PROSITE entry PS50263

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50263
Entry name [info]	CN_HYDROLASE
Accession [info]	PS50263
Entry type [info]	MATRIX
Date [info]	01-DEC-2002 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50263
Associated ProRule [info]	PRU00054

Name and characterization of the entry

Description [info]

Carbon-nitrogen hydrolase domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=252;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=247;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9488945; R2=0.0078549; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1089; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=580; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-38; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='V';  M= -12,-119, -85, -83,  23,-128,-119,  21, -66,  24,  39, -61, -45,-119, -79,-115, -75,  68,  38,  27;
/M: SY='Q';  M=-108,-126, -69, -11,-125, -23,   1, -53,  41, -47,-109,   0, -21,  79,  58, -27,  23, -57,-125,-112;
/M: SY='V';  M=   2,-119,-122,-119, -34,  22,   2,  25,-118,  11, -55,-116,  27, -41,-122, -58,   4,  63,-127,-110;
/M: SY='A';  M=  74, -47,  -9, -65, -81,  12, -54, -58, -82, -56, -45,  56, -50, -68, -82, -15,   3, -32,-128, -65;
/M: SY='I';  M=  26,  -7,-126, -75,-101, -96,-124,  59,-120,  31,   4,-120, -53,-118,-123, -64,  -1,  53,-126, -67;
/M: SY='V';  M=  17,  43,  -2, -19,-111, -35,-121,  27, -85, -50,-100, -78,  43, -83, -87, -23, -11,  63,-130, -46;
/M: SY='Q';  M=  -9, -13,-102, -50,-130,-112, -99,-120, -92, -46,-106,  30, -51, 122, -46, -26,  10,-119,-124,-111;
/M: SY='Y';  M=  26, -55,   7, -21,  -1, -59,  16, -48, -77,  28,  -8,   9,  24,  18,   6,   3, -33, -78,-117,  34;
/M: SY='N';  M=  15, -58, -25,  43, -43, -38, -15, -44,  -2,   5,   5,  51,   2,  30,  -2,   2, -48, -40,-127,-112;
/M: SY='P';  M= -31, -20, -55, -19, -38, -61, -60, -14,  59, -43,  22, -51,  62,  28, -37, -15,  12,  -2,-122, -13;
/M: SY='W';  M= -28,-125, -16, -85,  15, -29,-119, -20, -33, -35,  -8,-114,  48, -16, -21,  11,  24,  19, 115, -35;
/M: SY='W';  M=   2,-122,  44, -32,  -6,-116,-111,  -4, -36,  11, -56,  15,  14, -34,  12,   9,   5, -13,  73, -12;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='E';  M=  14, -56,  -7,  46, -13,  17,-113,-118, -52,   0,  19,   7,  -4, -27, -29,  -7, -27, -83,-127, -19; D=-22;
/I:         I=-22; DM=-55;
/M: SY='D';  M= -12,-125,  79,  31, -67, -26, -15, -64, -28, -33,-115,  12, -46,  37, -59,  -3, -35, -28,-132, -13; D=-22;
/I:         I=-22; DM=-55;
/M: SY='L';  M= -14, -30, -72, -83,  33, -87,-115,   2,   2,  41,  12, -60,  -2, -37,  19, -31,  -8,  19,  -4, -22; D=-22;
/I:         I=-22; DM=-55;
/M: SY='E';  M=  28,-122,  11,  50,-118, -83, -38, -55,   9,  -5, -42,   2,   4,  26,  -6,  10, -12, -97,  47, -40;
/M: SY='A';  M=  41,-120,  14,  38, -71,   6,  11,-118,   6, -47, -18,   3, -25,  21,   1,  -9,   7, -49,-126, -29;
/M: SY='N';  M= -35,-116, -68,-107,-116, -24, -55,   7, -78, -21, -36,  95, -78,  26, -55,   6,  50, -37,-132, -56;
/M: SY='L';  M=   1, -32,-125, -48,  27, -83, -21,  35, -81,  45,  33, -68, -46, -68, -59, -44,  -8,  36, -36, -31;
/M: SY='Q';  M=  12,-123,  49,  31,-124, -70, -57, -82,  24, -57,   4,   5,-114,  61,  28,  -3, -38, -32, -36, -56;
/M: SY='K';  M= -55,-123, -50, -12, -76, -50,   7,   7,  66, -21, -28,  -4,-116,  -4,  58, -17,   8, -24, -42, -58;
/M: SY='Y';  M=  24,  16,-118, -86, -32, -88,  40,  48, -74,   5, -15,  -5, -75,-112,-116, -45,  21,   2, -11,  66;
/M: SY='I';  M=  -4,  29, -72,  33, -64, -66, -15,  44,  -2,  29, -21, -55, -73, -12, -18, -51, -17,  12,  -2,  -5;
/M: SY='D';  M=  -9,-123,  47,  42, -79, -16, -31,-124,  34,-100,-116,  10, -68,  35,  23,  27, -24, -67, -26, -51;
/M: SY='L';  M=   6,-118, -52, -37,  -4, -47, -63,   7, -67,  60,  55,-116,-122,   3, -78,   2,  -9, -25,   7, -17;
/M: SY='I';  M=   4,-118,-123, -76, -71,-123,-121,  70,-118,  12,  -7,-116,-120, -62,-121,  13,  25,  40, -27,   3;
/M: SY='E';  M=  21, -56,  30,  43, -53, -29,  12, -67,   6, -10,  -6, -28,-115,  23,  36,  -6, -11, -25,-127,-112;
/M: SY='E';  M=   4,-124, -28,  65,-124,  -4, -44, -18,  32, -45, -65, -26, -20,  47,   2,  -4, -22, -45, -35,-115;
/I:         I=-24; MD=-60;
/M: SY='A';  M=  83,   2,-115, -50, -62, -48,   1, -36,-112, -31,   8, -15, -18, -47, -93, -24,   0, -17,-126, -64; D=-24;
/I:         I=-24; MD=-60;
/M: SY='A';  M=  50, -43, -76, -83, -55, -12,   7,  -5,  33, -29,  13, -52, -18, -30,  -6, -22, -15, -17,  21, -26; D=-24;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='N';  M=  15, -57,  -7,   9, -78, -20, -53, -94,  16, -14, -21,  30,-121,  27,   6,  27, -50, -64,-127,  12; D=-24;
/I:         I=-24; DM=-60;
/M: SY='Q';  M=  10,   4, -35,   5,-127,  -7, -54,-123,  42, -48, -24,  22,  44,  55,   1, -47, -40, -82, -33, -53; D=-24;
/I:         I=-24; DM=-60;
/M: SY='G';  M= -65,-125,  28, -49,-130,  83, -30,-132,  23,-130,-120, -29,  21,   3,  -4, -26, -38,-127,-125,-120;
/M: SY='A';  M=  70,  21, -77,-111,-114, -80, -62, -39, -40, -48,  35, -81,  28,-110, -74,  -4,   8,  38,-127, -60;
/M: SY='D';  M= -41, -13,  85,  17,-129, -71,  26,-127,  26,-125, -60,  33, -67,  46,  -4, -15, -53, -86,-135,-114;
/M: SY='L';  M= -45, -52,-132,-126,   2,-132,-120,  60,-124,  68,   8,-127,-127,-120,-124,-120,-108,  23, -31,  -4;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='I';  M= -28,-120,-130,-125, -44,-132,-127,  81,-119,  18, -31,-123,-124,-119,   0,-117,-104,  62,-124,-105;
