PROSITE entry PS50096

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PURL: https://purl.expasy.org/prosite/signature/PS50096

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General information about the entry

Entry name [info]	IQ
Accession [info]	PS50096
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50096
Associated ProRule [info]	PRU00116

Name and characterization of the entry

Description [info]

IQ motif profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ARNDCQEGHILKMFPSTWYVBZX'; LENGTH=30; TOPOLOGY=LINEAR;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=23;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6543000; R2=0.0183000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1022.9739990; R2=1.1948051; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=265; H_SCORE=1340; N_SCORE=6.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=211; H_SCORE=1275; N_SCORE=5.5; MODE=1; TEXT='?';
/DEFAULT: B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105; I=-20; D=-20;

...

                A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X
/I:         B1=0;
/M: SY='R';  M= -5,  5, -4, -9,-24,  6,  2,-18,  5, -9, -2, -1,  3,-15,-16, -8, -9,-23, -6,-11, -7,  2, -8;
/I:         B1=-10;
/M: SY='E';  M= -8,  9,  2, -3,-18,  4,  7,-18,  1,-17,-16,  3, -9,-20,-13,  0, -1,-27,-11,-14, -1,  4, -8;
/I:         B1=-20;
/M: SY='K';  M= -4,  6,  1,  2,-26,  0,  0,-11,  2,-20,-19,  7,-10,-21,-10, -4, -9,-22, -7,-16,  1, -2, -8;
/I:         B1=-30;
/M: SY='A';  M= 27,-14, -7,-11,-14, -7, -4, -6,-16, -9, -7, -7, -8,-18,-11,  5,  0,-23,-16, -3, -6, -5, -2;
/I:         B1=-40;
/M: SY='A';  M= 23,-22,-13,-26,-10,-14,-17,-16,-23,  8,  0,-17,  0,-12,-15,  0,  0,-22,-13, 11,-16,-17, -4;
/M: SY='T';  M= -1,-19,-15,-24,-16,-18,-20,-27,-25, 18,  7,-19,  5, -3,-18, -2, 15,-26, -6, 20,-17,-20, -5;
/M: SY='K';  M= -8, 19, -1, -8,-18,  0, -2,-20, -9,-18,-19, 21, -8,-19,-16, -5, -2,-21, -7,-11, -4, -2, -9;
/M: SY='I';  M=-10,-27,-22,-37,-26,-21,-28,-37,-27, 41, 24,-29, 18,  5,-22,-21, -9,-18,  1, 25,-30,-28,-10;
/M: SY='Q';  M=-10, 10,  0,  0,-30, 60, 20,-20, 10,-20,-20, 10,  0,-40,-10,  0,-10,-20,-10,-30,  0, 40,-10;
/M: SY='A';  M= 26, -4, -2,-11,-13, -3, -3, -3,-14,-16,-18,  0,-12,-21,-10, 13,  3,-25,-18, -6, -5, -3, -1;
/M: SY='L';  M= -2, -4,-10,-17,-19, -5,-10,-19, -8, -5,  0,-10, -2,  2,-20, -2,  1,-13,  6, -4,-14, -8, -6;
/M: SY='F';  M= -9,-21,-22,-32, -2,-26,-26,-26,-22,  1,  2,-24, -2, 21,-28,-16, -9,  8,  8,  2,-27,-25,-11;
/M: SY='R';  M=-20, 70,  0,-10,-30, 10,  0,-20,  0,-30,-20, 30,-10,-20,-20,-10,-10,-20,-10,-20,-10,  0,-10;
/M: SY='G';  M=  1,-19, -2,-12,-27,-17,-19, 57,-18,-32,-24,-18,-11,-26,-19, -1,-17,-20,-26,-24,-10,-18, -9;
/M: SY='H';  M=-18, -7, -5,-12,-29, -4,-12,-23, 43,-14,-10,-11, -2,  6,-25,-15,-15,  9, 38,-18,-11,-11,-10;
/M: SY='L';  M= -8, -8,-18,-21,-22, -5,-11,-27,-16,  9, 18, -9, 12, -5,-22,-17, -6,-21, -4,  5,-19, -9, -9;
