PROSITE entry PS50290

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50290
Entry name [info]	PI3_4_KINASE_3
Accession [info]	PS50290
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 23-FEB-2022 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00710
Associated ProRule [info]	PRU00269

Name and characterization of the entry

Description [info]

Phosphatidylinositol 3- and 4-kinases catalytic domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=279;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=274;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6666881; R2=0.0085123; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1038; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=568; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-24; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='F';  M= -46,  -9,   0,   5,  56,  31, -66,  20, -35, -28,  14,  -8, -74, -66, -32, -45, -61,  26,  13,  15;
/M: SY='P';  M=  -1,  -7,  16,  -1, -27, -26,  -8,  16, -11, -24, -36, -14,  62, -39, -15,   3,  -8,  13, -78, -22;
/M: SY='E';  M= -38, -78,  45,  46,  -2, -33, -33, -74,  10, -40, -68,  18,  41,  -5,   3,   7, -23, -73,  39,  -7;
/M: SY='P';  M= -21, -76, -26,  27, -12, -43, -41, -38,  23, -42, -49, -12,  55,  29,  11,  -6,  17,  14, -15, -64;
/M: SY='C';  M= -15,  62, -33,  44,  12, -44, -37,  27, -63,  -6, -11, -66, -72, -39, -39,  -6, -34,  37, -75,  -4;
/M: SY='R';  M= -29, -32, -15,  -8, -66, -40, -37,  27,  27,  -3,   0, -13,  -4, -27,  47,  14,  31, -47, -77, -39;
/M: SY='V';  M= -35, -71, -79, -75,   3, -81, -75,  61, -54,   8, -41, -73, -76, -48, -32,  -1, -33,  64, -73,  10;
/M: SY='M';  M=   0, -37, -55, -48,  41, -69, -25,   6, -24,   8,  60, -10, -20,  26,   1,  23, -15, -20, -66,  11;
/M: SY='S';  M= -24, -74,   9,   5, -52,  20, -23, -76,  37, -67, -68,  17,  19,  17,  15,  39,  13, -72, -79, -68;
/M: SY='S';  M= -32, -70, -46, -64, -74,  63,  31, -29, -62, -49, -67, -21, -66, -57, -67,  71,   4, -68, -79, -41;
/M: SY='S';  M=   3, -69, -60, -16, -62, -12, -61,  -9,  30,  28, -20,  34, -69, -54, -16,  38,   8, -21, -77, -29;
/M: SY='Q';  M=  -9, -72, -58, -15, -73,  20, -13, -53,  34, -30,  18,  -7, -42,  51,  -6,  38,  28, -42, -78, -65;
/M: SY='G';  M=   6,   9, -37, -22, -36,  40,  -9, -48,  39,  -9,   5, -57, -70, -22,  32, -16, -38,   2, -73,  -4;
/M: SY='P';  M=  22, -79, -65, -58, -76, -12, -67, -38, -62, -76, -67, -64, 104, -62, -71,  29, -16, -48, -76,  -8;
/M: SY='Y';  M= -40, -77, -66, -58, -34, -59,   9, -12,  57,  22, -50, -62, -19, -52,  41, -63, -62, -24, -58,  72;
/M: SY='K';  M= -66, -78, -48, -58,  41, -63, -60,  18,  53, -11,   6, -62, -73,   8,  49, -64, -49, -24,  53,  28;
/M: SY='I';  M= -31,  -8, -81, -44,  13, -22, -73,  51, -55,  42,  47, -75, -48, -70, -39, -52, -59,  36,  -5, -54;
/M: SY='T';  M= -21,  -7, -17, -19, -45, -46,   8, -26,  28, -21, -18,  19, -34,  19,  -6,   7,  51,  -9, -72,  37;
/M: SY='F';  M= -37,  19,  23, -69,  62, -31, -68,  43, -53,  12,  10,   3, -77, -70, -72, -35, -24, -14,  57,  -6;
/M: SY='R';  M= -61, -44,   1,  17, -27, -50,  -1,  10,  31, -27, -35,  -8,  26, -21,  53,   3,  -5, -11, -77, -26;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='G';  M= -28,  -8,   6, -41, -92,  62, -20, -73, -78, -41, -83, -33, -62, -48, -24, -40, -16, -58, -95, -87; D=-16;
/I:         I=-16; DM=-40;
/M: SY='S';  M= -37, -82, -68, -31, -55, -34,  23, -81, -39, -37, -40,   9,   2,  13, -41,  59,  11, -78, -92, -29; D=-16;
/I:         I=-16; DM=-40;
/M: SY='D';  M= -68, -81,  76, -44, -55, -24,  -2, -60, -27, -34, -12,  47, -76, -25, -49,  11,  -6, -65, -97, -44; D=-16;
/I:         I=-16; DM=-40;
/M: SY='G';  M= -23, -78, -62,   8, -46,  78, -68, -31,   3, -52, -69, -13, -15, -20, -14, -55, -65, -19,  39, -43; D=-16;
/I:         I=-16; DM=-40;
/M: SY='K';  M= -58, -46, -16,   3, -76,  29,   6, -46,  52, -33, -20,  13, -18,  21,  13,  16,  -8, -43, -79, -67; D=-16;
/I:         I=-16; DM=-40;
/M: SY='W';  M= -46, -75,   7,  28, -24, -70, -22,  12,  23,   9, -56,  25,   4,  -6,  11,   8, -15, -10,  46, -60;
/M: SY='Y';  M= -25,  27, -66, -66, -13, -73,  42,  26, -47, -22, -50,  11, -35,  13, -11,  -5, -48, -15, -52,  93;
/M: SY='P';  M=  12, -74, -26, -17, -70, -14, -33,  17,  15, -63, -41, -12,  52,  -1,  10,  24,  -9,  15, -77, -23;
/M: SY='F';  M=  24, -13, -75, -70,  53,   4, -67,  23, -69, -13,   1, -68, -75,  17, -70, -26, -38,  33,  -9,  34;
/M: SY='I';  M= -27, -71, -83, -78, -46, -84, -74,  66, -76,  46,  36, -78, -78, -72, -76, -71, -58,  44, -73,   1;
/M: SY='F';  M= -13,  42, -83, -78,  85, -80, -32, -12, -76,  20, -29, -75, -82, -79, -75, -68, -29,  42,  -2, -15;
/M: SY='K';  M= -62, -77, -55, -42, -78, -69, -57, -75, 105, -75,  -7, -18, -64,  12, -26, -57, -57, -45, -73, -65;
/M: SY='P';  M= -27,   0, -61, -60, -70,  37,   6, -51,  24, -42, -64,  30,  67, -59, -42,  -3,  -4,  -5, -75,  14;
/M: SY='G';  M= -56, -76,  20, -16, -76,  66,  28, -20,  27, -55,  -9, -10,   3, -34, -15,  -8, -14, -36, -79, -68;
