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PROSITE entry PS50069


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PURL: https://purl.expasy.org/prosite/signature/PS50069

Direct ScanProsite submission
General information about the entry

Entry name [info] CULLIN_2
Accession [info] PS50069
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00967
Associated ProRule [info] PRU00330

Name and characterization of the entry

Description [info] Cullin family profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=232;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=227;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.7993000; R2=0.0142630; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1573.7021484; R2=28.7375889; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=540; H_SCORE=17092; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=400; H_SCORE=13069; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; MM=1; M0=-1;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 62 in 61 different sequences
Number of true positive hits 61 in 60 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 7
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.39 %
Recall (true positives / (true positives + false negatives)) 89.71 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
60 sequences

ANC2_CAEEL  (P34514), ANC2_HUMAN  (Q9UJX6), ANC2_MOUSE  (Q8BZQ7), 
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UniProtKB/Swiss-Prot
False negative sequences
7 sequences

CACL1_HUMAN (Q86Y37), CACL1_MOUSE (Q8R0X2), CACL1_RAT   (Q5XI53), 
» more

UniProtKB/Swiss-Prot
False positive sequences
1 sequence

SAS4_YEAST  (Q04003)

		
PDB
[Detailed view]
112 PDB

1LDJ; 1LDK; 1U6G; 2HYE; 3DPL; 3DQV; 3RTR; 4A0C; 4A0K; 4A0L; 4F52; 4P5O;
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