PROSITE entry PS50054

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50054
Entry name [info]	TYR_PHOSPHATASE_DUAL
Accession [info]	PS50054
Entry type [info]	MATRIX
Date [info]	01-NOV-1997 CREATED; 12-AUG-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00323
Associated ProRule [info]	PRU00160

Name and characterization of the entry

Description [info]

Dual specificity protein phosphatase domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=145;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=140;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8843586; R2=0.0075851; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=2587; N_SCORE=21.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=609; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-22; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='N';  M=-40,-75, -4,  8, 14, 20,  3,-53,-12,-27,-62, 64,-43, 33,  3,-10,-31,-41, 43, 15;
/M: SY='P';  M=-21, -3,  8,-24, 47,-72,-30, 11,-36,-50,-10,-41, 86,-66,-70,-41,-60,-15,  4, 36;
/M: SY='S';  M=  0,  2, -5,-61,-66,  0,-19,-12,-38, -8,-57, 16,-69,-14,-65, 58, 26, 28,-83,-65;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='W';  M=-61,-78,-27, 43,-12,-72,-18,-30, 18,-24, 26,-17, 11, 32, 37, -8,-12, -4, 62,-31;
/M: SY='I';  M=-59,-72,-45,-52,-50,-84,-78, 75,-74, -1, 10,-74,-75,-72,-77,-25,-27, 63,-76, -5;
/M: SY='W';  M=  6,-72, 18, -2,-28,-68,-20, -6,-32, 21,-13,  9,  1, -6,  7,  9, 28,-12, 33,-21;
/M: SY='P';  M=-28,-81, 44, 16,-39, -7,-14,-51,-22,-77,-69, 10, 88,-36, -7,-26,-10,-43,-81,-29;
/M: SY='N';  M=-59,-74,  3,  7,  8, 35, 49,-75,  6,-73,-18, 64,-27, -3,-22,  2, -2,-74,-17,  0;
/M: SY='L';  M=-39,-73,-76,-39, 13,-54,-68, 45,  3, 53,-11,-72,-77,-27, 30,-69,-61, 11,-71,-54;
/M: SY='Y';  M=-47,-15,-78,-77, 66,-81,-52, 23,-72, 10,-45,-75,-83,-70,-70,-70,-64,-33, 11,102;
/M: SY='L';  M=-20,-73,-35,-37,  6,-81,-66, 37,-63, 56,-39,-73,-79,-28, 30,-69,-61, 16,-68, 18;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='G';  M=-38,-72,-63,-68,-16, 77, 17,-76,-65,-28,-22,-50,-68,-60,-70, 58,-55,-72,-72,  3;
/M: SY='S';  M= 21, 36, 19,-40,-78, 38,-60,-49,-58,-76,-69, 44,  7,  0,-43, 51,-51,-48,-83,-71;
/M: SY='Y';  M= 22, 21,-22, 11, 35,-37, -5,-20,-14, 13,-52,-63,-73, 40,-12,-37,-60,-16, -6, 50;
/M: SY='P';  M= -6,-80, 17, -1,-15,-65,-62,-50, -4,-57,-66,-32, 90,  7, -9, 21, -9,-70,-16, -8;
/M: SY='R';  M= 18,-27, 15,-15, -7,-45,-11,-41,-20,-23,  5, 27,-35, -6, 40, 10, 33, -3,-80,-62;
/M: SY='A';  M= 49,-72, -5, 28,-16,-31,-22,-25, -9,-28,-20,-60, 34, 16,-20, -6,-18,-17, 38,-63;
/M: SY='E';  M=-34,-16, -5, 38,-42,-25,-30, 16,  3, -9, 18, 17,  1,  3, -8, 35,  0,-28,-79,-64;
/M: SY='N';  M=-19,-30, 44, 14,-36,-62, 29,-33, -1,-42,-65, 77,-18, 11,  9,-12,-29,-32,-86,-65;
