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PROSITE entry PS50084


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PURL: https://purl.expasy.org/prosite/signature/PS50084

Direct ScanProsite submission
General information about the entry

Entry name [info] KH_TYPE_1
Accession [info] PS50084
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
03-MAY-2023 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50084
Associated ProRule [info] PRU00117

Name and characterization of the entry

Description [info] Type-1 KH domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=67;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=62;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6368001; R2=0.0209632; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2311.8957520; R2=4.5809312; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=314; H_SCORE=3750; N_SCORE=8.2; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=232; H_SCORE=3375; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Post-processing [info]

COMPETES_HIT_WITH PS50823

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 1'495 in 1'213 different sequences
Number of true positive hits 1'495 in 1'213 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 151
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 90.83 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 14
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann, N_Hulo
Feature key [info] DOMAIN
Feature description [info] KH
Version [info] 7

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
1213 sequences

AKAP1_CAEEL (Q09285), AKAP1_HUMAN (Q92667), AKAP1_MOUSE (O08715), 
» more

UniProtKB/Swiss-Prot
False negative sequences
151 sequences

BBP_YEAST   (Q12186), DPA5A_MOUSE (Q9CQS7), DPA5B_MOUSE (P85965), 
» more

PDB
[Detailed view]
148 PDB

1DT4; 1DTJ; 1E3H; 1E3P; 1EC6; 1J4W; 1J5K; 1K0R; 1K1G; 1KHM; 1VIG; 1VIH;
» more