PROSITE entry PS50078

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50078
Entry name [info]	POLO_BOX
Accession [info]	PS50078
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 22-FEB-2023 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50078
Associated ProRule [info]	PRU00154

Name and characterization of the entry

Description [info]

POLO box domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=83;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=78;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4037728; R2=0.0090278; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=953; N_SCORE=11.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=454; N_SCORE=6.5; MODE=1; TEXT='RR';
/DEFAULT: M0=-29; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='W';  M= -43, -82, -24, -70,  42, -75,  21, -22, -68,  -3, -55, -73,  28, -26, -70, -68,  -5, -38, 123,  70;
/M: SY='V';  M= -39, -70, -83, -78, -49, -84, -78,  58, -76,  41,  22, -77, -78, -73, -76, -38, -56,  64, -78, -57;
/M: SY='R';  M= -58,   2, -61, -52, -70, -68,  -6, -69,  49,   3, -59, -53, -29,   9,  65,  44,  11, -66, -77, -63;
/M: SY='K';  M= -62, -76, -60, -50,  22, -70,  13, -68,  68, -37, -60,  -2, -69,  41,  33,   4, -11, -30,  39,   9;
/M: SY='W';  M= -68, -11, -87, -77, -38, -76, -73,   9, -71,  -4,   0, -82, -79, -69, -72, -15, -69,   7, 146,  67;
/M: SY='F';  M=   5, -68, -71, -70,  56, -72,  19,   0, -66,  -8, -49,  17, -75, -67, -14,   2,   7,  55, -71, -49;
/I:         I=-26; MD=-67;
/M: SY='D';  M= -92,-101,  59, -74,  50, -95,  -7, -19, -87, -63, -85, -75,  12, -89, -92, -86, -40, -85, -92, -69; D=-26;
/I:         I=-26; MD=-67;
/M: SY='Y';  M= -94,-104, -16, -94,   0,-104,  11, -32, -47, -79, -78, -91,-105, -90, -90, -90, -21,  -6, -72,  77; D=-26;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='S';  M= -30, -78, -13, -31, -78, -18, -68, -37,  22, -72,  10, -60,  -5, -58,  39,  46,  -1,  12, -87, -72; D=-26;
/I:         I=-26; DM=-67;
/M: SY='D';  M= -37, -73,  57,   0, -22, -63, -57, -71,   0, -51, -68,  38,  45, -30, -60,  24,  47, -68, -81,  -4;
/M: SY='K';  M= -59, -75,  35,  -1, -77,  20, -57, -74,  67, -41, -67,  40, -66, -48,   9,   5, -25, -26, -80, -68;
/M: SY='Y';  M= -58,  -6, -65, -62, -16, -70,  42,   5, -13, -56, -53,   4, -11,  26, -20,  36, -53,  42, -65,  65;
/M: SY='G';  M=  57, -70, -67, -70,  12,  77, -69, -73, -67, -71,  10, -56, -69, -65, -73, -48, -61, -66, -71, -67;
/M: SY='W';  M= -62, -72, -82, -76,  33, -80, -75,  49, -73,  26,  42, -74, -76, -72, -75, -19,  17,  38,  76, -48;
/M: SY='G';  M=  36, -69, -71, -70, -61,  50, -68,  -1, -68,   6,  48, -61, -71, -64, -71,  -3,  -6,  19, -73,  -1;
/M: SY='Y';  M= -64, -72, -73, -73,  56, -76, -52, -48, -68,   6,  55, -68, -77, -65, -67,  -2,  30, -17, -46,  93;
/M: SY='Q';  M= -61, -79, -55,  28, -70, -72,  71, -64, -45,   7,  12, -23, -69,  85,  35, -17, -61, -13, -79, -56;
/M: SY='L';  M= -68, -70, -85, -78,  36, -86, -69,  -1, -78,  85, -30, -83, -84, -73, -75, -77, -63, -40, -66, -48;
/M: SY='S';  M= -46,  59, -56, -56, -74, -55, -59, -73, -22, -75, -68,  12, -66,  28, -59,  90,  23, -66, -84, -67;
/M: SY='N';  M= -61, -73,  65, -20, -79, -59,  49, -78, -53, -79, -70,  79,  22,   2, -59,  18,  12, -76, -93, -66;
/M: SY='G';  M= -53, -76, -57,   0, -79,  87,  -1, -83,  -8, -34, -70,  32, -68, -59, -25, -23, -63, -79, -76, -73;
/M: SY='T';  M=   4, -44, -16, -10, -66, -26, -64,  -3, -53, -60,  -1, -54, -66, -56,  35,  32,  64,  19, -80, -13;
/M: SY='V';  M= -55, -68, -78, -75,  27, -79, -75,  13, -72, -43, -46, -71, -77, -73, -74,   6,   6,  84, -73,  21;
/M: SY='Q';  M= -30, -82, -61, -48, -80,  59, -58, -80, -51, -75, -64, -53, -68, 105, -53, -51, -66, -80,  76, -61;
/M: SY='V';  M=  -8, -68, -83, -77,   8, -82, -82,  36, -75, -25,   2, -77, -78, -76, -76, -66, -53,  88, -80, -57;