/M: SY='F';  M=  2,-73,-37, -9, 30,-50, 13, 19, 22, 16,  2,-42, 13,-23, 15,-21,-24,  5,-70,-16;
/M: SY='P';  M=-32,-76,  4, 33,-53,-35, 20,-43,-12,-43,-23, 26, 60, 24,-34, 25, -7,-23,-76, 14;
/I:         I=-19; MD=-47;
/M: SY='F';  M=-66,-77,  1,  2, 46,-44,-26,  0,-11, 10,  7,-32,-13, 36,-43,-15,  6, -3,-10,-20; D=-19;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='L';  M=-44,-75,-84,-41, 22,-57,-22, -2,-13, 68, 23,-80,-84,-31,-73,-76,-45,-32,-73,-55; D=-19;
/I:         I=-19; DM=-47;
/M: SY='Q';  M=-19,-80,-17, 25,-78,-72, 24,-29, 49,-26,-63,-13,-69, 59, 26, -9,-19,-46,-29,-65; D=-19;
/I:         I=-19; DM=-47;
/M: SY='K';  M=-24,-76, 25, 28,-80,-43, 20,-79, 45,-60,-69, 23,-67, 14,  1, 27, 21,-73,-85,-68; D=-19;
/I:         I=-19; DM=-47;
/M: SY='L';  M=-13,-16,-64,-12, -4,-73, 29,-19,-17, 50,-46, 45,-77,-12,-23,-24,-35,-39,-71, 28; D=-19;
/I:         I=-19; DM=-47;
/M: SY='G';  M=-25,-74,-14,-33,-41, 61, 12,-81, 42,-80,-69, 57,-68,  1, -2, -4,-58,-78,-78,-68;
/M: SY='I';  M=-29,-14,-84,-80, 23,-85,-79, 72,-77, 26,-10,-77,-78,-75,-78,-71,-57, 53,-73,-53;
/M: SY='T';  M=-28,  3,  5,-31,-32, -6,-62,-40, 52,-69,-63,-50,-65, -6, 28,  4, 65,-25,-79,-65;
/M: SY='H';  M=  5, -5,-33,-61,-56,-30, 93,-62,-29,  3,-10,-25,-71,-56,-18,  8, 33,-21, 36, 41;
/M: SY='I';  M=-61, -4,-46,-77, -6,-85,-22, 80,-75,  1,-40,-74,-76,-26,-77,-38,-38, 54,  4,-55;
/M: SY='I';  M=-62,-31,-85,-79,  2,-87,-78, 64,-77, 49, -6,-79,-79,-75,-78,-73,-58, 51,-74,-54;
/M: SY='N';  M=-42, 15, 20,-56,-34,-59,-53,-69,-51,-40,-65, 79,-71,-29, 26, 40, 19,-30, 33,  9;
/M: SY='L';  M=  4, 39,-80,-39, 10,-79,-73,  0,-74, 56, 16,-76,-79,-71,-74,-67,-38, 49,-75,-55;
/M: SY='C';  M= 32, 61, -9,-38,-71,-12,-30, -4,-57,-41,-26, 27,-69, 23, -6,  7, 47,-30,-12,-67;
/I:         I=-8; MD=-20;
/M: SY='P';  M=-22,-83,  5, 28,-44, 11,-15,-38,  0,-36, -4,-11, 33, 23,-26, -4,-12,-46,-85,-44; D=-8;
/I:         I=-8; MD=-20;
/M: SY='E';  M=-76,-94, -7, 43,-30,  5, -9,-50,-18,-88,-82, -9, 23, -3,-14,-71,-14,-31,-95,-83; D=-8;
/I:         I=-8; MD=-20;
/M: SY='C';  M=-49, 18, -4,-16,-46,-30,-79,-38,-27,-44,-32,  9,  6,-18,-35,-45,  6,-20,  1, 16; D=-8;
/I:         I=-8; MI=0; MD=-20; IM=0; DM=-20;
/M: SY='Y';  M=-61,-74, 11, 36,-58, -9,  4,-23,-28,-22, 11, 47,-25,-22,  5, -3, 16,-30,-68, 56;
/M: SY='N';  M=-60, 26, 46,-17, 11,-14,-58, -3,-46,-10, 20, 50,  3,-16,-39, 13, 25,-60,-79,-19;
/M: SY='P';  M= 24,-73,  2,-40,-71,-42,-62,-59,  9,  5,-16,-25, 55, 42, -3,  8,  2,  1,-78,-67;
/M: SY='N';  M=-21,-75, 12, 30,-48,-65,  2,-70, 30,-52,-65, 46, 32,-22, 28,  7, -6,-20,-77, 11;
/M: SY='F';  M=-33,-75,-32,-22, 61,-56, 30,-10, 10, 18,-50,-65, 23,-18,-22,-45, -5,-43,-56, 58;