/M: SY='V';  M=   6,  21,-128,-123, -11, -49,-127,  47,-121,  10, -49,-121,-124,-121,-123, -46, -36,  79,-127,-106;
/M: SY='W';  M= -50,-122,-131,-125,  92, -14,-121, -33,-122,  29, -97,-122,-127,-124,-122,-116,  22, -80, 113, -51;
/M: SY='P';  M=-112,-137,-113,-102,-133, -68,-116,-122,-109,-131,-117,-117, 129,   8,-120, -13,-105,-126,-127,-129;
/M: SY='E';  M=-107,-129, -79, 119,-131,-123,-101,-132, -89,-124,-120,-104,-103, -81, -53, -63,-108,-124,-128,-121;
/M: SY='T';  M=  26,  41,  10,-112, -64, -13,-110, -41,-112,  25,  17, -25,-119,-110,-116,  19,  46,  -5,-119,  41;
/M: SY='W';  M=  50, -19,-115,  -3,  53,  -3,-117, -80,-112, -68, -46,-109,-117,-109,-116,  44,   9, -41,  98, -60;
/I:         I=-45; MD=-115;
/M: SY='I';  M= -44,-119, -62, -51,  22,-128, -44,  60,-120,  49, -45,   8,-124,-118,-122, -50,  23,  13,-121, -48; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='P';  M= -60,  24,  -8,-105, -42, -18,  41, -57,-108, -65,  16,  -7,  89,   3, -69,  17,  27, -51,-123,  23;
/I:         I=-9; MD=-22;
/M: SY='G';  M= -37,-129, -38,-124,  35,  78,-121, -57,-121, -61,-118, -65,  21, -45, -53, -41, -65, -32,-120,   0; D=-9;
/I:         I=-9; MD=-22;
/M: SY='Y';  M= -74,  -6, -72,-130,  44, -22, -47,   7,-126,   2, -31,-127, -49,-123,-125, -67,-120, -52,  30,  99; D=-9;
/I:         I=-9; MD=-22;
/M: SY='P';  M= -17,-140, -19, -85, -12,   4,-126, -41, -69, -65,  21,  34,  50, -74, -67,   5,-121, -93,-142, -41; D=-9;
/I:         I=-9; MD=-22;
/M: SY='C';  M= -47,  39, -88, -90,  38, -57,  -5, -91, -64, -99,-133, -60, -41,-140, -23, -52,   7,-137,  36,  35; D=-9;
/I:         I=-9; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='W';  M= -58, -26,   1, -14,  -9, -53, -63, -36,  -5, -12, -69,  10, -87,-128,   0, -22, -78,-135,  14, -26; D=-9;
/I:         I=-9; DM=-22;
/M: SY='W';  M= -24,-140,  -2,   0, -20, -37, -14, -12, -20, -28,  -2, -10,   7, -22, -31, -30, -16, -61,  70, -14; D=-9;
/I:         I=-9; DM=-22;
/M: SY='W';  M= -27,   2,  -1,   5, -88, -85,  23,  -9, -11,-100,-125,   4,  23,  -5,   2,  -8,  -7, -55,  31, -42; D=-9;
/I:         I=-9; DM=-22;
/M: SY='E';  M= -56, -12, -37,  37,  -5,-135, -61, -33,  -7, -20, -54, -32,  25,  -8,   4, -47, -15, -74,   3,  16; D=-9;
/I:         I=-9; DM=-22;
/M: SY='Y';  M= -62,  42,  25, -47,   3,-134, -27, -80, -45,   3,  15, -52,-137, -51,-127, -18,   1, -29,  -4,  56; D=-9;
/I:         I=-9; DM=-22;
/M: SY='H';  M= -42, -26, -48,  23, -19, -94,  44, -30, -39,   5,  -8,  -6,   9, -33,   1, -38, -54, -32,  -9,   2; D=-9;
/I:         I=-9; DM=-22;
/M: SY='E';  M=  -2,-136,  12,  47,   5,-129, -25, -57,  -8, -31, -65,   3, -39,  17, -29, -35, -81, -72,-132,   5; D=-9;
/I:         I=-9; DM=-22;
/M: SY='N';  M=  -2,-131,   3, -35, -13, -91,-118,  -8, -18,  -2, -60,  42,  20,  -2, -41, -34,  -5, -31, -18,   5; D=-9;
/I:         I=-9; DM=-22;
/M: SY='A';  M=  32,-126, -11,   5, -50, -85,  -9, -28, -18, -19, -10, -13, -30,  12, -16,  30,  -7, -59, -10, -18; D=-9;
/I:         I=-9; DM=-22;
/M: SY='P';  M= -18,  14,  -4,  22, -53, -71, -25,  -5, -40,  18,   3, -64,  23,   9,  12,  -6, -20, -33,  -9, -44; D=-9;
/I:         I=-9; DM=-22;
/M: SY='F';  M=  -7, -67,  26, -16,  34, -49, -20, -28, -16,   6, -25, -21,  27, -17, -19,   8,  20, -73,-124, -21; D=-9;
/I:         I=-9; DM=-22;
/M: SY='L';  M= -20,-124,  -4, -12, -12, -11,  13,  21, -26,  21,   9,   7,  -2, -17, -80, -45, -21,  17, -33,   7; D=-9;
/I:         I=-9; DM=-22;
/M: SY='D';  M= -31, -51,  58,  28, -33, -42,  19, -62, -47,   0,-111,  15,  55, -12, -52,  -1, -18, -63, -24,  -8; D=-9;
/I:         I=-9; DM=-22;
/M: SY='G';  M= -17, -19, -18,   0, -33,  51, -33, -70, -76, -39,-114,  -8,  -9,  -2, -16,  47,  30, -83,  18, -29; D=-9;
/I:         I=-9; DM=-22;
/M: SY='P';  M= -26,-128,  36,  52,-127, -59,  17,-120, -16, -57, -67, -26,  77,  30, -29, -15, -26, -26,-130, -62; D=-9;
/I:         I=-9; DM=-22;
/M: SY='E';  M=   0,  -4, -53,  50,  10,-117, -22, -21, -53,  -7,  -1,   9, -73,  -5, -54,  27,  -1,  27, -30,   7; D=-9;
/I:         I=-9; DM=-22;
/M: SY='M';  M= -15, -30,  -8, -20,   9, -66, -47,   3, -54,  21,  52, -86,   4,  35, -54, -32,  36,  14,  37, -27;
/M: SY='Q';  M=  24,-122,  34,  40,-125, -17, -65, -86,   6, -70, -58,   4,  -1,  53,  19,  -7,   2, -25, -35,-115;
/M: SY='R';  M=  21, -11,-116, -24,  45, -75, -31,  -6,  -6,  -4, -21, -69,  -9,  14,  53, -38, -12, -22,  38,  11;
/M: SY='L';  M= -46, -49,-128, -79,  32, -96,-115,  47, -67,  67,  38, -52,-127, -70,-120, -81, -64, -20, -25,  14;
/M: SY='S';  M=  22,  28,   1, -22, -41, -66, -69, -47,  13,  -9, -28, -50, -69,  48,  28,  51,   6, -70,-126,-111;
/M: SY='C';  M=  22,  55,  23,  47,-121, -43,  -8, -59,   7, -55, -12,  17,-115,  33,  14,   6, -31, -98, -28, -20;
/M: SY='L';  M=  47, -38, -75, -39,  -9, -85, -64,  23, -59,  51,  43, -75, -51, -48,-117, -42, -27,  10,-121, -68;
/M: SY='A';  M=  78,  65,   0, -70,-118, -38,-115, -45, -45, -21, -52, -51, -23, -46, -43,   5, -52, -15,-127, -73;
/M: SY='K';  M=  12, -48,  -1,  27,-123, -43, -28, -44,  57, -72, -33, -25, -27,  21,  56,  -8, -11, -46,-125,-113;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='E';  M= -10, -12,  30,  54,-130,-118,  -5,-127,  33, -88, -39,   6, -26,  30,  17, -12,   9, -83,-133,-119; D=-28;
