PROSITE entry PS50135

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PURL: https://purl.expasy.org/prosite/signature/PS50135

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General information about the entry

Entry name [info]	ZF_ZZ_2
Accession [info]	PS50135
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 02-JUN-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50135
Associated ProRule [info]	PRU00228

Name and characterization of the entry

Description [info]

Zinc finger ZZ-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=57;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=52;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3384571; R2=0.0091303; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1332; N_SCORE=14.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=456; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-26; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='H';  M=  -6, -13, -58, -21,   6, -15,  97, -70,  17,  -8, -57,  -3, -17, -26,   0,  31, -12, -68, -80, -30;
/M: SY='H';  M= -47,  -1,  27, -12,  20, -16,  66, -55,   4,   8,  33, -33,   5, -27, -40,   0, -38,  15,  27, -52;
/M: SY='Q';  M=  -8, -75,  12,  18, -75,  25,   5, -68,  21, -26, -62,   8,  11,  56, -34,  13, -56,  -4, -78, -33;
/M: SY='Y';  M=  -3, -73, -69, -66,  19, -72,  10,  18,  -1, -37, -20, -31,  20, -25, -64,  -4,  15,  34, -59,  70;
/M: SY='H';  M= -10,  32, -60, -16, -31, -49,  52,   3,  16, -63, -10, -16,   5,  15,  11,  28,  32, -10, -78,   0;
/M: SY='C';  M= -61, 152, -80, -80, -71, -76,  12, -79, -76, -69, -68, -66, -91, -82, -82, -64, -61, -66,-101, -79;
/M: SY='D';  M= -30,  18,  70, -48, -20, -60,  14, -72, -10, -75, -69,  68, -69, -54, -18,  25,  18, -26, -90, -65;
/M: SY='H';  M=  -8,  -8, -61, -28, -57,  26,  69,  12, -18, -38, -56,  25, -71, -58, -32, -14,  23,   0, -70,  52;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='C';  M= -30,  52, -17, -36, -72,  20,  31, -71,  27,   1, -60,   5, -70,  44,  19,  35, -36, -69, -80, -64;
/M: SY='Q';  M=   3,  10, -37,   0, -44,   0,  16, -22,  30, -29, -11, -15, -67,  49, -10,  11,  24,   7, -79, -63;
/M: SY='D';  M= -28,  29,  43,  23,  19, -47,  38, -20, -58,   1, -59,  21,  39, -18, -12, -28, -40, -36, -74,  14;
/I:         I=-45; MD=-115;
/M: SY='P';  M= -54,  40, -82, -75, -79, -45, -81,   4, -20, -25,  32, -27,  73, -77, -81,  -6, -67,   3, -92, -81; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='I';  M= -13, -72, -72,   4,  19, -77, -73,  69, -69,   9,   4, -68, -21, -66, -73,  14,  -1,  22, -73, -55;
/M: SY='T';  M= -43, -70, -59, -29, -48, -25, -23,  15, -22, -38,  14,  39, -12,  17,  15,  18,  56,  16, -82, -63;
/I:         I=-38; MD=-97;
/M: SY='G';  M= -44, -83, -65,   9, -86,  77, -73, -92, -32, -66, -79,  -2, -75, -65,  -9,  -2, -37, -86,   7, -80; D=-38;
