='G';  M= -24,-100,  -9,   8, -96,  27, -83, -97, -27, -26, -87, -31, -26,  -4,  -3, -50, -85, -94, -98, -30; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='P';  M= -29,   1,  -1,  -3,  -4, -87, -77, -79, -78, -18, -76,  -2,  55, -21, -84, -78, -77, -45,  45,  31; D=-6;
/I:         I=-6; DM=-16;
/M: SY='Y';  M= -72, -87,  46, -59, -65, -20,  25, -82,  11, -46, -72,   8, -44,  -5,  13,   5, -67, -82, -73,  62; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M= -21,  -6,  -4,  22, -84, -10, -67, -77, -56, -79,  16, -67,  91, -20,  33, -64, -64, -48, -83, -78; D=-6;
/I:         I=-6; DM=-16;
/M: SY='E';  M= -21, -82, -55,  58, -74, -76, -63, -20,  -1,  -5, -63,   1,  35,  40, -22, -61, -11, -22, -80,  -9; D=-6;
/I:         I=-6; DM=-16;
/M: SY='D';  M=  28, -79,  57,  43, -74, -70, -61,  18, -58, -67,  20,  -3, -70,  29, -64, -58, -62, -62, -82,   5; D=-6;
/I:         I=-6; DM=-16;
/M: SY='L';  M=  -9, -80,  -4, -13, -60, -88,  -6,  19, -79,  42,  33, -80, -85, -74, -80, -76, -68,  23, -84, -12; D=-6;
/I:         I=-6; DM=-16;
/M: SY='F';  M=  24, -78, -87, -83,  65, -20, -81, -12, -81,  -2, -59, -78, -86, -81, -83,   3, -66,  23, -72, -53; D=-6;
/I:         I=-6; DM=-16;
/M: SY='S';  M=  -4,   2,  42,  28, -78, -66, -62, -73, -58, -76, -71,   6, -69,  20, -64,  46,  35, -21, -87, -15; D=-6;
/I:         I=-6; DM=-16;
/M: SY='H';  M= -68, -80, -75, -40,   1, -82,  44,  34, -70,  18, -52, -70,  31, -69, -14,  -9,  27, -19, -75,  28; D=-6;
/I:         I=-6; DM=-16;
/M: SY='Q';  M=  26, -76,  13,  -3, -75,   0, -63, -48, -58, -10, -64,   8,  23,  50, -27,  23,  -7, -67,  44, -67; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='F';  M=  25,  21,  11,  15,  43,  15, -61, -33, -60, -66, -63, -60, -73,  37, -18,  -8, -23, -66, -65,  36; D=-6;
/I:         I=-6; DM=-16;
/M: SY='F';  M= -43, -76,  16, -74,  91,  -2, -66, -54, -75, -10, -55, -70, -82, -77, -75, -32, -66,  -7,  52,  42; D=-6;
/I:         I=-6; DM=-16;
/M: SY='F';  M=  -7, -77, -37, -31,  60, -77,  -2, -56,  17, -23,  20, -66, -77,  30,  22, -65, -64,   5,  25,  48; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='R';  M= -67, -82, -32,  13, -29, -29,  31, -84,  47, -80, -70,  25, -73,   6,  61,  -6, -25, -80, -83, -67; D=-6;
/I:         I=-6; DM=-16;
/M: SY='D';  M= -66, -79,  71,  16, -81, -65,  47, -85, -11, -84, -76,  66, -72, -53, -24,  12, -57, -82, -94, -13; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M= -20, -90, -66, -19, -83, -70, -69, -76, -29, -45, -71,  23, 107,   3, -72, -64, -63, -80,  46, -78; D=-6;
/I:         I=-6; DM=-16;
/M: SY='E';  M=   5, -82, -26,  54, -84, -73, -64, -78,  26, -37, -70, -61,   2,  46,   1,  14, -62, -39, -84, -74; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M=  -5,  -3, -73,   1, -77, -19, -73, -21,  14,  -7,  32, -72,  55, -34,  15, -28, -67, -25, -86, -76; D=-6;
/I:         I=-6; DM=-16;
/M: SY='F';  M= -67, -78, -81, -79,  61, -24, -71, -21, -70, -35,  -7,  -1, -85, -75,  16,  -9, -64,  48, -68,  25; D=-6;
/I:         I=-6; DM=-16;
/M: SY='W';  M= -76, -90, -82, -70,  37, -81,  -6, -68, -61,  -9, -63, -19, -84,  41,  33, -74, -76, -41, 123,  30; D=-6;
/I:         I=-6; DM=-16;
/M: SY='R';  M=  33, -77,   7,  24, -81,   0, -64, -32,  26, -75, -31, -18, -70,   4,  37, -27,  10, -69, -82, -72; D=-6;
/I:         I=-6; DM=-16;
/M: SY='W';  M= -42, -80, -86, -79,  81, -84, -68, -26, -69,  11,  -6, -79, -86, -74,  24, -75, -71, -29,  84,  45; D=-6;
/I:         I=-6; DM=-16;
/M: SY='W';  M=  32, -80, -75, -71,   2, -72,   3,   2, -69, -25, -58, -14, -80,   5, -69, -19, -66, -61,  89,  84; D=-6;
/I:         I=-6; DM=-16;
/M: SY='N';  M=  19, -76,  -4, -37, -78, -65,  20, -74,  39, -23,   5,  47, -72,  32,  10,  19, -57, -71, -84, -68; D=-6;
/I:         I=-6; DM=-16;
/M: SY='W';  M=  -4, -80, -20,  50,   5, -75, -21, -66, -50,   2,  22, -64, -71,  38,  39, -61, -28, -66,  68,  27; D=-6;
/I:         I=-6; DM=-16;
/M: SY='R';  M= -13, -75, -71, -67,  -1, -21, -64,  24, -54,  30,  18,  13, -77, -59,  60,  -5, -60,  -1, -76, -59; D=-6;
/I:         I=-6; DM=-16;
/M: SY='R';  M= -46, -91, -87, -80,  30, -93,   2, -12, -67, -41,  -7, -81,   5, -75,  47, -79, -35,  14, -77,  30; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='K';  M=   5, -84, -74,  11, -73, -44, -75,  -4,  23,  -4, -20, -74,  -1, -65,  14, -25, -68,  14, -84,  -9; D=-6;
/I:         I=-6; DM=-16;