/I:         I=-28; DM=-70;
/M: SY='N';  M=  16,  17,  -4, -42, -15, -46,  43, -62,   3,  -9,-108,  62, -68,   8, -23, -50,   4,-114,   5,  43; D=-28;
/I:         I=-28; DM=-70;
/M: SY='N';  M=-106, -51,  28, -28,-128,  47,  23,-129,  43, -72, -46,  54, -22,  26, -10,  12,-105,-126,-130,-117; D=-28;
/I:         I=-28; DM=-70;
/M: SY='I';  M=  -7,  24, -74,-118,-106, -95, -55,  64, -64, -26,  49, -28, -17,   0, -76, -12,  22,  45,-128,-109; D=-28;
/I:         I=-28; DM=-70;
/M: SY='W';  M=  19, -43, -11, -61,   0, -75,  -8,   0,-112, -26, -12, -22,  35,-111, -51, -24,  12,  12,  88,  68;
/M: SY='I';  M= -36,  17,-128,-125,   0,   2,-123,  54,-122,  50, -19,-121,-125,-120, -82,-114, -19,  48,-122,-104;
/M: SY='V';  M= -21,   7,  -9,-119, -31, -86, -55,  58,-120,  19, -19, -58, -40,-118,-122,   8,-102,  64,   6,-106;
/M: SY='I';  M=  26,-116,-123,-120,  33, -19,-119,  39,-118,  18,  36,-115,-121,-116,-120, -19,  31,  38, -36, -40;
/M: SY='G';  M= -97,-121,-106,-118,-128,  96,-113,-133,-112,-132,-121,  39, -42,-110,-119,  32, -66,-128,-125,-123;
/I:         I=-13; MD=-32;
/M: SY='M';  M=   9,   2,-122, -54,  19,   9,-116,  33,-118,  -1,  57, -73, -41,-115,-121,  13,   4,   7, -34,  25; D=-13;
/I:         I=-13; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='F';  M= -21, -52,-124, -41,  45, -14,-120,  43,-119,   9,   1,-117,   9,-118,-122,  -1,   9,  41, -41, -11; D=-13;
/I:         I=-13; DM=-32;
/M: SY='E';  M= -47,-125,  34,  54, -70,  -9,  21, -59, -57, -48,  39, -18,  20, -29,  43,  13, -39, -48,-127, -16; D=-13;
/I:         I=-13; DM=-32;
/M: SY='E';  M= -11,-125,  -3,  63, -18, -89,  46, -55,  24, -21, -77,  -8, -41,  -3,  29, -35, -45, -36,  36,  -5; D=-13;
/I:         I=-13; DM=-32;
/M: SY='R';  M= -23,-125,  32,  36,-123, -63, -20, -47,  32, -58, -57,  11, -29,  36,  55, -16,  -9, -27,-127, -38; D=-13;
/I:         I=-13; DM=-32;
/M: SY='P';  M= -62, -29,  -5,  10, -30,  20,  30, -66,  -3, -54,-129,  -9,  39, -63, -32, -68, -48, -53,-143, -74; D=-13;
/I:         I=-13; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='H';  M= -67,-153,   1, -10, -61,  10,  17,-154, -25,-111,-144, -10,   8,  -6, -57,   0,-101, -87,-157,-142; D=-13;
/I:         I=-13; DM=-32;
/M: SY='D';  M= -41,-144,  53, -36,-143,  -4,   9,-112, -63, -65,-135,  -8,  23,  -7, -40, -23, -13, -65, -37, -51; D=-13;
/I:         I=-13; DM=-32;
/M: SY='N';  M= -15, -95,  13, -14,-136,  32,   5, -34,   8, -98,-125,  33, -41,   9,  -4, -34, -24, -53,-140, -77; D=-13;
/I:         I=-13; DM=-32;
/M: SY='G';  M= -34,-124,   8, -43, -32,  41,   8, -94,   3, -37, -57,  40,   1,   9,  22,   5,  -4, -82,-122,  26; D=-13;
/I:         I=-13; DM=-32;
/M: SY='R';  M= -25,-122,  -9, -12, -59, -17,  23, -48,  28, -70,  -9,   9, -75,  19,  37,  28,  14,   8, -31,  19; D=-13;
/I:         I=-13; DM=-32;
/M: SY='Y';  M= -26,-123, -58,-112, -16,-124,  -9,  21,-110,  45, -47,-117,  33,  42,   6, -45, -33,  -2,  -6,  56;
/M: SY='Y';  M= -65, -63,-119, -80,  33,-124,   4, -63,-111, -47, -50, -75,-128, -38, -10,-112, -13, -78,  54, 125;
/M: SY='N';  M=-109,  19, -88,-107,-120,-102, -95, -10, -98, -52, -24, 123,-121, -61, -59, -12, -33, -67,-140,-117;
/M: SY='T';  M=  18,  49,-108,-109,-119, -12,-113, -76,-107,-116, -45, -47,-112, -58, -74,  66,  84, -52,-132,-115;
/M: SY='Q';  M=  37,  10, -21,-108, -69, -56,  11,  17,-107,  15,  11,  19,-119,  48, -13, -10, -12,  20, -28,-109;
/M: SY='V';  M=   8,  -4,-125, -41,  14,-125,-118,  33,-119,  24,  -4,-121,-124, -69,-120, -31, -41,  63,  -5,  40;
/M: SY='V';  M=   2, -15,-127,-122,  19, -47,-122,  41, -79,  38, -11, -72,-124,-119,-122, -46,  -2,  57,   1, -24;
/M: SY='F';  M= -39, -23,-132,-128,  73,-131,-122,  69,-124,  28, -22,-124,-127,-124,-125, -85, -75,  27,  -4, -19;
/M: SY='D';  M= -35, -55,  81, -13, -75,  23,   9, -66, -27, -33, -54,  44,-115, -34, -22,  35, -41,-120,-135,-115;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='P';  M=  -8,-124,  38, -16,-128, -14, -17,-124,  10, -97,-117,  54,  74, -14,  15,  23, -46,-122,-131,-119;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='Q';  M= -44,-131,  38,   4,-132, -52,  -4,-130,  17, -51, -80,  40, -57,  55, -16,   8,   3,-128,  20,-120; D=-21;
/I:         I=-21; DM=-53;
/M: SY='G';  M= -64,-126, -47,-119, -58,  96,-115,-133, -33, -62,-120, -15, -33, -65,  -2, -58, -54,-128,-121, -11; D=-21;
/I:         I=-21; DM=-53;
/M: SY='E';  M= -33,-124,  17,  56,-125, -20,   4, -43,  35, -63, -62,  17, -13,  38,   8, -22,  15, -29,-129,-115; D=-21;
/I:         I=-21; DM=-53;
/M: SY='I';  M= -60,-120, -46, -62, -25, -28,-119,  66, -31,  28,   7,-116, -34, -35, -41, -21,   6,  36,-120,   6;
/M: SY='V';  M= -15,-118, -30, -27,-103, -90,-120,  42, -26,  38, -24,-117, -10, -82, -10,  -9,  -7,  55,-126,-108;
/I:         I=-42; MD=-106;
/M: SY='G';  M=  28, -31,   0, -47,  -7,  44, -16, -54, -39,   1,  11,  20, -40,  40,-112,   6, -52, -62, -37, -50; D=-42;
/I:         I=-42; MI=-106; MD=-106; IM=-106; DM=-106;
/M: SY='R';  M= -37,-125,-111, -13, -36,-123,  36,  19,  47, -47,-105, -35, -70, -12,  65, -37,  12,   2, -27,  -5; D=-42;
/I:         I=-42; DM=-106;
/M: SY='Y';  M= -28,-127,-115,-114, -31,-122,  54, -46,-103, -81,-100,-112, -71, -58,  42, -33, -42, -36, -89, 121;
/M: SY='R';  M= -55,-127,  52, -96, -68, -63,  64,-125, -22, -55,-112,   0,  15, -27,  88, -15,-108, -69,-128, -24;