/M: SY='D';  M=  -8, -76,  95,  35, -82, -62, -35, -44, -41, -78, -75,  29, -65, -50, -61,  11, -33, -43, -93, -70;
/I:         I=-15; MD=-38;
/M: SY='D';  M= -44,  -4,  98,  46, -87, -33, -57, -84, -31, -82, -80, -15, -67, -17, -62, -57, -34, -49, -96, -73; D=-15;
/I:         I=-15; MI=0; MD=-38; IM=0; DM=-38;
/M: SY='L';  M= -19,  41, -16, -72,  28, -78, -69, -14, -74,  68,  -4, -73, -56, -70, -74,   1, -43,   4, -71, -52;
/M: SY='R';  M= -62, -80, -61, -14, -75,   9,  19, -80, -13, -74,  -3, -54, -33, -44, 100,   3, -23, -74, -77, -63;
/M: SY='Q';  M= -61, -81, -59, -42, -78, -70, -52, -68,   8, -10, -56, -29,  -9, 105,  55, -25, -39, -28, -74, -62;
/M: SY='D';  M= -63, -79, 102,  37, -82,  -9, -54, -83, -53, -81, -78, -19, -36, -51, -62,  -4, -12, -79, -92, -21;
/M: SY='M';  M=  24,  55, -57,  43, -69,  -6, -21, -36, -56, -22,  55,   9, -68,  49, -60, -11, -41,  -4, -79, -34;
/M: SY='R';  M= -66, -76, -71, -14,   6, -81, -25,  10, -37,  51, -23, -68, -21,  -2,  71, -68, -63, -14, -72, -55;
/M: SY='M';  M=  18, -68, -76, -72,  -7,  -1, -71,  31, -24, -20,  67, -68, -73, -67, -70, -60,   7,  58, -75, -14;
/M: SY='M';  M= -63,   0, -67,  28, -18, -39, -62, -22, -64,  45,  84, -27,  35,  -2, -67, -58, -40, -10, -73, -25;
/M: SY='Q';  M= -60, -81, -33,  19, -86, -66, -48, -77,  19, -73, -61,  32, -66, 116, -41, -34, -59, -77, -75, -63;
/M: SY='M';  M= -63, -71, -78, -70,  34, -81, -24,  21, -27,  46,  62, -71, -77,  14, -14, -67,  -2,  31, -70, -50;
/M: SY='F';  M= -36, -72, -74, -75,  64,  23, -69,  47, -41,  25, -46,   3, -76, -71, -45, -16, -18, -18, -63, -16;
/M: SY='Y';  M= -24, -35,  -2,   6, -40,  14, -56, -32,   8, -56, -63,   1, -68,  18,  41,  32,  14, -37, -28,  41;
/M: SY='L';  M= -31, -72, -73, -47, -52, -54,  22,  23, -17,  51,  50, -68, -40,  23,   7, -34, -16,   5, -73,  -5;
/M: SY='M';  M= -58,  44, -77, -21,  29, -77, -68,  14, -70,   9,  87, -70, -76, -67, -71,   7, -36,  50, -74, -53;
/I:         I=-23; MD=-58;
/M: SY='N';  M= -50, -39,  55,  25, -56,   5, -51, -77, -14, -80, -72,  86, -69,  -8, -33,  -4, -34, -34, -89, -51; D=-23;
/I:         I=-23; MD=-58;
/M: SY='T';  M=   8, -87, -14,  21, -31, -56, -13, -49,   0, -82, -78, -16, -24, -28, -21, -11,  22, -24, -91,  -6; D=-23;
/I:         I=-23; MD=-58;
/M: SY='L';  M= -18,   5, -95, -93, -38,   8, -87,  13, -91,  26,  17, -87, -94, -86, -92, -28, -48, -15, -89,  -7; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='K';  M=  28, -74,  -3, -54, -79, -13, -19, -50,  48, -40, -67,  46, -71,   9,  16,   4,  -9, -70, -83, -70; D=-23;
/I:         I=-23; DM=-58;
/M: SY='D';  M= -57, -16,  56, -58, -25, -58,  -4,  51, -31,  -3, -28,  31, -74, -25, -28,   3, -36, -23, -77,  20; D=-23;
/I:         I=-23; DM=-58;
/M: SY='W';  M= -21, -17, -49, -43,  11, -74, -28, -31,  14,  19, -56, -37,   2, -20,  47, -19, -15, -15, 104, -51; D=-23;
/I:         I=-23; DM=-58;
/M: SY='E';  M=  -1, -77, -23,  73, -74, -73, -59, -54,  37,  -5, -61, -39, -44,  33, -13, -38, -37,   1, -79, -68; D=-23;
/I:         I=-23; DM=-58;
/M: SY='T';  M= -11,  39,  29, -12, -51, -65, -62, -37,  10, -16, -34,  12, -28,  20, -45,  24,  57,  -4, -84, -66;
/M: SY='R';  M=  30, -15, -44,  35, -19, -40, -32, -29, -30, -57, -24,   2, -68,  33,  57,   8,  -6, -20, -21, -34;
/M: SY='R';  M=   3, -75, -40, -19, -76,  33, -57, -42,  49, -36, -64,  33, -68,  26,  52, -16, -45, -59, -76, -67;
/M: SY='R';  M= -47, -76, -70, -30, -53, -59, -20, -24, -20,  46,  -2, -66, -40, -20,  76, -33, -62, -16, -68,  33;
/M: SY='D';  M= -47,  -1,  63,   8,  -9,   7,  45, -19,  11, -17, -64,  39,   2, -41,  -6, -17, -58, -70, -83, -62;
/M: SY='L';  M= -27, -13, -83, -75,  -3, -83, -67, -13, -54,  80,  33, -79, -81, -70, -73, -73, -35,  -4, -70, -12;
/M: SY='W';  M= -45,  16,  29, -53,   1,   0,  46, -73,  12, -70, -25,  24, -71,  32,  20,  12,   1, -72,  63,  29;
/M: SY='I';  M=  -9, -72, -80, -75,  16, -81,  24,  58, -73,  39,  46, -73, -77, -69, -73, -68, -24,  23, -69,  11;
/M: SY='R';  M= -49, -24, -39, -45,   0, -72,  -5, -26,   3, -34, -57,   4,  34,  32,  56, -32,  34,  20, -75, -12;
/M: SY='P';  M= -53, -75, -64, -59, -71, -35,  20,   3, -23, -45, -21, -27,  80, -33,  11, -14,  61,  -1, -82, -67;
/M: SY='Y';  M= -68, -79, -70, -69,  26, -76, -44, -56, -20, -38,   7, -69,  24, -61, -23, -26, -14, -36, -37, 117;
/M: SY='K';  M=  18, -72, -59, -23, -74,  24, -37, -41,  41, -28, -63,  -1,   6, -11,  29,  25,  23, -54, -77, -67;
/M: SY='V';  M= -18,  56, -39, -69, -59, -52, -76,  25,  -4, -22, -48, -18, -39,  -4, -68, -13, -25,  74, -84, -64;
/M: SY='V';  M= -45, -70, -81, -75, -37, -83, -75,  55, -29,  40,  35, -74, -76, -70, -27, -68,  -3,  55, -77, -57;
/M: SY='P';  M=  31, -76, -67, -58, -76, -63, -69, -29, -29, -70, -63, -65,  97, -62, -15,  23, -33,  18, -80, -74;
/M: SY='T';  M= -61, -22, -74, -70,   7, -77, -41,   6, -69,  48,  41, -67,   8, -68, -71, -21,  56,   7,  26, -21;
/M: SY='S';  M= -18, -69, -22, -63, -36,  49, -64, -10, -61, -18, -63,   0, -21, -59, -29,  60,  39, -49, -79, -67;