/M: SY='N';  M= -62, -72, -56, -57,  23, -66,  18, -14, -56,  26, -12,  69, -73,  67, -58,  -5,  -5, -59, -71,  14;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='F';  M= -73,  18, -85, -82, 112, -82, -64, -48, -77, -23, -50, -76, -86, -84, -74, -72, -66, -18, -41,  49;
/M: SY='N';  M= -24, -70, -51, -59,  -2,  -5,  18, -64,   0,  -5, -59,  85, -72,  10, -30,   7,  -2, -30, -73,  31;
/M: SY='D';  M= -64, -77, 107, -37, -83,  -5, -55, -78, -56, -80, -77,  33, -67, -56, -64, -53,   5, -25, -98, -70;
/M: SY='H';  M= -57, -75, -27, -16, -73,  55,  98, -77,   1, -31, -62,  18, -68, -53, -23,  17, -33, -36, -84, -57;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='T';  M=   5, -65, -61, -61, -64, -62,   8, -36, -57, -61,  28, -51, -65, -56,  -1,  57,  73,   4, -80,   1;
/M: SY='K';  M= -61, -77,  -6,   4, -75, -70,  56, -69,  64, -69,   3, -10, -66,  57,  27, -31,   7,  -7, -79, -60;
/M: SY='M';  M= -62, -71, -83, -77, -47, -83, -70,  56, -75,  57,  72, -76, -77, -69, -74, -15, -58,  18, -74, -55;
/M: SY='I';  M=  14, -70, -74, -69, -58, -72, -71,  55, -29, -14,  45, -66, -72, -62,  11,  31, -52,  45, -78, -60;
/M: SY='W';  M= -64, -71, -84, -76,  12, -84, -74,  26, -73,  59,  26, -79, -80, -71, -22, -72, -24,  41,  68, -50;
/M: SY='C';  M= -59,  77, -19, -62, -58, -69,   1,  25, -24,  21, -52,  13, -75,  37, -33,  42, -54, -53, -74,  27;
/I:         I=-22; MD=-55;
/M: SY='P';  M=  20, -76, -14, -59, -79,   3, -66, -32, -62, -75, -67,   6,  82,  -6, -70,  44, -32, -12, -82, -75; D=-22;
/I:         I=-22; MD=-55;
/M: SY='D';  M=  -2, -77,  46,  32, -73,   9, -62, -19,  -2,  -1, -63,  16,  -7,  15, -27, -25, -23, -17,  23, -67; D=-22;
/I:         I=-22; MD=-55;
/M: SY='M';  M=   4,  14,   1,   9, -69,  31, -63, -26, -25, -13,  57,   9, -71, -23,  18, -12, -21,   4, -81, -67; D=-22;
/I:         I=-22; MD=-55;
/M: SY='Q';  M=  -7, -78,  12,  47, -80, -30, -56, -44,  33, -71,  29,  -2, -16,  63, -17,  12, -34, -71, -80, -68; D=-22;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='Q';  M=  15, -11, -12, -36, -71,  19,  31, -68, -27,   7, -61, -26, -73,  49, -63,  30,  -3, -41, -80,  -6; D=-22;
/I:         I=-22; DM=-55;
/M: SY='V';  M= -61, -73, -83, -77, -52, -87, -80,  60, -22,  31, -39, -78, -79, -73, -14, -72, -58,  65, -80, -60; D=-22;
/I:         I=-22; DM=-55;
/M: SY='T';  M= -30, -69, -11, -33, -66, -70,  34,  10, -25, -62, -58, -52, -65,  10, -63,  15,  86, -13, -82,   3; D=-22;
/I:         I=-22; DM=-55;
/M: SY='Y';  M= -71, -79, -76, -77,  61, -80, -47, -54, -70, -14, -50, -74, -85, -68, -68, -21, -65, -29, -35, 116; D=-22;
/I:         I=-22; DM=-55;
/M: SY='I';  M= -39, -72, -20, -70, -55, -78, -71,  56, -68, -13,  28, -19, -73,   4, -72, -16,  45,  35,  24,  12; D=-22;
/I:         I=-22; DM=-55;
/M: SY='D';  M=   4, -75,  60,  32, -77, -63, -56, -68, -53, -20,  -5,  38,  33,  40, -60,  10, -54, -18, -85, -69;
/M: SY='P';  M=  -4,  10,  25,  44, -77, -68, -11, -77,   7, -76, -68, -54,  51,  19,  45,   9, -22, -73, -78, -12;
/M: SY='N';  M= -60, -73,  36,  17, -32,  -1,   0, -22,   7, -42, -65,  71, -28, -19,  10,  10,   8, -40, -84, -66;
/M: SY='G';  M= -30, -76, -59, -15, -77,  67,   8, -31,  19, -75, -66,   9, -69,   0,  44, -14, -24, -19, -77, -68;
/I:         I=-21; MD=-53;
/M: SY='Q';  M= -64, -80,  20,  22, -79, -73, -11, -11,  26, -43, -67,  13,  26,  36,  -2,  -3,  23, -26, -86, -71; D=-21;
/I:         I=-21; MD=-53;
/M: SY='S';  M=   4, -78, -34,  -7,  28, -15,  30,  16, -69, -65,   2, -64,  -7, -66, -27,  40,  -3, -15, -81, -62; D=-21;
/I:         I=-21; MD=-53;
/M: SY='T';  M= -66,   1, -68,  16,  -9, -36, -44, -29, -65, -22, -66, -65,  10, -47,   3, -19,  67, -12, -87, -36; D=-21;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='Y';  M= -89,-102,  16,   8,  21, -96,  13, -48, -82, -83, -81, -81, -95,  -5, -84, -38, -33, -88,  30,  60; D=-21;
/I:         I=-21; DM=-53;
