PROSITE entry PS50280

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PURL: https://purl.expasy.org/prosite/signature/PS50280

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General information about the entry

Entry name [info]	SET
Accession [info]	PS50280
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 26-FEB-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50280
Associated ProRule [info]	PRU00190

Name and characterization of the entry

Description [info]

SET domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=130;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=125;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.1733967; R2=0.0052056; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=16593.4804688; R2=2.7213621; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1408; H_SCORE=20425; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=1024; H_SCORE=19380; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-36; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M=  -9,  18,  -3,  39, -24, -56, -31, -97,  16, -25, -93,  13,  69,  15, -29,   4, -30, -21,   3, -39;
/M: SY='K';  M= -62, -13,  -5,   8, -55,  26, -50,-105,  55, -50, -97,  13,  41,  -5,  22,  19, -18, -70, -21, -98;
/M: SY='V';  M= -92,   5,-113,-108,  32,-115,-106,  54,-106,  48,  -5, -62, -52,-105,-107,-101, -43,  55,   7, -81;
/M: SY='E';  M= -20,  38, -48,  70, -99, -38, -29, -25,   6, -64, -92, -45, -95,  42,   1,  10,   2,  -9,-105,  17;
/M: SY='I';  M= -90, -45,-108, -70,  22, -74,-103,  55, -71,  36, -12,-102, -49, -11, -35,  -7, -18,  52,-102, -30;
/M: SY='F';  M=  18,  26, -45, -59,  40, -18, -40, -41,  17,   0, -38,  -1,-104, -89,  30,  14, -27,   6, -96,  30;
/M: SY='R';  M= -33, -41,   6,   4,  -1, -99, -87, -19,  32, -56,   9,   0,  -3,  26,  51,  15,   0, -36,   7,  20;
/M: SY='T';  M= -62,  -2,   0, -41,  20, -70,  -7,  16, -91, -31, -87, -47, -97, -25, -96,  62,  66,  -1,-107, -20;
/I:         I=-15; MI=0; MD=-37; IM=0; DM=-37;
/M: SY='P';  M=   4,  -7,  13,  34,-109,  -7, -94, -40,  15, -39, -39, -31,  69, -24,  -9,  18, -23,-100,-112,-103; D=-15;
/I:         I=-15; MI=0; MD=-37; IM=0; DM=-37;
/M: SY='I';  M= -92, -20,  -3,  26, -43,  22, -56,  31,  -1, -44, -11,  23,-103, -15,   1, -10, -46,  19, -11, -98; D=-15;
/I:         I=-15; DM=-37;
/M: SY='K';  M=   9, -59, -89, -13, -11, -12,  45, -66,  68,-103, -63, -12,   0, -13,  20,  13, -13, -48,-107, -92; D=-15;
/I:         I=-15; MI=0; MD=-37; IM=0; DM=-37;
/M: SY='G';  M= -27,-109, -63,  -2,-115,  96, -42,-120, -47,-116, -41, -21,-100, -95, -47, -45, -98,-114,-108,-108; D=-15;
/I:         I=-15; MI=0; MD=-37; IM=0; DM=-37;
/M: SY='W';  M= -40, -65, -31, -38,  17, -72, -91,  20,  32,  -1,   0, -11,-104, -85,  56, -28, -23, -53,  86,  34;
/M: SY='G';  M= -18,  40, -53,-101, -41,  87, -47,  -7, -64,-105, -98,   1,-100, -94,-103,  19, -55, -72,-105, -21;
/M: SY='V';  M= -37,  25,-112,-107, -42,-112,-105,  37,-105,  55,  29, -45,-109,-103,-105, -99, -42,  63,-108, -87;
/M: SY='F';  M= -94, -17,-103, -32,  67, -68, -24,   5, -29, -46,  16,  -1,-108, -95,  34, -96, -33,  47,  45,  41;
/M: SY='A';  M=  77,  63, -95, -39,-101, -86, -98, -71, -62, -34, -90, -30, -98, -90, -97,  34,  29, -19,-111,-100;
/M: SY='T';  M=   6, -41,   3,  -9, -96, -98, -91,  -6,  46,  21, -51,  12, -69,  -2,   9, -14,  49, -65, -34, -93;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='R';  M= -18,  23,  14,  37, -55, -27, -45, -54,  42, -67, -94,  17, -97,  27,  53, -27,   6, -32,-109, -96;