/M: SY='F';  M= -42, -84,  17, -41,  23,   3, -72, -67, -24,   9, -27,  11, -84,  22,   0, -31, -28,  -7, -84, -67; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='P';  M= -90,-102, -91, -15, -89, -49, -90, -37, -56,   8,  17,  -9,  24, -86,  -6, -88,  -6, -57,-106, -92; D=-6;
/I:         I=-6; DM=-16;
/M: SY='Y';  M= -43, -84, -46, -71,  26, -82, -65, -37, -41,  -9, -63,  -1, -31,  34,   5, -14,   9, -19, -67,  59; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M= -37, -77,   8, -64,  46, -40,  -2, -34, -31, -61,  36,  -5,  47, -10, -68,  33, -25,  -2, -69,  22; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M=  23, -80,  -1,  -4, -40,  27, -68, -75, -22,  -8, -68, -15,  36, -32,   1,  15, -63, -72, -81, -14; D=-6;
/I:         I=-6; DM=-16;
/M: SY='N';  M= -22, -79,  34,  36, -29, -46, -24, -83,   3, -82, -74,  54, -71,  43, -25,  31, -57, -79, -87, -71; D=-6;
/I:         I=-6; DM=-16;
/M: SY='A';  M=  60,  10, -72, -65,  17, -66,  34,   5,  -5, -39, -56, -65, -74,   5, -41, -55, -24,  17, -72,  12; D=-6;
/I:         I=-6; DM=-16;
/M: SY='Q';  M= -19,  -5,  -1,  39, -79, -72, -57, -16,  34, -42,  -5, -56,   2,  77,  36, -57, -62, -70, -78, -67; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M= -66, -87, -69, -58, -74, -71, -70, -28, -65,  -6, -62, -74, 119, -67, -75, -65, -59, -17, -77, -18;
/M: SY='N';  M= -57, -66, -15, -57, -75, -12, -50, -72, -52, -77, -68, 104, -68, -53, -60,  17,  56, -69, -92, -70;
/M: SY='P';  M=  14, -76,  -5,  14, -23, -69,   0,  11,  27,  -5, -56, -17,  57,  13,  -4, -31, -36,  -8, -75, -26;
/I:         I=-14; MD=-34;
/M: SY='C';  M=  48,  54, -64, -68,  23,  31, -67, -14, -65, -40, -62,  33, -71, -65, -71,  -7,  27, -59, -76, -63; D=-14;
/I:         I=-14; MD=-34;
/M: SY='H';  M= -70, -82, -55, -55, -65, -72, 146, -85, -59, -68, -54, -44, -71, -49, -53, -60, -69, -85, -96,  14; D=-14;
/I:         I=-14; MD=-34;
/M: SY='Y';  M= -65, -78, -30,  -1, -49, -77, -55, -38,   3,  22,  37, -65, -75,  42,  30, -30, -30,  -5,  48,  67; D=-14;
/I:         I=-14; MD=-34;
/M: SY='A';  M=  63, -68,  -6, -64,  49, -63, -68,  10,   2,   0,   7, -25, -72, -63, -65, -12, -57, -50, -68, -53; D=-14;
/I:         I=-14; MD=-34;
/M: SY='L';  M= -67, -73, -86, -80, -11, -88, -73,  61, -78,  70,  39, -81, -81, -72, -77, -77, -62, -33, -72, -54; D=-14;
/I:         I=-14; MD=-34;
/M: SY='A';  M=  63,  -6, -63, -59, -29, -34, -65, -64,  18, -68, -63,   8, -69, -55,  24,  30,  -7,   0, -79, -67; D=-14;
/I:         I=-14; MD=-34;
/M: SY='Q';  M= -18, -77,  -5,  50, -70, -73, -56, -65,  21,  17,  -4, -20, -67,  66,  19, -57,  -3, -65, -75, -18; D=-14;
/I:         I=-14; MD=-34;
/M: SY='W';  M= -68,  22, -87, -79,  23, -83, -74,   6, -78,  73, -37, -83, -84, -73, -76, -34, -66, -45,  93, -47; D=-14;
/I:         I=-14; MD=-34;
/M: SY='E';  M=   5, -83, -15,  76, -83, -75,  47, -81,  10, -28, -68, -59, -66,  49, -54, -59, -65, -76, -84, -69; D=-14;
/I:         I=-14; MD=-34;
/M: SY='R';  M=   9, -81,  41,  43, -84, -39, -60, -82,   0, -78,  -8, -22, -70,  13,  55, -17, -23, -76, -86, -72; D=-14;
/I:         I=-14; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='K';  M=  -2, -78, -16,   7, -71, -42, -19, -64,  44,  14,  39, -61, -73,  14,  24, -32,   6, -36, -81, -67; D=-14;
/I:         I=-14; DM=-34;
/M: SY='G';  M= -63, -84,  20, -46, -35,  65, -72, -83,  24, -13, -73, -18, -76, -23, -37, -25, -70, -82,  45, -72; D=-14;
/I:         I=-14; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='K';  M= -46, -80,  -3, -30, -38, -12, -67,  -3,  43,  30, -54, -66,  25, -59,  29, -67, -64,  -6, -77, -12; D=-14;
/I:         I=-14; DM=-34;
/M: SY='L';  M= -63, -72,  -5,  -9, -17, -39,  -8,  20, -65,  57, -42,  11, -77, -64,   3, -25, -11,  16, -77, -58; D=-14;
/I:         I=-14; DM=-34;
/M: SY='H';  M= -63, -74,  -9, -31,   2, -38,  57, -48,  26,  35, -12, -62, -75,  17, -26, -20, -28,  27, -72,  23; D=-14;
/I:         I=-14; DM=-34;
/M: SY='W';  M=   7,   2, -70, -64,  16, -38,  53, -67, -52, -23, -61, -61, -75, -58,  59,  -5,  29, -18,  74, -54; D=-14;
/I:         I=-14; DM=-34;
/M: SY='V';  M= -62,  30, -80, -77, -46, -83, -71,  35, -75,  48, -39,   0, -81, -73, -75, -70, -58,  56, -72,  33; D=-14;
/I:         I=-14; DM=-34;
/M: SY='Y';  M= -63,  -8, -82, -79, -41, -84, -69,  63, -74, -43, -45, -77, -79, -72, -75, -70, -28,  53,  74,  74; D=-14;
/I:         I=-14; DM=-34;