/I:         I=-38; MI=-97; MD=-97; IM=-97; DM=-97;
/M: SY='F';  M= -64, -76, -21, -65,  32, -76, -14,  19,  -7,   8,  -7,   5,  25,  -2,  15,   2,  -6,  22, -75, -56; D=-38;
/I:         I=-38; DM=-97;
/M: SY='R';  M= -67,  -8, -66, -57, -63, -17,  13, -80, -34, -73, -64, -59, -77, -46, 100, -20, -66, -76,  28,  46; D=-38;
/I:         I=-38; DM=-97;
/M: SY='W';  M= -71, -83, -83, -78,  44, -78, -58,  14, -71, -42,  -7, -79, -81, -69, -70, -72, -70, -22, 126,  98;
/M: SY='H';  M= -64, -79, -58, -49, -34, -72,  86, -39,  53, -68, -58,  -8, -29,  45,  56, -40, -61,   2, -80, -55;
/M: SY='C';  M= -57, 143, -72, -75, -72, -69, -74, -77, -71, -71, -69,   6, -85, -74, -77,  35, -55, -66, -97, -78;
/M: SY='Q';  M=  14, -70, -59,   4, -64, -66, -21, -56,  -6,  36, -51,  15, -27,  52, -17,  20,  25, -25, -77, -62;
/M: SY='K';  M= -58, -74, -12,  35, -69, -73, -23,  -3,  49, -22, -35, -14, -67,  37,  -2,  -6,  -2,  38, -79, -64;
/M: SY='C';  M=  -8, 142, -72, -33, -73, -72,  -1, -77,  -5, -70, -67, -14, -84,   3, -71, -60, -60, -67, -95, -77;
/M: SY='P';  M= -16, -77,  17,  11,  28,  -7,   1, -38,  25, -18, -24, -58,  56,  24, -10, -12, -22, -32, -71, -14;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='D';  M= -63, -76,  92, -10, -83, -29, -24, -82,   4, -83, -76,  68, -13, -51, -57,   6, -53, -80, -95, -70;
/M: SY='Y';  M= -70, -27, -77, -77,  78, -80, -52,   9, -71, -19,  -9, -73, -82, -71, -69, -68, -11, -16, -39, 100;
/M: SY='D';  M= -38, -78,  98,  -7, -13, -65,  25, -77, -53, -26, -70,  29, -69,  27, -31, -55, -58, -76, -88, -13;
/M: SY='L';  M= -42, -70, -84, -78,  -2, -86, -73,  43, -77,  74,  -8, -81, -81, -72, -76, -74, -61,  21, -72, -53;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='Q';  M= -34,  -2,  33,  26, -44, -68, -59,  10, -21, -18, -59,   2,   7,  56, -29,  20,  19, -14, -79, -18;
/M: SY='S';  M=  -9, -73,  35,  18, -76,   3, -58, -17,   7, -54, -27,  18,  -3,  30,   1,  36,  15, -32, -82, -68;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='Y';  M= -71, -76, -73,  -3,  90, -79, -15, -54, -20, -38, -19, -71, -81, -68, -65, -34, -65, -43, -39,  94;
/M: SY='W';  M=  12, -72,  12,  17,   0, -39,  34, -66,  -3,  -5, -10,   8,  -7,  25, -58,  35,  19, -64,  36, -58;
/M: SY='T';  M=  23,  -4,  -6,   1, -41,  -5,  22, -46,  14, -68, -62, -23, -67,  27,  18,  25,  32,   4, -80, -64;
/I:         I=-21; MD=-53;
/M: SY='G';  M= -33,  -7,  -3,  20, -80,  70, -17, -80,   3, -40, -70,  25,  12,  -9, -64, -53, -15, -56, -80, -74; D=-21;
/I:         I=-21; MD=-53;
/M: SY='R';  M=  11,  -7, -28, -24, -18, -38,  38, -47,  28, -13, -61, -37, -74,  38,  52, -16, -63, -24, -77,  -7; D=-21;
/I:         I=-21; MD=-53;
/M: SY='F';  M=  -7, -26, -67,  34,  42, -59,  -5, -46, -11, -73, -72,   5, -81, -33, -18, -42,  15, -45, -76,  20; D=-21;