/I:         I=-10; MI=0; MD=-26; IM=0; DM=-26;
/M: SY='P';  M=   5, -76,  22,  26, -73, -57, -16, -72,  23, -64, -19, -29,  64,  -9, -12,  29,   9, -54, -76,   7;
/M: SY='Q';  M= -38, -28,  22,  15, -69,   2,  16, -24,   8,  -3,  -3,  26,  -7,  37,  30, -29, -20,  -2, -79, -31;
/M: SY='C';  M=   7,  57, -51, -20,  -3,  13, -12,   7, -62, -35,  33, -57, -70, -15, -16,  41,  25,   5, -79, -62;
/M: SY='G';  M= -37, -75, -62, -68, -80,  88, -65, -84, -40, -81, -13, -15, -68, -59,  27,  28, -61, -78, -75, -73;
/M: SY='M';  M= -44, -22, -83, -76,  47, -83, -71,  52, -74,  46,  54, -76, -79,  -5, -74, -55, -60,  18, -67, -47;
/M: SY='I';  M= -11, -74, -76, -70, -32, -58, -73,  80, -69,   7,   6, -23, -73,  40, -71, -30, -37,  24, -75, -58;
/M: SY='E';  M= -40, -79,   9,  89, -78,   7,  23, -54, -24, -17, -36,  -4, -61,  27, -54, -42, -60, -72, -80, -68;
/M: SY='W';  M= -65,   3,  16, -71,  62, -31, -76,   9, -71, -33,  19, -71, -31, -73, -74, -46,  -3,  35, 114, -40;
/M: SY='V';  M= -48,   8, -76, -54, -56, -31, -76,  36, -42,   0,   5,  -7,  13, -30, -73, -38, -54,  76, -82, -62;
/M: SY='P';  M= -38, -79,  10,  17, -13, -37,  11, -67,  16, -31, -33,  10,  88, -21, -40, -29,   2, -20, -79, -68;
/I:         I=-31; MD=-79;
/M: SY='N';  M= -34, -74,  32, -34, -80,  36,  39, -81, -57, -83, -72,  82,  -2, -56, -56,   7,   2, -79, -91, -71; D=-31;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='S';  M=  19,  46, -45, -38,   0, -62, -61, -32, -40, -43, -59,  -3, -69, -59, -41,  54,  45,  -5, -69,  46;
/M: SY='K';  M= -16,  20,  30,  12, -67, -40,   4,  18,  33, -26,  22, -21, -68, -35,  -8, -28,  25,  24, -82, -63;
/M: SY='T';  M= -32, -69,  -9, -16, -72, -16, -64, -63, -25, -38, -63, -25,  51, -18, -38,  51,  68, -12, -83, -68;
/M: SY='L';  M=   9, -70, -47, -72,  -1, -79,   1,  34, -69,  61,  32, -74, -78, -66,   2, -68, -45,   4, -72, -34;
/M: SY='H';  M=  15, -75,  32, -13,  13, -18,  81, -34,   7, -46,  -9, -43, -32,   3,  28, -25, -13, -35, -76,  -2;
/M: SY='E';  M=  -1, -73,  17,  46, -32, -14,   8, -73,  25, -72, -21,   0, -47,  33, -38,  39,  -9, -42, -75,   9;
/M: SY='I';  M= -39, -75, -81, -78,  31, -83, -73,  74, -51,  19,  -1, -42, -76, -72, -43, -69,  -6,  13,  57,  22;
/M: SY='L';  M= -64, -12, -70, -64,  27, -16,   7,  14,  13,  45, -16,  -8, -39,  40, -60, -26, -61, -43,  15,  36;
/M: SY='K';  M= -20,  -3,   8, -10, -68, -53,  26, -43,  41, -10,   9,  21, -44,  -2,  41,  16, -28,  -1, -78, -18;
/M: SY='Q';  M= -42, -76,   3,  34, -44,  11, -15, -44,  33, -53, -13,  21,  19,  38,  11,   9,   3, -41, -79, -66;
/M: SY='Y';  M=   3, -13, -63,   0,  30, -50,  34, -20,   8,  -4, -55,   7, -38, -22, -24,   9,  10, -30,  44,  56;
/M: SY='Y';  M= -60,  40,  -1,   4, -59,  21,  51, -25, -18, -53,  26, -55,   5,  12,  12,   9,  -7, -33, -68,  53;
/I:         I=-2; MD=-6;
/M: SY='K';  M=  14, -43,  -9,  20, -72,   6, -64, -28,  21, -12, -23,  16, -72,  15, -21,   8, -12, -42,   4,  -6; D=-2;
/I:         I=-2; MD=-6;
/M: SY='K';  M= -40, -25, -39, -16, -55, -35, -17,  -5,  30, -63,  -3,   6, -14,  12,  15,  20, -11, -19, -89, -74; D=-2;
/I:         I=-2; MD=-6;
/M: SY='K';  M= -20, -22,   2,  -4, -46,  11, -38, -56,  14, -60,  14, -15, -83, -22,  -2, -15,   1, -81, -89,  -1; D=-2;
/I:         I=-2; MD=-6;
/M: SY='G';  M= -10, -92, -21, -19, -73,  21,  -2, -53,  13, -91, -10,   6, -86, -17, -54,   2, -22, -87, -96, -27; D=-2;
/I:         I=-2; MD=-6;
/M: SY='I';  M= -21,-101, -68, -68, -18, -68, -50,  28,  -7, -27, -21, -93,   1, -89, -40, -89, -30, -21, -23, -20; D=-2;
/I:         I=-2; MI=0; MD=-6; IM=0; DM=-6;
/M: SY='F';  M= -60,-102, -51, -69,  20, -10, -10, -88,   2, -50, -28,  -1, -49, -16, -22, -46, -70, -19, -99, -81; D=-2;
/I:         I=-2; DM=-6;
/M: SY='F';  M= -62, -42, -51, -49,  35, -96, -17, -23,  -3, -85, -84,   5,  28, -45, -62, -56, -16, -55, -22, -16; D=-2;
/I:         I=-2; DM=-6;
/M: SY='P';  M= -86,-103,  22, -14, -99, -92,   5, -42,  27, -57, -23, -75,  33, -29,  -4, -21, -58, -92,-104, -89; D=-2;
/I:         I=-2; DM=-6;
/M: SY='P';  M= -67, -51,  13, -38,  -3, -90, -35, -36, -45, -17, -79, -39,  65, -83, -64, -23, -30, -29, -97, -83; D=-2;
/I:         I=-2; DM=-6;
/M: SY='V';  M=   0, -39, -32, -64, -77,  -1, -85, -20, -45, -27,  28, -79, -13, -26, -63, -61,   3,  36, -94, -27; D=-2;
/I:         I=-2; DM=-6;
/M: SY='M';  M= -75, -83, -89, -83,  24, -89, -25, -14, -20,  42,  51, -83, -37, -77, -47,  -1, -71, -17, -77,   4; D=-2;
/I:         I=-2; DM=-6;
/M: SY='H';  M= -31, -83, -74, -33, -23, -58,  42, -52,  28,  23, -58, -49, -82, -40,  37, -23, -69,  -8, -76,  29; D=-2;
/I:         I=-2; DM=-6;
/M: SY='Q';  M= -58, -84,  26,  26, -71, -75,  51, -76,   6, -12, -16,  27, -75,  56, -27, -62, -36, -77, -80,  29; D=-2;
/I:         I=-2; DM=-6;
/M: SY='W';  M= -31, -87, -86, -76,  45, -80,  -3, -49,  -8, -36,  17, -80, -83, -21, -27, -45, -75, -34, 128,  59; D=-2;
/I:         I=-2; DM=-6;
/M: SY='F';  M= -20,  -3, -85, -39,  97, -83, -71, -12, -78,  31, -26, -78, -85, -81, -77, -44, -22, -52, -55, -34; D=-2;