/M: SY='T';  M= -52, -62, -58, -61, -69, -67, -68, -61, -58, -65, -62, -47, -60, -61, -66,  19, 110, -53, -89, -66; D=-14;
/I:         I=-14; DM=-34;
/M: SY='Q';  M= -58, -81, -55, -36, -86, -67, -49, -73, -41, -70, -58, -49, -65, 125, -42, -46,  31, -73, -74, -61;
/M: SY='N';  M= -62, -67, -35, -57, -77, -50, -43, -76, -48, -84, -70, 125, -73, -50, -56, -44, -47, -78, -96, -72;
/M: SY='I';  M= -17,  19, -82, -79, -48, -84, -78,  78, -75, -38, -41, -75, -77, -74, -78, -68, -56,  63, -72,  33;
/M: SY='D';  M= -68, -81, 119, -31, -88, -64, -53, -86, -55, -85, -84, -35, -67, -54, -63, -56, -57, -83,-103, -70;
/M: SY='G';  M=  -5, -73,  25,  -9, -21,  61, -59, -77, -54, -75,  -7,  52, -68, -56,  23, -49,  26, -72, -80, -69;
/M: SY='L';  M= -19, -69, -84, -76, -41, -84, -68, -33, -77,  90, -29, -83, -83, -70, -75, -75, -63, -40, -71, -54;
/M: SY='H';  M= -67, -80, -11,  47,  -3, -74, 127,   7, -56, -36, -55, -49, -67, -47, -55, -60, -65, -69, -89, -44;
/M: SY='E';  M= -60, -78, -51,  63, -71, -74, -57, -67, -41, -15, -61, -57, -65,  52,  58, -17,  25, -12,  46, -63;
/M: SY='R';  M=  -7, -77, -62, -24, -71, -73, -58, -26,  56, -67, -59, -57, -71,  22,  80, -58, -60,  17, -74, -14;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='A';  M=  88, -63, -66, -61, -77, -30, -68, -68, -63, -71, -64, -59, -67, -58, -67,  42, -50, -56, -78, -72; D=-21;
/I:         I=-21; DM=-53;
/M: SY='G';  M= -51, -77, -66, -75, -77,  97, -71, -80, -70,  -8, -68, -53,  11, -67, -77, -52, -67, -78, -74, -75;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='S';  M= -14,  24, -64, -65,   5, -63, -63,  24, -63,   0, -55,  19,  -3, -20, -67,  66,  -3, -19,  26,   9;
/M: SY='P';  M= -61,  -9,  35,  12, -80, -68, -59, -74,  40, -76, -67, -52,  64,  45,  21, -10,  24, -44, -80, -69;
/I:         I=-18; MD=-45;
/M: SY='R';  M= -32, -97, -17, -32, -93, -90,  -6, -82, -33, -86,  -9,   1,  24, -13,  49, -77, -32,   1,-102, -85; D=-18;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='N';  M= -25, -85,  24, -63, -84, -46,   8, -20,  32, -38, -73,  48, -16, -20, -30, -12, -23, -19, -96, -77; D=-18;
/I:         I=-18; DM=-45;
/M: SY='V';  M= -59, -69, -82, -77, -49, -85, -78,  43, -75,  47, -37, -77, -78, -74, -76, -68,   3,  70, -79, -58;
/M: SY='I';  M= -12, -71, -76, -74,   2, -78,   3,  61, -71,   4, -43, -69, -74, -69, -73,  -3,  18,  47, -70,  33;
/M: SY='H';  M= -35, -80,   4,  81, -79, -71,  86, -82,  14, -75, -66, -19, -13,  29, -49, -24, -60, -78, -84, -60;
/M: SY='M';  M=  24,  26, -81, -74,   1, -76, -67,  16, -73,  62,  76, -75, -78, -67, -72, -67, -60, -41, -72, -54;
/M: SY='H';  M= -69, -81, -53, -52, -68, -71, 147, -86, -57, -68, -54, -43, -70,   9, -51, -58, -68, -85,-101, -37;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/M: SY='N';  M= -54,  38,  29,  23, -23, -59, -55, -74, -52, -75, -69,  65, -67, -51,  -8,  58,  33, -69, -87, -67;
/M: SY='M';  M= -35, -70, -83, -77,  52, -43, -66,  17, -74,  51,  70, -76, -79, -71, -73, -70, -29,  18, -63,  12;
/M: SY='F';  M=  24, -75,  14,  34,  56, -17,  28, -62, -20,  -9, -57, -62, -18, -58, -22, -59, -62, -47,  13,  52;
/M: SY='H';  M= -39, -74, -57,  28, -68, -73,  62,  -1,  32, -23, -56, -54, -67,  10,  42, -24,  36,  12, -81, -59;
/M: SY='W';  M=  29,  45, -67,  15,   3, -69, -69, -22, -65,  -8,   7, -30,   2, -63, -69,  -5,   6,  42,  46,   4;
/M: SY='H';  M= -59, -74, -22,  13, -27, -71,  53, -33,  12, -23, -57, -55, -69,   9,  52,  28,  10,  13, -74,  20;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='C';  M= -65, 150, -85, -85, -75, -81, -85, -82, -81, -73, -73, -71, -96, -88, -87, -68, -65, -70,-105, -86; D=-19;
/I:         I=-19; DM=-49;
/M: SY='T';  M=  -9,   1, -70, -68, -64, -44, -11, -10, -67,  26,  -2, -11,   6,   3, -71,  14,  55,   8, -84, -66; D=-19;
/I:         I=-19; DM=-49;
/M: SY='K';  M= -34, -77,   8, -28, -79,  -4,  14, -32,  40, -75, -67,   2, -70,  34,  13,  37,  10, -15, -84, -68; D=-19;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='C';  M= -65, 147, -84, -85, -76, -80, -85, -83, -81, -74, -74, -71, -95, -87, -87, -24, -65, -70,-105, -86; D=-19;
/I:         I=-19; DM=-49;
/M: SY='H';  M= -26, -81,   2,  13, -79,  34,  56, -32,   9, -23, -67,  18, -74,  -4,  30, -24, -65, -50, -86, -68; D=-19;
/I:         I=-19; DM=-49;
/M: SY='Q';  M= -13,  -5, -62,  13,  -3, -34,  24, -71,  17, -71, -11,   9,  -3,  29,   4, -11,  22, -21,  19,  11; D=-19;