/M: SY='D';  M= -24,  -9,  82,  26, -15, -59, -64,-104,   7, -20, -98,  -2,  14, -28,  -6,  11, -20,-101, -15, -38;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='I';  M= -48, -17,-114,-110,  28, -84, -60,  89,-106,  31, -15,-107,-107,-104, -69,-102, -90,   0,  11,  -8;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='P';  M=   7,-110,   6,  18,-109, -35, -39, -67,  38, -53, -96,   4,  65,  30,  26, -27, -51, -42, -22,-100; D=-36;
/I:         I=-36; DM=-90;
/M: SY='K';  M=  28,-107, -14,  24, -68, -98, -92, -18,  66, -60, -93, -40,  30,  14,   7, -31, -88, -22,-106, -23; D=-36;
/I:         I=-36; DM=-90;
/M: SY='G';  M= -28,-106,  39,  -1,-111,  85, -56,-114, -90, -58,-102,  33, -98,  -7, -25, -40, -92,-109,-109,-104;
/I:         I=-2; MD=-4;
/M: SY='E';  M= -20,-104,  27,  72, -27, -71, -31,-100, -42, -37, -36,  -8, -93,  42, -48, -40,  59, -68,-112, -96; D=-2;
/I:         I=-2; MD=-4;
/M: SY='L';  M= -49, -11, -38, -12,-105,-119, -15, -10, -14,  19, -20, -66, -11,  -9, -14,  -4,  -7,  13, -26,-106; D=-2;
/I:         I=-2; MD=-4;
/M: SY='I';  M=-109,-118,-122, -19,  35,-127,-117,  44,-117,  25,  -8,-119,-123, -47, -74,  -6,-104,   2,-114, -95; D=-2;
/I:         I=-2; MD=-4;
/M: SY='F';  M= -53,-122,-124, -72,  40,  12, -45,  18,-120,  19, -38, -38,-126, -30, -70, -61, -63, -41,   5, -97; D=-2;
/I:         I=-2; MD=-4;
/M: SY='P';  M= -20,-126, -60, -42,-125,-115, -22,-120,  32, -63, -31, -39,  32,  22,   8,   3, -17, -74, -10,-115; D=-2;
/I:         I=-2; MD=-4;
/M: SY='E';  M= -79,  28, -25,  30,   7,-131,-117,   8, -68, -27,-103,-118,-125, -19,-118, -79,-111,  20,-122,   3; D=-2;
/I:         I=-2; MD=-4;
/M: SY='P';  M= -78,-134, -29,  -3,-129,-123, -15, -76,  -9, -61,-116, -34,  66,  -5, -20, -43, -20, -32,-133, -62; D=-2;
/I:         I=-2; MD=-4;
/M: SY='P';  M=  -3, -26, -71, -36, -49,   2,-118, -71,  -9, -39,-115, -54,  38, -46,   5, -33, -69, -31,-130,-121; D=-2;
/I:         I=-2; MD=-4;
/M: SY='Y';  M= -73, -42, -34,  15, -26,-124,-110,-115, -30, -11, -39, -55, -16, -10,   1,   2, -21, -77, -26,  26; D=-2;
/I:         I=-2; MD=-4;
/M: SY='I';  M= -23, -32,-125, -40, -35,-129, -40,  30, -46, -10, -48, -29, -66,-119,-124,  -9, -37,   7,-130, -36; D=-2;
/I:         I=-2; MD=-4;
/M: SY='W';  M= -23,   4,-134,-127, -70, -55,-130, -11, -52,   2,-107,-127, -37, -23, -50, -39, -33,   6,  45, -42; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='E';  M= -24,  -4, -34,   9, -71, -57, -52, -10, -19,  -7,-110, -62, -50, -25, -64,  -4, -26, -52,-131, -31; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M= -46, -34, -15, -40, -15, -76, -39, -25,  -7, -36,  -9,  43, -22, -52, -41,   9, -69, -70,-131, -62; D=-2;
/I:         I=-2; DM=-4;
/M: SY='K';  M= -43,-124,-112, -10, -37,  -2, -17, -17,   0, -12,  -5, -35,  -1, -11, -67,  -3, -26, -22,-125, -49; D=-2;
/I:         I=-2; DM=-4;
/M: SY='W';  M= -21,   4, -16, -12,  -3,-121,  -1,-115, -61,  -8, -16, -29, -58,  -7, -30,  10, -19, -78,  28,-109; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M= -29, -51,  14, -11,  -6, -81,  10,  -8, -53, -26, -12, -39,-124,  -5, -41,  -6, -31, -37, -15,-110; D=-2;
/I:         I=-2; DM=-4;
/M: SY='T';  M=  -7, -39, -30, -13, -71, -55, -44, -27, -40, -23,  -2,  -3, -12, -23, -69,   1,   5, -59, -15, -23; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M= -37,   6, -61, -41, -34, -62,-114, -31, -34,  11, -41,   8, -18, -25, -28,  20, -40, -39,-129,-113; D=-2;
/I:         I=-2; DM=-4;
/M: SY='W';  M= -21,  24, -28, -26,  -1, -67,  13, -13, -30,  -9,-101,  12,-121, -20, -19, -14, -57, -15,  37, -20; D=-2;