/I:         I=-2; MI=0; MD=-6; IM=0; DM=-6;
/M: SY='M';  M= -70, -80, -78, -53, -11, -85,   1,   7,  22,  22,  27, -72, -81, -19,   6, -26,   6,  13,   9,   6; D=-2;
/I:         I=-2; DM=-6;
/M: SY='E';  M=  -2, -35,  14,  39, -84, -32,  -4, -56,  27, -66, -73, -28,  -5,  30,  -6,  15,  -5, -76, -86, -45; D=-2;
/I:         I=-2; DM=-6;
/M: SY='H';  M= -51, -35, -44,  -9, -71, -68,  64, -43,  37, -49,   5,  42, -69,  20,  10,  12,  32, -55, -35,  -7; D=-2;
/I:         I=-2; DM=-6;
/M: SY='F';  M= -42,  -8,  38,  -4,  74, -51,  -7, -62, -61, -59, -61,  48, -74, -40, -65,  20, -19, -36, -59,  45;
/M: SY='P';  M= -36, -77, -62,  -9,  -3,  30,  -7, -53, -15, -10, -41, -27,  76, -38,  -3,  18,  11, -48, -74, -18;
/M: SY='D';  M= -32, -72,  65,  11, -50,  -5, -14, -27, -43,  -4, -64,  29, -67, -36, -25,  46,  18, -65, -86, -66;
/M: SY='P';  M=  26,  33, -22,  37, -54, -65, -64, -71, -16, -51, -66, -49,  90, -56, -65,   0, -34, -48, -76,   0;
/I:         I=-21; MD=-53;
/M: SY='E';  M=  -2, -16,  17,  38,  -8, -10, -11, -18, -52, -60, -16,  18, -70, -30, -39,  22,  30,  -6, -85, -68; D=-21;
/I:         I=-21; MD=-53;
/M: SY='D';  M=   4, -78,  51,  30, -80, -16, -20, -16, -44, -56,   7,  -4, -54, -12, -55,  20,   9, -17, -90, -73; D=-21;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='W';  M= -66, -91, -63, -30,  54, -84, -75, -69, -77, -28, -67, -85, -87, -48, -79, -26, -13, -75, 127,  61; D=-21;
/I:         I=-21; DM=-53;
/M: SY='W';  M= -37, -78, -22,  29,  52, -59,  10, -23, -29,  16,  15, -46, -15,  16,  -1, -43, -64, -40,  84,  33;
/M: SY='E';  M=   9, -36,   3,  31, -24,  15, -13, -52,  17, -16, -32,  30, -66,  10,  -1,   2,  20, -33, -19, -64;
/M: SY='A';  M=  51, -24, -69, -62,  21, -63, -66, -16,   0,  -7,  23, -62,  13, -59,  11,  12,  16,  -5, -72, -28;
/M: SY='R';  M= -62, -77, -64, -55, -69, -25, -56,  -7,  -6, -13,  19,   1, -73,  30,  88, -11, -15,  -4, -77, -62;
/M: SY='K';  M= -16, -34,  26,  12, -29, -65, -57, -46,  42, -14, -62,  24, -67,   1,  24,  29,  16, -31, -78, -19;
/M: SY='N';  M=   1, -70, -53, -27,  30, -51,   9, -65, -12, -37,  13,  73, -70,  42,   1,   5,  29, -44, -76, -57;
/M: SY='F';  M= -72, -75, -77, -76,  93, -79, -55, -52, -71,  -4, -50, -28,  24, -74, -70, -69, -26, -57, -41,  86;
/M: SY='T';  M=  26, -10, -69, -64, -32, -70, -70,  19, -62,  -7, -16, -62, -70,  20,  -9, -11,  56,  46, -80, -62;
/M: SY='R';  M= -46, -54, -36,  -6,  -9, -72,  30, -12,  21,  -1, -56, -41, -71,  23,  64,  19, -11, -44, -69,  33;
/M: SY='S';  M= -34, -30, -54,   7, -77,  -8, -58, -74, -53, -75, -68, -47, -49,  52, -58,  90,   9, -68, -80, -66;
/M: SY='C';  M= -50,  82, -78, -75,  25, -79,   7, -27, -72,  40,  29, -70, -80, -71, -73, -29,  11,  32, -70,  29;
/M: SY='A';  M=  84, -17, -61,  14, -74, -55,  57, -65, -60, -66, -60, -59, -66, -28, -63, -14, -54, -11, -79, -65;
/M: SY='G';  M=  11,  -3, -68, -65, -66,  44, -68, -30,  14,  -7, -56, -59, -71, -60,  23,   2,   5,  39, -77, -26;
/M: SY='Y';  M= -36, -13, -77, -74,   3, -77, -56,  34, -69,  20,  79, -52, -77, -64, -69,  -8, -27, -45,  52,  81;
/M: SY='C';  M= -10,  83, -64, -65, -33,   4, -67, -23, -64, -43, -63, -34, -71, -60, -69,  79, -27,  10, -83, -67;
/M: SY='M';  M= -60, -71, -83, -76,   2, -83, -73,  58, -73,  11,  79, -75, -76, -23, -74, -69, -28,  59, -75, -54;
/M: SY='V';  M=  20,   2, -79, -74, -30, -73, -24,  42, -73,  35,  11, -73, -76, -70, -74, -22, -37,  55, -76, -16;
/M: SY='G';  M= -55,  45,  51,   8, -76,  54,   7, -39, -61, -48, -37, -48, -66, -59, -68,   9,  49, -68, -85, -70;
/M: SY='Y';  M= -70, -80, -72, -73,  24, -78,  50,  11, -67, -23, -49, -69, -81, -63, -65, -34, -65, -28,  53, 114;
/M: SY='I';  M= -41, -73, -80, -75,   5, -84,   9,  70, -66,  16,  12, -73, -77, -68,  24, -69, -58,  47, -75, -54;
/M: SY='L';  M= -64,  14, -84, -77, -11, -84, -69,  32, -76,  72,  56, -79, -80, -70, -75, -38, -61,  -2, -72, -53;
/M: SY='G';  M= -11, -76, -26, -45, -47,  77,  -4, -78, -56, -26, -17,  20, -69,  42,  17, -31, -63, -75, -75, -69;
/M: SY='I';  M= -64, -71, -70, -74, -26, -77, -67,  60, -70,  54, -38,  56, -33, -68, -73, -67, -57,   9, -76, -58;
/M: SY='G';  M= -11,  10, -60, -65, -77,  77, -66, -77,  29, -45, -68,   9, -67, -60, -61, -28,  38, -71, -77, -72;
/M: SY='D';  M= -67, -81, 114, -33, -87, -41, -53, -85, -53, -84, -82,  -1,  -6, -54, -11, -55, -57, -82,-100, -71;
/M: SY='R';  M= -67, -82, -65, -53, -72, -78, -53, -39, -26, -30,   9, -58, -76, -42, 112, -62, -65, -70, -75, -61;
/M: SY='H';  M= -65, -78, -23, -55, -69,   6, 137, -49, -58, -70, -57,  18, -69, -50, -55, -34, -17, -81, -98, -43;
/M: SY='N';  M=   9,  31, -58, -63, -67,  12, -61, -61, -62,  27, -56,  67,  57, -61, -68,  -5, -20, -45, -81, -69;
/M: SY='D';  M= -38, -76,  72,  29, -82,  45,  29, -83, -39, -80, -41,  16, -66,   4, -61,  23, -57, -79, -86, -69;
/M: SY='N';  M= -62, -68, -38, -55, -76, -52, -44, -74,   5, -79,  11, 119, -72,   1, -53, -46, -48, -76, -92, -70;