/M: SY='K';  M=-110,-125,-102, -89,-127,-117,-105,-127, 117,-125,-113, -95,-110, -18, -71,-104,-105,-122,-120,-113;
/M: SY='H';  M= -44, -29, -46,-113, -49,-122,  65,  49, -72,  20,  41,   8,-121,  10,  -3,  -1,  -1,  10, -27,   4;
/I:         I=-4; MD=-11;
/M: SY='H';  M= -52,-127,-106, -56,   5,-119, 121, -18,  34, -70, -14,  31,-120, -26,  -5, -51, -57, -87,  10, -31; D=-4;
/I:         I=-4; MD=-11;
/M: SY='L';  M= -34,-125,-136,-128, -99,-137,-123,  -3,-129,  82,  -8,-135,  16,-124, -80,-128,-116, -58,-127,-110; D=-4;
/I:         I=-4; MD=-11;
/M: SY='W';  M= -14,   0,-133,-126,  52,-130,-126, -94,-125, -34, -50,-128,  34, -46,-127,-118,  -8,  59,  65,  28; D=-4;
/I:         I=-4; MD=-11;
/M: SY='P';  M= -50, -41,  43, -48, -28, -61,  13, -79,-113, -57,  -6,  19,  88, -69, -17, -83, -31, -37, -23, -73; D=-4;
/I:         I=-4; MD=-11;
/M: SY='F';  M= -58, -19, -13,  -8,  74,  -8, -41, -88,-127, -25,  -5, -52,  19,-128, -87, -86, -32, -12, -25,   3; D=-4;
/I:         I=-4; MD=-11;
/M: SY='G';  M= -18,-136, -32,  25, -71,  70,-127, -26, -70,-134, -62, -68, -29,-119, -53, -50, -46, -38,-137,-133; D=-4;
/I:         I=-4; MD=-11;
/M: SY='E';  M= -84,-144,   9,  83,-144, -48,-118, -60, -42,-140, -53,  12,-125, -65, -12,-120, -80,-138,-146, -67; D=-4;
/I:         I=-4; MD=-11;
/M: SY='Y';  M=-135, -54,-137, -48,  37, -60, -59, -64, -17, -79,-122, -71,  -1, -69, -48, -60, -18, -84,  25,  83; D=-4;
/I:         I=-4; MD=-11;
/M: SY='W';  M=-133,-146,-144, -42, -34,-112,-139,  25, -87,  -1,  15, -18,-146, -20,  -6,-138, -88,  15,  75, -35; D=-4;
/I:         I=-4; MD=-11;
/M: SY='P';  M= -60,-162, -75,  33,-158, -94,-140,-151,-131,-156,-146,-142,  88, -86,-142,-135, -90,-152,   1,-152; D=-4;
/I:         I=-4; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='F';  M= -25, -16, -29, -11,  32, -46, -33, -81, -38, -48, -22, -91, -75,   4, -16, -50, -12, -17,-142, -60; D=-4;
/I:         I=-4; DM=-11;
/M: SY='F';  M= -71,-139, -30, -57,  58, -74, -20, -24, -47, -12, -10, -26, -79, -20, -57, -57, -79,  -4, -30,  38; D=-4;
/I:         I=-4; DM=-11;
/M: SY='D';  M= -53,-140,  47, -17,  -3, -60, -53, -35, -25, -19, -31,  18, -53,   3, -25, -26, -92, -57, -24,  18; D=-4;
/I:         I=-4; DM=-11;
/M: SY='M';  M= -23,-128, -77,  -7,  -2, -44,-122,  13, -54,  23,  61, -17,  -3,-120,-125, -32, -36,  14,-128,  -1; D=-4;
/I:         I=-4; DM=-11;
/M: SY='P';  M=-116,-138,-118, -27,-130, -53,-120, -43, -44, -51,  17,-122, 117, -82, -96, -39, -48, -52,-130, -68; D=-4;
/I:         I=-4; DM=-11;
/M: SY='G';  M= -35, -31, -19, -30, -30,  55, -38, -67,  -6, -31,   6, -11, -33,-110,   0,  10,  33, -65,  46,-115; D=-4;
/I:         I=-4; DM=-11;
/M: SY='D';  M= -25, -12,  45,  13,  -9,  39,  43, -54,  -4, -54, -11,   7, -64, -25, -62,   3, -32, -34,-131, -64; D=-4;
/I:         I=-4; DM=-11;
/M: SY='F';  M= -66, -41, -16,-120,  57, -15,-119,  21, -58,  18,  -5, -24,  29,-119, -12, -20, -15,  15,-118, -22; D=-4;
/I:         I=-4; DM=-11;
/M: SY='E';  M= -23,-124, -12,  50,   8,  20, -46, -21, -62, -53, -35, -57, -18,   9, -15,  36,  22, -44,-127,-114; D=-4;
/I:         I=-4; DM=-11;
/M: SY='R';  M=  -8,-127,   1,  -3,  23, -44,  20, -10,   2,  -2,  15, -75,  -2,  11,  52, -46, -32, -67, -37,   0; D=-4;
/I:         I=-4; DM=-11;
/M: SY='G';  M= -12, -23, -40, -59, -69,  45, -37, -36, -16,  -6,  -8, -62,  41, -23,   6, -20,   2,  26, -33, -31; D=-4;
/I:         I=-4; DM=-11;
/M: SY='W';  M= -39,-121, -13,  21,  15, -13, -53,   6, -28,   0,-102, -47,   8,-110, -61, -21,  40,  33,  47,  -1; D=-4;
/I:         I=-4; DM=-11;
/M: SY='W';  M= -25,   7,  -6,  11,  57, -11, -26, -25,  -6, -60, -21, -12,   2, -29, -45,  18,  -6, -33,  64,  36; D=-4;
/I:         I=-4; DM=-11;
/M: SY='E';  M= -14,-125,  43,  44, -53,  28, -59, -35, -13, -99, -55,  -4,   7,  43,   5, -16, -34,  -9,-127, -44; D=-4;
/I:         I=-4; DM=-11;
/M: SY='T';  M= -32, -60,  13,   9, -14,   8,   6, -56, -53, -61, -56, -13, -70,  36,  10, -16,  50, -69,-133, -34; D=-4;
/I:         I=-4; DM=-11;
/M: SY='P';  M= -25,-135,   3,  -8, -48,  24,-123, -91,  -4, -35,-123, -42,  54,  -2, -34, -15,  12, -46,-137,-128; D=-4;
/I:         I=-4; DM=-11;
/M: SY='F';  M= -72, -42,-136, -69,  37, -41, -35, -40, -62, -30,   4, -24, -25, -13, -45, -11,  14,  -3,-133,   4; D=-4;
/I:         I=-4; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='F';  M= -98,-150,  10, -30,  17, -75,-136, -10, -50, -15, -41,-134,  -3,  11, -86, -26, -32, -59,-142,  -3; D=-4;
/I:         I=-4; DM=-11;
/M: SY='P';  M= -17, -18, -85, -22, -32, -43,-137, -51, -69, -55,-129, -35,  38, -48, -13,   5, -20,  11, -33,-135; D=-4;
/I:         I=-4; DM=-11;
/M: SY='V';  M= -53,   0, -38,-137,  -1, -69,-136, -20,-135, -15, -21, -80,   3, -82, -40, -31, -16,  40,-138,  13; D=-4;
/I:         I=-4; DM=-11;
/M: SY='F';  M= -38,  -7, -54, -23,  34,-103, -38,   1, -61,  -1, -64, -32, -98, -51, -67, -36, -13,  15,-134,  -1; D=-4;
/I:         I=-4; DM=-11;
/M: SY='D';  M= -40,-138,  53,  18, -81, -40, -67, -28,  -9, -22, -78, -41, -55,  21, -38, -20, -20, -22, -29,-127; D=-4;
/I:         I=-4; DM=-11;
/M: SY='T';  M= -17, -54, -19, -77, -29, -46, -63, -18, -33,  -5, -38,-118,  28, -66, -79,   1,  57, -12,  30, -61; D=-4;
/I:         I=-4; DM=-11;
/M: SY='P';  M=  -8,-133,  20, -14, -22,  10, -37, -58,  29, -57,-121,   3,  47, -47, -13, -21, -41, -65,   1, -10; D=-4;
