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PROSITE entry PS50179


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PURL: https://purl.expasy.org/prosite/signature/PS50179

Direct ScanProsite submission
General information about the entry

Entry name [info] VHS
Accession [info] PS50179
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50179
Associated ProRule [info] PRU00218

Name and characterization of the entry

Description [info] VHS domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=130;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=125;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.1228000; R2=0.0167642; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=7779.0566406; R2=4.9245281; TEXT='Heuristic 0.1%';
/CUT_OFF: LEVEL=0; SCORE=441; H_SCORE=9951; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=321; H_SCORE=9360; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 91 in 91 different sequences
Number of true positive hits 89 in 89 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 1
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 97.80 %
Recall (true positives / (true positives + false negatives)) 98.89 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann, CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] VHS
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
89 sequences

GGA1_HUMAN  (Q9UJY5), GGA1_MOUSE  (Q8R0H9), GGA1_YEAST  (Q06336), 
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UniProtKB/Swiss-Prot
False negative sequences
1 sequence

LSB5_YEAST  (P25369)

		
UniProtKB/Swiss-Prot
False positive sequences
2 sequences

FES1_YARLI  (Q6C239), NHAK_BACVZ  (A7Z8R4)

		
PDB
[Detailed view]
24 PDB

1DVP; 1ELK; 1JPL; 1JUQ; 1JWF; 1JWG; 1LF8; 1MHQ; 1PY1; 1UJJ; 1UJK; 1VDY;
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