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PROSITE entry PS50215


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50215
Entry name [info] ADAM_MEPRO
Accession [info] PS50215
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
13-FEB-2019 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50215
Associated ProRule [info] PRU00276

Name and characterization of the entry

Description [info] ADAM type metalloprotease domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=197;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=192;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.9201000; R2=0.0119942; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4341.5732422; R2=24.3668575; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=632; H_SCORE=19741; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=466; H_SCORE=15697; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-70; E1=-70; MI=-105; MD=-105; IM=-105; DM=-105; MM=1; M0=-1;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 301 in 301 different sequences
Number of true positive hits 301 in 301 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 34
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.67 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] Peptidase M12B
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
301 sequences

AD26A_MOUSE (Q9R158), ADA10_BOVIN (Q10741), ADA10_CAEEL (G5EFD9), 
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UniProtKB/Swiss-Prot
False negative sequences
1 sequence

VM3AH_NAJAT (P0DJJ1)

		
UniProtKB/Swiss-Prot
'Partial' sequences
34 sequences

FIBR_GANLU  (P86051), VM1B1_BOTAT (P0DJE1), VM1B1_BOTPA (P0C6S0), 
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PDB
[Detailed view]
90 PDB

1ATL; 1BKC; 1BSW; 1BUD; 1DTH; 1HTD; 1IAG; 1KUF; 1KUG; 1KUI; 1KUK; 1ND1;
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