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PROSITE entry PS50293


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PURL: https://purl.expasy.org/prosite/signature/PS50293

Direct ScanProsite submission
General information about the entry

Entry name [info] TPR_REGION
Accession [info] PS50293
Entry type [info] MATRIX
Date [info] 01-JAN-2004 CREATED;
01-JAN-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50005
Associated ProRule [info] PRU00339

Name and characterization of the entry

Description [info] TPR repeat region circular profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34; TOPOLOGY=CIRCULAR;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=31;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2877; R2=0.03368536; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=185; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=126; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105; M0=-10;
...
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Post-processing [info]

DEMOTED_BY PS51375

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 1'446 in 1'005 different sequences
Number of true positive hits 1'381 in 970 different sequences
Number of 'unknown' hits 0
Number of false positive hits 65 in 35 different sequences
Number of false negative sequences 304
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 95.50 %
Recall (true positives / (true positives + false negatives)) 81.96 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 8
Matrix type [info] repeat_region
Scaling database [info] reversed
Author [info] K_Hofmann, N_Hulo
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
970 sequences

ACL4_EMENI  (C8V3W6), ACL4_SCHPO  (Q1MTN8), ACSC_KOMXY  (P37718), 
» more

UniProtKB/Swiss-Prot
False negative sequences
304 sequences

ACL4_YEAST  (Q03771), AFSR_STRGR  (Q9S0Y6), ALTH1_PLAF7 (C6KTB7), 
» more

UniProtKB/Swiss-Prot
False positive sequences
35 sequences

CLF1_ASPFU  (Q4WT84), CLF1_CANGA  (Q6FW76), CLF1_CRYNB  (P0CO11), 
» more

PDB
[Detailed view]
508 PDB

1A17; 1E96; 1ELR; 1ELW; 1FCH; 1HH8; 1IHG; 1IIP; 1IYG; 1KT0; 1KT1; 1NZN;
» more