PROSITE entry PS50088

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PURL: https://purl.expasy.org/prosite/signature/PS50088

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General information about the entry

Entry name [info]	ANK_REPEAT
Accession [info]	PS50088
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50088
Associated ProRule [info]	PRU00023

Name and characterization of the entry

Description [info]

Ankyrin repeat profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=33;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=30;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.4177999; R2=0.0267100; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=952.6560059; R2=0.8840000; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=266; H_SCORE=1188; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=191; H_SCORE=1122; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; M0=-10;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='B';  M=-10,  9,-23,  9,  5,-18,-12,  2,-20, -1,-17,-12,  9,-15,  2, -2, -1, -4,-19,-26, -8,  2;
/M: SY='G';  M= -3, -4,-28, -4,-11,-26, 40,-13,-33,-11,-25,-17,  2,-18,-12,-12, -1,-15,-26,-22,-23,-11;
/M: SY='R';  M= -9, -3,-22, -5, -2,-11,-16, -3,-15, -1,-12, -7,  0,-18, -1,  3, -6, -7,-14,-16, -4, -2;
/M: SY='T';  M=  0,  0,-13, -7, -8,-11,-16,-14,-11, -9,-13,-11,  3,-11, -8, -9, 17, 32, -4,-30,-10, -8;
/M: SY='P';  M=  8,-17,-23,-16, -7,-21,-15,-20,-11,-12,-16,-12,-16, 35,-11,-19, -4, -5,-13,-27,-22,-12;
/M: SY='L';  M= -9,-29,-20,-31,-22, 11,-30,-21, 21,-28, 41, 19,-28,-28,-20,-20,-26, -9, 13,-19,  1,-21;
/M: SY='H';  M=-15, -5,-25, -6, -5,-12,-20, 55,-17,-11,-11,  3,  1,-20,  3, -5,-10,-14,-18,-24, 13, -4;
/M: SY='L';  M= -8,-19,-20,-21,-14,  1,-25,-12,  5,-15,  9,  5,-18,-23,-12,-13,-15, -7,  3, -8,  5,-14;
/M: SY='A';  M= 39,-11, -7,-20,-12,-16, -4,-19, -9,-12, -9, -9,-10,-13,-11,-19,  8,  0,  0,-20,-16,-12;
/M: SY='A';  M= 16,-17,  1,-24,-18,-11,-17,-22,  3,-17, -2, -1,-15,-20,-16,-20,  0,  0, 11,-27,-14,-18;
/M: SY='R';  M= -5, -8,-20,-10, -2,-14,-16, -6,-12,  1,-10, -3, -5,-17,  1,  3, -4, -5,-10,-20, -7, -2;
/M: SY='N';  M= -5, -2,-20, -6, -2,-13,-12,  0,-15, -1,-14, -7,  3,-17, -1,  0, -1, -3,-14,-21, -4, -2;
/M: SY='G';  M= -3,  1,-25, -1, -8,-26, 29,-10,-31, -8,-26,-17,  8,-17, -8, -8,  1,-12,-25,-24,-22, -8;
/M: SY='H';  M=-12, 10,-23,  9,  3,-19,-14, 18,-22,  0,-19,-11, 13,-17,  5,  1, -1, -7,-22,-27, -3,  2;
/M: SY='L';  M= -6,-13,-21,-14, -8, -6,-22,-12,  0,-11,  1,  0,-12,-13, -9,-10, -8, -3,  1,-22, -5,-10;
/M: SY='E';  M= -7,  9,-25, 13, 16,-25,-12, -3,-23,  3,-20,-15,  5, -6,  5, -2,  1, -5,-21,-29,-16, 10;
/I:         I=-9; MI=0; MD=-15; IM=0; DM=-15;
/M: SY='V';  M= -4,-22, -9,-28,-22, -1,-27,-20, 16,-20, 11, 11,-19,-23,-18,-19,-12, -3, 17,-24, -6,-21;
/M: SY='V';  M=  3,-24,-11,-28,-23, -1,-24,-24, 17,-20, 12,  8,-22,-24,-21,-20,-10, -2, 23,-24, -7,-22;
