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PROSITE entry PS50200


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50200
Entry name [info] RA
Accession [info] PS50200
Entry type [info] MATRIX
Date [info] 01-JAN-2003 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50200
Associated ProRule [info] PRU00166

Name and characterization of the entry

Description [info] Ras-associating (RA) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=96;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=96;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6480339; R2=0.0002715; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=518350.1875000; R2=0.5565736; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=21555; H_SCORE=530347; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=14188; H_SCORE=526247; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: B1=*; E1=*; MM=*; II=*;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 132 in 128 different sequences
Number of true positive hits 129 in 125 different sequences
Number of 'unknown' hits 1
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.47 %
Recall (true positives / (true positives + false negatives)) 97.73 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] Ras-associating
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
125 sequences

AB1IP_CHICK (Q5ZL23), AB1IP_DANRE (Q6PFT9), AB1IP_HUMAN (Q7Z5R6), 
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UniProtKB/Swiss-Prot
False negative sequences
3 sequences

HUM6_CAEBR  (Q622K8), HUM6_CAEEL  (P91443), MYOG_DICDI  (Q86AC8)

		
UniProtKB/Swiss-Prot
'Unknown' sequences
1 sequence

EXOC2_DICDI (Q54VX5)

		
UniProtKB/Swiss-Prot
False positive sequences
2 sequences

FRPD1_MOUSE (A2AKB4), PKHH3_RAT   (Q3B7L1)

		
PDB
[Detailed view]
36 PDB

1EF5; 1LFD; 1LXD; 1RAX; 1RLF; 1WGR; 1WXA; 2B3A; 2BYF; 2C5L; 2CS4; 2RGF;
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