PROSITE entry PS50199

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PURL: https://purl.expasy.org/prosite/signature/PS50199

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General information about the entry

Entry name [info]	ZF_RANBP2_2
Accession [info]	PS50199
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50199
Associated ProRule [info]	PRU00322

Name and characterization of the entry

Description [info]

Zinc finger RanBP2 type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=30;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=27;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.1729000; R2=0.0112922; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=941.1036377; R2=2.0848954; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=605; H_SCORE=2202; N_SCORE=8.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=472; H_SCORE=1925; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='R';  M= -9, -6,-27, -5,  2,-23,-18, -9,-21, 20,-20, -9, -3, -7,  4, 22, -4, -6,-15,-24,-12,  1;
/M: SY='E';  M=  2, -2,-24,  0, 11,-17,-17,-12,-13, -3,-15,-12, -5, -2, -2,-10,  1, -5,-11,-26,-14,  4;
/M: SY='G';  M= -4,  4,-28,  4, -6,-29, 39,-12,-35, -8,-29,-20,  9,-17,-10,-11,  2,-14,-28,-26,-25, -8;
/I:         I=-8; MI=-5; MD=-10; IM=-5; DM=-10;
/M: SY='D';  M=-11,  9,-27, 15, 11,-21,-15,  0,-25,  1,-22,-16,  2, -9,  8, -4,  1, -5,-23,-18, -5,  9;
/M: SY='W';  M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='E';  M= -9,  8,-26, 11, 12,-26,-17,  2,-21,  4,-18,-11,  4, -9, 10, -1, -1, -4,-19,-29,-12, 11;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         MI=-5; MD=-10; IM=-5; II=-9; DM=-10; I=0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='S';  M= -4,  6,-22,  5,  4,-23,-11, -5,-22, -1,-26,-17,  9,  9, -1, -6, 11,  7,-19,-34,-18,  0;
/M: SY='S';  M=  1, -8,-18, -9, -5,-17,-10,-12,-11, -3,-13, -8, -4,-15, -5, -6,  8,  7, -2,-29,-13, -5;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T';  M= -5, -6, -7,-11,-12,-10, -3,-13,-14,-14, -8, -9,  0,-21,-12,-13,  1,  3,-11,-26,-11,-12;
/M: SY='V';  M= -7,-13,-18,-17,-15,  4,-24,-14,  8,-14,  6,  2, -9,-25,-18,-12,-10, -2, 12,-22, -1,-16;
/M: SY='Q';  M= -8, -6,-23, -8, -3,-16,-19, -4, -9,  4,-11,  3, -3,-16,  8,  6, -2, -1, -7,-24, -8,  2;
/M: SY='N';  M=-10, 37,-13, 17, -2,-20, -2,  8,-21, -2,-29,-20, 56,-21, -2, -2,  9, -1,-29,-41,-21, -2;
/M: SY='F';  M= -8,-10,-20,-12,  2,  3,-20,-12,-18, -1,-15,-12, -8, -7, -8, -4, -6, -7,-15,-12, -2, -3;
/M: SY='A';  M= 22,-11,-17,-14, -6,-20, -7,-17,-13, -7,-15,-11, -9,  4, -6,-12,  7,  1, -7,-25,-19, -7;
/M: SY='E';  M= -5, -1,-23, -2,  3,-15,-15, -4,-20,  0,-16,-12, -1,-14, -1,  3,  3,  3,-15,-17, -8,  0;
/M: SY='R';  M=  7, -2,-20, -2,  1,-22,-10,-10,-21,  4,-20,-14,  0, -7,  0,  9,  7, -1,-13,-27,-17, -1;
/M: SY='T';  M= -6, -6,-20,-11, -8,-10,-19,-12, -3, -6, -6, -3, -1,-14, -7, -4,  1,  6, -2,-27, -8, -9;
/M: SY='K';  M= -6, -4,-26, -3, 10,-22,-19,  0,-21, 20,-20, -9, -3,-13,  5, 15, -5, -8,-13,-22, -7,  6;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='V';  M= -5,-10,-18,-17,-18,  8,-21,-17,  7,-16,  0, -1, -4,-23,-20,-15, -7, -4, 10,-22, -4,-19;
/M: SY='A';  M=  9, -9,-12,-14, -7,-19,-13,-11,-12,  1,-14, -7, -4,-16,  0,  6,  3, -2, -5,-25,-15, -5;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G';  M= -7, -2,-29, -3,  2,-25,  8, -8,-27,  0,-24,-13,  2,-15,  8, -2, -1,-10,-26, -8,-14,  5;
/M: SY='S';  M=  9,  2,-13, -7, -7,-14, -4,-12,-15, -8,-17,-13,  8,-14, -8,-10, 13, 13, -9,-28,-14, -8;
/M: SY='P';  M= -3,-12,-27, -7,  0,-21,-17,-12,-14,-10,-15,-12,-11, 28, -7,-12, -1, -2,-15,-30,-19, -6;
/M: SY='K';  M=-10, -1,-28, -2,  4,-25,-16, -7,-27, 34,-25,-11,  3,-14,  7, 34, -7, -9,-18,-22,-12,  4;
/M: SY='P';  M= -8, -8,-29, -4,  1,-21,-10,-13,-21, -1,-20,-13, -7, 17, -4, -7, -3, -5,-20,-25,-16, -3;
/M: SY='D';  M= -3,  3,-24,  4,  1,-24, -2,-11,-20, -6,-19,-14,  1, -3, -3,-10,  3, -1,-16,-29,-19, -2;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	179 in 105 different sequences
Number of true positive hits	179 in 105 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	12
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	93.72 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	8
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	K_Hofmann
Feature key [info]	ZN_FING
Feature description [info]	RanBP2-type
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