/I:         I=-19; DM=-49;
/M: SY='Q';  M= -26, -76, -57,  31, -70, -72, -10,  24,  -8, -34, -57,  13,  11,  50,  16, -10,  21,  15, -81, -65; D=-19;
/I:         I=-19; DM=-49;
/M: SY='Y';  M=  -1, -73, -27, -10,  26, -43, -59, -55,  -2, -26, -56, -63, -73, -61,   4, -56,  48,  15,  43,  71; D=-19;
/I:         I=-19; DM=-49;
/M: SY='P';  M= -14, -76,   7,  35, -70, -70,  -5, -34,   5, -67, -62,  -5,  67, -56, -62, -28,  34,  22, -79,   7; D=-19;
/I:         I=-19; DM=-49;
/M: SY='W';  M= -39,   0,   6, -34,   8,  10,  -7, -27,  -8,  16, -28,  18,  -9, -20,  46, -62, -63, -25,  69,   6; D=-19;
/I:         I=-19; DM=-49;
/M: SY='D';  M= -22, -76,  46,  46, -70,   1, -57,   8, -28, -45, -63,   8, -28,  29,  -9,  15, -14, -19, -78,   6;
/I:         I=-3; MD=-9;
/M: SY='W';  M= -21, -77,  37,  26, -40, -16, -62, -65,  35, -12, -63, -56,  11, -53,  21, -36,  21,  -5,  54, -10; D=-3;
/I:         I=-3; MD=-9;
/M: SY='D';  M= -44,  -4,  38,   4,  21, -75,  -7,   5, -65,   6,  26, -23,   3, -26, -69, -13,  -6,  27, -73,  23; D=-3;
/I:         I=-3; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='Q';  M= -38, -79,   9, -12,   9, -79, -68,  -8,  21,   5,  -1, -66,  20,  39,  -1, -66, -63,  33,  19, -61; D=-3;
/I:         I=-3; DM=-9;
/M: SY='E';  M=  -7, -85,  15,  29,   5,   5,  -5,   9,  -8,   0, -66, -22, -79, -28, -71, -22, -69, -67, -83, -19; D=-3;
/I:         I=-3; DM=-9;
/M: SY='R';  M= -71,  21,  39, -35, -84, -80, -69, -25,  34, -78,   0, -61, -27, -13,  39,   8,  -9, -23, -92, -76; D=-3;
/I:         I=-3; DM=-9;
/M: SY='M';  M= -29,   7, -87, -34,  21, -47, -82,  11, -33,   3,  24, -82,   1,  17, -26, -77, -13, -13,   4, -67; D=-3;
/I:         I=-3; DM=-9;
/M: SY='M';  M=  -5, -89,   0,  22,  15, -15, -73, -79, -70, -49,  45,  16, -44,  -3, -11, -71, -13, -79, -90, -73; D=-3;
/I:         I=-3; DM=-9;
/M: SY='N';  M= -20, -89, -19, -22, -79, -23,  -8, -15, -35,  -3, -71,  12,   2, -74, -14,  12, -71,  -6, -94, -18; D=-3;
/I:         I=-3; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='Q';  M=  15, -82,  22,  24,  29, -23, -12, -14,   1, -32, -66, -63, -36,  49, -63, -34, -40, -44, -79, -63; D=-3;
/I:         I=-3; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='T';  M= -17, -81,   5,  -9, -73, -80, -73,  17,   4, -11, -60, -66,  25,  26, -12, -42,  26,  19, -87, -72; D=-3;
/I:         I=-3; DM=-9;
/M: SY='P';  M= -65, -80,   5, -45, -32,   5, -77,  32, -71,  -4,  17, -71,  38, -72, -12, -67,   7,  36, -85, -69; D=-3;
/I:         I=-3; DM=-9;
/M: SY='P';  M= -39, -92, -40, -59, -88, -75, -12, -78, -11, -85, -73, -71, 106, -23,  18, -66,  -6, -49, -85, -81; D=-3;
/I:         I=-3; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='H';  M= -21, -26, -27,   4, -72, -39,  43, -34,  28,   4, -59, -60, -28,   8,  41,  -5,  -3,   0, -84, -65; D=-3;
/I:         I=-3; DM=-9;
/M: SY='C';  M= -65, 148, -83, -83, -75, -80,  16, -82, -80, -73, -72, -70, -94, -86, -85, -67, -65, -70,-105, -82; D=-3;
/I:         I=-3; DM=-9;
/M: SY='P';  M=   8, -82,  28,  25, -78, -46,  55, -75, -60, -32, -68, -60,  72, -58, -15, -23,   9, -53, -86, -28; D=-3;
/I:         I=-3; MD=-9; DM=-9;
/M: SY='K';  M= -26,  39,  23,  14, -77, -43, -11, -67,  40, -46, -67, -18, -76,  11,  16, -30, -63,  20, -86, -16; D=-3;
/I:         I=-3; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='C';  M= -65, 150, -85, -85, -75, -81, -85, -82, -81, -73, -73, -71, -96, -88, -87, -68, -65, -70,-105, -86; D=-3;
/I:         I=-3; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='G';  M= -39, -76, -26,   6, -77,  67,  34, -79, -31, -77, -68,  -9, -35,  31,   0,  19, -12, -31, -77, -15; D=-3;
/I:         I=-3; DM=-9;
/M: SY='G';  M=  14, -72, -60,  15, -36,  73, -66, -14, -26, -72, -13, -53, -66, -58, -68,  31, -20, -35, -74, -35;
/M: SY='P';  M= -62,   4, -22,  -4, -58, -11, -27,  13,   6,  36,  -9,  -4,  41,  18, -63, -64, -59,  26, -76, -14;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='M';  M= -38, -69, -81, -76,  17, -81, -69,  28, -74,  59,  62,  -6, -79, -70, -73, -71, -59,  36, -72, -52;
/M: SY='R';  M= -65, -81,  -2,  -4, -78, -73, -54, -81,  71, -76, -65, -51, -68,   8,  87, -58, -61, -76, -75, -64;
/M: SY='P';  M= -66, -88,  22, -54, -80, -69,  -1, -14, -63, -31, -66, -67, 117, -65, -73, -63, -23, -71, -81, -77;