/I:         I=-4; DM=-11;
/M: SY='G';  M= -10, -50,  10, -48,  11,  60, -51, -25, -39, -39,-116,   6, -28,-117, -81, -27, -28, -14, -33,   8; D=-4;
/I:         I=-4; DM=-11;
/M: SY='G';  M= -37,  -6,-120,-120,  -2,  63, -27,  -5, -97, -10, -10,-110, -18,   6, -39, -19,  -1,  18,   4,  -1; D=-4;
/I:         I=-4; DM=-11;
/M: SY='K';  M= -38,   8,-107, -46,-124,-118, -51, -80,  81, -78,-113,   1,  20, -21,  56, -14,  -6, -41,-125, -69; D=-4;
/I:         I=-4; DM=-11;
/M: SY='I';  M= -27,-120,-133,-127,  55,-132,-124,  63,-125,  37,  11,-126,-127,-124,-125, -85, -72,  44, -30, -96; D=-4;
/I:         I=-4; DM=-11;
/M: SY='G';  M=  41,-119,-113,-115,-122,  78, -23, -68, -38, -40, -47, -76,-116, -71, -49,  20,  -8, -62,-123, -21; D=-4;
/I:         I=-4; DM=-11;
/M: SY='P';  M=   9, -26,-120,-115, -19, -16,   4,  18,-116,  17,   4, -23,  51, -22,-119, -19,  -2,  48,-125, -61;
/M: SY='L';  M=  29,   7,-113,   6,  35, -15,-112,   4,-112,  37,   7,  18,  -8,  -1,-116,  -3, -20, -65,-118, -40;
/M: SY='I';  M= -38, -18,-123,-124,-101,-128,-125,  99,-119, -40, -39,   9,-119, -65,-124, -49,  36,  -4,-125,-107;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='Y';  M= -75,-129, -12,  20,  53,-124,  27, -72,-112, -73, -18, -58,-125,-109,-112,-115,-115,-113, 105, 108;
/M: SY='E';  M=-110,-128,  89,  93,-133, -21,-101,-133, -95,-128,-125, -94,-108, -90,-104,-103,-107,-127,-136,-120;
/M: SY='H';  M= -22,-121,  11, -40, -63,  17,  53,  53,-110,  14,  23,   8,-119, -32,  -4,   2, -50,  -4, -41,-106;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='W';  M=   2,-121,-117, -46,  23, -87,   6,  35, -50,   3,  56,   5,-121, -55,  46, -25,   9, -42,  60, -12;
/M: SY='F';  M= -41,-120, -29,-118, 101, -84,  15, -45, -77, -15,   9,  -6,-126,  16,-116, -28,  -7, -45, -13,  35;
/M: SY='P';  M= -18,-132, -41, -72, -52,  18,  -1,-122, -67,-127,-116, -25, 114, -46, -54, -33, -57, -80, -28, -12;
/I:         I=-17; MI=0; MD=-44; IM=0; DM=-44;
/M: SY='E';  M= -32,-124,  30,  83, -23, -46, -15,-117, -17,   5, -34, -22,  -6,  -8, -53,   3, -46, -82,-125, -20; D=-17;
/I:         I=-17; DM=-44;
/M: SY='P';  M=  -6, -59, -71, -12,  21, -55,-111,   0, -39,  41,  22,   8,  48,  22, -31, -65, -65, -15,  -5,   8; D=-17;
/I:         I=-17; DM=-44;
/M: SY='W';  M=  50, -24,-118,-112, -30, -72,  35, -10, -14,  -3, -47,-111, -44,-108,  -4,  19, -16,  18,  73,  26; D=-17;
/I:         I=-17; DM=-44;
/M: SY='R';  M=   7,-123, -65, -36, -78, -62, -33,   4, -34,   3,  13,-109, -29,  21,  77, -31, -19,   4,-119,  21; D=-17;
/I:         I=-17; DM=-44;
/M: SY='A';  M=  34,-121,  32,  28, -45, -26,  13, -10, -10, -47, -11,   6, -54,  16, -26, -23,  12, -27,  -6,  32; D=-17;
/I:         I=-17; DM=-44;
/M: SY='M';  M=  15,  42, -41, -52,   0, -68, -18, -59, -59,  33,  56,  33, -40,  10, -81,   2, -29, -46,-117,  41; D=-17;
/I:         I=-17; MI=0; MD=-44; IM=0; DM=-44;
/M: SY='A';  M=  60, -54, -71, -79, -62, -13, -26, -15, -24, -21, -12,  -3, -45, -21,   4,   1, -41,  27,-121,  21; D=-17;
/I:         I=-17; DM=-44;
/M: SY='Q';  M=   6, -55,  -4,   4, -71, -36,  -8, -45,  11,  19,  26,  -7,  -2,  33,  29,  -1, -17, -50,-121,  14; D=-17;
/I:         I=-17; DM=-44;
/M: SY='Q';  M=   5,-124,  42,   4,-123, -32, -37, -40,  40, -40,   2,  31, -36,  65,  20, -30, -83, -57,-126, -42; D=-17;
/I:         I=-17; DM=-44;
/M: SY='G';  M=  -8,-122, -25, -82, -14,  90, -20, -92, -33,-125,-117, -12, -37, -14, -57, -10, -19, -46,-122, -61;
/I:         I=-16; MD=-40;
/M: SY='A';  M=  66,  26,  24,  16, -62, -89,   3, -18,-109, -86, -36, -86, -42,  13,-113, -10, -17,  23, -31,-114; D=-16;
/I:         I=-16; MD=-40;
/M: SY='E';  M= -37,-124,   3,  68,   7,-121,  16,  -6, -14, -48, -18,  13,-115,  45, -36, -48,  -9,  11, -37, -19; D=-16;
/I:         I=-16; MD=-40;
/M: SY='I';  M= -93,-121,  -5,-123, -18,-133, -60,  71, -61,  50, -19,-123, -53, -67,-124,-120,-108,  40,  -6,-104; D=-16;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='I';  M=  -7,-120,-130,-125,   3,-130,-122,  67,-123,  38,  21, -72, -51,-120,-124, -52, -70,  44,-120,   0; D=-16;
/I:         I=-16; DM=-40;
/M: SY='T';  M=  18,  28,-117,-115,  19, -79,-118,  12,-114,  -5, -28, -73,-118,-113,-118,  49,  59,  26,-126,-107; D=-16;
/I:         I=-16; DM=-40;
/M: SY='N';  M= -53, -48, -74,-112,   1,-112, -21, -50, -71, -64, -60,  98, -70, -44,  20, -53, -69, -14,  52,  55; D=-16;
/I:         I=-16; DM=-40;
/M: SY='P';  M= -24,  25,  68,-102,-126, -84,-115, -27,-113, -21, -55,   1,  86,-114,-121, -29, -19, -45,  -4, -70; D=-16;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='S';  M=  57, -56, -31,-110,-124,   8, -64, -80, -72, -94,  -2, -22, -37,   1,-115,  58,  19, -53,-130, -44; D=-16;
/I:         I=-16; DM=-40;
/M: SY='W';  M=  50, -53,-125, -64, -55,  36, -38, -84,-117, -61,   0, -48, -18, -45,-121, -54, -57,-119, 137, -61; D=-16;
/I:         I=-16; DM=-40;
/M: SY='W';  M= -60,-125,-126,-123,  84, -94,-111, -41,-118, -64, -51, -75,  -5,-119,-119,  23,  -2,-109, 106,  74; D=-16;
/I:         I=-16; DM=-40;
/M: SY='M';  M= -59, -49, -22, -60, -56,  48,  33, -53, -29, -49,  60,  32,  55,-108, -81,  -7,  18, -23,-127, -30; D=-16;
/I:         I=-16; DM=-40;
/M: SY='Y';  M=  -7, -63,  20, -31, -56, -27,  27, -18,   3, -26,  24,  39,   1, -21,  -8,  17,  30, -59,-121,  41;