/I:         I=-24; MD=-60;
/M: SY='Y';  M=-24, 11,-75,-75, 58,-76,-59, 11,-71, 17,-24,  9,-27,-36,-71,-12,-62,-15, 39, 75; D=-24;
/I:         I=-24; MD=-60;
/M: SY='E';  M=-33,-28, 27, 47,-74,-62, 27,-11, 40,-30,  1,-56, 17,-22, 12,-47,  2,-49,-10,-33; D=-24;
/I:         I=-24; MD=-60;
/M: SY='K';  M= -9,-81, 33, 26,-84,  2,-63,-55, 33,-58,-73, 13, 19, 19, -7,  0,-35,-48,-86,-75; D=-24;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='H';  M=-25,-15, 15,  6,-45,-32, 45,-29,-10,-13, -1, 28,  1,-13,-37,  6, -8,-47,-87, -8; D=-24;
/I:         I=-24; DM=-60;
/M: SY='G';  M=-40,-19, 32, 10,-35, 60, 32,-40,-10,-20,-67, 13,-70,-12,-42,-11,-34,-31,-82,-68; D=-24;
/I:         I=-24; DM=-60;
/M: SY='I';  M=-66,  4,-42,-43, 51,-85,-74, 73,-27, -1, 15,-74,-28,-40,-25,-55,-61, 12,-66, -1; D=-24;
/I:         I=-24; DM=-60;
/M: SY='K';  M=-32,-25,  9, 24,-70,-68,  6,-13, 47,-25,-31, 28,-45, 32,  6,-26, 35,-31,-78,-15;
/M: SY='Y';  M=-46,-76,-70,-49,  7,-44, 54,  3,-66,  3,-12,-66,-77,-29,-65,-26,  2,  7, 18, 99;
/M: SY='H';  M=-44, -6,-73,-67,-27,-79, 66, 35, 13, 41, 27,-66,-76,-32,-40,-51,-61,  9,-68, 44;
/M: SY='H';  M=-62, 26, 11,-17,-41, -5, 80,-41, 16,-71,-62, 38,-71, 25, 27, -5,-33,-28, 33, 10;
/M: SY='I';  M=-34,-73,-56,-45, 22,-84,-19, 65,-73, 40, 32,-76,-77,-71,-42,-71,-60, 22, 31,  2;
/M: SY='P';  M=-18,-16, -8, 15, -7,  5, -2,-47, -1,-52,-66,  7, 81, 22,  7,-12,-59,-73, -7,-28;
/M: SY='W';  M=  7, 31,-79,-75, 42,-77,-72, 53,-72,  5, 47,-25,-76,-71,-74,-64,  9, 13, 54, -1;
/M: SY='D';  M= -1,-75, 47, 32,-28,-47, -9,-42, 16,-16,-17,-13, 30,  5,-10,-15, -5,  3,-79,-20;
/M: SY='D';  M=-62,-79,105,-38,-85, 27, 17,-85,-20,-83,-79,-38,-67,-55,-63,-14,-16,-81,-95,-69;
/M: SY='H';  M=-32,-73, 27, -3,  4, 24, 46,-42,-12,-29, 37, 23,-69, -7, -7, 27,-17,-20,-76, -6;
/I:         I=-10; MD=-25;
/M: SY='P';  M=-10,  7, 17, 15,-29, 14,-33,-27, -9,-72,-66,  7, 51,  2, -1, 11, 18,-24,-14,-36; D=-10;
/I:         I=-10; MD=-25;
/M: SY='T';  M=-20, 18,  6, 25,-25,-24, 26,-59, -2,-66,-62, 20, 12,  5,-42, 19, 33, 27,-84,-65; D=-10;
/I:         I=-10; MD=-25;
/M: SY='P';  M=  7,-11,-31, 19, 19,-69,-30,-16,-31,-48,-62, -9, 73, 23,-34, -8, 10, -7,-75,-39; D=-10;
/I:         I=-10; MD=-25;
/M: SY='D';  M=-30,-80, 70, -5,-83,-12,-59,-55,-17,-82,-75, 46, 50, -2,-64,  3,-20,-54,-89,-34; D=-10;
/I:         I=-10; MD=-25;
/M: SY='I';  M=-69,-23,  1,-45,-60,-50,-73, 56,-20, 27,-50,  2,-20,-68,  5,-26,  3,-33,  6,-24; D=-10;
/I:         I=-10; MD=-25;
/M: SY='S';  M=-68,-85,-17,  0,-75,-12,-73,-26,-67,  1,  4,-68,-38,  6,  8, 34, 11,-34, -6,-12; D=-10;
/I:         I=-10; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='Q';  M= -3,-84, 20, 23,-82,-74,-28,-75, 23,-14, -8,-62, 19, 50,-18,  7,-64,-38,-86,-73; D=-10;