/I:         I=-21; MD=-53;
/M: SY='S';  M= -10, -86, -35, -81, -76, -14, -82,  10, -51,  -1, -68, -75, -35, -77, -12,  25,   9, -11, -91, -11; D=-21;
/I:         I=-21; MD=-53;
/M: SY='K';  M= -40, -94, -19,  -4, -44,  11, -81, -58,  19, -91, -85, -23,  -2, -43, -20, -14,   3, -29, -95, -25; D=-21;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='N';  M= -43, -85,  -7, -65, -87,  23, -22, -30,   2, -86, -77,  38,  27, -35,  33,  22, -38, -81, -90, -79; D=-21;
/I:         I=-21; DM=-53;
/M: SY='H';  M= -67, -78, -55, -56,   3, -70, 140, -77, -59, -63,  34, -10, -70, -49, -54, -15, -65, -78, -93, -38;
/M: SY='P';  M= -52, -77,  16, -27, -77, -13,  20, -73,  28, -22, -64,   2,  65,  26,  22,  30,  -6, -72, -80, -67;
/I:         I=-31; MD=-79;
/M: SY='S';  M= -40,  29, -19,  -4, -75, -54, -66, -46,  -7,  -6, -16,  36,  22, -60,  -1,  36,  24, -21, -89, -73; D=-31;
/I:         I=-31; MD=-79;
/M: SY='N';  M= -63, -88,  39,  -5, -85, -77,  32, -89, -66, -89, -82,  43, -32, -13, -17,   5,  22, -87,  33, -15; D=-31;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='H';  M= -13, -78, -56, -56, -63, -43, 137, -78, -59, -25, -54, -46, -70, -50, -55,   4, -63, -77, -89,  18;
/M: SY='P';  M=   5, -76,  54,   4, -34, -24, -62, -12,   0, -50, -65, -35,  56,  19, -17,   6,  16, -25, -81, -68;
/M: SY='M';  M= -67, -73, -81, -76,  64, -81, -57,   6, -41,  24,  84, -74, -79, -68, -68, -71, -63,  -5, -50,  73;
/M: SY='Q';  M= -46, -74, -47,  29, -24, -47,  13,  16,  11,  10,  14, -60, -29,  44,   5, -24,  18,   9, -73,   6;
/M: SY='R';  M= -16,  26, -57,  44, -27, -73, -61,  11,  20, -15, -58, -15,  26, -26,  51, -16, -18, -11, -77, -65;
/M: SY='M';  M= -48, -74, -77, -47,  -4, -81,  33,  47, -66,   3,  74, -71, -76, -64,   5, -68, -60,  40,   3,  48;
/M: SY='D';  M=  -7,  48,  49,  42, -72, -24, -59, -51, -15, -36, -67, -26,  39, -20,   0,  -2,  13, -69, -79,   8;
/M: SY='T';  M= -26, -70, -32, -11, -31, -10, -63,  31,  -1, -37,  -8,  15,  -1, -27,   7,  44,  44, -23, -79, -64;
/M: SY='P';  M=  -1, -75,  14,  -6, -69,  -3, -61, -12, -27,  -3,   7,  33,  54,  24,  -8,  -5, -17, -16,  24, -38;
/M: SY='T';  M= -33, -12,   5,  -5,  -2,  10,  -8,  -2,  -2, -20,  -4,  39,   2, -32, -14,  -3,  39,   2, -79, -31;
/M: SY='D';  M= -36, -72,  40, -40,  33,  -1, -62,  -7, -14, -33, -60, -14,   6,  10, -33,  32,  27,   3, -72,   4;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	113 in 103 different sequences
Number of true positive hits	113 in 103 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.12 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	3
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	ZN_FING
Feature description [info]	ZZ-type
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