/M: SY='S';  M=   0,-118, -22,  16,-119, -36, -33, -92, -27, -44, -56, -31,  37,  33, -54,  58,  41,   2,-127, -26;
/M: SY='P';  M=  -9, -48,  -2, -36, -29, -85,-114,  33,-109,  30,  10, -54,  34, -49,   6,  18,  32, -13, -26, -23;
/I:         I=-5; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='G';  M=   2, -58, -87,  -7, -45,  60, -64,-140, -51, -62,-132, -71,-132,-122, -11,  -1, -27, -88, -37, -72; D=-5;
/I:         I=-5; DM=-13;
/M: SY='P';  M= -46,-129, -78,  12,-124, -81, -30, -65,  32, -31, -10, -16,  96,  -4,  17,  12, -76, -68,-125, -61;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='W';  M=  26,-123,  33,  15,   6, -62,   6, -44, -35,  21,-103, -65, -33,   5, -15, -22, -39, -48,  63,  49;
/M: SY='Q';  M= -17,-126, -13, -34,-120, -80,  96, -63, -55,  -4, -12, -15, -53,  96, -51, -11, -66, -31,-129,-102;
/M: SY='W';  M= -24, -53, -48, -31,   0,-119, 102, -49, -79, -69, -38, -72, -78,  37, -46, -40,  -8, -67, 131,  10;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='F';  M= -28,-124,  -9,  18,  32, -80,   9,  14, -15,  22,  16,-112, -24,  19,  16,  -2, -27,  -8,-121, -53; D=-26;
/I:         I=-26; DM=-67;
/M: SY='Q';  M=   9,-120, -27,   1, -52, -43,  10,  -3, -79,  23,   5,   6, -41,  51,   0,   1,  -4,  13,   2,  -7;
/M: SY='M';  M= -27,  -8, -47, -28,  10, -70,  16,  23, -63,  49,  55, -73,-122,  21,-115, -21,  13,   4, -27, -66;
/M: SY='A';  M=  59, -54, -15,-108,-113,  -3,  -3, -17,-110,  12,  42,   5,-117,  17,-113,  23,  10, -43,-126, -65;
/M: SY='R';  M= -21,-125, -71, -56, -67, -66, -54, -42,  33, -59,  -4, -75, -58,  68,  84,  -2, -39, -14,-123,-110;
/M: SY='M';  M=  58,-114,-116, -79,   4, -26,   1, -38,-112,   9,  66,  -8,-118, -45,-115,  24,  -9,  -3,-120,  -3;
/M: SY='R';  M= -11,-126,-111,-105, -13, -51,   5, -46, -68,-113,  34,  29,-122, -44,  96, -40, -90, -66,  34,  39;
/I:         I=-9; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='A';  M=  98, -54,-113,-107,-123, -98,-115,-113, -56, -80,-110, -28,-114,-105,-113,  28, -56, -74,-125,-118;
/M: SY='W';  M= -26,-121,-125, -81,   6, -61, -38,  60, -25,  23,  24, -65,-123, -14, -17, -77,  -1,  30,  69,  -4;
/M: SY='E';  M=  11, -26,  14,  94,-128, -33,  -6, -78, -42, -71, -40, -14,-108,  28, -32, -41, -37,-119,-129,-117;
/M: SY='N';  M= -24, -22,-100, -76,  -9,  11,   6, -80, -48,   0,  -3,  87,-118, -47, -77,   9,  42, -60,-126,   2;
/M: SY='Q';  M= -17,   0,  -7, -43,-123,  62,  10,-121, -43, -11, -52,  30,-118,  63,  23, -39, -31, -58,-126,-115;
/M: SY='C';  M= -11,  84,-119,-114, -72, -25,-114,   0,  -1,  -7,  47, -43,-123,-108,  47, -13,  10,  28,-127, -34;
/M: SY='Y';  M=  -6,-126, -25,-113,  58, -31,-104, -67, -74, -85,-106,  16,  67, -35,-116, -75, -16, -51,  56,  85;
/M: SY='V';  M= -46,   5,-126,-122, -23,-127,-119,   8,-119,  37,  56, -68,-124,-118,-121, -41,  25,  69,-124,  -4;
/I:         I=-13; MD=-32;
/M: SY='L';  M=  26, -19,-145,-140,-116, -67,-136,  -2,-139,  36, -34,-141,-144,-135,-140, -78,-125,  13,-137,  13; D=-13;
/I:         I=-13; MD=-32;
/M: SY='A';  M=  41, -22,-136,-133, -50, -57,  12, -80,-132, -35,   3, -39,-139, -69,-135,   1, -23,   2,-140,  16; D=-13;
/I:         I=-13; MD=-32;
/M: SY='C';  M=  30,  34,-149,-144,-138,-141,-147, -38,-144, -30, -54,-143,  -8,-142,-148, -17, -33,   2,-153, -16; D=-13;
/I:         I=-13; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='N';  M= -39,  -8, -18, -30,-148,  -8,-126,-144,-124,-106, -71,  65,  -1,   7, -43, -67,  -5, -69,-156, -73; D=-13;
/I:         I=-13; DM=-32;
/M: SY='Q';  M=   2,  -1, -20, -39,-139,  -3,-133, -69, -16, -22,  14, -84,-140,  19, -26, -33, -10, -30,-148, -72; D=-13;
/I:         I=-13; DM=-32;
/M: SY='G';  M= -17,  11, -38, -11,-142,  18, -38, -88,  -9, -75,-133, -50, -31, -26,   0, -29,  -9, -17,  16,-136; D=-13;
/I:         I=-13; DM=-32;
/M: SY='G';  M= -11, -32, -15, -67,-144,  57,  -9, -65, -33, -71,-136,  -2, -73, -21, -60, -66, -77, -99, -36, -49; D=-13;
/I:         I=-13; DM=-32;
/M: SY='H';  M= -46,  34, -33,   3,  -8,  -8,  47, -52, -58, -44, -17, -79, -34,-124, -31,  -1, -23, -90, -60,   7; D=-13;
/I:         I=-13; DM=-32;
/M: SY='D';  M= -99,-144,  53,   6,-143, -74,  48, -72, -36, -73,-134,  15,  -3,  -5, -81,   6, -74, -79,-154, -45; D=-13;
/I:         I=-13; DM=-32;
/M: SY='D';  M= -21, -25,  30,   0, -30,  29, -58,  24, -82,  14, -37,   3,  -8, -28, -42,  -7,  -8,  16, -44, -24;
/M: SY='R';  M= -27,-123,   5, -27, -15, -21,   8, -52,   2, -31,  -5, -35,   2,  13,  69,  14,   6,   6, -41, -68;
/M: SY='A';  M=  39,  10,  -1, -35,   2, -16, -55, -11, -38,  -7, -19, -32, -53, -30,  26,  17,  -9,  -1,-118,  32;
/M: SY='T';  M=  27,  -5, -35, -24,-110, -37,  19, -20, -19,  -1, -24, -23,  -6, -19, -51,  14,  59,   6,-125,   9;
/M: SY='N';  M= -16, -36,-103,-112,  36,  14,  -6, -76, -80, -55, -31,  84, -79, -43, -44,  23, -30, -51,-112,  64;
/M: SY='Y';  M= -22, -55, -21,-112,  35,   9, -28, -58,-108, -63,  17,  36, -61, -48, -27,  14,  54, -60,  59,  59;
/M: SY='G';  M= -74, -57,   9,-118,-127, 101,-116,-135, -77,-132,-122, -62,-116,-113,-122, -30, -41,-130,  12, -35;
/M: SY='H';  M= -24, -29, -55,   1, -16,  26,  87,  36, -82, -54, -62, -28,   4,  -7, -75,   5, -23,  -2, -44,  12;
/M: SY='S';  M= -21,  24,-105, -59,-120,   4, -14,-119,-106,-121,-115, -59,-112, -34,-111,  94,  51,-112,-129, -27;
/M: SY='A';  M=  62,  28, -45, -73, -19,  -1, -52, -13, -59, -47,  55, -76,-118,  -9,  -5,  -4,   3,  -2,-122,  -3;