/I:         I=-10; DM=-25;
/M: SY='Y';  M=-35,-11,  3,-42, 26,-77, 51, -8,-16,-37,  0, 12,-38, 18,-37,-42, -1,-16,  5, 55; D=-10;
/I:         I=-10; DM=-25;
/M: SY='F';  M=-69,-75,-85,-44, 67,-87,-76, 31,-28, 41,-44,-79,-83,-77,-76,-74,-17, 21, 37,-44; D=-10;
/I:         I=-10; DM=-25;
/M: SY='D';  M=-22,-19, 55, 43,-21,-65,-30,-44,-10,-40,-68, 30, 47,  6,-10, 14,-33,-71,-81,-34;
/M: SY='E';  M= -8,-75, 11, 25,-71,-52,-15, 17, 25,-15, -8, 16, 16, 25, 21,  9,  2,-59,-79,-65;
/M: SY='W';  M= 35, 54,-75,-36, 25,-21,-74,  1,-69,-30, 27,-68,-17,-69,-72,-24,  8, 40, 69,-55;
/M: SY='V';  M=-10, 19,-15,-41, 15,-73, 12, 19,  2,  6,-16, 16,-74,-64,-65,-15,  4, 45,-72, 24;
/M: SY='E';  M= -4, -2, 45, 51,-78,-22, 17,-79, 26,-76,-68,-25,-33, 44,  2, 10,-30,-74,  2,-28;
/M: SY='F';  M= -8,-71,-79,-29, 93,-79,-68, 15, -9, 18,  4,-73,-79,-73,-69,-43,-62,  2,-54, -5;
/M: SY='I';  M=-32,-10,-83,-79,-29,-85,-77, 78,-77, 47,  6,-34,-78,-73,-78,-72,-59, 22,-74,-56;
/M: SY='H';  M=-33,-77, 47, 51,-73,-33, 51,-51, 23,-38,-64, 17,-66, 19,  2,-19,-25,-13,-81, -8;
/M: SY='E';  M=-15,-75, 31, 38,-44,-51,-21, -6, 28,-33,-61,  1,-66, 30, 24, -9, 20,-19,  1,-28;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='C';  M= 34, 65,-69,-41, 19,-10,  5,-37,-15, 16,-13, 12,-77,-31, -9,-24,-59, -1,-74, -6; D=-18;
/I:         I=-18; DM=-45;
/M: SY='D';  M=-24,-75, 32, 16,-13, -7, 12,  3, 17, 16,  3, 15,-35,  3, 16,-19,-58,-20,-76,-23;
/M: SY='R';  M=-13,-74,-25, 23,-74,-26, -1,-36, 33,-42,-62, 28, -1, 29, 41, 14, -4,  1,-80,-66;
/M: SY='Q';  M=-18,-34, 34, 24,-73,-31,-17,-72, 16,-13,-63, 36,  7, 45, 30, -2,-13,-70,-78,-11;
/M: SY='N';  M=-42, 11, 21,-23,-79, 57, -1,-79, 16,-64,-70, 62, 10, -5,-24, -5,-57,-52,-82,-71;
/M: SY='G';  M= -8,-32,-31,  6,-71, 62, 25,-49, 26,-76,-67, -9,  6,  4, -8,-17,-34,-74,  8, 22;
/M: SY='P';  M=  0, -5,-60,-16,-74,  6, -9,-68, 46,-23,-62,-12, 47,-52, 38,  6,  5,-15,-78,-68;
/M: SY='V';  M=-42, 38,-81,-77,-52,-83,-80, 53,-74, -1, 13,-74,-77,-74,-76,-66,  1, 75,-81,-18;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='L';  M=  6,-71,-77,-74, 13, 23,-16,-44,-73, 67,-39,-72,-79,-68,-72,-66,-63,-49,-60, 52;
/M: SY='V';  M=-40,-69,-84,-78,-52,-85,-84, 56,-76,-10, -3,-78,-77,-76,-77,-68,-53, 87,-83,-60;
/M: SY='H';  M=-68, 23,-55,-55,-34,-71,143,-81,-59,-51,-15,-23,-71,-49,-54,-42,-37,-81,-98,-21;
/M: SY='C';  M=-60,150,-79,-79,-71,-55,-80,-78,-75,-70,-69,-66,-89,-81,-82, -5,-60,-66,  7,-79;
/M: SY='T';  M= -5,-24,-35,-40, -6,-26,  0,-35, 33,-16, 30, 26,-69, 25, -3,-11, 41, -1,-73, 10;
/M: SY='A';  M= 67,  4,-64,-30,-46,-11, 44,-61,-19,-24, 50,  3,-69,-10,  2,-35,-32,-29,-78,-62;
