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PROSITE entry PS50234


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PURL: https://purl.expasy.org/prosite/signature/PS50234

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General information about the entry

Entry name [info] VWFA
Accession [info] PS50234
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50234
Associated ProRule [info] PRU00219

Name and characterization of the entry

Description [info] VWFA domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=177;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=172;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.9193000; R2=0.0176105; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=8288.6396484; R2=8.4804182; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=431; H_SCORE=11944; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=317; H_SCORE=10977; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; MM=1; M0=-8;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 460 in 331 different sequences
Number of true positive hits 445 in 316 different sequences
Number of 'unknown' hits 6 in 6 different sequences
Number of false positive hits 9 in 9 different sequences
Number of false negative sequences 94
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.02 %
Recall (true positives / (true positives + false negatives)) 82.56 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 12
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] VWFA
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
316 sequences

ANTR1_HUMAN (Q9H6X2), ANTR1_MOUSE (Q9CZ52), ANTR1_RAT   (Q0PMD2), 
» more

UniProtKB/Swiss-Prot
False negative sequences
94 sequences

CPNA1_CAEEL (H2KYS8), CPNA2_CAEEL (Q09221), CPNA5_CAEEL (Q09219), 
» more

UniProtKB/Swiss-Prot
'Unknown' sequences
6 sequences

MED25_DANRE (Q6PEH8), MED25_XENLA (Q6GP15), MED25_XENTR (A4IHD9), 
» more

UniProtKB/Swiss-Prot
False positive sequences
9 sequences

DER_MYCPU   (Q98RC1), KU70_RHIAP  (Q26228), KU80_ASPFU  (Q4WI96), 
» more

PDB
[Detailed view]
429 PDB

1AO3; 1AOX; 1ATZ; 1AUQ; 1BHO; 1BHQ; 1CK4; 1CQP; 1DGQ; 1DZI; 1FE8; 1FNS;
» more