PROSITE logo

PROSITE entry PS50055


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50055
Entry name [info] TYR_PHOSPHATASE_PTP
Accession [info] PS50055
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
12-AUG-2020 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00323
Associated ProRule [info] PRU00160

Name and characterization of the entry

Description [info] PTP type protein phosphatase domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=255;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=250;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.3013000; R2=0.0105123; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3465.4118652; R2=26.7058830; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=780; H_SCORE=24296; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=590; H_SCORE=19222; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
» more

Post-processing [info]

COMPETES_HIT_WITH PS50054; PS51181

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 233 in 186 different sequences
Number of true positive hits 233 in 186 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 25
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 90.31 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] Tyrosine-protein phosphatase
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
186 sequences

CSW_DROME   (P29349), CSW_DROVI   (Q24708), DEP1_CAEEL  (G5EGJ9), 
» more

UniProtKB/Swiss-Prot
False negative sequences
25 sequences

CDC14_CAEEL (P81299), HOPD2_PSESM (Q79LY0), PRL1_DROME  (O61722), 
» more

PDB
[Detailed view]
713 PDB

1A5Y; 1AAX; 1BZC; 1BZH; 1BZJ; 1C83; 1C84; 1C85; 1C86; 1C87; 1C88; 1ECV;
» more