PROSITE entry PS50073

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50073
Entry name [info]	COPPER_FIST_2
Accession [info]	PS50073
Entry type [info]	MATRIX
Date [info]	01-NOV-1997 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00863
Associated ProRule [info]	PRU00055

Name and characterization of the entry

Description [info]

Copper-fist DNA-binding domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=40;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.2387000; R2=0.0126923; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3371.3508301; R2=0.4912281; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=651; H_SCORE=3691; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=494; H_SCORE=3614; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-40; E1=-40; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='M';  M=-10,-20,-20,-30,-20,  0,-20,  0, 20,-10, 20, 60,-20,-20,  0,-10,-20,-10, 10,-20,  0,-10;
/M: SY='V';  M= -3,-28,-19,-28,-25, -5,-30,-28, 24,-20,  4,  6,-27, -7,-25,-22,-12, -3, 32,-28,-12,-26;
/M: SY='V';  M= -4,-30,-18,-33,-29,  1,-33,-29, 36,-24, 18, 14,-27,-27,-26,-23,-15, -4, 39,-26, -6,-29;
/M: SY='I';  M=-12,-30,-28,-40,-30, 13,-38,-28, 42,-30, 18, 17,-20,-22,-23,-28,-20,-10, 25,-15,  5,-30;
/M: SY='N';  M=-10, 36,-21, 20,  8,-21, -3,  9,-21,  1,-29,-20, 52,-17,  3,  0,  9, -1,-30,-39,-20,  5;
/M: SY='G';  M= -1, -3,-29, -6,-17,-29, 61,-16,-37,-17,-30,-20,  8,-20,-17,-17,  1,-17,-30,-23,-29,-17;
/M: SY='I';  M= -6,-13,-20,-19,-16,-10,-26,-16, 18,-14,  1,  6, -8,-22, -7,-14, -7, -4, 18,-27, -9,-13;
/M: SY='K';  M=-10,  0,-30,  0, 10,-30,-20,-10,-30, 50,-30,-10,  0,-10, 10, 30,-10,-10,-20,-20,-10, 10;
/M: SY='Y';  M=-17,-20,-27,-23,-20, 21,-27, 14,  6,-10,  6, 19,-20,-27, -7,-10,-20,-10, -4, 14, 55,-17;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E';  M= -1,  7,-26, 11, 17,-26,  1, -7,-24, -3,-17,-10, -1,-10,  2,-10, -1,-10,-20,-27,-19,  9;
/M: SY='R';  M= -4, -6,-23, -5,  0,-22,-13,-10,-23,  7,-25,-15,  0,  6,  1, 13, 10,  7,-16,-30,-17, -2;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='I';  M=-10,-30,-30,-40,-30,  0,-40,-30, 50,-30, 20, 20,-20,-20,-20,-30,-20,-10, 30,-20,  0,-30;
/M: SY='R';  M=-18, -8,-30, -8,  2,-22,-20, -2,-30, 34,-22,-10,  0,-18, 10, 63,-10,-10,-20,-20,-10,  2;
/M: SY='G';  M=  2, -8,-26, -8,-16,-28, 57,-18,-36,-18,-30,-20,  2,-18,-16,-18,  7,-13,-26,-24,-28,-16;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='R';  M=-18, -8,-30, -8,  2,-22,-20, -2,-30, 34,-22,-10,  0,-18, 10, 63,-10,-10,-20,-20,-10,  2;
/M: SY='A';  M= 19,-10,-10,-13,-10,-15, -7,-18, -5,-12,-15,-10, -5,-15,-10,-15, 19,  9,  7,-32,-18,-10;
/M: SY='S';  M= 19, -3,-10, -9, -6,-17, -6,-16,-14,-10,-18,-14,  1,-10, -6,-13, 26, 23, -4,-31,-17, -6;
/M: SY='T';  M= -3,  0,-19, -4,  4,-24,-17, -8,-18,  7,-19, -8,  1,-10, 15,  3, 11, 18,-14,-27,-11,  9;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='N';  M= -9, 12,-22,  5, 10,-21,-14, -3,-22, 11,-22,-15, 17,-13,  4, 13,  5,  7,-20,-30,-15,  6;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='T';  M= -5,  9,-17, -1, -7, -8,-12, -2,-13, -7,-18,-13, 17,-17, -5, -7, 13, 19,-13,-24,  1, -7;
/I:         I=-6; MI=-6; IM=-6; DM=-15; MD=-15;
/M: SY='D';  M=-17, 28,-30, 40, 24,-35,-15, 17,-34,  2,-25,-19, 12,-10, 13, -4, -2,-12,-30,-34,-12, 18;
/M: SY='R';  M=-15, -8,-30, -8,  3,-26,-10,  0,-29, 20,-21, -9,  0,-18, 19, 46, -7,-11,-23,-20,-12,  7;
/M: SY='P';  M= -8,-18,-30,-13, -1,-20,-22,-16, -6, -9,-14, -2,-19, 39, -8,-16,-10, -8, -9,-28,-20, -7;
/M: SY='L';  M=-10,-28,-20,-30,-20,  8,-28,-16, 20,-26, 45, 27,-28,-28,-16,-18,-28,-10, 10,-20,  0,-18;
/M: SY='I';  M=-10,-20,-24,-26,-16,  1,-29,-18, 15, -7,  3, 12,-16,-20, -8, -9,-14, -8, 12,-18, -1,-13;
/M: SY='P';  M=-11,-17,-31,-18, -8,-17,-24,-13, -2,  1, -9,  7,-14, 16, -4,  0,-14,-10, -8,-23,-12, -9;
/M: SY='I';  M= -7,-30,-21,-35,-28,  2,-35,-28, 38,-27, 22, 17,-25,-25,-23,-25,-18, -7, 33,-23, -3,-28;
/M: SY='R';  M=-16, -6,-30, -6,  4,-24,-20, -4,-30, 38,-24,-10,  0,-16, 10, 53,-10,-10,-20,-20,-10,  4;
/M: SY='P';  M= -9,-12,-32, -8,  0,-26,-20,-16,-21,  5,-26,-16,-11, 44, -4,  0, -5,  0,-22,-27,-21, -5;
/M: SY='R';  M=-13, -7,-32, -5,  5,-27,-20, -8,-28, 32,-27,-12, -4,  5,  6, 35,-10,-10,-22,-22,-14,  3;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='S';  M=  5,-14,-20,-15, -9,-14,-14,-18, -2,-16, -6, -6, -9,  4, -9,-18,  6,  2, -3,-29,-16,-11;
/I:         E1=0; IE=-105; DE=-105;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	10 in 10 different sequences
Number of true positive hits	10 in 10 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	K_Hofmann
Feature key [info]	DNA_BIND
Feature description [info]	Copper-fist
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

10 sequences

AMT1_CANGA  (P41772), CRF1_YARLI  (P45815), CUF1_CRYNH  (J9VT33),

CUF1_SCHPO  (Q09728), CUF2_SCHPO  (O94588), CUP2_YEAST  (P15315), 
GRISA_PODAS (Q92258), HAA1_YEAST  (Q12753), MAC1_CANAL  (Q5AFK0), 
MAC1_YEAST  (P35192)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

1 PDB

1CO4