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PROSITE entry PS50109


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50109
Entry name [info] HIS_KIN
Accession [info] PS50109
Entry type [info] MATRIX
Date [info] 01-JAN-2002 CREATED;
13-FEB-2019 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50109
Associated ProRule [info] PRU00107

Name and characterization of the entry

Description [info] Histidine kinase domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=217;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=212;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.9493000; R2=0.0205773; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6812.4682617; R2=16.1011562; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=683; H_SCORE=17810; N_SCORE=15.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=270; H_SCORE=11160; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-70; E1=-70; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 570 in 566 different sequences
Number of true positive hits 570 in 566 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 66
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 89.62 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] Histidine kinase
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
566 sequences

AFSQ2_STRCO (Q04943), AHK1_ARATH  (Q9SXL4), AHK2_ARATH  (Q9C5U2), 
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UniProtKB/Swiss-Prot
False negative sequences
66 sequences

BTSS_ECOL6  (P0AD15), BTSS_ECOLI  (P0AD14), BTSS_SHIFL  (P0AD16), 
» more

PDB
[Detailed view]
181 PDB

1B3Q; 1BXD; 1GJV; 1GKX; 1GKZ; 1I58; 1I59; 1I5A; 1I5B; 1I5C; 1I5D; 1ID0;
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