PROSITE logo

PROSITE entry PS50234


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50234
Entry name [info] VWFA
Accession [info] PS50234
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50234
Associated ProRule [info] PRU00219

Name and characterization of the entry

Description [info] VWFA domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=177;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=172;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.9193000; R2=0.0176105; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=8288.6396484; R2=8.4804182; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=431; H_SCORE=11944; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=317; H_SCORE=10977; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; MM=1; M0=-8;
...
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 457 in 329 different sequences
Number of true positive hits 442 in 314 different sequences
Number of 'unknown' hits 6 in 6 different sequences
Number of false positive hits 9 in 9 different sequences
Number of false negative sequences 94
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.00 %
Recall (true positives / (true positives + false negatives)) 82.46 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 12
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] VWFA
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
314 sequences

ANTR1_HUMAN (Q9H6X2), ANTR1_MOUSE (Q9CZ52), ANTR1_RAT   (Q0PMD2), 
» more

UniProtKB/Swiss-Prot
False negative sequences
94 sequences

CPNA1_CAEEL (H2KYS8), CPNA2_CAEEL (Q09221), CPNA5_CAEEL (Q09219), 
» more

UniProtKB/Swiss-Prot
'Unknown' sequences
6 sequences

MED25_DANRE (Q6PEH8), MED25_XENLA (Q6GP15), MED25_XENTR (A4IHD9), 
» more

UniProtKB/Swiss-Prot
False positive sequences
9 sequences

DER_MYCPU   (Q98RC1), KU70_RHIAP  (Q26228), KU80_ASPFU  (Q4WI96), 
» more

PDB
[Detailed view]
419 PDB

1AO3; 1AOX; 1ATZ; 1AUQ; 1BHO; 1BHQ; 1CK4; 1CQP; 1DGQ; 1DZI; 1FE8; 1FNS;
» more