/M: SY='G';  M=-49,-77,-64,-76,-83,103,-71,-91,-70,-86,-75,-50,-68,-67,-77,-49,-68,-84,-74,-78;
/M: SY='I';  M=-45,-73,-74,-35, 12,-82, 10, 44, 20, 35,-42,-69,-76,-62, 28,-68,-59, 39,-73,-34;
/M: SY='S';  M=-49,-69,-29,-60,-75, 46, 60,-78,-59,-50,-68, 41,-67,-53,-63, 76,-29,-73,-84,-64;
/M: SY='R';  M=-67,-83,-64,-52,-75,-77,-52,-43,-24,-74,-63,-57,-75,-40,116,-61,-66,-74,-76,-62;
/M: SY='S';  M=  5, -7,-58,-59,-71,-55,-63,-36,-58,-70,-65,-47,-63,-54,-64, 88, 61,-35,-83,-66;
/M: SY='G';  M= 50,  8,-66,-66,-76, 59,-70,-67,-65,-72,-65,-57, 38,-64,-72,  9, -2,  3,-78,-73;
/M: SY='T';  M= 25, 54,-67,-66,-10,-44,-67,-18,-64,  1,-54,-58,-69,-64,-69, 17, 70,  2,-74, 24;
/M: SY='L';  M=-21,-15,-82,-76, -5,-82,-74, 32,-75, 56, 30,-77,-79,-72,-75,-69,-17, 53,-75,-55;
/M: SY='V';  M= -1, 31,-81,-76,-55,-55,-81, 57,-74,-16,-12,-73,-76,-74,-77,-40,-12, 74,-82,-61;
/M: SY='C';  M= 36, 62,-76,-74,-60, 28,-76, 55,-72,  4,  1,-67,-74,-70,-76,-58,-25, 12,-78,-65;
/M: SY='C';  M= 67, 92,-70,-66,-69,-11,-69,-11,-62,-34,-61,-38,-73,-63,  7, -3,-31,-55,-78,-13;
/M: SY='Y';  M=-11,-78,-74,-51, 37,-77,-13,-17,-68, 10, -6,-73,-81,-64,-66,-67,-65,-55, 45,113;
/M: SY='L';  M=-53,-28,-81,-72,-14,-83,-65, 23,-64, 71, 45,-76,-80,-64, 35,-73,-63,-29,-70,-22;
/M: SY='M';  M=-24,-15,-78,-69,-11,-77,  6, 30, 13,-12,115,-68,-72,-59,-15,-67,-59, 13,-73,-22;
/M: SY='W';  M=-64,-22,  9, 26,-10,-73,-15,-33, 46,  9, 28,-24,-70, 20, 15,-31,-43,-27, 62, 25;
/M: SY='Q';  M=-41,-31,-31,  4, -9,-46, 24,-37, 30,-29, 20,-56,-69, 36, 27, 13, 19, 14,-70, 30;
/M: SY='Y';  M=-62,-18, 11, 11,-10, 12, 40,-40, -1,  3, 11, 30,-71, 21, 14,-21, -5,-65,-69, 42;
/I:         I=-29; MD=-75;
/M: SY='W';  M=-63,-20, 22, -3,-50, 43,  7,-50,  8,-81,-36, 48,-73, 14,  5,-21,-64,-81, 68,-66; D=-29;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='W';  M=-27, -9,-79,-71, -4,-76,-18, 19,-21, 19, 83,-32,-75,-13,-67,-67, -2,  4,103, 18;
/M: SY='S';  M=-26,  1,-17,-56,-72,-11,-60,-71,  7,-74,-67, 15, 10,-53, -6, 72, 52,-65,-80,-11;
/M: SY='P';  M= 11,-72,-76,-70, 29,-74,-66, -6,-70, 45,-23,-73, 48,-68,-72,-24, -4, 14,-12, 36;
/M: SY='D';  M= -4,-72, 30, 27, -6,-29, 21,-40,-15,  4,-59, 27,-68, 26,-16, 28,  4,-22,-14,-60;
/M: SY='D';  M= -8,-77, 64, 63,-77,-39,-54,-76,  7,-57, -3,-49,-40, 40,-30,  3,-24,-72,-79, -1;
/M: SY='A';  M= 83, 28,-66,  1,-70,-55,-69,  0,-62,-63,-59,-62,-67,-59,-67,  6,-34, -6,-76,-25;
/M: SY='Y';  M=-67,-10,-78,-52, 30,-82, 11, 56,-71, 16, 19,-73,-79,-30,-46,-70,-62,  9, 28, 78;
/M: SY='Q';  M= 16,-74, 30, 29,-14,-13, 23,-25,  1,-56,-28, 21,-67, 39, 18, 21,-39,-67,-78,-25;
/M: SY='Y';  M= -6,-75,-65, 25, 45,-74, 32, -7,-27, 13, 14,-65,-73,-58,  6,-25,  6,-56, 55, 56;
/M: SY='V';  M=-60,-28,-82,-77, 48,-83,-72, 25,-74, 23, 18,-76,-79,-75,-75,-40,-21, 67,-66, 22;