/M: SY='I';  M= -66, -75, -87, -81,   0, -86, -77,  79, -77,  41,  47, -79, -77, -72, -78, -75, -62, -10,  74, -50;
/M: SY='M';  M= -65, -70, -82, -73, -21, -81, -13, -19, -71,  67, 101, -76, -78, -17, -69, -73, -62, -27, -69,   4;
/M: SY='I';  M= -63, -71, -84, -79,  26, -86, -75,  60, -76,  45,  30, -78, -79, -74, -77, -72, -37,  47, -71, -36;
/M: SY='D';  M= -20,  -7,  81, -43, -52, -45,   9, -74,  33, -75, -70,  -1, -66, -52,  -6,   7,  43, -45, -89, -66;
/M: SY='K';  M= -43, -44,  11,  20, -66, -55, -18, -17,  52, -21,  36, -29, -21,  31,  30,   1, -17, -53, -72,  22;
/M: SY='D';  M= -50,  15,  56,  23, -34, -33, -18, -13,  10, -13, -43,  30, -67,  12, -25,   4,  28, -40, -82, -16;
/I:         I=-9; MD=-23;
/M: SY='T';  M= -70, -16,   1, -20, -84, -39, -28, -84, -25, -64, -81, -45, -80, -73, -78,  26,  65, -77, -35,  -9; D=-9;
/I:         I=-9; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='G';  M= -11, -24, -68, -75, -36,  90, -72,  -6, -70, -17, -23, -55, -70, -68, -76, -52, -40, -14, -74, -71;
/M: SY='H';  M= -49, -78,  -4,  49, -75, -16,  78, -72,  55, -38, -61, -23, -65,  22,   7, -48, -39,  -8, -81, -59;
/M: SY='L';  M= -44,  27, -82, -76,   4, -83, -73,  46, -75,  51,  38, -77,   7, -72, -76, -71, -41,  36, -73, -20;
/M: SY='F';  M=  -3, -70, -77, -76,  53, -48, -74,  53, -72,   2, -10,   6, -76, -73, -74, -27, -15,  46,  21, -48;
/M: SY='H';  M=   2, -78, -56, -56, -70, -20, 129, -44, -59, -48, -56,  10,  35, -52, -58, -34, -35, -39, -93, -47;
/M: SY='I';  M= -24, -76, -81, -77, -53, -84, -81,  96, -42, -37, -39, -72,  -8, -30, -35, -30, -32,  20, -75, -59;
/M: SY='D';  M= -67, -80, 114, -18, -37, -65, -53, -83, -28, -81, -80, -15, -67, -54, -62, -31, -57, -81, -93,   2;
/M: SY='F';  M= -47, -72, -73, -74,  97, -77,  61, -51, -71,  18, -48,  24, -82, -72, -69, -68, -64, -56, -51,  37;
/M: SY='G';  M= -45, -75,   4, -67, -80,  89, -65, -84, -36, -41, -72,  24, -69, -61,   1,  -9, -63, -80, -77, -74;
/M: SY='F';  M= -67,  49,   1, -68,  63, -79,  61,   2, -22,  20,  -2, -66, -14, -68, -51, -68, -62,   8, -62,  40;
/M: SY='C';  M=  35,  85,   3, -19,  15, -69, -70,  40, -69,   3,  21, -65, -75, -67, -73,   3, -57, -32, -76, -34;
/M: SY='F';  M= -70, -70, -86, -80,  92, -84, -68,  -6, -78,  58,  19, -79, -84, -78, -75, -75, -65, -28, -54, -33;
/M: SY='P';  M= -57, -79,  27,  49, -80,  48, -61, -78, -56, -50, -71,  16,  62, -53, -31,   0, -23, -48, -20, -74;
/M: SY='Q';  M= -24, -74,   1,  19, -13, -38,  30, -43,  29, -36, -33,  35, -29,  45,   5,  13,   5, -24,   4,  -8;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='G';  M= -46,  -1, -24,  -6, -79,  53, -69, -51, -17, -73,  42, -57,  35, -27, -70,  17,  35, -59, -83, -74; D=-28;
/I:         I=-28; DM=-70;
/M: SY='D';  M= -43, -82,  50,  -8,  -1, -45, -12, -72,  42,   0, -65, -12,  46,   3,  14, -62, -29, -73, -81, -66; D=-28;
/I:         I=-28; DM=-70;
/M: SY='C';  M= -27,  39,  -5,  17,  15,  16, -67,   8, -32,   3, -33, -25, -74, -43,  18,   3,   8, -15, -77, -39; D=-28;
/I:         I=-28; DM=-70;
/M: SY='W';  M= -63, -75,  34,   4,  14,  23, -63, -58, -64,  41, -53,  23, -74, -15, -68, -23,   0, -61,  74, -21; D=-28;
/I:         I=-28; DM=-70;
/M: SY='P';  M= -30, -81, -67, -19,  27, -53,  43,   9,   8, -25, -14, -65,  76, -35,  29, -63, -26, -16,  13, -31; D=-28;
/I:         I=-28; DM=-70;
/M: SY='N';  M= -10, -72, -13,   6,  10, -15, -59,   8,  28, -28, -55,  38, -51, -12, -20, -20,   0,  23, -69,  37;
/M: SY='P';  M= -43, -83, -69, -61,  48, -45, -63, -28, -41, -66, -62,  -8,  92, -25,  31, -63, -20, -68,  53,  27;
/I:         I=-25; MD=-63;
/M: SY='E';  M= -67, -85,  18,  91, -23, -81,   9, -80, -33, -11, -38, -61, -65,   5, -59, -64, -66, -77, -85, -71; D=-25;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='R';  M= -21, -45, -68, -17, -69, -77,  10,  -7,  14,  -2, -40, -11,  31,  -6,  36, -12,  10, -30, -79,  12; D=-25;
/I:         I=-25; DM=-63;
/M: SY='W';  M=  19, -76, -85, -75, -63, -78, -84, -14, -75, -55,  15, -79,   0,  -5, -78, -24, -61,  69,  83, -63; D=-25;
/I:         I=-25; DM=-63;
/M: SY='P';  M= -38, -94, -41, -61, -87, -73, -18, -76, -68, -38, -72, -77, 118, -71, -80, -68, -64, -81, -84, -85; D=-25;
/I:         I=-25; DM=-63;
/M: SY='F';  M= -75, -77, -86, -77, 105, -85, -68,  -8, -75, -25,  29, -76, -85,  37, -73, -74, -69, -56, -50, -15; D=-25;
/I:         I=-25; DM=-63;
/M: SY='R';  M=   9, -81, -68, -56, -76, -76, -62,  -9,  44, -71, -64, -61, -75, -49,  86, -40, -64,  -7, -80, -68; D=-25;
/I:         I=-25; DM=-63;
/M: SY='L';  M= -65, -71, -79, -71,  17, -80, -67, -27, -31,  77,   0, -76,  25, -67, -24,  -5, -61, -45, -69, -53;
/M: SY='T';  M= -54,  -9, -59, -26,   7, -69, -65, -27, -36, -37, -58, -14, -28, -61, -38,   0,  99, -26, -79,  -4;
/M: SY='P';  M= -45, -82, -18, -30, -73, -28,  42, -37,  -3, -74, -63, -57,  75,  36,  56,   2, -23, -57, -75,  10;
/M: SY='W';  M= -64, -77,  52,  42,  19, -44, -30, -54, -53, -69,  25,  67, -31,  25, -59, -56, -35, -72,  74,  -6;