/I:         I=-2; DM=-4;
/M: SY='H';  M= -35,   1,  -8, -66, -54, -35,  37,  -1, -70, -14,  -1, -13, -32, -14, -15,  20,   2, -46,-126, -51; D=-2;
/I:         I=-2; DM=-4;
/M: SY='W';  M= -16,   5, -48, -31,   5, -14, -33, -76,  -5, -20,-104, -12,  19, -23, -16, -14, -39, -18,  50, -27; D=-2;
/I:         I=-2; DM=-4;
/M: SY='F';  M= -40, -46, -67, -50,  81, -71,-101, -74,-107,  49,   9,-108, -11,-107,-107,-102, -15,   5,  -6,  -5; D=-2;
/I:         I=-2; DM=-4;
/M: SY='I';  M= -56,-104,-115,-111, -10, -79,-109,  77, -63,  21,  24,-108,-109,-105,-108,-103, -89,  54,-105, -17; D=-2;
/I:         I=-2; DM=-4;
/M: SY='C';  M= -48,  97, -51, -51,  13, -35,-100,  16, -45,   8,  23, -27,-109, -19,  -9,  -5,  -1, -39,  66,  -5; D=-2;
/I:         I=-2; DM=-4;
/M: SY='E';  M= -22, -38, -21,  96,-107,-103, -39, -30,  20, -73, -97, -85, -90, -17,  17, -18, -42, -44,-108, -42;
/I:         I=-1; MD=-2;
/M: SY='T';  M= -56, -27, -12,   0, -10, -23, -45, -11,  15, -26, -13,  -5, -14, -31,  -2,   5,  26, -27,-109,  22; D=-1;
/I:         I=-1; MD=-2;
/M: SY='C';  M= -16,  44,-105, -20, -21, -25,-106,   4,-104,  15, -35,  28, -67, -44, -45,   5,   5, -39,  19, -27; D=-1;
/I:         I=-1; MI=0; MD=-2; IM=0; DM=-2;
/M: SY='G';  M= -76,-122, -30,  -2, -15,  20,   8,-112, -67, -10, -39,   9,  -2, -45,  15, -14, -29, -56,-119,  -7; D=-1;
/I:         I=-1; DM=-2;
/M: SY='P';  M= -44,-123,   3,  -6, -58,  -3,-113, -13, -34,   0,-103, -24,   8, -69,  -7, -27, -40,  -3,-126, -47; D=-1;
/I:         I=-1; DM=-2;
/M: SY='V';  M= -45,  -9, -70,-118, -44, -50, -39,  13, -38, -17, -43,   7, -54,  -8, -64,  -5, -44,  16,-131, -56; D=-1;
/I:         I=-1; DM=-2;
/M: SY='F';  M= -59,-130,   3, -22,   3, -74,  -8, -22, -85,   1,-108,  -7, -57, -35,-122,  -7, -70, -23,-129, -14; D=-1;
/I:         I=-1; DM=-2;
/M: SY='F';  M= -51,  -6, -20,  -7,  11, -51, -39, -69,  -6, -66, -20,   0, -74, -24, -67, -58, -68, -48, -12,   8; D=-1;
/I:         I=-1; MI=0; MD=-2; IM=0; DM=-2;
/M: SY='W';  M= -37,   0, -53, -65,-114, -55, -17,  -2, -61, -29, -61,-121, -20, -14, -25,  -2, -86, -55,  38,  19; D=-1;
/I:         I=-1; DM=-2;
/M: SY='E';  M= -27, -51, -17,  14, -18, -18, -14, -57, -51, -24,   6, -64,  12, -54, -48, -87, -37, -73,-125,   7; D=-1;
/I:         I=-1; DM=-2;
/M: SY='W';  M= -40, -41, -20, -13, -20, -20, -28, -18, -32, -14,-107, -81, -10, -46, -24,  -1, -32, -10,   9, -18; D=-1;
/I:         I=-1; DM=-2;
/M: SY='P';  M= -45,  11, -13, -37, -20, -39, -37, -45, -74, -22,-104,  -3,  24,  -5, -28, -37,  17,   0, -14,  -2; D=-1;
/I:         I=-1; DM=-2;
/M: SY='P';  M= -25, -31,   9,   8,   1, -43, -38, -30, -43,  -3,  12,  -5,  35, -11, -25,   1, -21, -73,  18, -10; D=-1;
/I:         I=-1; DM=-2;
/M: SY='K';  M= -97,-110, -46, -83, -64,-104, -95, -72,  90, -66, -37,  -4,-101, -81,   2,   5,  23,-105,-112,-101; D=-1;
/I:         I=-1; DM=-2;
/M: SY='W';  M= -24,-135,  15,   6, -36, -59,   7,  -6, -44, -32,-117, -31,-128,-114, -32, -79, -50, -81,  43, -47; D=-1;
/I:         I=-1; DM=-2;
/M: SY='Q';  M= -72,-133, -28, -39,-121, -45, -65, -22, -18, -10, -37,  -5,-130,  12, -41, -22, -26, -21,-135, -20; D=-1;
/I:         I=-1; MI=0; MD=-2; IM=0; DM=-2;
/M: SY='I';  M=  -8, -37,-126, -43, -42, -56,-127,  15,  -3, -35,-111,-120, -67,   0, -52, -20, -17, -28,-135,-121; D=-1;
/I:         I=-1; DM=-2;
/M: SY='Y';  M=-115, -28, -84, -67,  32,-129,-104,  -7,-119,  -3, -17, -52,-129, -59,-118,-116, -41,   4, -96,  79; D=-1;
/I:         I=-1; DM=-2;
/M: SY='N';  M= -47, -11, -64,-107,-101,-112,  23,  24,-102,  -4,   1,  45,-117, -17,   0,  -1, -53,  14,-121,  -5; D=-1;
