PROSITE entry PS50103

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PURL: https://purl.expasy.org/prosite/signature/PS50103

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General information about the entry

Entry name [info]	ZF_C3H1
Accession [info]	PS50103
Entry type [info]	MATRIX
Date [info]	01-JUN-2008 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50103
Associated ProRule [info]	PRU00723

Name and characterization of the entry

Description [info]

Zinc finger C3H1-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=28;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=28;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0802505; R2=0.0093891; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=684; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=418; N_SCORE=6.0; MODE=1; TEXT='R?';
/DEFAULT: M0=-58; D=-400; I=-400; B0=-50; E0=-50; B1=-310; E1=-250; MI=-155; MD=-155; IM=-155; DM=-155;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B0=0; B1=0; BI=-155; BD=-155;
/M: SY='P';  M=  -5, -59,  19,  -4, -20, -12, -56, -41,  23, -25,  -8,  23,  33,  -2,  15,  13,  -8, -50,   8, -24;
/I:         B1=-50; BI=-155; BD=-155;
/M: SY='Y';  M= -29, -50, -19,   1,  11, -35,-106, -56,  25, -29,  -4,   0,  38,   4,  17,   0,   4, -35, -13,  53;
/M: SY='K';  M= -23, -69,   7, -19, -90,   4, -18, -80,  57, -75, -87,  22,   7,  -5,  34,  18,   0, -59,-254, -47;
/M: SY='T';  M=  -5,-135, -35,  -7, -40, -47, -42, -42,  24, -25,  15, -17,   9,  28,  27,  14,  59,  -7, -81, -58;
/I:         I=-121; MD=-47;
/M: SY='P';  M=   3,-243, -31,  22, -42, -38,-109, -11,  31, -80, -14, -20,  52,  25,  16, -27,   1,   3, -47, -80; D=-121;
/I:         B1=-90; BI=-155; BD=-155; I=-121; MI=-47; IM=-47; DM=-47;
/M: SY='P';  M= -28, -50, -19, -29, -33,-250, -12,  40, -54,  42,  21, -65,  53, -33, -15, -89, -36,  20,-242, -34;
/M: SY='C';  M=-214, 153,-270,-271,-243,-256,-255,-224,-259,-230,-224,-248,-255,-250,-268,-221,-220,-220,-260,-251;
/M: SY='R';  M= -47, -90, -31, -11, -22, -86,  11, -51,  60, -59, -35, -16,  41,  20,  64, -22, -13, -39,  -7, -16;
/I:         I=-111; MI=0; MD=-43; IM=0; DM=-43;
/M: SY='Y';  M= -37,-142,  25, -39,  71,-137,  59, -93, -18, -41, -38,  16, -73, -11, -13, -15, -71,-110,  18,  60;
/M: SY='F';  M= -54,-245,-129,-103,  97,-137,   0, -77,-242, -60, -54, -86,-259, -64,-128, -84,-149, -59,  89,  87;
/M: SY='L';  M=  13,-108, -32,   4, -52, -70, -18, -11,   3,  39,  25,   5, -37,  37,  -3,   0,  -5,  -9,-244, -53;
/I:         I=-26; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='R';  M=  -9, -96, -38,  16, -94,-113,   8, -68,  50, -45, -10,  23, -43,  40,  48,  -3,  14, -56,-251, -46; D=-56;
/I:         I=-27; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='G';  M= -60,-253, -54, -70,-141,  99, -80,-167, -13,-101,-247,  17, -74, -51, -49, -28,-127,-252,-256,-114;
/I:         I=-83; MD=-32;
/M: SY='R';  M= -17, -42, -37,  -3,  16, -61,  30, -35,  17, -39, -19,  26, -91,  19,  42,   5,  18, -39,  16,  22; D=-83;
/I:         I=-83; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='C';  M=-214, 153,-270,-271,-243,-256,-255,-224,-259,-230,-224,-248,-265,-250,-268,-221,-220,-220,-260,-251;
/M: SY='P';  M= -12, -60, -29, -15, -35, -71, -23, -53,  41, -37, -23,  16,  64,   0,  44,  18,  13, -47, -48, -76;
/I:         I=-121; MD=-47;
/M: SY='Y';  M= -56,-119, -51, -40,  65,-177,  17,-124,  37, -38, -17,  35,-241, -35,  61, -53,-109,-150, -19,  65; D=-121;
/I:         I=-121; MI=-47; IM=-47; DM=-47;
/M: SY='G';  M= -33,-251, -36, -16,-110, 105, -88,-136, -45,-123,-246,   7, -47, -46, -62, -32, -69,-105,-256,-254;
/I:         I=-83; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='D';  M=   3,-247,  66,  40, -86, -44, -66, -65,  -1, -66, -68,   8,  30, -18, -57,  29, -18, -63,-264, -96; D=-83;
/I:         I=-83; DM=-32;
/M: SY='N';  M=   3,-120,  18,   1, -42, -36,   6,-121,  42, -53,  -9,  49, -73,  33,  39,  35,  -3,-118,-254, -92;
/M: SY='C';  M=-214, 153,-270,-271,-243,-256,-255,-224,-259,-230,-224,-248,-255,-250,-268,-221,-220,-220,-260,-251;
/M: SY='P';  M= -31, -66, -38, -24, -30, -93,   0, -51,  49, -33, -12,  27,  60,  28,  59, -12,  -3, -74, -40, -65;
/M: SY='F';  M=-168,-123, -50, -86, 100,-169, -28,-214, -20, -39, -37, -18,-255, -51, -21, -84,-228,-224, -59,  94;
/I:         I=-73; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='A';  M=  46,-105, -37, -52, -76,-108, -29,   0,   9,  13,  -1, -35, -37, -14,  25,  42, -55, -10, -95, -16;
/M: SY='H';  M=-230,-255,-222,-205,-222,-238, 159,-262,-213,-249,-231,-195,-237,-188,-202,-215,-225,-256,-255,-173;
/M: SY='P';  M= -21, -22,  51,  18, -65,  30, -38,  -9, -64, -64, -66, -10,  52, -44, -52,  18,  -3,  16, -81, -70;
/M: SY='P';  M= -20, -51,  14,  27, -21, -62, -16,   8,   8,  12, -15, -15,  39,  11,  10,  -7,   5, -20, -46,   2;
/M: SY='P';  M=  -8, -41,  22,  31, -41, -34,   6, -32,  -3, -17, -47,   7,  56,  15,  10,  10,   1, -12, -28, -59;
/I:         E0=0; E1=0; IE=-155; DE=-155;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	1'053 in 516 different sequences
Number of true positive hits	1'051 in 514 different sequences
Number of 'unknown' hits	0
Number of false positive hits	2 in 2 different sequences
Number of false negative sequences	38
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	99.81 %
Recall (true positives / (true positives + false negatives))	96.51 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	6
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	N_Hulo
Feature key [info]	ZN_FING
Feature description [info]	C3H1-type
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	514 sequences 132L_IIV6 (O55741), AMO1_CHATD (G0S381), AMO1_SCHPO (O74315), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	38 sequences DUS3_BOTFB (A6RMI1), DUS3_CANAL (Q5ALL3), DUS3_CHAGB (Q2HDP2), » more
UniProtKB/Swiss-Prot False positive sequences	2 sequences PLD6_CHLRE (A8IW99), TOPZ1_SHEEP (E5FYH0)
PDB [Detailed view]	119 PDB 1M9O; 1RGO; 2CQE; 2D9M; 2D9N; 2E5S; 2FC6; 2N5K; 2RHK; 2RPP; 3D2N; 3D2Q; » more