/M: SY='M';  M= -11, -71, -79, -75,  39, -52, -66,  48, -71,  26,  84, -70, -75, -67, -71,   9, -37,  -8, -66,   7;
/M: SY='W';  M= -10, -34, -14,   3, -38, -45, -70,  23, -38,  -3,   8, -66, -39,   3, -17,   2,  -2,  55,  56, -23;
/M: SY='D';  M= -35, -76,  61,  46, -41, -69,  15, -16, -28,  -2,  10,  30, -67,  -2, -35, -20,  -9, -51, -76,  30;
/M: SY='P';  M=  30, -71, -69,  -3,  25,  25, -70,  -7, -67,   9, -53, -66,  36, -66, -72, -47,  -1,  31, -71, -17;
/M: SY='M';  M= -47, -72, -81, -72,  18, -81, -64,  44, -69,  36, 100, -73, -76,  22, -37, -70, -61,  -2, -70, -50;
/I:         I=-22; MD=-55;
/M: SY='G';  M=  -4, -80,  13, -25, -84,  75, -69, -85, -43, -37, -74, -14, -73,   3, -14, -12, -38, -80, -82, -77; D=-22;
/I:         I=-22; MD=-55;
/M: SY='Y';  M= -85,-105, -48, -35, -84,  34, -84, -62,  -5, -46, -89, -50, -39, -25, -87, -29, -66, -97, -88,  39; D=-22;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='D';  M= -33,-100,  26,   4,-101, -43, -84, -92,  -2, -77,  12, -17,  17, -45, -47, -78,   4, -47,-108, -94; D=-22;
/I:         I=-22; DM=-55;
/M: SY='P';  M= -31,  -3,  15,   1,  22, -48,  -2,  20,  -3, -41, -57,  15,  60, -13, -65, -23, -14,  29, -77, -60;
/M: SY='S';  M=  -6, -35, -25,   2,  -6, -24, -33, -15, -60,  -4,  15, -53, -49, -57, -65,  62,  58, -18, -79, -61;
/M: SY='G';  M= -38, -16,   5,  30, -53,  56, -13, -57,  37, -52, -67, -51, -13,  54, -35, -33, -30, -75, -74, -20;
/M: SY='D';  M= -27, -74,  41,  21, -10, -57,   7,  18, -26, -13,   6,  -9, -15,   4, -11, -44,  19,  28, -77,   6;
/M: SY='E';  M= -29,  12,  -9,  57,  52, -26, -59,  11, -47, -39,   1, -18, -69, -25, -63, -22,   9, -45,  22,  43;
/M: SY='G';  M= -24, -77,  21,  20, -81,  68,  -2, -82,   4, -48, -69, -12, -67,  39,  14, -31, -41, -77, -77, -70;
/M: SY='L';  M= -54, -73,  18, -25, -40, -59, -63,   3,   7,  29,  17, -12,   8,  13,  -6,  -1,  14,  14,  26,   3;
/M: SY='F';  M= -72, -72, -84, -79,  98, -83, -16, -35, -76,  44, -16, -77, -85, -78, -73, -74, -66, -42, -47,  45;
/M: SY='R';  M= -34, -45, -37, -45, -14, -46, -60,  -7,  37, -22,  -1, -17, -72,  11,  70, -21, -25,  19,  36, -18;
/M: SY='R';  M= -13, -72,   9,  24,  -7, -35, -29, -19,  10,   9, -12, -29, -31,  -4,  30,  29,  14, -20, -75, -25;
/M: SY='C';  M= -24,  46, -63,  -2, -58, -53,  40, -25, -62,  23,  32,  11,  15, -32, -38,  29,  20, -11, -76,  18;
/M: SY='C';  M= -19, 122, -76, -73, -51,  -7, -71, -10, -16,  -4,  57, -64, -80, -69, -32,   2, -44, -29, -85, -41;
/M: SY='E';  M= -16,  51, -26,  55, -11, -50, -10,  23, -11, -12,   6, -66,  -8, -35, -63, -62, -43,  23,  52,   4;
/M: SY='H';  M=  11, -71, -41,  10, -17, -65,  34, -18,  24, -38,   9,   4, -67,  32,   7,  29,  18,   2, -77, -20;
/M: SY='T';  M=  41, -14,   3, -64, -65,   5, -71,  25, -65, -33, -15, -58, -68, -64, -70,   6,  50,  32, -81, -66;
/M: SY='Y';  M=  -6,  -7, -74, -46,  34, -57, -57, -48, -34,  34,  58, -70,  20, -32,   6, -26, -25, -27, -57,  64;
/M: SY='N';  M= -32,  14, -23,  31, -69, -32,   1,  -5,   6,   6, -58,  49, -18,   4,  46, -12,  -5, -63, -21, -64;
/M: SY='A';  M=  41,  34, -73, -31,   8, -69,  -9,  24, -67,  13, -29, -67, -73, -14, -70,   3,   0,  32,  31, -30;
/M: SY='M';  M=  -5,  43, -82, -75,  18, -78, -69,  12, -74,  56,  59, -75, -79, -70, -73, -31, -34,  13,  31, -21;
/M: SY='R';  M= -10, -78, -63, -17, -71, -57, -56,  -9,  10, -19, -60, -57, -72,  12,  93,   8, -37, -65,   6, -62;
/M: SY='R';  M= -37, -77,  35,  12, -79, -67, -23, -78,  55, -76, -67,   6, -16,  33,  55,  11,  -2, -74, -80, -66;
/M: SY='H';  M= -61, -44, -10,  18, -63, -32,  62, -61, -56,   5, -57,  59,  28,  13, -44,   5, -18,   3, -78,  22;
/M: SY='K';  M=  -1,  25, -14,   1, -37, -34, -20, -62,  31,  10,  18,  -3,  15,   2,   0,  28,   5, -42, -22, -16;
/M: SY='E';  M= -62, -77,  51,  53,  -9, -11,   7, -38, -15, -53, -65,  44, -45,  13,  13, -44, -32,  -8, -78,   3;
/M: SY='L';  M=  -7, -72,  28,   0, -60, -46, -20,  12,  12,  29, -16, -40, -51,   5, -20,  11,   6,  10, -77, -11;
/M: SY='L';  M= -63,  33, -82, -77,  32, -83, -73,  50, -54,  56, -19, -75, -80, -73, -75, -10, -38,  22, -70, -51;
/M: SY='M';  M= -46, -32,  -6, -68,  -5, -77, -40,  26, -40,  32,  78, -30, -73, -64, -37, -36,  38,  15, -72,  15;
/M: SY='N';  M=   0,   2, -27,   7, -69, -32, -31,  -4, -54, -39,  43,  59, -68,  11,  -7,  32,  34, -14, -83, -65;
/M: SY='L';  M= -51, -40, -78, -74,  16, -81, -69,  41, -53,  53,  18, -26,  -9, -70, -73, -36,   1,  26, -69,  12;
/M: SY='L';  M= -66, -34, -85, -78,  60, -84, -70,   1, -77,  65,  26, -80, -45, -74, -75, -74, -44,  23,   2, -44;
/M: SY='E';  M= -16, -20,  23,  61, -77, -34, -36, -74,  42, -34, -66,  20, -63,  12,  -9,  22, -27, -41, -80, -48;
/M: SY='M';  M=   7, -29, -68,  -2, -58, -73, -67,  14,   2,  27,  37, -26, -28,   3, -25, -27,  28,  27,  36, -59;
/M: SY='M';  M=  -6, -30,  31, -67,  66, -14, -62, -11, -47,  13,  89, -34, -75, -67, -69, -65, -61, -21, -64, -16;
/M: SY='V';  M=   9, -71, -69,  -8, -58, -74, -67,  23,  10,  31,   7, -66, -26,  27,   8, -18, -42,  40, -77, -61;