/M: SY='K';  M= -9,  1,-25,  2, 11,-24,-17, -2,-22, 15,-19,-10,  2,-13, 10, 14, -4, -7,-18,-25,-11,  9;
/M: SY='L';  M= -7,-18,-20,-21,-13,  4,-24,-12,  4,-14, 10,  5,-16,-22,-12,-11,-13, -5,  2,-13,  5,-13;
/M: SY='L';  M=-10,-29,-19,-31,-21, 12,-30,-20, 20,-28, 42, 19,-28,-29,-20,-20,-27,-10, 11,-18,  1,-21;
/M: SY='L';  M= -8,-26,-18,-29,-21,  3,-30,-20, 22,-24, 28, 15,-24,-26,-18,-19,-21, -8, 15,-21, -2,-21;
/M: SY='E';  M= -5,  7,-24,  8, 14,-25,-11, -2,-23,  6,-20,-13,  5,-11,  9,  4,  3, -4,-20,-27,-14, 11;
/M: SY='H';  M= -3, -3,-20, -8, -4,-12,-14,  4,-15,  1,-13, -7,  2,-18, -1,  3, -3, -6,-14,-21, -3, -3;
/M: SY='G';  M= -2, -3,-27, -4,-13,-27, 44,-14,-34,-13,-27,-18,  4,-18,-13,-13,  1,-14,-26,-23,-24,-13;
/M: SY='A';  M= 26,-11,-11,-18,-11,-16, -5,-18, -7,-12, -9, -8,-10,-11,-12,-18,  5, -1,  1,-23,-16,-12;
/M: SY='D';  M=-11, 26,-24, 30, 10,-28, -8, -1,-27,  0,-26,-21, 20,-11,  1, -4,  5, -4,-24,-35,-17,  5;
/M: SY='I';  M= -4,-24,-21,-26,-19, -4,-27,-23, 16,-18,  8,  6,-21, -8,-18,-18,-13, -4, 15,-23, -8,-20;
/M: SY='N';  M= -9, 22,-21, 17,  4,-20, -8,  2,-21, -2,-22,-16, 26,-15, -1, -4,  5, -1,-22,-33,-15,  1;
/M: SY='A';  M=  4,-12,-17,-16,-10,-10,-18,-14,  1,-11, -1,  0,-11,-17, -8,-12, -4, -2,  3,-23, -8,-10;
/M: SY='R';  M= -6, -9,-20,-10, -3,-16,-18,-10,-11,  3,-11, -5, -7,-13,  0,  6, -5, -4, -7,-23,-10, -3;
/M: SY='D';  M=-10, 27,-22, 30,  7,-27, -6, -1,-28, -2,-25,-21, 20,-12, -2, -7,  6,  0,-23,-35,-17,  3;
/M: SY='N';  M= -6,  3,-22,  2,  2,-19,-12, -3,-18,  3,-18,-11,  5,-13,  0,  2,  0, -4,-15,-26,-10,  0;
/I:         E1=0;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	4'245 in 1'173 different sequences
Number of true positive hits	4'241 in 1'169 different sequences
Number of 'unknown' hits	0
Number of false positive hits	4 in 4 different sequences
Number of false negative sequences	170
Number of 'partial' sequences	3

Precision (true positives / (true positives + false positives))	99.91 %
Recall (true positives / (true positives + false negatives))	96.15 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	24
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	K_Hofmann
Feature key [info]	REPEAT
Feature description [info]	ANK
Version [info]	7

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	1169 sequences 36010_ASFK5 (P0C9P4), 36010_ASFM2 (Q65122), 36010_ASFP4 (P0C9P5), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	170 sequences 36012_ASFK5 (P0C9Q0), 36012_ASFM2 (Q65125), 36012_ASFP4 (P0C9Q1), » more
UniProtKB/Swiss-Prot 'Partial' sequences	3 sequences LATA_LATMA (P0DJE4), LITD_LATHA (P0DJE6), LITD_LATHE (P0DJE7)
UniProtKB/Swiss-Prot False positive sequences	4 sequences MURA_ACIAD (Q6FED0), MURA_DESPS (Q6AJM7), WECD_ECOL6 (Q8FBQ3), WECD_ECOLI (P27832) » more
PDB [Detailed view]	583 PDB 1A5E; 1AP7; 1AWC; 1BD8; 1BI7; 1BI8; 1BLX; 1BU9; 1D9S; 1DC2; 1DCQ; 1G3N; » more