PROSITE logo

PROSITE entry PS50212


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50212
Entry name [info] RASGEF_NTER
Accession [info] PS50212
Entry type [info] MATRIX
Date [info] 01-APR-2003 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00594
Associated ProRule [info] PRU00135

Name and characterization of the entry

Description [info] Ras guanine-nucleotide exchange factors N-terminal domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=117;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=112;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.8479941; R2=0.0229533; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=247; N_SCORE=8.5000; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=160; N_SCORE=6.5000; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-40; I=-40; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 115 in 115 different sequences
Number of true positive hits 115 in 115 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 98.29 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] N_Hulo
Feature key [info] DOMAIN
Feature description [info] N-terminal Ras-GEF
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
115 sequences

BUD5_YEAST  (P25300), C3G_DROME   (O77086), CDC25_CANAL (P43069), 
» more

UniProtKB/Swiss-Prot
False negative sequences
2 sequences

PIAA_DICDI  (O77203), TSC11_YEAST (P40061)

		
PDB
[Detailed view]
105 PDB

1BKD; 1NVU; 1NVV; 1NVW; 1NVX; 1XD2; 1XD4; 1XDV; 2BYV; 2II0; 3CF6; 3KSY;
» more