/M: SY='I';  M=  -4, -23,-130,-125,   1, -72,-124,  79,-122, -10,  43, -66, -54,-120,-124,-115, -67,  52, -23, -10;
/M: SY='I';  M= -11,  13, -32, -61,  17,-129, -35,  80,-121, -55, -35,-120,-123,-120,-124, -55, -44,  52,   9,  13;
/M: SY='D';  M=  27,-120,  76, -61, -40,  34,-106,-123, -72, -53, -53,  44, -69,-104, -45,  28, -49, -84,   2,-116;
/M: SY='P';  M=   0,-130,-112,  11,  30, -61, -13, -50,-109, -67, -15,-116, 109, -42, -60, -11, -80, -62, -32, -53;
/M: SY='W';  M= -78, -16,  70, -22,   5, -72, -17, -93, -17, -19,-113,  47,-119,   3,  14,   5,  -1, -72,  76,   2;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='G';  M= -52,-124, -70,-122,-130, 106,-118,-137,-117,-133, -63, -56, -58,-114,-124, -29,-114,-130,-122,-125;
/M: SY='R';  M= -27, -43,  -8,  38,-124, -82,  16, -69,  37,-120, -31, -10, -73,  21,  66,  16,  17, -37,-128,-112;
/M: SY='I';  M= -62,  12, -46, -35, -62,-128,-122,  62, -60,  16, -47, -52, -19, -30, -14, -66,  34,  49,-127, -61;
/I:         I=-16; MI=0; MD=-41; IM=0; DM=-41;
/M: SY='L';  M= -38, -59,-127,-121, -17, -97, -21,  48, -70,  51, -12,-121, -75,   1, -58, -84,   5,  47,-122, -26;
/M: SY='A';  M=  65, -55, -45, -17, -34,  16, -11,-111,  -3, -82, -16, -28,   2, -28, -22,  13, -39,   3, -11, -35;
/M: SY='Q';  M= -11,-125,   2,  43,-123,  -3,  16, -40,  -2, -29,   5, -27,  -4,  69,  19,  -2, -17, -57, -50, -71;
/M: SY='L';  M=  24,  34, -28, -76, -46,  19,-116,  -1, -47,  42, -19,-112,  24, -47, -40, -14,   9, -25,-123, -18;
/M: SY='P';  M= -12, -58,  33, -13, -73,  28,  15, -66, -19, -42,-115,  25,  64, -18, -52,  38, -27, -87,-130,-118;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='F';  M= -72, -53,  16,  48,  59,-101, -31,-117,  13, -51, -63, -31, -14,  23,  39, -12,   3,-106, -36,  -6;
/M: SY='E';  M=  -1,-121,  -1,  43,   7,  19,   3, -54, -15, -66, -45,  30, -66,  31, -40,  22,  14, -48,-125, -43;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='E';  M= -53,-128,  35,  83,-130,-119,-104,-126, -29,-100,-118, -36,  39,  38,   3, -12, -11, -58,-130, -64;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='G';  M=  19,-123,  13,  39, -77,  70, -13,-127, -21, -50, -51, -60, -56,  -2, -74, -38,   2,-120,-126,-120;
/M: SY='V';  M= -25,-119,-130, -86, -27, -99,-125,  59,-122,  38, -47, -88,-126,-121, -56, -83, -13,  63, -34, -23;
/M: SY='L';  M= -46, -12,-127,-100, -46, -49, -20,  49,-120,  58, -54, -40,-127,  -2, -49, -80, -28,  36,-123, -20;
/M: SY='Y';  M= -56, -39,  12, -34,  -7, -76, -12,   6, -89,  -9, -43, -44, -10, -23,  -7, -18,  47,  28, -33,  65;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='A';  M=  80, -37, -74, -45, -38,   5, -65, -58, -51, -72,-109, -53, -67, -60, -55,   9,  -4,  10,-125, -52;
/M: SY='D';  M= -41,-126,  67,  60, -88, -77, -27, -76,  -8, -90, -63, -13, -33,  43, -22, -10,  30,-120, -40, -46;
/M: SY='V';  M= -75,-119,-131,-126,  -9,-133,-124,  53,-124,  48, -19, -44, -67,-122, -65,-119, -44,  63,-123, -24;
/M: SY='D';  M= -35, -73,  87, -35, -49,-114, -33, -57, -22, -88, -58,   4,  31,   6,   3,  14,   8, -88,-133,  -5;
/M: SY='L';  M= -46,-122,-123,-116,  -2, -22,-116, -36, -34,  55,  14, -50,  53, -45, -10,  -7,  -7,   2,  -7, -47;
/I:         E1=0; IE=-380; DE=-380;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	306 in 306 different sequences
Number of true positive hits	306 in 306 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	1

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	CN hydrolase
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

306 sequences

AGUB_ORYSJ  (Q93XI4), AGUB_SOLLC  (Q9XGI9), AGUB_SOLTU  (Q3HVN1),

AMIE_ALCBS  (Q0VN20), AMIE_BACSP  (Q9L543), AMIE_BRADU  (Q89VS2), 
AMIE_BRASB  (A5EDA7), AMIE_BRASO  (A4Z057), AMIE_BURCH  (A0B137), 
AMIE_BURO0  (B1K2X7), AMIE_BURO1  (Q1BP24), AMIE_DELAS  (A9C011), 
AMIE_GEOSE  (Q9RQ17), AMIE_HELAH  (Q17YA2), AMIE_HELP2  (B6JKM3), 
AMIE_HELPG  (B5ZA60), AMIE_HELPH  (Q1CUK9), AMIE_HELPJ  (Q9ZME1), 
AMIE_HELPS  (B2USC5), AMIE_HELPY  (O25067), AMIE_MARN8  (A1U7G1), 
AMIE_NOCFA  (Q5Z1U0), AMIE_PSEA7  (A6V262), AMIE_PSEA8  (B7V2X1), 
AMIE_PSEAB  (Q02QK0), AMIE_PSEAE  (P11436), AMIE_PSEFS  (C3K9E6), 
AMIE_PSEP1  (A5W2C0), AMIE_RHOE4  (C0ZNE8), AMIE_RHOER  (Q01360), 
AMIE_THISH  (B8GQ39), AMIE_VARPS  (C5CWZ4), AMIF_ALLAM  (B9K1J4), 
AMIF_BACAA  (C3P6U6), AMIF_BACAC  (C3LI05), AMIF_BACAH  (A0RHV8), 
AMIF_BACAN  (P59700), AMIF_BACC0  (B7JK27), AMIF_BACC2  (B7IVH6), 
AMIF_BACC3  (C1EPV3), AMIF_BACC4  (B7H6S5), AMIF_BACCQ  (B9IW18), 
AMIF_BACCR  (P59701), AMIF_BACCZ  (Q635Y7), AMIF_BACHK  (Q6HEM5), 
AMIF_BRADU  (Q89H51), AMIF_BRASO  (A4Z3G9), AMIF_HELAH  (Q17WY3), 
AMIF_HELP2  (B6JN78), AMIF_HELPG  (B5Z8N3), AMIF_HELPH  (Q1CS25), 
AMIF_HELPJ  (Q9ZJY8), AMIF_HELPS  (B2UV01), AMIF_HELPY  (O25836), 
AMIF_NITV2  (Q72CW9), AMIF_NITV4  (A1VEP0), AMIF_PHOLL  (Q7N278), 
AMIF_PSESM  (Q887D9), AMIF_PSEU2  (Q4ZXA2), BTD_BOVIN   (A6QQ07), 
BTD_HUMAN   (P43251), BTD_MOUSE   (Q8CIF4), BTD_RAT (Q5FVF9), 
BTD_TAKRU   (Q8AV84), BUP1_ARATH  (Q8H183), BUP1_DICDI  (Q964D8), 
BUP1_HUMAN  (Q9UBR1), BUP1_MOUSE  (Q8VC97), BUP1_PONAB  (Q5RBM6), 
BUP1_RAT(Q03248), CHT_ALTBR   (Q7Z8M6), CHT_ASPNG   (A9QXE0), 
CHT_BOTF4   (G2XQT1), CHT_EMENI   (C8V9R7), CHT_FUSSL   (Q96UG7), 
CHT_GIBBA   (P32963), CHT_GIBZE   (I1RP53), CHT_LEPMC   (Q9P8V3), 