103 sequences

ADA2_CANAL  (Q59WH0), ADA2_SCHPO  (Q9P7J7), ADA2_YEAST  (Q02336),

BIG_ARATH   (Q9SRU2), BIG_ORYSJ   (B9G2A8), CBP1_CAEEL  (P34545), 
CBP_HUMAN   (Q92793), CBP_MOUSE   (P45481), CBP_RAT (Q6JHU9), 
DMDA_DROME  (Q9VDW6), DMDB_DROME  (Q9VDW3), DMDD_DROME  (Q0KI50), 
DMDE_DROME  (Q7YU29), DMD_CAEEL   (Q9TW65), DMD_CANLF   (O97592), 
DMD_CHICK   (P11533), DMD_HUMAN   (P11532), DMD_MOUSE   (P11531), 
DMD_PIG (Q5GN48), DMD_RAT (P11530), DRP2_HUMAN  (Q13474), 
DRP2_MOUSE  (Q05AA6), DRP2_RAT(Q9EPA0), DTN1_CAEEL  (Q9Y048), 
DTNA_HUMAN  (Q9Y4J8), DTNA_MOUSE  (Q9D2N4), DTNB_HUMAN  (O60941), 
DTNB_MOUSE  (O70585), DTNB_RAT(P84060), DYTN_DANRE  (A2CI97), 
DYTN_HUMAN  (A2CJ06), DYTN_MOUSE  (A2CI98), EP300_HUMAN (Q09472), 
EP300_MOUSE (B2RWS6), HAC12_ARATH (Q9FWQ5), HAC1_ARATH  (Q9C5X9), 
HAC2_ARATH  (Q9FYH1), HAC4_ARATH  (Q9LG11), HAC5_ARATH  (Q9LE42), 
HACL1_ORYSJ (Q6YXY2), HACL2_ORYSJ (Q5Z8V7), HACL3_ORYSJ (Q9XHY7), 
HERC2_HUMAN (O95714), HERC2_MOUSE (Q4U2R1), JOKA2_SOLTU (M1BJF6), 
KCMF1_BOVIN (Q1LZE1), KCMF1_CAEEL (P34664), KCMF1_DANRE (Q7T321), 
KCMF1_DROME (Q95RX5), KCMF1_HUMAN (Q9P0J7), KCMF1_MOUSE (Q80UY2), 
KCMF1_XENLA (Q6GPB6), MIB1_DANRE  (Q804S5), MIB1_HUMAN  (Q86YT6), 
MIB1_MOUSE  (Q80SY4), MIB1_XENLA  (Q6GNY1), MIB2_CHICK  (Q5ZIJ9), 
MIB2_HUMAN  (Q96AX9), MIB2_MOUSE  (Q8R516), MIB2_RAT(Q68LP1), 
MIB_DROME   (Q9VUX2), NBR1_ARATH  (Q9SB64), NBR1_HUMAN  (Q14596), 
NBR1_MOUSE  (P97432), NBR1_PONAB  (Q5RC94), NBR1_RAT(Q501R9), 
NBR1_SCHPO  (Q9P792), PRT1_ARATH  (Q8LBL5), REF2P_DROME (P14199), 
REF2P_DROSI (Q24629), RSC8_YEAST  (P43609), SQSTM_HUMAN (Q13501), 
SQSTM_MOUSE (Q64337), SQSTM_PONAB (Q5RBA5), SQSTM_RAT   (O08623), 
SSR1_SCHPO  (O13788), SSR2_SCHPO  (O14470), SWI3C_ARATH (Q9XI07), 
SWI3C_ORYSJ (Q53KK6), SWI3D_ARATH (Q8VY05), TAD2A_ARATH (Q9SFD5), 
TAD2A_BOVIN (Q3SZP8), TAD2A_CHICK (Q5ZJF3), TAD2A_DROME (Q7KSD8), 
TAD2A_HUMAN (O75478), TAD2A_MOUSE (Q8CHV6), TAD2A_RAT   (Q6AYE3), 
TAD2B_ARATH (Q9ATB4), TAD2B_DANRE (Q503N9), TAD2B_DROME (Q8I8V0), 
TAD2B_HUMAN (Q86TJ2), TAD2B_PONAB (Q5RBN9), TAD2B_XENLA (Q6NRB5), 
TADA2_ORYSJ (Q75LL6), UTRN_HUMAN  (P46939), UTRN_RAT(G3V7L1), 
Y3893_DICDI (Q54QG5), ZSWM2_HUMAN (Q8NEG5), ZSWM2_MOUSE (Q9D9X6), 
ZZEF1_HUMAN (O43149), ZZEF1_MOUSE (Q5SSH7), ZZZ3_HUMAN  (Q8IYH5), 
ZZZ3_MOUSE  (Q6KAQ7)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

1 sequence

VLG_ARATH   (Q6NQN8)

PDB
[Detailed view]

53 PDB

1TOT; 2DIP; 2E5R; 2FC7; 2N1A; 4XI6; 4XI7; 4XIB; 5U7G; 5YP7; 5YP8; 5YPA;
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