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PROSITE entry PS50072


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50072
Entry name [info] CSA_PPIASE_2
Accession [info] PS50072
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00154
Associated ProRule [info] PRU00156

Name and characterization of the entry

Description [info] Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=158;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=153;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.3487000; R2=0.0100965; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=-1814.7358398; R2=23.3429527; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=877; H_SCORE=18657; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=679; H_SCORE=14035; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; MM=1; M0=-1;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 319 in 319 different sequences
Number of true positive hits 319 in 319 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 2
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.38 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] PPIase cyclophilin-type
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
319 sequences

BPPI_STRP6  (Q5XAQ1), CP18A_ARATH (Q9LPC7), CP18B_ARATH (Q9SIH1), 
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UniProtKB/Swiss-Prot
False negative sequences
2 sequences

CWC27_EREGS (Q75A74), CWC27_YEAST (Q02770)

		
UniProtKB/Swiss-Prot
'Partial' sequences
4 sequences

PPIA_NAEFO  (P84342), PPIA_PENGL  (P85444), PPIM_MAIZE  (Q10724), 
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PDB
[Detailed view]
379 PDB

1A33; 1A58; 1AK4; 1AWQ; 1AWR; 1AWS; 1AWT; 1AWU; 1AWV; 1BCK; 1C5F; 1CLH;
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