/I:         I=-1; DM=-2;
/M: SY='S';  M= -60,  56, -99,-104,-114,  54,-104, -71,-101, -81,-108, -15, -68, -43, -69,  62,  13,-107,-120,-110; D=-1;
/I:         I=-1; DM=-2;
/M: SY='N';  M= -96,-110,   2,  58,-110, -52, -13, -58, -13, -57, -99,  67, -56, -20,  67, -88, -71, -55,-115,-100; D=-1;
/I:         I=-1; DM=-2;
/M: SY='C';  M=  35,  62,   6, -12, -29, -37, -97, -13, -40,   0, -84,  10, -59,  12, -27, -63,   1,  42,-111, -62;
/I:         I=-6; MD=-16;
/M: SY='I';  M=-118,  -1, -69, -31, -36,-136,-122,  37, -75,  15,  -6, -53, -78, -20, -14,-122, -76,  -8,-127, -34; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='N';  M= -72,-134,  13,  -1,-135, -31, -10, -85, -59,-134,-127,  21, -17, -39,  -8,   8, -71, -38,-143, -66; D=-6;
/I:         I=-6; DM=-16;
/M: SY='N';  M= -47,-131, -26, -19,-117, -48, -35,-120,  -3, -21, -15,  18, -33, -29,  14, -25, -73, -66,  15,   5; D=-6;
/I:         I=-6; DM=-16;
/M: SY='D';  M= -47, -14,  26,   2, -61,  -2, -22, -20,-106, -33, -48, -22,   2,  21, -68, -25, -48, -16, -34, -14; D=-6;
/I:         I=-6; DM=-16;
/M: SY='F';  M= -60,-102, -33,  10,  55, -78,  18,  -1, -46,  47,   5,   7,-105, -92, -41, -15,  -4, -35, -92,  37;
/M: SY='C';  M= -38,  48, -39,  40,  14,  -4, -30, -23, -54, -25, -88,  16,-100, -13, -56,  16,  21,  13, -17,  44;
/M: SY='I';  M= -50,-103, -60, -61, -19, -82,-106,  80, -22,  11,  -4,-102, -56, -99,  -6, -59, -48,  47,-104, -25;
/M: SY='D';  M= -46,   0,  87,   9,-102, -96, -87, -34, -87, -35,  20,  29,  41,  -4, -94, -24, -87, -37,  53, -17;
/M: SY='A';  M=  46,  22,   8,   6, -52,  24,  13, -97, -89, -37, -17, -10,  17,  13, -58,   5,  15, -37, -10, -31;
/I:         I=-14; MD=-34;
/M: SY='T';  M= -29, -36,   0,  42, -63, -20, -40, -74,  -9,-103, -30,  -8,   8, -15,  20,  40,  46, -70,-110,  -2; D=-14;
/I:         I=-14; MD=-34;
/M: SY='D';  M= -22,-108,  34,  20, -31,   4,  -7, -74,  27, -31, -41,   4,   6, -18,   9,  21, -11, -68,-109,  -2; D=-14;
/I:         I=-14; MD=-34;
/M: SY='E';  M= -15,-111,  18,  41,  -7,   2,  -6, -45,  -4, -23,   2, -37,   5, -87,  12,  -6, -23, -41, -37,  20; D=-14;
/I:         I=-14; MD=-34;
/M: SY='G';  M= -51,-108, -10,   9, -23,  50, -98, -25, -23, -16, -48,  -2, -15, -31, -13,  25,  17, -63,-111, -58; D=-14;
/I:         I=-14; MD=-34;
/M: SY='N';  M= -65,  11,   6, -19, -39,  20,  32, -73,  13, -49, -44,  77,  -8, -49, -52,  -1, -34, -75,-120,-102; D=-14;
/I:         I=-14; MD=-34;
/M: SY='C';  M= -18,  40, -30, -33, -44, -47,-113, -15,-110,   6, -38,   0, -58, -32, -35,  26, -16, -51,-129,-112; D=-14;
/I:         I=-14; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='N';  M= -44,  -9,  -4,  -1,-116,  -1,-104, -50,-105, -39,   7,  55,  11,-103,-112,   3, -24, -71,-128, -16; D=-14;
/I:         I=-14; DM=-34;
/M: SY='C';  M= -36,  16, -19,  -4,-124, -55, -38, -37,-117,  -6, -40, -10, -16,  -7, -63,  -5, -51, -30,-140,-123; D=-14;
/I:         I=-14; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='W';  M= -46,-106, -38, -43, -12,-108,-103,  50, -19,  38,  -3, -40,   1, -97, -55, -26, -44,  18, 100,  -4;
/M: SY='M';  M=  43, -57,-101, -97, -29,  10, -18,  15, -96,  12,  56, -47, -40,   1, -99,   9,   5,  16,  -8, -53;
/M: SY='D';  M= -14, -17,  70, -50,-107, -28, -10,-107, -37, -76,   2, -77, -99, -15,  68,  53, -53,-102,-114, -95;
/M: SY='F';  M=-100,   0,-109,-105,  85,-111,  15, -10, -31,  38,  29,-103,-112,-100, -30, -52, -94, -80, -79,  68;