/M: SY='R';  M=  4,-76,-57,  0,-75,-40,  8,-52, 54,-46,-18,-13,-68, 33, 70,-30, -5,-45,-76,-63;
/M: SY='Q';  M=  5,-73,  8, 21,-38,  4,-58,-29, 22,-14,-60, -8,-28, 37, 14, 27,-17,-19,-75, -4;
/M: SY='K';  M= 20, 46,-65,-58,-12,-26,-16, -1, 51,-16,-18, -4,-72,-53, 38, -3,-57,-21,-71, 16;
/M: SY='R';  M=-23,-80,-33,-28,-76,-72, 33,-81, 15,-75,-64,-11,-73,-41,104,-20,-62,-75,-78,-61;
/M: SY='P';  M=-14,-38,-62,-44,-26, 34,-63,-73,-10,-44,-67,  2, 80, -7, 13, 33,-56,-47,-28,-32;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='H';  M=-13, 16,-40, -2,-46, -8, 33, 32,-15,-32,-59,-19,-34, 17,  6, 20,-45,  3, -1,-28; D=-28;
/I:         I=-28; DM=-70;
/M: SY='I';  M= -3, 31,-39,-72,-15,-77,-74, 76,-38,-31, 11, 10,-30,-23,-73,-62,  9, 21,  1,-21;
/M: SY='Y';  M=-47, 33,-10, -1,-16,  4,-16, 12,  3,-19,-12, 25,-71, 30, 17, 22,-56,-30,-69, 39;
/M: SY='P';  M=-30,-83,-14, 22,-76,-70,-66, -5, 15,-20,-62,-65,101,  6,-62,-60,-18,-30,-78,-73;
/M: SY='N';  M=-29,-73,-24,-29,-78, -8, 34,-76,-28,-56,-65, 95,-71, 61, 25,-34,-33,-76,-86,-65;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='M';  M=  1,-15, 27, 26, 10,-46, 11,-13,-36,  0, 48,-59, 24,  3,  5,-34,  5,-21,  4,-23;
/M: SY='G';  M= -1,-73,-13,  5,-11, 54, 18,-73,-10,-41,-66, 51,-69, -8,-37, 11,-32,-41, 26, -5;
/M: SY='F';  M=-47,-73,-39,-75, 97,-80,-21,-17,-73, 29,-46,-28,-83,  0,-71,-71,-65,-38,  9, 41;
/M: SY='M';  M=-23,-73,-18,-45, -2,-78,  7, 44, 19, 30, 50,-67,-73,-38,-36,-65,  3,  8, 49, -8;
/M: SY='E';  M= -7,-25,  1, 32,  4, -4, 22,-26, 31,-25,-62,  5,-67, 23, 23,  9, -3,-66, -8,-33;
/M: SY='Q';  M=  9,-76,-11,  2,-39,-65,-16,-46, -7,-44, 29, 14,-67, 97,-11, -5,-20,-45, 13,-23;
/M: SY='L';  M=-28,-71,-77,-36, 30,-80,-63, -5,-70, 69,-37,-74,-79, 11,-42,-44, -9,-18,-62, 35;
/M: SY='Q';  M=-36, 30,  5,-19,-19,-72,-19, 15, 32,  0,  1, 11,-72, 43, 33,-24,-42, -5,-73, 10;
/M: SY='D';  M=-20,-76, 57, 49,-26,-31,-16,-30,  2, -7,-63,-18,  2, 11,  0, -9, -2,-23,-81,-65;
/M: SY='W';  M=-42, -2,-40,-35, 51,-48,-58,-19, 12, 15,-16,-28,-78,-62,  6,-23,-35,-39, 77, 75;
/M: SY='E';  M=-43,-79, -1, 59,-21, -2, 19,-39, 11,-18,-62,  1, -6, 35, 22,-36,-34,-70, 18, 14;
/M: SY='K';  M= -6,-74, 15, 22,-40,-52, 23,-21, 47,-12,-60, 21,-67, 29, 23, -1, -9,-29,-79,-63;
/M: SY='K';  M=-12,-27, -2,-41,-64,  0,-10, 21, 35,-26, 25,  3,-71, 11, 10, -8, -6,  2, 15,  5;
/M: SY='L';  M=-19,-25,  3,-23, -3, -7, -1, 10, 24, 31,-27,  6,  6, -5, 10,-26,-61,-33,-76,-34;
/M: SY='C';  M=-50, 29,-14, -6, -1, 10, -3,-16, -9,-13,-26, 17,-13, 12, 16,  2, 10,-10,-73, 24;
/M: SY='N';  M=  4, 15,  8, 13,-26, -5,-29,-50, 30, -5,-63, 34,-32, 26,-21,  4,-35,-53, 28,-22;
/I:         E1=0; IE=-380; DE=-380;

