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PROSITE entry PS50055


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PURL: https://purl.expasy.org/prosite/signature/PS50055

Direct ScanProsite submission
General information about the entry

Entry name [info] TYR_PHOSPHATASE_PTP
Accession [info] PS50055
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
12-AUG-2020 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00323
Associated ProRule [info] PRU00160

Name and characterization of the entry

Description [info] PTP type protein phosphatase domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=255;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=250;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.3013000; R2=0.0105123; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3465.4118652; R2=26.7058830; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=780; H_SCORE=24296; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=590; H_SCORE=19222; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Post-processing [info]

COMPETES_HIT_WITH PS50054; PS51181

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 233 in 186 different sequences
Number of true positive hits 233 in 186 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 25
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 90.31 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] Tyrosine-protein phosphatase
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
186 sequences

CSW_DROME   (P29349), CSW_DROVI   (Q24708), DEP1_CAEEL  (G5EGJ9), 
» more

UniProtKB/Swiss-Prot
False negative sequences
25 sequences

CDC14_CAEEL (P81299), HOPD2_PSESM (Q79LY0), PRL1_DROME  (O61722), 
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PDB
[Detailed view]
713 PDB

1A5Y; 1AAX; 1BZC; 1BZH; 1BZJ; 1C83; 1C84; 1C85; 1C86; 1C87; 1C88; 1ECV;
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