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PROSITE entry PS50268


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50268
Entry name [info] CADHERIN_2
Accession [info] PS50268
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00205
Associated ProRule [info] PRU00043

Name and characterization of the entry

Description [info] Cadherins domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=106;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=101;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.8381; R2=0.02192269; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=350; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=259; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B0=-60; B1=-60; E0=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 2'381 in 342 different sequences
Number of true positive hits 2'379 in 340 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.92 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes
Maximum number of repetitions [info] 34
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann, N_Hulo
Feature key [info] DOMAIN
Feature description [info] Cadherin
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
340 sequences

CAD10_CHICK (P79995), CAD10_HUMAN (Q9Y6N8), CAD10_MOUSE (P70408), 
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UniProtKB/Swiss-Prot
False positive sequences
2 sequences

CHIA_PSEO7  (P32823), FREM2_LYTVA (Q9GV77)

		
PDB
[Detailed view]
196 PDB

1EDH; 1FF5; 1L3W; 1NCG; 1NCH; 1NCI; 1NCJ; 1O6S; 1Q1P; 1SUH; 1WUZ; 1WYJ;
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