/M: SY='I';  M=  -5,  21,-113,-107,  49,-111,-103,  55,-105,  34,  47,-105,-108,-103,-105, -98, -35,  38, -98, -43;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='N';  M= -92, -46, -68, -86,-106, -83, -31,-104, -38,-111, -98, 124,-103, -40,  19, -59, -51, -48,-123,-100;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='H';  M= -64,  34, -85, -57, -98, -62, 145, -67, -40, -98, -86, -76, -50, -79,  -1, -58, -96,-111, -34, -34;
/M: SY='S';  M=  -4, -58,  54, -20,-105, -32, -13, -61, -17, -53, -99,  18, -96, -46, -66,  85, -44, -65,-115, -97;
/I:         I=-6; MD=-16;
/M: SY='C';  M= -17, 132, -11,-104, -58, -43,-107,-110, -58,-106,-103, -15,   0,-106,  11, -31, -53, -55,-127,-111; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='E';  M= -77,  17,  46,  63, -45,-101, -37, -65,   2, -73, -58,  11, -98, -17, -34,  24,   9, -31, -23,-101; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='P';  M= -26, -29, -94, -84,-111, -51,  -9,-106, -22,-110, -98,  -9, 107,  54,  -6, -26, -90,-108,-107,  -3; D=-6;
/I:         I=-6; DM=-16;
/M: SY='N';  M= -49, -98, -36, -54,-107, -82,  -4,-106, -43,-111, -99, 124,-102, -37, -16, -75, -12,-106,-124,-100;
/M: SY='C';  M=  46,  78,-105,-100, -89, -48,-103,  19,-100,  33, -48, -98,-105, -35,-103,  -8, -10,  32,-110, -94;
/M: SY='Y';  M=   0, -30, -55,  33,   9, -99,  29, -26,  18, -33, -48,   5, -17,  13,   9,   2,  12,  -3, -98,  43;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='V';  M=  29,-102, -29, -99,  -3,-103,  24,  28, -40,   4,  -6, -43,  -1, -97, -67, -65,   0,  47,  30,  21; D=-28;
/I:         I=-28; DM=-70;
/M: SY='Y';  M= -63,   3,  37,  35,  16, -65, -39,   1, -21, -61, -89, -88,-101,  31,   4,   0,  -6,  18,  -8,  49; D=-28;
/I:         I=-28; DM=-70;
/M: SY='Q';  M= -39,-106, -18, -30,  33, -66,  -6, -33,  -4, -10, -20,  33,  12,  59,   4, -11,  -2, -29, -19,  46;
/M: SY='W';  M= -52, -56,  30,  21, -34, -30,  30,   3, -27, -93, -45,  32,  10, -43,  12,   3, -24,  32,  46,  -1;
/M: SY='N';  M= -48,-105,  17,  13,   2,  41, -38, -29,  -7, -44, -96,  52,  17, -48, -20,  15,  -8, -39,  37, -94;
/M: SY='N';  M= -62, -29, -48,  22,  -9,  40,  32, -35, -16, -65, -23,  53, -42,  -3,   2,  11,   9,  -2, -21, -66;
/I:         I=-13; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='H';  M=-114,-131,  34, -54, -66,  36,  52,-137,-111, -92,-124,  12,-124,-110, -15, -49, -42,-134,-140,-117; D=-13;
/I:         I=-13; DM=-32;
/M: SY='D';  M= -47,-125,  21,  11,  -4, -74, -26,  -3, -12, -18,-107,  -5, -50,  -1, -66, -34, -35, -31,-126, -42; D=-13;
/I:         I=-13; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='C';  M= -30,  63, -10, -12, -50, -25,  40, -31,   5,  -6, -15,   6,-102,  29,  40,  -6,  11, -55,  -1,  22;
/M: SY='I';  M=  -1, -29,-111,-106,  15,-110,-101,  66, -64,  37,  50,-105,-107,-100, -65, -75, -56,  27, -98,  19;
/I:         I=-45; MD=-115;
/M: SY='Y';  M=  -7,  16,   8,  18,  21,  -7,   3, -22, -14, -27,  -4, -58,-102,   6,  -7,  -1,  11,   9, -13,  33; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='F';  M= -68,  13,-109, -23,  53,-112, -97,  44,-103,  44,  22,-105,-109,-101,-103, -55, -29,  24, -91,  40;
/M: SY='R';  M= -66, -14, -39, -61,  47, -66, -15,   7,  33, -45, -84, -54,-104, -18,  54, -51,  12,  12, -91,  53;
/M: SY='A';  M=  75,  -7, -22, -90,-100, -86, -97, -23, -92, -39,  -7, -87, -42, -89, -97,  41,  41, -16,-110, -98;
/M: SY='C';  M= -27,  42, -54, -77, -48, -31, -30,  26,  -2,  35,  -5, -16, -16, -25,   0,   7,  18,  23,-108, -91;