/M: SY='T';  M= -73, -87, -15,  -1, -80, -42,  23, -72,   2, -35, -73, -69, -24, -69,  15, -29,  41,  10, -94, -12; D=-21;
/I:         I=-21; DM=-53;
/M: SY='L';  M=   4,   0, -84, -21,   4,  -9, -24, -63, -31,  28, -25, -82, -35, -19, -30, -76, -75, -13, -79,  21; D=-21;
/I:         I=-21; DM=-53;
/M: SY='S';  M= -37, -78,   1, -22,   1, -70,  42, -20, -17, -73, -67, -27, -19,  -1,  40,  46,  19, -70,   6,  -4; D=-21;
/I:         I=-21; DM=-53;
/M: SY='Y';  M= -40, -73, -69, -26,  26, -77,  53,  17, -68,  22, -47,  -9, -36, -64, -68, -16,  19,  13, -61,  66;
/M: SY='L';  M= -64, -75, -40, -68,  30,  26,   2,   2, -23,  42,   8, -18,   7,  16, -68, -64, -25, -17, -66,  22;
/M: SY='E';  M= -42, -75,  -7,  45, -65, -69, -14, -65, -13,   5,  11,  30,  -1,   9,  28,  14,   2, -37, -75,  22;
/M: SY='N';  M=   5, -71,  -8,  17, -19, -49,   5,   4, -60,   5,  22,  38, -71,   6, -36,  17, -11,  28, -81, -62;
/M: SY='D';  M= -17, -74,  52,  11, -26, -10,  27, -75, -22, -42, -68,  33,  -9, -18,  -7,  39,  15, -71, -83, -10;
/M: SY='D';  M=  -5, -77,  53,   4, -84,  51, -59, -83,  21, -80, -72, -11, -67,  46, -19,  11, -59, -78, -81, -71;
/M: SY='C';  M=   8,  82, -35, -71,   5, -35,  -2,  -9, -26,  28, -13, -70, -80, -17, -71, -64, -60,  33, -71,  35;
/M: SY='P';  M= -32,  54, -22, -58, -77, -68,  -4, -67, -64, -17, -64, -65, 101,  -3, -72,  20, -19, -22, -83, -75;
/M: SY='E';  M= -13, -76, -22,  47,   0, -45, -59, -51,  40,  -7,  -5,  16,  29, -48,  21,  10, -43, -67, -76, -64;
/M: SY='E';  M=  19, -73,  21,  43, -69, -44,  -1, -64,   7, -34, -63,  13,  -1,  -9, -58,  22,  -5,   9, -78,  11;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='L';  M= -66, -72, -85, -79,  38, -87, -73,  42, -78,  65, -35, -80, -82, -75, -77, -74, -25,  19, -67, -13;
/M: SY='R';  M=  -2, -78,   2, -52, -68, -25,   2, -26,  29, -23, -10, -27, -71,  37,  67,   2, -33, -67, -72,  21;
/M: SY='H';  M= -38, -77,  37,  47, -80, -66,  48, -80,  29, -77, -69,  -6, -17,  28,  11,  39, -22, -75, -84, -65;
/M: SY='K';  M= -33, -80, -61, -11, -78, -33,   6, -73,  72, -74, -65, -55, -70,  13,  62, -24, -61,   0, -78, -66;
/M: SY='L';  M= -67, -74, -85, -78, -47, -87, -72,  41, -21,  65,  46, -81, -82, -71, -74, -76, -63,  15, -74,  -7;
/M: SY='T';  M= -27, -76, -57,  15, -12,   4,  20, -75,  21, -73, -66,  -2, -68,  45,  30,   3,  50, -70, -80, -64;
/M: SY='Y';  M= -66,  34, -75, -69, -46,  -9,  11,  -6, -68,  37,   2, -71,  -8,  42, -68, -67, -65,   1, -61,  72;
/M: SY='L';  M=  29, -71, -84, -77, -16, -79, -74,  39, -77,  58,  27, -79, -80, -72, -77, -69, -61,   6, -75, -59;
/M: SY='Q';  M= -62, -80, -16,  -6, -74, -70, -59, -72,  44, -15,   9, -45,  44,  48,  29,  33, -58, -72, -77, -11;
/M: SY='Y';  M=  -5, -18, -56,  23, -13, -32,  21, -69, -57, -32, -62,  41, -72,  16, -22,  23,  19, -68, -66,  65;
/M: SY='F';  M= -67, -74, -78, -19,  72, -31,  18,  31, -18, -17,  56, -71, -78, -72, -71, -69,  -3,  24, -65, -43;
/M: SY='L';  M=  -6, -78,  -8, -65, -61, -80, -70,  18,   0,  46, -48, -70, -80,  36,  12, -30, -64,   7, -80, -64;
/M: SY='N';  M= -64, -14, -19,   2, -73, -42,   0, -61,  25,   5,  29,  34, -74,  11,  31,  21,  -7, -69, -85, -68;
/M: SY='Y';  M= -69, -83, -20,   7, -55, -77,  37, -70,  31, -20,   7, -16, -75,  39,  -4, -28,  -2, -71, -63,  75;
/M: SY='M';  M= -70, -77, -84, -76,  28, -84, -66, -12, -23,  42,  98, -21, -82, -38,   0, -76, -67, -51,  23, -52;
/M: SY='S';  M=  13,  19, -19,   3, -72, -42, -65, -39,  17,  15,   0,  25, -74,  -8, -10,  28, -23, -43, -84, -70;
/M: SY='N';  M=  -2,  26, -15,  26, -74, -41, -60, -78,  -9, -78, -71,  43,   1,   4,  -1,  18,  27, -73, -81,  19;
/I:         E1=0; IE=-380; DE=-380;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	71 in 48 different sequences
Number of true positive hits	71 in 48 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	POLO box
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