/M: SY='Y';  M=  -2, -31,  28,  -1,  10,  10,  33, -53,   2, -58, -28, -18, -43,  12,  17, -14, -33, -49,  41,  63;
/M: SY='D';  M=  19, -37,  81,  -1,  26, -24, -57, -73, -37, -71, -21,  -3, -39, -55, -10,  16,  -4, -69, -78, -12;
/M: SY='P';  M= -43, -79,  25,  20, -82,  45, -61, -78, -25, -67, -71,  34,  77, -56, -15,  -7, -34, -61, -81, -75;
/I:         I=-18; MD=-45;
/M: SY='L';  M= -72, -79, -37, -81, -22, -48, -76,  38, -63,  54,   5,   1, -86, -76, -81, -20, -35, -14, -80, -18; D=-18;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='P';  M= -79, -92, -89, -81,  35, -89, -36, -15, -82, -21,  22, -87,  70, -83, -86, -80, -27,  -3,  28,  30; D=-18;
/I:         I=-18; DM=-45;
/M: SY='C';  M= -68,  69,  52,  27, -84, -49,  -5, -25, -28, -81, -77,  -3, -76,  27, -68,  16, -30, -78,  29, -74; D=-18;
/I:         I=-18; DM=-45;
/M: SY='W';  M= -69, -11, -80, -23,  27, -71, -19,  -1,   2,  39,  25, -77, -34, -64,   0, -73, -69, -56, 127,   0;
/M: SY='T';  M=  16, -70,   1, -54, -72, -18, -61, -14,  33, -42,  -4,   1,   2,  -1,  25,  34,  42, -51, -80, -66;
/M: SY='C';  M=   5,  44, -35,  12, -34,  -9, -33,  -1,   3,   2,  32,  16,  -5, -12,  -5,  14,   2, -17,   3, -63;
/M: SY='F';  M= -38, -74,   7,  -9,  59,  -2,  19,   8,  -9, -23,  12,   1, -31,  28, -43,  21, -36, -21, -65,   1;
/M: SY='E';  M= -23, -79,  22,  50, -79,  -3,  18, -74,  18, -61,  -9,   3,  47,  24,  18, -24, -23, -31, -81, -68;
/M: SY='D';  M= -10, -76,  42,  25, -14, -13, -37,   2,  21,  -2, -59,   5,  13,  22,   8, -26,  -5, -46, -78, -64;
/I:         I=-20; MD=-51;
/M: SY='Q';  M= -68, -16, -56, -62, -51,  -1, -68, -41,  37, -33,  20,   1, -77,  46,  14,  -6,  23, -74,   2, -72; D=-20;
/I:         I=-20; MD=-51;
/M: SY='M';  M= -20, -88, -81, -35, -84, -17, -79, -38,   0, -34,  57, -23, -37,  10, -59,  14,  -4, -16, -96, -80; D=-20;
/I:         I=-20; MI=0; MD=-51; IM=0; DM=-51;
/M: SY='I';  M= -10, -71, -38, -40, -45, -32, -21,  50,  -6,  10,  -5, -16, -43, -60,  -3,  40,  12,   6, -76, -22;
/M: SY='K';  M= -11, -75, -26,  18, -46, -21, -35, -14,  34, -25, -28, -28,  25,  17,  31, -15, -42,  31, -75,   1;
/M: SY='M';  M= -33, -74, -31,  -1,   1, -28, -17, -19,  36,  13,  55,  27, -71,  36, -20, -38, -59,  -9, -66,  39;
/M: SY='C';  M= -12,  50, -17, -32, -12, -19, -63,  -5,   9,  26, -51,  20, -74,   2,  22, -10, -22,  16, -76, -19;
/M: SY='R';  M= -18, -78, -31,  -4, -26,  34, -15,  -8,  29, -18, -61, -19,  -3,  29,  56, -19, -48, -66, -73, -30;
/M: SY='Q';  M=   7, -76,  36,  42, -79, -23,  15, -59,  12, -41, -64,  16, -35,  69, -22,  -7, -28, -32, -81, -66;
/M: SY='R';  M=  12, -73, -22, -10, -44,   5, -11,   7,  10,  -9, -16,  21, -51, -28,  52, -12,  10, -36,  32, -62;
/M: SY='F';  M= -36, -72, -40,   6,  58, -36, -27,  -7, -16,  40,   7,  -1, -34,  -2, -29, -31,  -5, -18, -63,  11;
/M: SY='N';  M= -13,  -4, -16,   6, -39,  -7,  41, -37,   5, -70,  -3,  48,  -2,  26,  31,  16,   2, -24, -14, -63;
/M: SY='L';  M=  -8, -73,   3,  17, -22,  -4,   5, -10,  -5,  38,   7, -12,  33, -58, -50, -11, -19, -18, -74,  -6;
/M: SY='D';  M= -59, -75,  34,  16, -40,  23, -16,  12,  -6, -57, -15,  34,   4,  22, -22,  -5,   5,   0, -14, -19;
/M: SY='M';  M= -44, -71,  11,  24, -65, -33, -57, -56,   9,  18,  61,  33, -35,  20, -45,  32, -19, -12, -80, -63;
/M: SY='T';  M=   0, -12,  -4,  -9, -20, -49, -62, -47, -38, -14, -15,  24,  -1,  -8, -45,  41,  52,  14, -79, -13;
/M: SY='E';  M= -24, -75,  43,  51, -68, -46, -59,  12, -31,   3,  12,  21,  -7,  -3,  -6,  -5,  -6, -26,  -4, -65;
/M: SY='E';  M=  -6, -76,   1,  68, -75, -60,  13, -48,  23, -27, -45, -37, -29,  32,  11,   3,   3, -32, -16, -65;
/M: SY='E';  M=   5, -76,  52,  58, -39, -11,  13, -71,   2, -38, -26,  10, -47,  25, -20, -28, -22, -17, -82, -66;
/M: SY='A';  M=  48,  32, -15, -17, -68,   5, -65,  -8, -30,   9, -16,  12,  11, -16, -38,   5,  -5, -32, -14, -67;
/M: SY='W';  M=  10,  23, -12, -46, -61, -33, -67,  18,  22,   8, -52,  -7, -36, -15,  -2,  -4,  26,  20,  32, -28;
/M: SY='Q';  M= -31, -72, -18,  22, -21, -43,  25, -27,  13,  -2,  14,   9, -46,  34, -14,  33,  20,  -5, -76, -11;
/M: SY='H';  M= -25, -76, -25,  28,  38,  -1,  41, -38,   3,   2, -57,   1,  31,  -6,   0, -14, -22, -54, -67,  23;
/M: SY='F';  M=  18, -29, -28, -41,  45, -61, -69,  35,  -7, -14,  27, -67, -18, -11,  12, -26, -45,  37, -70, -52;
/M: SY='Q';  M= -29, -75,   2,  25, -33, -44,  33,   7,   3,   9,  38, -26, -53,  58,   4, -32,   3, -19, -76, -22;
/M: SY='D';  M=  -2, -34,  36,   8, -74, -10, -12, -51,  30, -14, -62,  25, -48,  28,  16,  18,   1, -22, -81, -66;
/M: SY='L';  M=  12,  11,  14,  -7, -30, -31, -30,   0,  -7,  31,  30, -43, -38,  25, -35, -11, -45,  23, -77, -39;
/M: SY='I';  M= -32,  19, -69, -11,  -8, -58, -12,  56, -15,  10, -19,  -2, -57,  14, -42, -18,   0,  34, -76, -22;
/M: SY='M';  M= -48,  -8,  19,  31, -40, -19,  -3, -16, -10, -16,  31,  21, -18,  24,  11,  22,   8, -29, -79, -12;
/M: SY='E';  M=   1, -75,  17,  41, -74,   6,   4, -40,  -3, -20, -63,   4,  34,  -6,  -7,  17,  -4, -16, -80, -42;