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Post-processing [info]

COMPETES_HIT_WITH

PS50055; PS51181

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	233 in 233 different sequences
Number of true positive hits	233 in 233 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	2
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.15 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Tyrosine-protein phosphatase
Version [info]	7

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

233 sequences

123R_IIV6   (O55737), CC14A_DANRE (A0A0R4IVA4), CC14A_HUMAN (Q9UNH5),

CC14A_MOUSE (Q6GQT0), CC14B_HUMAN (O60729), CC14B_MOUSE (Q6PFY9), 
CC14C_HUMAN (A4D256), CC14C_SYMSY (A6N3Q4), CDC14_CAEEL (P81299), 
CDC14_CANAL (Q59NH8), CDC14_EMENI (Q5B323), CDC14_YEAST (Q00684), 
CDKN3_HUMAN (Q16667), CDKN3_MOUSE (Q810P3), CDKN3_PIG   (Q9MYN5), 
CDKN3_RAT   (B2RZ50), CPP1_CANAL  (Q5APU2), D1060_DICDI (Q1ZXG8), 
DPHS1_ARATH (Q75QN6), DS13A_HUMAN (Q6B8I1), DS13A_MOUSE (Q6B8I0), 
DS13B_HUMAN (Q9UII6), DS13B_MOUSE (Q9QYJ7), DS22A_DANRE (Q1LWL2), 
DS22B_DANRE (Q566R7), DSP1_ARATH  (Q9ZVN4), DSP1_ORYSJ  (Q6K461), 
DSP2_ARATH  (Q84MD6), DSP2_ORYSJ  (Q0DX67), DSP3_ARATH  (Q681Z2), 
DSP4_ARATH  (Q940L5), DSP5_ARATH  (Q9FFD7), DSPG4_ARATH (Q9FEB5), 
DSPG4_CASSA (G4LTX4), DUS10_BOVIN (Q0IID7), DUS10_HUMAN (Q9Y6W6), 
DUS10_MOUSE (Q9ESS0), DUS11_BOVIN (Q5E999), DUS11_CAEEL (Q22707), 
DUS11_HUMAN (O75319), DUS11_MOUSE (Q6NXK5), DUS11_RAT   (Q4KM79), 
DUS12_HUMAN (Q9UNI6), DUS12_MOUSE (Q9D0T2), DUS12_RAT   (Q9JIM4), 
DUS14_BOVIN (Q17QM8), DUS14_HUMAN (O95147), DUS14_MOUSE (Q9JLY7), 
DUS15_HUMAN (Q9H1R2), DUS15_MOUSE (Q8R4V2), DUS15_RAT   (B4F7B7), 
DUS16_HUMAN (Q9BY84), DUS18_BOVIN (Q5BIP9), DUS18_HUMAN (Q8NEJ0), 
DUS18_MOUSE (Q8VE01), DUS18_PONAB (Q5R8X2), DUS18_RAT   (Q6AXW7), 
DUS19_HUMAN (Q8WTR2), DUS19_MOUSE (Q8K4T5), DUS1A_XENLA (Q91790), 
DUS1B_ARATH (Q9M8K7), DUS1B_XENLA (Q90W58), DUS1_ARATH  (Q9ZR37), 
DUS1_HUMAN  (P28562), DUS1_MOUSE  (P28563), DUS1_RAT(Q64623), 
DUS21_HUMAN (Q9H596), DUS21_MOUSE (Q9D9D8), DUS22_HUMAN (Q9NRW4), 
DUS22_MOUSE (Q99N11), DUS22_XENLA (Q6GQJ8), DUS22_XENTR (Q5XHB2), 
DUS23_HUMAN (Q9BVJ7), DUS23_MOUSE (Q6NT99), DUS26_BOVIN (Q17QJ3), 
DUS26_HUMAN (Q9BV47), DUS26_MOUSE (Q9D700), DUS26_PONAB (Q5R6H6), 
DUS26_RAT   (Q5FVI9), DUS28_HUMAN (Q4G0W2), DUS28_MOUSE (Q8BTR5), 
DUS29_ANOCA (P0C598), DUS29_BOVIN (P0C591), DUS29_CALMI (P0C5A2), 
DUS29_CHICK (P0C597), DUS29_DANRE (Q29RA3), DUS29_GASAC (P0C5A0), 
DUS29_HORSE (P0C592), DUS29_HUMAN (Q68J44), DUS29_MONDO (P0C593), 
DUS29_MOUSE (Q8BK84), DUS29_ORYLA (P0C5A1), DUS29_PANTR (P0C594), 
DUS29_PIG   (P0C596), DUS29_RAT   (P0C595), DUS29_TAKRU (P0C599), 
DUS29_TETNG (Q4RQD3), DUS29_XENLA (Q4KL92), DUS29_XENTR (A4IHU7), 
DUS3_HUMAN  (P51452), DUS3_MOUSE  (Q9D7X3), DUS3_PONAB  (Q5RD73), 
DUS4_CHICK  (Q9PW71), DUS4_HUMAN  (Q13115), DUS4_MOUSE  (Q8BFV3), 
DUS4_RAT(Q62767), DUS5_HUMAN  (Q16690), DUS5_RAT(O54838), 