/M: SY='R';  M= -65, -39, -19,   5, -52, -73, -11, -54,  43, -41, -67,  -2, -99,  38,  84, -29,   2, -71,-106, -43;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='D';  M= -11,-107,  83, -14, -26, -18,  -2, -67, -40, -65, -38,  29,  34, -84,  14,   7, -54, -60,-112,   3;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='I';  M= -92, -28, -56,-109, -44,-115,-111,  99,-106,  -4, -68,-103,-105,-103,-109, -13, -38,  28,-105, -39;
/M: SY='K';  M=   0,-107, -22,  36,-109, -65, -14, -72,  49, -88, -95,  15,  47,  40,  26,   8, -28, -51,-108, -98;
/M: SY='P';  M=  31,-106, -41,  16,-107, -95, -92, -34,  63, -72, -94, -87,  73,   9, -38, -10, -13, -55,-106, -58;
/I:         I=-45; MD=-115;
/M: SY='G';  M= -87,-108,  29, -13,-111,  83, -16,-114, -62, -49,  -9,  40, -22, -91, -25, -62, -94,-111, -39,-104; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='E';  M= -22, -40,  26,  88, -59, -70, -30, -38, -76,-102, -97, -35, -90,  42,  -6, -19,  32, -99,-111, -98;
/M: SY='E';  M= -90,-112, -64, 109,-114,-104, -82,-113, -70,-105,-100, -85, -87,  62, -31, -85, -91,-107,-109,-101;
/M: SY='L';  M= -94,-101,-115,-109, -44,-117,-105,  60,-108,  73, -62,-111,-110,-103,-107,-104, -90,  36,-104, -85;
/M: SY='T';  M= -62,  29,-100, -98,  63, -87, -94, -56, -62,  22, -81, -91,-103, -96,   6,   9,  71, -41,  -4,  26;
/M: SY='I';  M= -92, -37, -42,-103,  16, -48, -23,  67, -99, -16, -36,  42,-105, -98, -85, -54,   9,  39,  35,  31;
/M: SY='W';  M= -48,  45,  50, -62, -31, -64, -39, -61, -42,-103, -99,  45, -99,  -9, -93,  60,  30, -99,  89, -24;
/M: SY='Y';  M=-102, -39,-102,-104, -19,-109, -69, -87, -67, -84, -81,-103,-114, -92, -93, -97, -97, -67,  28, 137;
/M: SY='G';  M=  -6, -13, -12, -96, -52,  64, -97,  23, -53, -41, -91,  21,-100,  -5, -57,  22, -11,  -4,-108, -38;
/I:         E1=0; IE=-380; DE=-380;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	372 in 372 different sequences
Number of true positive hits	372 in 372 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	2
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.47 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	SET
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

372 sequences

ASH1L_HUMAN (Q9NR48), ASH1L_MOUSE (Q99MY8), ASH1_DROME  (Q9VW15),

ASHH1_ARATH (Q84WW6), ASHH2_ARATH (Q2LAE1), ASHH3_ARATH (Q945S8), 
ASHH4_ARATH (Q9M1X9), ASHR1_ARATH (Q7XJS0), ASHR2_ARATH (Q9ZUM9), 
ASHR3_ARATH (Q949T8), ATX1_ARATH  (Q9C5X4), ATX2_ARATH  (P0CB22), 
ATX3_ARATH  (Q9M364), ATX4_ARATH  (Q9SUE7), ATX5_ARATH  (Q8GZ42), 
ATXR2_ARATH (Q5PP37), ATXR3_ARATH (O23372), ATXR4_ARATH (Q9FG08), 
ATXR5_ARATH (Q8VZJ1), ATXR5_RICCO (B9RU15), ATXR6_ARATH (Q9FNE9), 
ATXR7_ARATH (F4K1J4), BLMP1_CAEEL (Q93560), CLF_ARATH   (P93831), 
CLF_ORYSJ   (Q5VN06), CLR4_CRYNH  (J9VWH9), CLR4_SCHPO  (O60016), 
CTM1_CANGA  (Q6FR37), CTM1_EREGS  (Q756K8), CTM1_KLULA  (Q6CMC0), 
CTM1_YEAST  (P38818), DIM5_NEUCR  (Q8X225), EFM1_YEAST  (P38732), 
EHMT1_HUMAN (Q9H9B1), EHMT1_MOUSE (Q5DW34), EHMT2_HUMAN (Q96KQ7), 
EHMT2_MOUSE (Q9Z148), EZ1_MAIZE   (Q8S4P6), EZ1_ORYSI   (Q84UI6), 
EZ1_ORYSJ   (Q10MI4), EZ2_MAIZE   (Q8S4P5), EZ3_MAIZE   (Q8S4P4), 
EZA1_ARATH  (Q9ZSM8), EZH1_BOVIN  (A7E2Z2), EZH1_HUMAN  (Q92800), 
EZH1_MOUSE  (P70351), EZH1_PONAB  (Q5RDS6), EZH2A_XENLA (Q98SM3), 
EZH2B_XENLA (Q4V863), EZH2_CHATD  (G0SDW4), EZH2_DANRE  (Q08BS4), 
EZH2_HUMAN  (Q15910), EZH2_MACFA  (Q4R381), EZH2_MOUSE  (Q61188), 
EZH2_XENTR  (Q28D84), EZ_DROME(P42124), GRA4_GIBZE  (I1R9A9), 
KMT1_FUSMA  (A0A1L7TZE5), KMT2A_HUMAN (Q03164), KMT2A_MOUSE (P55200), 
KMT2B_HUMAN (Q9UMN6), KMT2B_MOUSE (O08550), KMT2C_HUMAN (Q8NEZ4), 
KMT2C_MOUSE (Q8BRH4), KMT2D_HUMAN (O14686), KMT2D_MOUSE (Q6PDK2), 