105 sequences

ARI8_ARATH  (Q8W468), CAN15_HUMAN (O75808), CAN15_MOUSE (Q9JLG8),

CAND_DROME  (P27398), CAZ_DROME   (Q27294), DRI1_SCHPO  (O13801), 
DRI1_YEAST  (P32770), EWS_HUMAN   (Q01844), EWS_MOUSE   (Q61545), 
FUS_BOVIN   (Q28009), FUS_HUMAN   (P35637), FUS_MOUSE   (P56959), 
HOIL1_DANRE (A9JTG5), HOIL1_DICLA (E6ZIJ1), HOIL1_HUMAN (Q9BYM8), 
HOIL1_MOUSE (Q9WUB0), HOIL1_RAT   (Q62921), MDM2_CANLF  (P56950), 
MDM2_DANRE  (O42354), MDM2_FELCA  (Q7YRZ8), MDM2_HORSE  (P56951), 
MDM2_HUMAN  (Q00987), MDM2_MESAU  (Q60524), MDM2_MOUSE  (P23804), 
MDM2_XENLA  (P56273), MDM4_BOVIN  (Q2HJ21), MDM4_DANRE  (Q7ZUW7), 
MDM4_HUMAN  (O15151), MDM4_MOUSE  (O35618), MDM4_RAT(Q5XIN1), 
MDM4_XENLA  (Q7ZYI3), NEIL3_BOVIN (Q3MHN7), NEIL3_HUMAN (Q8TAT5), 
NEIL3_MOUSE (Q8K203), NEIL3_XENLA (A0A1L8HU22), NPL41_CAEEL (H2KYU6), 
NPL42_CAEEL (Q95QZ9), NPL4_DROME  (Q9VBP9), NPL4_HUMAN  (Q8TAT6), 
NPL4_MOUSE  (P60670), NPL4_RAT(Q9ES54), NU153_DROME (Q9VXE6), 
NU153_HUMAN (P49790), NU153_MOUSE (E9Q3G8), NU153_RAT   (P49791), 
NU153_XENLA (Q640Z6), RBL14_ARATH (Q8RXW0), RBM10_HUMAN (P98175), 
RBM10_MOUSE (Q99KG3), RBM10_RAT   (P70501), RBM5A_XENLA (A0JMV4), 
RBM5B_XENLA (Q6DDU9), RBM5_BOVIN  (Q1RMU5), RBM5_HUMAN  (P52756), 
RBM5_MOUSE  (Q91YE7), RBM5_RAT(B2GV05), RBM5_XENTR  (A4IGK4), 
RBP2_DROME  (A0A0B4K7J2), RBP2_HUMAN  (P49792), RBP2_MOUSE  (Q9ERU9), 
RBP2_PANTR  (H2QII6), RBP56_HUMAN (Q92804), RNF31_HUMAN (Q96EP0), 
RNF31_MOUSE (Q924T7), RYBPA_DANRE (Q7SYB3), RYBPB_DANRE (Q5EG55), 
RYBP_HUMAN  (Q8N488), RYBP_MOUSE  (Q8CCI5), SHRPN_BOVIN (E1BDF2), 
SHRPN_HUMAN (Q9H0F6), SHRPN_MOUSE (Q91WA6), SHRPN_RAT   (Q9EQL9), 
SUA_ARATH   (F4JCU0), TA15B_ARATH (Q94KD0), TAB2_DANRE  (Q5RFW2), 
TAB2_HUMAN  (Q9NYJ8), TAB2_MOUSE  (Q99K90), TAB2_RAT(Q5U303), 
TAB3_HUMAN  (Q8N5C8), TAB3_MOUSE  (Q571K4), TAB3_XENLA  (Q7ZXH3), 
TAF15_ARATH (Q9AST1), TRBID_DROME (Q9VH90), TX13A_HUMAN (Q9BXU3), 
TX13A_MOUSE (A2AFS9), VAR3_ARATH  (Q8S9K3), YAF2_HUMAN  (Q8IY57), 
YAF2_MOUSE  (Q99LW6), YDMD_SCHPO  (P87143), ZRAB2_CHICK (Q5ZLX5), 
ZRAB2_HUMAN (O95218), ZRAB2_MOUSE (Q9R020), ZRAB2_PIG   (Q19QU3), 
ZRAB2_PONAB (Q5R580), ZRAB2_RAT   (O35986), ZRAB3_BOVIN (E1BB03), 
ZRAB3_HUMAN (Q5FWF4), ZRAB3_MOUSE (Q6NZP1), ZRAN1_BOVIN (A6QP16), 
ZRAN1_HUMAN (Q9UGI0), ZRAN1_MOUSE (Q7M760), ZRAN1_XENTR (B1H2Q2), 
ZRN1A_XENLA (Q5U595), ZRN1B_DANRE (A0JMQ9), ZRN1B_XENLA (Q6NUB7)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

12 sequences

ARI13_ARATH (Q9FFN9), ARI14_ARATH (Q9FFP1), ARI15_ARATH (Q84RQ8),

ARI16_ARATH (Q9C5A4), HDA15_ARATH (Q8GXJ1), LUBEL_DROME (Q8IPJ3), 
TAMO_DROME  (Q9W1A4), TX13C_HUMAN (A0A0J9YWL9), TX13D_HUMAN (A0A0J9YY54), 
VPS36_SCHPO (O43038), VPS36_YEAST (Q06696), YZR3_ARATH  (Q8GZ43)

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PDB
[Detailed view]

71 PDB

1N0Z; 1NJ3; 1Q5W; 2C6A; 2C6B; 2CR8; 2CRC; 2D9G; 2EBQ; 2EBR; 2EBV; 2GQE;
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