/M: SY='D';  M=  -4, -75,  72, -19,  -7,  -5,  56, -76, -52, -73, -67,  43, -69, -17,  14, -52,  19, -73, -82,  10;
/M: SY='I';  M= -58, -72, -81, -77, -53, -84, -83,  81, -14, -37, -40, -73, -75, -72, -74, -17, -54,  68, -79, -59;
/M: SY='V';  M= -55, -68, -78, -72, -55, -82, -79,  25, -12, -10, -43, -72, -76, -70,  -8, -63,  18,  86, -84, -61;
/M: SY='W';  M= -20, -77,  -1, -72,  70, -22,  15, -54, -71,  26,  20,  -1, -79, -70, -71, -69, -67, -60, 116,  -3;
/M: SY='F';  M= -73, -74, -81, -13, 107, -81,  -5, -50, -74,   1, -50, -75, -83, -78, -72, -73, -67, -56,  56,  44;
/I:         I=-45; MD=-115;
/M: SY='G';  M= -53, -78, -57,  24, -84,  88, -67, -89, -14, -86, -76,  12, -68, -60, -69,  -7, -65, -83, -78, -78; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='E';  M= -59, -81,  35, 101, -84,  12, -55, -85, -45, -78, -74, -53, -58, -38, -55, -56, -61, -78, -82, -74;
/M: SY='N';  M= -12, -73,  32, -32, -72, -32, -58, -11,  -8, -64,  45,  45,  40,  11,   2,  14,  21,  -9, -83, -67;
/M: SY='L';  M= -32, -71, -78, -72, -50,   2,  29, -19, -74,  69, -37, -74,  24, -69, -74, -69, -61,  29, -76, -57;
/I:         I=-12; MD=-31;
/M: SY='P';  M= -71, -89,  16, -64, -84, -75, -73, -18, -70, -76,  31,  17,  91, -71, -79, -11, -10, -18, -91, -81; D=-12;
/I:         I=-12; MI=0; MD=-31; IM=0; DM=-31;
/M: SY='P';  M=   7, -81,  20,  25, -79, -71, -11, -70, -61,  -5, -67, -20,  63,  12, -32,  15, -24, -24, -87, -74; D=-12;
/I:         I=-12; DM=-31;
/M: SY='D';  M=  -4, -81,  55,  31, -33,  11, -10, -38, -25, -54, -72, -35, -72, -11,  36,   8, -62, -46, -86, -70; D=-12;
/I:         I=-12; DM=-31;
/M: SY='F';  M=   6, -78,   0,  -8,  63, -48, -66, -12,   7, -34,  34, -67, -15,   1,  12, -65, -18, -29, -67,  -6; D=-12;
/I:         I=-12; DM=-31;
/M: SY='W';  M= -35, -79,  17, -36,  10, -45,  47,   3, -34,  24,  13, -30,  -4, -68, -72,  -4, -64,  14,  50, -57; D=-12;
/I:         I=-12; DM=-31;
/M: SY='D';  M= -20, -81,  44,  31,  16, -78, -66,  -6,  14,  -4, -65, -60, -74, -19,  10, -36,  11, -66, -80, -23; D=-12;
/I:         I=-12; DM=-31;
/M: SY='E';  M= -17, -11, -60,  31,  -2, -10,  24,  10, -25,  -7, -60,  11, -73,  20,  28,   7, -15, -32, -80, -63; D=-12;
/I:         I=-12; DM=-31;
/M: SY='W';  M=  48,  34, -74,  -8, -61, -69, -71,  -2, -12, -45,  40, -70, -75, -64, -69, -10, -39,  19,  67,  27; D=-12;
/I:         I=-12; DM=-31;
/M: SY='M';  M=   9, -76,   0,  28, -24, -37,  21,  14, -28,  13,  42, -65, -73, -22, -27,  -9, -35,  -1, -78,   0; D=-12;
/I:         I=-12; DM=-31;
/M: SY='A';  M=  42,   4,   1,  34, -77, -39, -61, -75,   6, -42, -18,  -7, -70,  37,  28, -31, -25, -69, -80, -14; D=-12;
/I:         I=-12; DM=-31;
/M: SY='D';  M=  34, -75,  41,  24,   1, -69, -62, -65, -27,  19, -60, -10, -73, -19,  -2,   0, -60, -64, -76,   8; D=-12;
/I:         I=-12; DM=-31;
/M: SY='V';  M=  -5, -74,   2,  23, -30, -73, -68,  12, -28,   2,  -9,   8,  -3, -10, -67,  16,   9,  24, -84, -67; D=-12;
/I:         I=-12; DM=-31;
/M: SY='A';  M=  39, -76,  27,  31, -13, -67, -63, -73,  19, -39,  13,  -2, -71,  18,  -8,  -3, -60, -47, -82, -69; D=-12;
/I:         I=-12; DM=-31;
/M: SY='W';  M= -25, -88, -37,  31,  -5, -42,  -9, -53, -14,  -3, -20, -71, -81,   0,  -2,  21, -20, -76,  34, -71; D=-12;
/I:         I=-12; MI=0; MD=-31; IM=0; DM=-31;
/M: SY='C';  M=  61,  72, -73, -67, -77, -64, -75, -23, -12, -69, -65, -66, -17,  -5, -70,  11,  -8,   3, -86, -75; D=-12;
/I:         I=-12; DM=-31;
/M: SY='D';  M= -64, -78, 107, -36, -84, -64, -55, -78,  12, -80, -77,  -9,  -7, -53, -59,   3, -55, -20, -96, -70;
/M: SY='L';  M=   8,  46, -76, -72, -50, -37, -70, -14, -72,  64, -40, -70, -77, -69, -73, -22,  30,  11, -75, -18;
/M: SY='F';  M= -65,  35, -82, -77,  62, -81, -67,  22, -75,  47,  53, -75, -80, -72, -74,  -8, -60,   8, -62,  13;
/M: SY='I';  M= -64, -72, -85, -80,  -1, -87, -76,  67, -78,  57,   4, -80, -79, -74, -78, -74, -60,  29,  18, -53;
/M: SY='V';  M= -13,  37, -74, -12,  22, -76, -77,  38, -70, -45, -48, -68, -74, -70, -73,   8,  13,  70, -78, -57;
/M: SY='V';  M=  -2, -70, -83, -77, -50, -82, -78,  60, -75,  28,  40, -77, -77, -72, -76, -68, -56,  63, -78, -58;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/M: SY='T';  M= -51, -63, -59, -62,  -1, -65, -65, -58, -59, -63, -60, -49, -62, -60, -65,  46,  98, -12, -79,   5;
/M: SY='S';  M= -41, -64, -56, -57, -75, -10, -59, -74, -57, -78, -71, -44, -64, -49, -62, 107, -36, -67, -82, -67;