CHT_MICSH   (P32964), CHT_NEUCR   (Q7RVT0), CHT_PENRW   (B6HCY4), 
CHT_PYRTT   (E3RV84), CHT_STEHR   (P9WEU5), CTU_FRATT   (Q5NHL7), 
DCAS_AGRSK  (P60327), DCAS_ENSAD  (Q5S260), DCAS_RHIRD  (Q44185), 
LNT1_LEPIC  (Q72PB6), LNT1_LEPIN  (Q8F724), LNT1_TREDE  (P61037), 
LNT1_TREPA  (O83279), LNT2_LEPIC  (Q72MD8), LNT2_LEPIN  (Q8EYY4), 
LNT2_TREDE  (P61038), LNT2_TREPA  (O83432), LNT_AGRFC   (Q8UID7), 
LNT_ALLAM   (B9JZJ6), LNT_AQUAE   (O67000), LNT_AZOVD   (C1DMW2), 
LNT_BDEBA   (P61032), LNT_BLOFL   (Q7VRA5), LNT_BORBR   (Q7WMN7), 
LNT_BORBU   (O51253), LNT_BORPA   (P61033), LNT_BORPE   (P61034), 
LNT_BRADU   (Q89WA1), LNT_BRUME   (Q8YEA6), LNT_BRUSU   (Q8FXT9), 
LNT_CAMJE   (Q9PNJ9), LNT_CAUVC   (Q9AC16), LNT_CHLCV   (Q824Q5), 
LNT_CHLMU   (Q9PJK8), LNT_CHLPN   (Q9Z7Q1), LNT_CHLTE   (Q8KCC4), 
LNT_CHLTR   (O84539), LNT_CHRVO   (Q7NQI3), LNT_COXBU   (Q820B4), 
LNT_ECO57   (Q8XBK2), LNT_ECOL6   (Q8FJY4), LNT_ECOLI   (P23930), 
LNT_GEOMG   (Q39T32), LNT_GEOSL   (P61035), LNT_GLOVI   (Q7NJV1), 
LNT_HAEDU   (Q7VM56), LNT_HAEIN   (P44626), LNT_HELHP   (Q7VFP7), 
LNT_HELPJ   (Q9ZMQ0), LNT_HELPY   (O24982), LNT_METCA   (Q608N5), 
LNT_MYCS2   (A0QZ13), LNT_NEIMA   (Q9JVA8), LNT_NEIMB   (Q9K0A2), 
LNT_NITEU   (Q820C9), LNT_NOSS1   (Q8YYI9), LNT_PARMW   (Q7U5S4), 
LNT_PASMU   (Q9CM14), LNT_PHOLL   (Q7N750), LNT_PHOPR   (Q6LNA1), 
LNT_PROMA   (Q7VAT8), LNT_PROMM   (Q7V8K1), LNT_PROMP   (Q7V0G7), 
LNT_PSEA7   (A6V0C5), LNT_PSEA8   (B7V9D2), LNT_PSEAB   (Q02SF2), 
LNT_PSEAE   (Q9ZI86), LNT_PSEPK   (Q88DN4), LNT_PSESM   (Q87VX7), 
LNT_RALN1   (Q8Y210), LNT_RHIE6   (B3PZB2), LNT_RHILO   (Q98BJ6), 
LNT_RHILW   (B5ZMX7), LNT_RHIME   (P58377), LNT_RHIR8   (B9J8B4), 
LNT_RHOBA   (Q7UGJ8), LNT_RHOPA   (P61036), LNT_RICBR   (Q1RH27), 
LNT_RICCN   (Q92IC5), LNT_RICFE   (Q4ULZ6), LNT_RICPR   (Q9ZDG3), 
LNT_RICTY   (Q68X09), LNT_SALTI   (Q8Z8G7), LNT_SALTY   (O87576), 
LNT_SHEON   (Q8EHP1), LNT_SHIFL   (Q820C8), LNT_SINFN   (C3MF13), 
LNT_SINMW   (Q52910), LNT_SYNY3   (P74055), LNT_THEMA   (Q9WZ43), 
LNT_THEVB   (Q8DIC3), LNT_VEREI   (A1WJU9), LNT_VIBCH   (Q9KTE4), 
LNT_VIBPA   (Q87RP8), LNT_VIBVU   (Q8DFE4), LNT_VIBVY   (Q7MN04), 
LNT_WIGBR   (Q8D2A8), LNT_WOLSU   (Q7MAR3), LNT_YERPE   (Q8D124), 
MTNU_BACSU  (O31664), NADE2_THEMA (Q9X0Y0), NADE_ACIAD  (Q6F8K4), 
NADE_AQUAE  (O67091), NADE_ARATH  (Q9C723), NADE_BOVIN  (Q3ZBF0), 
NADE_CHICK  (Q5ZMA6), NADE_DICDI  (Q54ML1), NADE_DROME  (Q9VYA0), 
NADE_HUMAN  (Q6IA69), NADE_MACFA  (Q4R5Y2), NADE_MOUSE  (Q711T7), 
NADE_MYCBO  (P0A5L7), NADE_MYCLE  (Q9CBZ6), NADE_MYCTO  (P9WJJ2), 
NADE_MYCTU  (P9WJJ3), NADE_ORYSI  (A2YII8), NADE_ORYSJ  (Q0D8D4), 
NADE_RAT(Q812E8), NADE_RHOCA  (Q03638), NADE_SCHPO  (O74940), 
NADE_SYNY3  (P74292), NADE_TREPA  (O83759), NADE_XANC8  (A0A0H2X6L3), 
NADE_XYLFA  (Q9PC24), NADE_XYLFT  (Q87D47), NADE_YEAST  (P38795), 
NFT1_CAEEL  (O76463), NFT1_DROME  (O76464), NILP1_ARATH (Q8VYF5), 
NILP2_ARATH (Q94JV5), NILP3_ARATH (Q8RUF8), NIT1_ASPKW  (G7XTA8), 
NIT1_ASPNC  (A2R6M7), NIT1_BOVIN  (Q32LH4), NIT1_DICDI  (Q557J5), 
NIT1_HUMAN  (Q86X76), NIT1_MOUSE  (Q8VDK1), NIT1_RAT(Q7TQ94), 
NIT1_SYNY3  (P55175), NIT1_SYNYG  (P0DP66), NIT1_YEAST  (P40447), 
NIT1_YEREN  (P0DP68), NIT2A_XENLA (Q6IR61), NIT2B_XENLA (Q6INI7), 
NIT2_ASPKW  (G7X8S6), NIT2_ASPNC  (A2RA31), NIT2_BOVIN  (Q2T9R6), 
NIT2_DANRE  (Q4VBV9), NIT2_DICDI  (Q54JM9), NIT2_HUMAN  (Q9NQR4), 
NIT2_MOUSE  (Q9JHW2), NIT2_PENRW  (B6HVR6), NIT2_PONAB  (Q5R4L6), 
NIT2_RAT(Q497B0), NIT2_SCHPO  (O94660), NIT2_XENTR  (Q28IE5), 
NIT2_YEAST  (P47016), NIT3_YEAST  (P49954), NITR1_BRADU (Q89GE3), 
NITR2_BRADU (Q89PT3), NITR2_UNKP  (Q6RWK4), NITR3_UNKP  (Q6RWG0), 
NITR_PARP8  (B2JQY2), NITR_PSEU2  (Q500U1), NITR_PYRAB  (Q9UYV8), 
NIT_ARMGA   (A0A2H3E4G0), NIT_ARTBC   (D4B1Q8), NIT_ASPOR   (Q2U4D6), 
NIT_AURST   (A0A0P1DJE3), NIT_FUSV7   (C7YS90), NIT_GIBMO   (Q19A54), 
NIT_HYPVG   (G9N4E3), NIT_MACPH   (K2QXC4), NIT_NEUCR   (V5IPE4), 
NIT_PAENI   (Q93NG1), NIT_PICGU   (A5DNJ4), NIT_SINF1   (G9AIU0), 
NIT_TALMQ   (B6Q5I3), NIT_TRAVS   (P9WEU6), NRL1_ARATH  (P32961), 
NRL1_RHORH  (Q02068), NRL2_ARATH  (P32962), NRL2_RHORH  (Q03217), 
NRL3_ARATH  (P46010), NRL4A_LUPAN (Q5QGZ8), NRL4A_TOBAC (Q42965), 
NRL4B_LUPAN (Q3LRV4), NRL4B_TOBAC (Q42966), NRL4_ARATH  (P46011), 
NRL4_ORYSJ  (Q6H849), NRLA_ALCFA  (P20960), NRLB_KLEPO  (P10045), 
NRL_BACSX   (P82605), NTA1_SCHPO  (O60178), NTA1_YEAST  (P40354), 
PPMNT_MYCBP (A0A0H3M5A8), PPMNT_MYCTU (O53493), RSAM_PSESP  (Q75SP7), 
SYMPP_STHOU (C6KYS2), TRAB_AGRFC  (Q44351), TRAB_SINFN  (P55416), 
VNN1_BOVIN  (Q58CQ9), VNN1_CANLF  (Q9TSX8), VNN1_HUMAN  (O95497), 
VNN1_MOUSE  (Q9Z0K8), VNN1_PIG(Q9BDJ5), VNN2_HUMAN  (O95498), 
VNN3_MOUSE  (Q9QZ25), VNNL1_DROME (Q9NFP1), VNNL2_DROME (Q8IRR1), 
VNNL3_DROME (P83548), Y480_MYCTO  (P9WJ00), Y480_MYCTU  (P9WJ01), 
YAFV_ECOBD  (A0A140NDS5), YAFV_ECOLI  (Q47679), YAFV_STAA4  (P0DP65), 
YAFV_YEREN  (P0DP67), YAG5_STAAU  (P55177), YAG5_STALU  (P55178), 
YAUB_SCHPO  (Q10166), YBEM_ECO57  (P58054), YBEM_ECOBD  (A0A140NCB4), 
YBEM_ECOLI  (P0DP64), YCU9_SCHPO  (O59829), YHCX_BACSU  (P54608), 
YIQ5_YEAST  (P40446), YOBB_ECOLI  (P76280), YPQQ_PSEPH  (P55176)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
'Partial' sequences

1 sequence

NRLA_ACISA  (P33036)

PDB
[Detailed view]

72 PDB

1EMS; 1ERZ; 1F89; 1FO6; 1UF4; 1UF5; 1UF7; 1UF8; 2DYU; 2DYV; 2E2K; 2E2L;
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