KMT2E_HUMAN (Q8IZD2), KMT2E_MOUSE (Q3UG20), KMT5A_BOVIN (Q2YDJ8), 
KMT5A_CAEEL (Q22795), KMT5A_DROME (Q9VFK6), KMT5A_DROPS (Q297V5), 
KMT5A_HUMAN (Q9NQR1), KMT5A_MOUSE (Q2YDW7), KMT5A_XENTR (Q0V9E9), 
KMT5B_BOVIN (Q29RP8), KMT5B_DANRE (Q5U3H2), KMT5B_HUMAN (Q4FZB7), 
KMT5B_MOUSE (Q3U8K7), KMT5B_RAT   (P0C2N5), KMT5C_HUMAN (Q86Y97), 
KMT5C_MOUSE (Q6Q783), KMT5C_RAT   (P0C2N6), KMT5C_XENLA (A0JMZ4), 
KT5AA_DANRE (Q071E0), KT5AA_XENLA (Q08AY6), KT5AB_XENLA (Q498E6), 
KT5BA_XENLA (Q6GP17), KT5BB_XENLA (Q5RJX8), LIN59_CAEEL (O44757), 
MECOM_HUMAN (Q03112), MECOM_MOUSE (P14404), MEDEA_ARATH (O65312), 
MES2_CAEEL  (O17514), MES4_CAEEL  (Q9NH52), MET2_CAEEL  (P34544), 
MSTAA_DROME (O46040), MSTAB_DROME (P83501), NSD1_HUMAN  (Q96L73), 
NSD1_MOUSE  (O88491), NSD2_HUMAN  (O96028), NSD2_MOUSE  (Q8BVE8), 
NSD3_HUMAN  (Q9BZ95), NSD3_MOUSE  (Q6P2L6), NSD_DROME   (Q8MT36), 
PRD10_DANRE (A2BID7), PRD10_HUMAN (Q9NQV6), PRD10_MOUSE (Q3UTQ7), 
PRD10_PONAB (Q5RAX9), PRD10_XENTR (B4F6U4), PRD11_HUMAN (Q9NQV5), 
PRD11_MOUSE (A2AGX3), PRD12_HUMAN (Q9H4Q4), PRD12_MOUSE (A2AJ77), 
PRD13_HUMAN (Q9H4Q3), PRD13_MOUSE (E9PZZ1), PRD14_HUMAN (Q9GZV8), 
PRD14_MOUSE (E9Q3T6), PRD15_HUMAN (P57071), PRD15_MOUSE (E9Q8T2), 
PRD16_HUMAN (Q9HAZ2), PRD16_MOUSE (A2A935), PRDM1_HUMAN (O75626), 
PRDM1_MOUSE (Q60636), PRDM2_HUMAN (Q13029), PRDM2_RAT   (Q63755), 
PRDM4_HUMAN (Q9UKN5), PRDM4_MOUSE (Q80V63), PRDM4_PONAB (Q5R5M1), 
PRDM4_RAT   (Q9QZP2), PRDM5_HUMAN (Q9NQX1), PRDM5_MOUSE (Q9CXE0), 
PRDM6_BOVIN (A6QPM3), PRDM6_HUMAN (Q9NQX0), PRDM6_MOUSE (Q3UZD5), 
PRDM7_HUMAN (Q9NQW5), PRDM8_HUMAN (Q9NQV8), PRDM8_MOUSE (Q8BZ97), 
PRDM9_DANRE (Q6P2A1), PRDM9_HUMAN (Q9NQV7), PRDM9_MOUSE (Q96EQ9), 
PRDM9_RAT   (P0C6Y7), PTA14_ARATH (Q84JF5), RBCMT_ARATH (Q9XI84), 
RBCMT_PEA   (Q43088), RBCMT_TOBAC (P94026), RKM1_YEAST  (Q08961), 
RKM2_YEAST  (Q03942), RKM3_YEAST  (P38222), RKM4_SCHPO  (Q9P6L2), 
RKM4_YEAST  (Q12504), SDG40_ARATH (Q6NQJ8), SDG41_ARATH (Q3ECY6), 
SE1BA_DANRE (Q1LY77), SET10_SCHPO (O74738), SET11_SCHPO (O74405), 
SET17_CAEEL (A0A163UT06), SET1A_HUMAN (O15047), SET1A_MOUSE (E9PYH6), 
SET1B_CHICK (Q5F3P8), SET1B_HUMAN (Q9UPS6), SET1B_MOUSE (Q8CFT2), 
SET1B_XENLA (Q66J90), SET1B_XENTR (Q08D57), SET1_ASPFU  (Q4WNH8), 
SET1_ASPOR  (Q2UMH3), SET1_CAEEL  (Q18221), SET1_CANAL  (Q5ABG1), 
SET1_CANGA  (Q6FKB1), SET1_CHAGB  (Q2GWF3), SET1_COCIM  (Q1DR06), 
SET1_CRYNB  (P0CO27), SET1_CRYNJ  (P0CO26), SET1_DEBHA  (Q6BKL7), 
SET1_DICDI  (Q54HS3), SET1_DROME  (Q5LJZ2), SET1_EMENI  (Q5B0Y5), 
SET1_EREGS  (Q75D88), SET1_GIBZE  (Q4I5R3), SET1_KLULA  (Q6CIT4), 
SET1_MYCMD  (Q4PB36), SET1_NEUCR  (Q8X0S9), SET1_PLAF7  (C6KTD2), 
SET1_SCHPO  (Q9Y7R4), SET1_YARLI  (Q6CEK8), SET1_YEAST  (P38827), 
SET23_CAEBR (A8XI75), SET23_CAEEL (Q95Y12), SET25_CAEEL (G5EEU2), 
SET2_ASPFU  (Q4WTT2), SET2_ASPOR  (Q2UTN6), SET2_CANAL  (Q59XV0), 
SET2_CANGA  (Q6FX50), SET2_CHAGB  (Q2H988), SET2_COCIM  (Q1DU03), 
SET2_CRYNB  (P0CO29), SET2_CRYNJ  (P0CO28), SET2_DEBHA  (Q6BM04), 
SET2_DROME  (Q9VYD1), SET2_EMENI  (Q5ASA5), SET2_EREGS  (Q757Y8), 
SET2_GIBZE  (Q4IB50), SET2_KLULA  (Q6CXP5), SET2_MYCMD  (Q4PBL3), 
SET2_NEUCR  (Q7RZU4), SET2_SCHPO  (O14026), SET2_YARLI  (Q6C5G5), 
SET2_YEAST  (P46995), SET3_CAEEL  (P34318), SET3_SCHPO  (Q10362), 
SET3_YEAST  (P36124), SET4_YEAST  (P42948), SET5_CANAL  (Q5A1M3), 
SET5_CANGA  (Q6FTT0), SET5_CRYNB  (P0CR43), SET5_CRYNJ  (P0CR42), 
SET5_DEBHA  (Q6BSV3), SET5_EREGS  (Q75BF1), SET5_KLULA  (Q6CX91), 
SET5_MYCMD  (Q4PBP5), SET5_PICGU  (A5DQN2), SET5_PICST  (A3M0J3), 
SET5_SCHPO  (O74467), SET5_VANPO  (A7TPV3), SET5_YARLI  (Q6C9E7), 