/M: SY='A';  M= 22,-14,-11,-18,-13, -2, -9,-12,-16, -2, -6, -9, -1,-17,-13,  4,  4,-22,-14,  5,-11, -6, -3;
/M: SY='R';  M=-19, 68,  0, -9,-30, 10,  0,-20,  0,-30,-20, 30,-10,-20,-19,-10,-10,-20,-10,-20, -9,  0,-10;
/M: SY='K';  M=-11, 21,  3,  1,-18, 10,  8,-18, -4,-25,-22, 21, -9,-25,-14, -4, -6,-25,-13,-20,  2,  8,-10;
/M: SY='K';  M= -3,  9,  1,  2,-24,  3,  8,-15,  0,-22,-17, 11,-11,-20,-13, -1, -4,-22, -7,-17,  2,  4, -7;
/M: SY='Y';  M= -9,-14,-19,-25,-23,-15,-21,-26,  0,  5,  5,-15,  5, 25,-26,-16, -8,  9, 42,  0,-21,-20, -8;
/M: SY='K';  M=-11, 26,  4, -2,-27, 14,  6,-17,  1,-24,-23, 27, -6,-26,-13, -4, -6,-23, -9,-20,  0,  9, -9;
/M: SY='K';  M= -9,  7,  1,  1,-25,  2,  0,-13, -4,-21,-20,  9, -9,-18,-11,  0, -3,-24, -9,-15,  0,  0, -8;
/M: SY='R';  M=-11,  8, -9,-10,-24,  0, -3,-16, -7, -6,  2, -2,  8,-12,-18,-10, -6,-23, -8, -7,-10, -3, -9;
/M: SY='L';  M= -9, 10,-12,-15,-24, -1, -3,-22, -9, -3,  6,  2,  9, -9,-18,-15, -9,-20, -6, -4,-14, -4, -9;
/I:         E1=-50;
/M: SY='R';  M= -2, 12,  2, -5,-20,  6,  2,-14, -1,-19,-16,  8, -9,-21,-10, -1, -3,-24,-12,-16, -1,  3, -7;
/I:         E1=-40;
/M: SY='E';  M= -2, -3, -4, -1,-17,  1,  6, -7, -1,-12, -8, -1, -5, -7, -9, -3, -6,-10,  0,-12, -2,  3, -5;
/I:         E1=-30;
/M: SY='L';  M=-10,  4, -4, -2,-19, -2,  0,-16, -1, -7, -1,  0, -2, -4,-13, -9, -7,-13,  0, -7, -4, -2, -7;
/I:         E1=-20;
/M: SY='K';  M= -6, 14,  6,  7,-17,  7,  7, -9, -1,-18,-16, 13, -9,-18, -8, -1, -4,-17, -9,-15,  6,  6, -6;
/I:         E1=-10;
/M: SY='S';  M=  1, -3,  1,  4,-14,  0,  3, -2, -6,-15,-16,  1,-11,-16,  2,  5,  0,-18,-12,-11,  2,  0, -3;
/I:         E1=0;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	1'369 in 450 different sequences
Number of true positive hits	1'345 in 426 different sequences
Number of 'unknown' hits	0
Number of false positive hits	24 in 24 different sequences
Number of false negative sequences	114
Number of 'partial' sequences	1

Precision (true positives / (true positives + false positives))	98.25 %
Recall (true positives / (true positives + false negatives))	92.19 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	42
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	K_Hofmann
Feature key [info]	DOMAIN
Feature description [info]	IQ
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	426 sequences ADGB_HUMAN (Q8N7X0), ADGB_MOUSE (G3UZ78), ASPM_AOTVO (P62283), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	114 sequences BAG8_ARATH (Q9LIB3), CNG11_ARATH (Q9SKD6), CNG13_ARATH (Q9LD40), » more
UniProtKB/Swiss-Prot 'Partial' sequences	1 sequence MYS_BOMMO (P82210)
UniProtKB/Swiss-Prot False positive sequences	24 sequences GAR3_RAT(Q66H38), GCH4_PSEP1 (A5W348), IF172_CHLRE (Q5DM57), » more
PDB [Detailed view]	191 PDB 1B7T; 1BR1; 1BR4; 1DFK; 1DFL; 1I84; 1KK7; 1KK8; 1KQM; 1KWO; 1L2O; 1M45; » more