/M: SY='L';  M= -12,   5, -76, -73,  38,  29,  20, -46, -73,  64, -42, -68, -78, -68, -73,   1, -61, -51, -68, -51;
/M: SY='Q';  M=  10, -72, -56,  30, -71, -69,   5,  -7,  35, -61,   9, -22, -66,  59, -23, -28,  27,  25, -79, -63;
/M: SY='V';  M= -31, -68,  17, -69, -57, -80, -80,  27, -71, -43, -45, -69, -75, -73, -75, -62,   9,  89, -87, -62;
/I:         I=-45; MD=-115;
/M: SY='Y';  M= -37, -82, -66,  -6, -48, -39,  21, -64, -57,  -3,  -4, -66,  45,  34,  13, -12, -29, -67,  23,  85; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='P';  M= -60, -83,  -7, -55, -83,  -8, -65, -75, -13, -82, -71,   2, 110, -61, -68,  26, -20, -76, -81, -78;
/M: SY='A';  M=  55, -67, -71, -65,  50,  14, -69, -51, -15,  -2, -54, -64, -72,   5, -66,  -4, -56,  27, -68, -53;
/M: SY='A';  M=  66,  22,  -3, -12,  13,   3, -60, -67,  -3, -65, -61, -20, -70, -59, -63, -23, -21, -60, -63,  55;
/M: SY='N';  M= -34, -26, -20,   3, -65,  20, -55, -14, -37, -31,  -8,  40,  -2,  21,  39,  38, -55, -66, -72,  32;
/M: SY='L';  M= -68, -73, -82, -76,  54, -85, -70,  56, -14,  57, -37, -76, -80, -71, -12, -74, -62, -37, -62,  -4;
/M: SY='P';  M=  13,  32, -73, -66, -62, -72,  19,  32, -69,  11, -50, -70,  74, -68, -74, -29, -15,  33, -80, -65;
/M: SY='H';  M=  -8, -74, -26,  17, -28, -19,  50, -31, -22,  18, -56,   3,  26, -15,  11,  38, -56, -63,  42, -12;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='C';  M=   4,  39, -28,  33,  13, -73,  -2,   1,  11,   8,  -4, -24, -71,  21,  17, -26,   1, -59, -76, -60; D=-33;
/I:         I=-33; DM=-84;
/M: SY='A';  M=  65, -67, -73, -67, -59, -64, -72,  22, -28, -52,  16, -67, -70, -64, -68, -52,  11,  43,  46,   7;
/I:         I=-42; MD=-106;
/M: SY='R';  M= -36,   0, -62, -52, -74, -71,  43, -70,  53, -25, -61, -56,  43,  19,  56,  -8,  -9, -20, -10, -63; D=-42;
/I:         I=-42; MD=-106;
/M: SY='R';  M=   8, -76, -14,  16, -73, -68,  22, -29,  26, -14,  16, -21, -70,  23,  40,  30, -57, -19, -81, -65; D=-42;
/I:         I=-42; MI=-106; IM=-106; DM=-106;
/M: SY='R';  M=   7, -75, -61,  -5, -68, -67,  46, -64,  11,   1,  -9,  -9,  14,  27,  51,  21, -57, -16,  41, -59;
/I:         I=-28; MD=-70;
/M: SY='G';  M= -34, -80, -70, -69, -74,  51, -11, -69,  27, -73,  13, -19, -18, -63,   7,  -1, -26,  13, -79,   7; D=-28;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='A';  M=  43, -75, -71, -68, -74,  26, -72,  -3,  13, -22,  -7,  -4,  -3, -64,  -6, -56,  -1,   4, -82, -73; D=-28;
/I:         I=-28; DM=-70;
/M: SY='P';  M= -11, -81, -63, -55, -32, -70,  63, -25,  39, -26, -61, -14,  82, -55,  19, -60, -24, -45, -77, -10; D=-28;
/I:         I=-28; DM=-70;
/M: SY='V';  M= -61, -73, -72, -27,   1, -80, -65,  44, -32,   9,   0, -68, -75,   8,  34, -31,   7,  44, -68,  33;
/M: SY='C';  M=  23,  66, -80, -74,   0, -76, -75,  42, -30,  17, -44, -73, -78, -72, -73, -63, -56,  53, -74,   5;
/M: SY='E';  M= -19, -74, -20,  52,  -2, -80, -67,  47, -63,  36, -45, -69, -71, -59, -68, -65,  -6,   9,  26,  -3;
/M: SY='I';  M= -32,  13, -84, -80,  23, -85, -79,  70, -77,  33, -38, -78, -79, -76, -78, -71, -58,  50, -73, -53;
/M: SY='N';  M= -61, -68, -37, -56, -77, -52, -44, -76,  -5, -83, -69, 120, -72, -49,  -7, -10, -47, -78, -93, -71;
/M: SY='P';  M= -35, -75, -69, -60, -58, -39,  20,  21,  34,  39,  -1, -64,  41, -13,  22, -30,  -9, -37, -73,  -8;
/M: SY='E';  M= -57, -77,  35,  72, -81,  26, -57, -76,   4, -75, -69, -17, -62,  46, -53,  -2,  -6, -22, -81, -70;
/I:         I=-6; MD=-16;
/M: SY='P';  M= -48, -83, -27,  35, -76, -72,  20, -70,   0, -24,   4,  -3,  88, -18, -28, -61,   6, -48,  41, -69; D=-6;
/I:         I=-6; MD=-16;
/M: SY='T';  M= -44, -69, -64, -64, -64, -37, -67, -30, -58, -21, -58, -20,  11, -62,  16,  11,  83,  14, -81,   8; D=-6;
/I:         I=-6; MD=-16;
/M: SY='P';  M= -10, -81, -63, -12, -25,  22, -62, -75,   9, -75,  -7,  -2,  65,  -7,  54, -31, -21, -45, -76, -13; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='H';  M=  22, -74, -14, -60,  -7, -70,  55,  11,  28,  21, -52, -24,  24, -11, -59, -10, -37, -12, -78, -59; D=-6;
/I:         I=-6; DM=-16;
/M: SY='D';  M=  -9, -77,  72,  13,   5, -29, -62, -73, -60, -24, -32,  -7,  15, -14, -67,   9,  30, -70, -86, -67; D=-6;
/I:         I=-6; DM=-16;
/M: SY='D';  M= -14, -80,  39,  31, -74, -35,  35, -73,   4, -27, -66,  24,  16,   9,  19, -14, -61, -22, -82,   2; D=-6;
/I:         I=-6; DM=-16;