/M: SY='S';  M=  28,  21, -15, -38, -68, -23, -64,   9,  13,  -7, -58, -10,  13, -24,   1,  46, -16, -20, -78, -30;
/M: SY='V';  M= -29, -71,   7, -25, -10, -57,  -3,  19, -41,  13,  32,   1, -36, -34,   3,   1,  21,  34, -76,   7;
/M: SY='N';  M= -13,   0,   8,   7, -43,  -8, -11, -11,   1,  -9, -38,  37, -21,  13,  14,  29,   3, -19, -80, -25;
/M: SY='S';  M=  18, -16,  -5,  32, -68,   3, -32, -51,  -5,   0, -59, -21, -22,   3,   5,  33, -15,   1, -77, -13;
/M: SY='W';  M=  14, -73,  23,  20,   5, -38,  -6,   5,  -7,  15, -55,   4, -18, -28,  -6,  14, -27, -12,  27, -59;
/M: SY='W';  M= -13, -16, -11, -16,   9, -27,  -4, -25,  16, -10,  17,  21,  11, -57,  25, -19,  37, -21,  51, -57;
/I:         E1=0; IE=-380; DE=-380;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	168 in 168 different sequences
Number of true positive hits	168 in 168 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	PI3K/PI4K catalytic
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

168 sequences

AGE1_CAEBR  (P0C5E7), AGE1_CAEEL  (Q94125), ATM_ARATH   (Q9M3G7),

ATM_ASPFU   (Q4WVM7), ATM_ASPOR   (Q2U639), ATM_CAEEL   (Q9N3Q4), 
ATM_CANAL   (Q5ABX0), ATM_CANGA   (Q6FRZ9), ATM_CRYNB   (P0CP61), 
ATM_CRYNJ   (P0CP60), ATM_DEBHA   (Q6BV76), ATM_DROME   (Q5EAK6), 
ATM_EMENI   (Q5BHE2), ATM_EREGS   (Q751J3), ATM_GIBZE   (Q4IB89), 
ATM_HUMAN   (Q13315), ATM_KLULA   (Q6CP76), ATM_MOUSE   (Q62388), 
ATM_NEUCR   (Q7RZT9), ATM_PIG (Q6PQD5), ATM_SCHPO   (O74630), 
ATM_YARLI   (Q6CAD2), ATM_YEAST   (P38110), ATR1_DICDI  (Q54ER4), 
ATR_ARATH   (Q9FKS4), ATR_CAEEL   (Q22258), ATR_CANAL   (Q59LR2), 
ATR_CANGA   (Q6FX42), ATR_DROME   (Q9VXG8), ATR_ENCCU   (Q8SSE7), 
ATR_EREGS   (Q75DB8), ATR_HUMAN   (Q13535), ATR_KLULA   (Q6CT34), 
ATR_MOUSE   (Q9JKK8), ATR_ORYSI   (A2YH41), ATR_ORYSJ   (Q5Z987), 
ATR_XENLA   (Q9DE14), ATR_YEAST   (P38111), LSB6_SCHPO  (Q9UT42), 
LSB6_YEAST  (P42951), MTOR_HUMAN  (P42345), MTOR_MOUSE  (Q9JLN9), 
MTOR_RAT(P42346), P3C2A_HUMAN (O00443), P3C2A_MOUSE (Q61194), 
P3C2A_PONAB (Q5RAY1), P3C2B_HUMAN (O00750), P3C2G_HUMAN (O75747), 
P3C2G_MOUSE (O70167), P3C2G_RAT   (O70173), P4K2A_DANRE (Q6PE18), 
P4K2A_HUMAN (Q9BTU6), P4K2A_MOUSE (Q2TBE6), P4K2A_RAT   (Q99M64), 
P4K2A_XENLA (Q08B31), P4K2A_XENTR (Q505I0), P4K2B_CHICK (Q5ZIK0), 
P4K2B_DANRE (Q49GP5), P4K2B_HUMAN (Q8TCG2), P4K2B_MOUSE (Q8CBQ5), 
P4K2B_RAT   (Q5XIL2), P4K2B_XENLA (Q6DCQ8), P4K2B_XENTR (Q28G26), 
P4KA1_ARATH (Q9SXA1), P4KA2_ARATH (Q9C680), P4KB1_ARATH (Q9FMJ0), 
P4KB2_ARATH (Q0WPX9), P4KG1_ARATH (O22199), P4KG2_ARATH (Q9SGW8), 
P4KG3_ARATH (Q9FNF8), P4KG4_ARATH (Q9ZPY9), P4KG4_ORYSJ (Q6K881), 
P4KG5_ARATH (Q9C671), P4KG6_ARATH (Q8W4R8), P4KG7_ARATH (Q9SI52), 
P4KG8_ARATH (Q0WMZ6), PI3K1_DICDI (P54673), PI3K1_SOYBN (P42347), 
PI3K2_DICDI (P54674), PI3K2_SOYBN (P42348), PI3K3_DICDI (P54675), 
PI3K4_DICDI (P54676), PI3K_ARATH  (P42339), PI4KA_BOVIN (O02811), 
PI4KA_HUMAN (P42356), PI4KA_MOUSE (E9Q3L2), PI4KA_RAT   (O08662), 
PI4KB_BOVIN (O02810), PI4KB_CALJA (B0KWC1), PI4KB_DANRE (Q49GP3), 
PI4KB_HUMAN (Q9UBF8), PI4KB_MOUSE (Q8BKC8), PI4KB_OTOGA (B4UT09), 
PI4KB_PAPAN (A9X1A0), PI4KB_PLEMO (B1MTG7), PI4KB_RAT   (O08561), 
PI4KB_RHIFE (B2KI64), PI4KB_SORAR (B3EX61), PI4KB_XENLA (Q6GN16), 
PI4KB_XENTR (A4IID4), PI4K_DICDI  (P54677), PI4P2_HUMAN (A4QPH2), 
PIK1A_CANAL (Q9UW24), PIK1_CANAL  (Q9UW20), PIK1_SCHPO  (Q10366), 
PIK1_YEAST  (P39104), PIKI1_CAEEL (G5EDY0), PK3C3_CAEEL (Q9TXI7), 
PK3C3_HUMAN (Q8NEB9), PK3C3_MOUSE (Q6PF93), PK3C3_PIG   (Q5D891), 
PK3C3_RAT   (O88763), PK3C3_XENLA (Q6AZN6), PK3CA_BOVIN (P32871), 
PK3CA_HUMAN (P42336), PK3CA_MOUSE (P42337), PK3CA_RAT   (A0A0G2K344), 
PK3CB_HUMAN (P42338), PK3CB_MOUSE (Q8BTI9), PK3CB_RAT   (Q9Z1L0), 
PK3CD_HUMAN (O00329), PK3CD_MOUSE (O35904), PK3CG_HUMAN (P48736), 
PK3CG_MOUSE (Q9JHG7), PK3CG_PIG   (O02697), PRKDC_CANLF (Q8WN22), 
PRKDC_CHICK (Q8QGX4), PRKDC_DICDI (Q54UC0), PRKDC_HUMAN (P78527), 
PRKDC_MOUSE (P97313), PRKDC_XENLA (Q9DEI1), RAD3_SCHPO  (Q02099), 
SMG1_CAEBR  (Q61CW2), SMG1_CAEEL  (O01510), SMG1_DANRE  (C5J7W8), 
SMG1_DICDI  (Q553E9), SMG1_DROME  (Q70PP2), SMG1_HUMAN  (Q96Q15), 
SMG1_MOUSE  (Q8BKX6), STT4_ENCCU  (Q8SQY7), STT4_SCHPO  (Q9USR3), 
STT4_YEAST  (P37297), TOR1_SCHPO  (O14356), TOR1_YEAST  (P35169), 
TOR2_SCHPO  (Q9Y7K2), TOR2_YEAST  (P32600), TOR_ARATH   (Q9FR53), 
TOR_CAEEL   (Q95Q95), TOR_DICDI   (Q86C65), TOR_DROME   (Q9VK45), 
TOR_ORYSJ   (Q0DJS1), TRA1_DICDI  (Q54T85), TRA1_DROME  (Q8I8U7), 
TRA1_SCHPO  (Q9HFE8), TRA1_YEAST  (P38811), TRR1_CAEBR  (A8WTE8), 
TRR1_CAEEL  (G5EEV2), TRRAP_DANRE (A0A0R4ITC5), TRRAP_HUMAN (Q9Y4A5), 
TRRAP_MOUSE (Q80YV3), VPS34_CANAL (A0A1D8PDV7), VPS34_CANAX (Q92213), 
VPS34_CANGA (Q6FSR7), VPS34_ENCCU (Q8SR56), VPS34_SCHPO (P50520), 
VPS34_YEAST (P22543), YAMB_SCHPO  (Q10064), YL615_MIMIV (Q5UR69)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

464 PDB

1E7U; 1E7V; 1E8W; 1E8X; 1E8Y; 1E8Z; 1E90; 1HE8; 2A4Z; 2A5U; 2CHW; 2CHX;
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