48 sequences

CCR1_MAIZE  (P0C8M8), CDC5_ENCCU  (Q8SWM6), CDC5_YEAST  (P32562),

PLK1_BOVIN  (Q2TA25), PLK1_CAEEL  (P34331), PLK1_HUMAN  (P53350), 
PLK1_MOUSE  (Q07832), PLK1_RAT(Q62673), PLK1_XENLA  (P70032), 
PLK1_XENTR  (P62205), PLK2_CAEEL  (Q9N2L7), PLK2_HUMAN  (Q9NYY3), 
PLK2_MOUSE  (P53351), PLK2_PONAB  (Q5R4L1), PLK2_RAT(Q9R012), 
PLK3_CAEEL  (Q20845), PLK3_HUMAN  (Q9H4B4), PLK3_MOUSE  (Q60806), 
PLK3_RAT(Q9R011), PLK4_AEDAE  (Q16W24), PLK4_BOVIN  (A2VDZ4), 
PLK4_CULQU  (B0WAU8), PLK4_DANRE  (Q7ZVS3), PLK4_DROAN  (B3M6I4), 
PLK4_DROER  (B3NE99), PLK4_DROGR  (B4J3F1), PLK4_DROME  (O97143), 
PLK4_DROMO  (B4KYX8), PLK4_DROPE  (B4HBU3), PLK4_DROPS  (Q2LYK3), 
PLK4_DROSE  (B4IAQ8), PLK4_DROSI  (B4QK53), PLK4_DROVI  (B4LDJ6), 
PLK4_DROWI  (B4MXR8), PLK4_DROYA  (B4PDM5), PLK4_HUMAN  (O00444), 
PLK4_MOUSE  (Q64702), PLK4_NEMVE  (A7SNN5), PLK4_PONAB  (Q5R9Z7), 
PLK4_RAT(B2GUY1), PLK4_XENLA  (Q6PAD2), PLK4_XENTR  (B3DL84), 
PLK5_HUMAN  (Q496M5), PLK5_MOUSE  (Q4FZD7), PLK_DICDI   (Q86HN7), 
PLK_GIAIC   (A8BPK8), PLO1_SCHPO  (P50528), POLO_DROME  (P52304)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

73 PDB

1MBY; 1Q4K; 1Q4O; 1UMW; 2N19; 2OGQ; 2OJX; 3BZI; 3C5L; 3FVH; 3HIH; 3HIK;
» more