/M: SY='W';  M=  -5, -77, -70,  -9,   1, -22,  -9,  11,  -5,  16,  -2, -32,  22, -31,  27,  -4, -33,  -4,  53, -23; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='F';  M=  42,  25, -77, -72,  52, -43, -70,   3, -46, -58,  -2, -12, -80, -69,  23, -61, -34,   9, -68,  13; D=-6;
/I:         I=-6; DM=-16;
/M: SY='D';  M=   2,  15,  82, -46, -24, -69, -11, -71, -15, -30, -69, -49, -21,  18,  -7, -17,   9, -17, -90, -68; D=-6;
/I:         I=-6; DM=-16;
/M: SY='L';  M= -64, -73,  -2,  26,  13, -82, -67,   9, -68,  48,   1, -72, -77, -64, -35, -14, -60,  33, -72,  13; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='K';  M=  -8,  -4,  -7, -23,  -5, -70,  33, -36,  53, -12,  -9,   3, -28, -54,   4,   7, -26,   9, -75,   9; D=-6;
/I:         I=-6; DM=-16;
/M: SY='W';  M= -66, -76, -73, -11,  20, -81,  -2,  31, -16,  36,  -4,  -1, -78,   9, -32, -69, -32,  17,  70,  12; D=-6;
/I:         I=-6; DM=-16;
/M: SY='Y';  M= -65,  -2,   7, -10, -51, -75,  61, -27, -59,  28,  -5, -13, -41,  20,  12,   0, -61, -16, -67,  61; D=-6;
/I:         I=-6; DM=-16;
/M: SY='G';  M=  -8,   1, -62,   3, -72,  68, -66, -31, -64, -47,  39,   3, -69,  -5, -70,   5,   7, -68,  17, -15; D=-6;
/I:         I=-6; DM=-16;
/M: SY='D';  M= -34, -82,  59,  28, -74, -42, -58, -42,  33, -77, -70, -53,  53, -51,  27, -59,  -3, -74, -77,  24; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='C';  M=  47,  96, -76, -72, -66, -70,  18,  32, -31, -23, -55, -67, -77, -70, -73, -35, -26,  21, -85, -68; D=-6;
/I:         I=-6; DM=-16;
/M: SY='G';  M= -33, -74,  45, -25, -23,  47, -12,   2, -63, -68, -65, -52, -69,  15, -69,  22,  24,  12, -83, -67; D=-6;
/I:         I=-6; DM=-16;
/M: SY='E';  M= -18, -80,  36,  65, -81, -73,  11, -15, -17, -72, -67, -55, -20,  53, -57, -13,  10, -20, -85, -69; D=-6;
/I:         I=-6; DM=-16;
/M: SY='V';  M=  13, -13, -73,  -1,   4,   3, -75,  34, -29, -18, -52, -70, -75,   4, -71, -62,  -7,  50, -77, -20; D=-6;
/I:         I=-6; DM=-16;
/M: SY='L';  M=  -3,  33, -84, -77,  14, -80, -72,  12, -76,  56,  50, -78, -81, -72, -76, -21, -61,  24, -75, -56; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M=  11, -26,  18,  -2, -81, -70, -65, -15, -15, -33, -66, -18,  79,  40,   3, -59,  -7, -69, -82, -74; D=-6;
/I:         I=-6; DM=-16;
/M: SY='R';  M=  12, -76, -57,  44, -72, -30,  25, -70,  13,   3,  -5, -58, -13,   4,  50,  -3, -10, -67, -79, -65; D=-6;
/I:         I=-6; DM=-16;
/M: SY='I';  M=  10, -72, -27, -76,  30, -81, -75,  50, -76,  48,  18, -77, -79, -73, -77, -70, -61,  15,  14, -52; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='M';  M=   8,   1,  -5, -10, -61, -76, -69,  -6, -26,  22,  59, -67, -74,   1, -29, -62,  21,  38, -82, -63;
/M: SY='E';  M=  -4, -80,  15,  52, -81, -41,   0, -36,  16, -49, -68,  23,  19,  25,  26, -20, -30, -73, -83, -71;
/I:         I=-45; MD=-115;
/M: SY='H';  M= -38,   8, -61,  23, -30, -41,  43, -12,   7,  13, -58,  17, -21,  35,  16, -62,  -7, -65, -78,   4; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='L';  M= -70,  36, -35, -16,   0, -49,  18,  21, -77,  59,  -6, -78, -85, -73, -48, -76, -67,   2, -79, -59;
/M: SY='G';  M= -67, -86,  -2,   0, -76,  46, -70, -42,  20,  -8,  -3, -64, -15,  -7,   6, -34, -71, -45, -80,   6;
/M: SY='W';  M=  10, -84, -75, -18, -26, -16, -28, -39,  21,  -3, -15, -44, -78,   5, -27, -16,  12, -71,  95, -62;
/M: SY='E';  M= -23, -91,  -3,  39, -90, -20, -12, -43,  28, -27, -79, -69, -18, -26, -31, -26,  -1, -82, -95, -83;
/I:         E1=0; IE=-380; DE=-380;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	213 in 213 different sequences
Number of true positive hits	213 in 213 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Deacetylase sirtuin-type
Version [info]	7

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

213 sequences

HST1_CANAL  (Q5AQ47), HST1_EMENI  (C8V3W5), HST1_YEAST  (P53685),

HST21_EMENI (Q5AW69), HST22_EMENI (P0CS88), HST2_CANAL  (Q5A985), 
HST2_SCHPO  (Q9USN7), HST2_YEAST  (P53686), HST3_CANAL  (Q5A1W9), 
HST3_YEAST  (P53687), HST4_EMENI  (Q5BE04), HST4_SCHPO  (Q9UR39), 
HST4_YEAST  (P53688), NDP_MYCS2   (A0R2N3), NPD1_ARCFU  (O28597), 
NPD1_BRADU  (Q89LY4), NPD1_CALS4  (Q8R9N6), NPD1_COREF  (Q8FUC8), 
NPD1_GEOKA  (Q5L014), NPD1_MYCA1  (A0QDH4), NPD1_PSEAE  (Q9I4L0), 
NPD1_PSESM  (Q88A13), NPD1_PYRAE  (Q8ZU41), NPD1_STRCO  (Q9RL35), 
NPD2_ARCFU  (O30124), NPD2_BRADU  (Q89EA6), NPD2_CALS4  (Q8R984), 