SET5_YEAS7  (A6ZTB4), SET5_YEAST  (P38890), SET6_CAEEL  (O17679), 
SET6_SCHPO  (O94256), SET6_YEAST  (Q12529), SET7_SCHPO  (Q9Y7Q6), 
SET8_SCHPO  (O14135), SET9_ASPFU  (Q4X1W8), SET9_ASPOR  (Q2TZH4), 
SET9_ASPTN  (Q0C9E6), SET9_CHAGB  (Q2H8D5), SET9_COCIM  (Q1E9C0), 
SET9_EMENI  (Q5AZY3), SET9_GIBZE  (Q4I8C9), SET9_NEUCR  (Q7SBJ9), 
SET9_PHANO  (Q0U3A4), SET9_SCHPO  (Q9USK2), SET9_YARLI  (Q6C519), 
SETB1_DROME (Q32KD2), SETB1_DROPS (Q28Z18), SETB1_HUMAN (Q15047), 
SETB1_MOUSE (O88974), SETB1_XENLA (Q6INA9), SETB2_DANRE (Q06ZW3), 
SETB2_HUMAN (Q96T68), SETB2_MOUSE (Q8C267), SETB2_XENLA (Q6YI93), 
SETB2_XENTR (A4IGY9), SETD2_HUMAN (Q9BYW2), SETD2_MOUSE (E9Q5F9), 
SETD3_CALJA (B0VX69), SETD3_CANLF (E2RBS6), SETD3_CHICK (Q5ZML9), 
SETD3_DANRE (Q7SXS7), SETD3_DASNO (C1FXW2), SETD3_DROME (Q9W3U1), 
SETD3_HUMAN (Q86TU7), SETD3_MOUSE (Q91WC0), SETD3_OTOGA (B5FW36), 
SETD3_PAPAN (A9X1D0), SETD3_PLEMO (B1MTJ4), SETD3_RAT   (G3V6U9), 
SETD3_RHIFE (B2KI88), SETD3_XENTR (B7ZUF3), SETD4_ARTPA (A0A140C435), 
SETD4_HUMAN (Q9NVD3), SETD4_MOUSE (P58467), SETD5_HUMAN (Q9C0A6), 
SETD5_MOUSE (Q5XJV7), SETD6_BOVIN (E1BI64), SETD6_CHICK (Q5ZK17), 
SETD6_DANRE (Q803K4), SETD6_HUMAN (Q8TBK2), SETD6_MOUSE (Q9CWY3), 
SETD6_RAT   (D3ZSK5), SETD6_SALSA (C0H8I2), SETD6_XENLA (Q6INM2), 
SETD6_XENTR (A4QNG5), SETD7_DANRE (Q6DHG0), SETD7_HALRO (Q7Z0G7), 
SETD7_HUMAN (Q8WTS6), SETD7_MOUSE (Q8VHL1), SETD7_XENTR (Q4QQN5), 
SETD9_HUMAN (Q8NE22), SETD9_PONAB (Q5RBW0), SETMR_BOVIN (Q0VD24), 
SETMR_HUMAN (Q53H47), SETMR_MOUSE (Q80UJ9), SETMR_RAT   (Q5I0M0), 
SETVS_PLAF7 (Q8IE95), SMY2A_DANRE (Q5BJI7), SMY2A_XENLA (Q7ZXV5), 
SMY2B_DANRE (Q5RGL7), SMY2B_XENLA (Q6GN68), SMYD1_HUMAN (Q8NB12), 
SMYD1_MOUSE (P97443), SMYD2_BOVIN (Q0P585), SMYD2_CHICK (E1C5V0), 
SMYD2_HUMAN (Q9NRG4), SMYD2_MOUSE (Q8R5A0), SMYD2_PIG   (C3RZA1), 
SMYD2_RAT   (Q7M6Z3), SMYD3_HUMAN (Q9H7B4), SMYD3_MOUSE (Q9CWR2), 
SMYD4_CHICK (Q5F3V0), SMYD4_DANRE (Q08C84), SMYD4_HUMAN (Q8IYR2), 
SMYD4_MOUSE (Q8BTK5), SMYD4_PONAB (Q5R5X9), SMYD5_CHICK (Q5ZIZ2), 
SMYD5_DANRE (F1RET2), SMYD5_HUMAN (Q6GMV2), SMYD5_MOUSE (Q3TYX3), 
SMYD5_XENLA (Q6GPQ4), STB1A_DANRE (Q1L8U8), STB1B_DANRE (Q08BR4), 
SUV39_DROME (P45975), SUV39_DROPS (Q294B9), SUV42_CAEBR (A8WTV9), 
SUV42_CAEEL (Q09265), SUV42_DROME (Q9W5E0), SUV91_BOVIN (Q2NL30), 
SUV91_HUMAN (O43463), SUV91_MOUSE (O54864), SUV91_PONAB (Q5RB81), 
SUV91_XENLA (Q6NRE8), SUV92_BOVIN (Q32PH7), SUV92_CHICK (Q5F3W5), 
SUV92_HUMAN (Q9H5I1), SUV92_MACFA (Q4R3E0), SUV92_MOUSE (Q9EQQ0), 
SUV92_XENTR (Q28CQ7), SUVH1_ARATH (Q9FF80), SUVH1_TOBAC (Q93YF5), 
SUVH2_ARATH (O22781), SUVH3_ARATH (Q9C5P4), SUVH3_CHLRE (Q5QD03), 
SUVH4_ARATH (Q8GZB6), SUVH5_ARATH (O82175), SUVH6_ARATH (Q8VZ17), 
SUVH7_ARATH (Q9C5P1), SUVH8_ARATH (Q9C5P0), SUVH9_ARATH (Q9T0G7), 
SUVHA_ARATH (Q3EC60), SUVR1_ARATH (Q946J2), SUVR2_ARATH (Q9FNC7), 
SUVR3_ARATH (Q9SRV2), SUVR4_ARATH (Q8W595), SUVR5_ARATH (O64827), 
SV91A_DANRE (Q6DGD3), TRR_DROME   (Q8IRW8), TRX1_ORYSJ  (Q6K431), 
TRX_DROME   (P20659), TRX_DROVI   (Q24742), Y1806_PHANO (P0CY36), 
Y2140_DICDI (Q54DL6), Y2454_DICDI (Q54D67), Y3443_DICDI (Q54R14), 
Y3589_DICDI (Q557F7), Y3591_DICDI (Q557F6), Y4059_DICDI (Q54Q80), 
Y7331_DICDI (Q54ZX8), Y8495_DICDI (Q54IV4), YBD1_SCHPO  (O42925), 
YL222_MIMIV (Q5UQB9), YL678_MIMIV (Q5UNT8), ZN488_DANRE (B8A5Y1)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

2 sequences

SET26_CAEEL (Q9U263), SET9_CAEEL  (O44498)

PDB
[Detailed view]

362 PDB

1H3I; 1ML9; 1MLV; 1MT6; 1MUF; 1MVH; 1MVX; 1N6A; 1N6C; 1O9S; 1OZV; 1P0Y;
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