NPD2_COREF  (Q8FRV5), NPD2_GEOKA  (Q5KZE8), NPD2_MYCA1  (A0QC96), 
NPD2_PSEAE  (Q9I4E1), NPD2_PSESM  (Q885X7), NPD2_PYRAE  (Q8ZT00), 
NPD2_STRCO  (Q8CJM9), NPD3_PSESM  (Q882K4), NPD4_PSESM  (Q87W79), 
NPD_AERPE   (Q9YB13), NPD_AGGAC   (Q9ZAB8), NPD_AQUAE   (O67919), 
NPD_BACAN   (Q81NT6), NPD_BACC1   (Q735N7), NPD_BACCR   (Q81BT4), 
NPD_BACCZ   (Q639M6), NPD_BACHK   (Q6HH09), NPD_BACSU   (O07595), 
NPD_BACTN   (Q8A3H9), NPD_BDEBA   (Q6MJJ2), NPD_BORBR   (Q7WLE5), 
NPD_BORPE   (Q7VX46), NPD_CALMQ   (A8MBU4), NPD_CAMJE   (Q9JN05), 
NPD_CAMJR   (Q5HU51), NPD_CAUVC   (Q9A2S6), NPD_CHRVO   (Q7P1B9), 
NPD_CLOAB   (Q97MB4), NPD_CLOPE   (Q8XNS6), NPD_CLOTE   (Q899G3), 
NPD_CORGL   (Q8NSM4), NPD_CUTAK   (Q6A5T5), NPD_DEIRA   (Q9RYD4), 
NPD_DESOH   (A9A0B2), NPD_ECO57   (Q8X8E0), NPD_ECOL6   (Q8FIM4), 
NPD_ECOLI   (P75960), NPD_ENTFA   (Q839C6), NPD_FUSNN   (Q8REC3), 
NPD_HALH5   (Q9KEE5), NPD_HALMA   (Q5V4Q5), NPD_HELHP   (Q7VIN2), 
NPD_HELPJ   (Q9ZJW8), NPD_HELPY   (O25849), NPD_LACPL   (Q88ZA0), 
NPD_LARHH   (C1DBX3), NPD_LEPIC   (Q72RR0), NPD_LEPIN   (Q8F3Z6), 
NPD_LISIN   (Q927A7), NPD_LISMF   (Q71W25), NPD_LISMO   (Q8Y3U2), 
NPD_METCA   (Q607X6), NPD_METKA   (Q8TWG0), NPD_MYCBO   (P66814), 
NPD_MYCLE   (Q9CBW6), NPD_MYCPA   (Q73WM7), NPD_MYCTA   (A5U1J9), 
NPD_MYCTO   (P9WGG2), NPD_MYCTU   (P9WGG3), NPD_OCEIH   (Q8ELR0), 
NPD_PASMU   (Q9CM50), NPD_PROMH   (B4EVF5), NPD_PSEPK   (Q88BY5), 
NPD_PYRAB   (Q9UZE7), NPD_PYRFU   (Q8U1Q1), NPD_PYRHO   (O58669), 
NPD_RALN1   (Q8Y015), NPD_RHOBA   (Q7UFQ9), NPD_RHOPA   (Q6N6U0), 
NPD_SACS2   (Q97VX5), NPD_SALTI   (P0A2F3), NPD_SALTY   (P0A2F2), 
NPD_SHEON   (Q8EFN2), NPD_SHIFL   (Q83RR8), NPD_SHOC1   (Q5WKC8), 
NPD_STAA8   (Q53700), NPD_STAAC   (Q5HE07), NPD_STAAM   (P66815), 
NPD_STAAN   (P66816), NPD_STAAR   (Q6GEN2), NPD_STAAS   (Q6G7B7), 
NPD_STAAW   (Q8NVC8), NPD_STAEQ   (Q5HM33), NPD_STAES   (Q8CNF4), 
NPD_SULAC   (Q4JBN2), NPD_SULTO   (Q974M6), NPD_SYMTH   (Q67KQ0), 
NPD_THEKO   (Q5JG47), NPD_THEMA   (Q9WYW0), NPD_THESM   (C6A243), 
NPD_THET2   (Q72IV5), NPD_THET8   (Q5SIH7), NPD_THEYD   (B5YJW3), 
NPD_TREDE   (Q73KE1), NPD_VIBCH   (Q9KRX4), NPD_VIBPA   (Q87PH8), 
NPD_VIBVU   (Q8D9J9), NPD_VIBVY   (Q7MKT7), NPD_XANAC   (Q8PQK3), 
NPD_XANC8   (Q4UZX0), NPD_XANCB   (B0RM75), NPD_XANCP   (Q8PDM9), 
NPD_YERPE   (Q8ZFR1), NPD_YERPS   (Q669P6), SIR1_ARATH  (Q9FE17), 
SIR1_HUMAN  (Q96EB6), SIR1_MOUSE  (Q923E4), SIR1_RAT(A0A0G2JZ79), 
SIR24_CAEEL (Q95Q89), SIR2A_DICDI (Q54QE6), SIR2A_PLAF7 (Q8IE47), 
SIR2B_DICDI (Q54LF0), SIR2B_PLAF7 (Q8IKW2), SIR2C_DICDI (Q54P49), 
SIR2D_DICDI (Q54GV7), SIR2E_DICDI (Q55DB0), SIR2_CAEBR  (Q60L58), 
SIR2_CAEEL  (Q21921), SIR2_CANAL  (O59923), SIR2_CANGA  (Q6FWI7), 
SIR2_DANRE  (Q7ZVK3), SIR2_EREGS  (Q757M7), SIR2_HUMAN  (Q8IXJ6), 
SIR2_KLULA  (P33294), SIR2_LEIMA  (Q25337), SIR2_MACFA  (Q4R834), 
SIR2_MOUSE  (Q8VDQ8), SIR2_PONAB  (Q5RBF1), SIR2_RAT(Q5RJQ4), 
SIR2_SCHPO  (O94640), SIR2_TRYB2  (Q57V41), SIR2_YEAST  (P06700), 
SIR3_HUMAN  (Q9NTG7), SIR3_MOUSE  (Q8R104), SIR41_CAEEL (Q20480), 
SIR42_CAEEL (Q20481), SIR4_ARATH  (Q94AQ6), SIR4_BATDJ  (F4P804), 
SIR4_BOVIN  (Q1JQC6), SIR4_DROME  (Q8IRR5), SIR4_HUMAN  (Q9Y6E7), 
SIR4_LEIMA  (Q4QB33), SIR4_MONBE  (A9UVV1), SIR4_MOUSE  (Q8R216), 
SIR4_TRYB2  (Q57YZ9), SIR5A_XENLA (Q5HZN8), SIR5B_XENLA (Q68F47), 
SIR5_BOVIN  (Q3ZBQ0), SIR5_CANAL  (Q5AI90), SIR5_CANLF  (E2RDZ6), 
SIR5_CHICK  (E1BRE2), SIR5_COPC7  (A8NWP2), SIR5_DANRE  (Q6DHI5), 
SIR5_DAPPU  (E9GD30), SIR5_FUSO4  (A0A0J9UVG7), SIR5_HUMAN  (Q9NXA8), 
SIR5_LEIMA  (Q4Q2Y6), SIR5_MACMU  (F7EZ75), SIR5_MONDO  (F7D4X9), 
SIR5_MOUSE  (Q8K2C6), SIR5_PHYPA  (A9SDL4), SIR5_PONAB  (Q5R6G3), 
SIR5_RAT(Q68FX9), SIR5_TRYB2  (Q584D5), SIR5_XENTR  (F7DKV7), 
SIR6_CASCN  (A0A250YGJ5), SIR6_DROME  (Q9VH08), SIR6_HUMAN  (Q8N6T7), 
SIR6_MACFA  (A0A2K5TU92), SIR6_MOUSE  (P59941), SIR7_BOVIN  (Q0P595), 
SIR7_DROME  (Q9VAQ1), SIR7_HUMAN  (Q9NRC8), SIR7_MOUSE  (Q8BKJ9), 
SIR7_RAT(B2RZ55), SIRT1_DROME (Q9VK34), SIRT2_DROME (Q9I7I7), 
SIRTM_STAAM (A0A0H3JQ59), SIRTM_STRPG (P0DN71), SRT1_ORYSI  (B8ARK7), 
SRT1_ORYSJ  (Q7XWV4), THSA_ACIB7  (P0DW59), THSA_BACCS  (J8G6Z1), 
THSA_CYTDA  (A0A5B8Z1N3), THSA_ENTFC  (P0DW60), THSA_STRE4  (C0MAL8)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

239 PDB

1ICI; 1J8F; 1M2G; 1M2H; 1M2J; 1M2K; 1M2N; 1MA3; 1Q14; 1Q17; 1Q1A; 1S5P;
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