DUS6_BOVIN  (Q2KJ36), DUS6_HUMAN  (Q16828), DUS6_MOUSE  (Q9DBB1), 
DUS6_RAT(Q64346), DUS7_HUMAN  (Q16829), DUS7_MOUSE  (Q91Z46), 
DUS7_RAT(Q63340), DUS8_HUMAN  (Q13202), DUS8_MOUSE  (O09112), 
DUS9_HUMAN  (Q99956), DUSK3_DROME (Q9VVW5), DUSK4_DROME (Q9VWF4), 
DUSL_CAEEL  (V6CIV8), DUSP1_DICDI (Q55E39), DUSP2_DICDI (Q54R42), 
DUSP2_HUMAN (Q05923), DUSP2_MOUSE (Q05922), DUSP3_DICDI (Q55BI8), 
DUSP4_DICDI (Q54T76), DUSPR_DICDI (Q556Y8), DUSP_FOWPN  (Q9J592), 
DUSP_MONPV  (A0A7H0DN78), DUSP_MYXVL  (Q85297), DUSP_RACVI  (P80994), 
DUSP_VACCC  (P20495), DUSP_VACCW  (P07239), DUSP_VAR67  (P0DOQ5), 
DUSP_VARV   (P0DOQ6), EPM2A_CANLF (Q1M199), EPM2A_HUMAN (O95278), 
EPM2A_MOUSE (Q9WUA5), EPM2A_RAT   (Q91XQ2), FLP1_SCHPO  (Q9P7H1), 
IBR5_ARATH  (Q84JU4), LSF1_ARATH  (F4J117), LSF2_ARATH  (Q9SRK5), 
MCE1_CAEEL  (Q17607), MCE1_DANRE  (Q6NY98), MCE1_HUMAN  (O60942), 
MCE1_MOUSE  (O55236), MKP1_ARATH  (Q9C5S1), MPL1_DICDI  (Q55CS7), 
MPL2_DICDI  (Q55CS8), MPL3_DICDI  (Q54Y32), MSG5_YEAST  (P38590), 
OCA1_CANAL  (Q59XY9), OCA1_CANGA  (Q6FSZ8), OCA1_DEBHA  (Q6BLZ8), 
OCA1_EREGS  (Q75B37), OCA1_KLULA  (Q6CTE4), OCA1_MYCMD  (Q4P7L6), 
OCA1_PICGU  (A5DE24), OCA1_PICST  (A3LW52), OCA1_YARLI  (Q6C4X9), 
OCA1_YEAS7  (A6ZRY1), OCA1_YEAST  (P50946), OCA2_YEAST  (P53949), 
OCA6_YEAST  (Q12454), PLIP_DICDI  (Q86IG3), PMP1_SCHPO  (O13453), 
PPS1_YEAST  (P38148), PRL1_DROME  (O61722), PRL1_LEIMA  (Q4QEZ7), 
PRL1_TRYCC  (Q4CUJ8), PTP1_NPVOP  (O10274), PTP2_NPVOP  (O10273), 
PTP3_CHLMO  (Q39491), PTP5_CAEEL  (P34442), PTPC1_BOVIN (A7E379), 
PTPC1_DANRE (A1L1R5), PTPC1_HUMAN (A2A3K4), PTPC1_MOUSE (Q6NZK8), 
PTPH_AMEPV  (Q9EMX1), PTPH_MIMIV  (Q5UR74), PTPM1_DROME (Q86BN8), 
PTPM1_HUMAN (Q8WUK0), PTPM1_MOUSE (Q66GT5), PTPM1_RAT   (P0C089), 
PTPX_CANAW  (P43078), PTP_NPVAC   (P24656), PVH1_SCHPO  (O13632), 
PVH1_YEAST  (Q02256), SDP1_YEAST  (P40479), SIW14_SCHPO (Q9UUF3), 
SIW14_YEAST (P53965), SSH1_HUMAN  (Q8WYL5), SSH1_MOUSE  (Q76I79), 
SSH2_HUMAN  (Q76I76), SSH2_MOUSE  (Q5SW75), SSH3_HUMAN  (Q8TE77), 
SSH3_MOUSE  (Q8K330), SSH3_RAT(Q5XIS1), SSH_DROME   (Q6NN85), 
SSH_XENLA   (Q6IVY4), STYL1_HUMAN (Q9Y6J8), STYL2_DANRE (F1QWM2), 
STYL2_HUMAN (Q5VZP5), STYL2_MOUSE (Q148W8), STYXA_XENLA (Q4V7N3), 
STYXB_XENLA (Q5U593), STYX_HUMAN  (Q8WUJ0), STYX_MOUSE  (Q60969), 
STYX_PONAB  (Q5RDP3), TP4A1_HUMAN (Q93096), TP4A1_MACFA (Q9TSM6), 
TP4A1_MOUSE (Q63739), TP4A1_PONAB (Q5R7J8), TP4A1_RAT   (Q78EG7), 
TP4A2_HUMAN (Q12974), TP4A2_MOUSE (O70274), TP4A2_RAT   (Q6P9X4), 
TP4A3_BOVIN (A2VDT1), TP4A3_HUMAN (O75365), TP4A3_MOUSE (Q9D658), 
TP4AA_DICDI (Q54DU9), TP4AB_DICDI (Q86IL4), TPMT1_ARATH (Q9ZQP1), 
TPMT2_ARATH (Q6NKR2), VF197_IIV3  (Q196Z3), VF197_IIV6  (Q91FX3), 
VHP1_CAEEL  (Q10038), Y7071_DICDI (Q550K8), YNBD_ECOLI  (P76093), 
YO42_CAEEL  (P34680), YVH1_PLAF7  (O77334)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

2 sequences

TPBA_PSEAB  (A0A0H2ZFK2), TPBA_PSEAE  (Q9HXC7)

PDB
[Detailed view]

154 PDB

1FPZ; 1FQ1; 1I9S; 1I9T; 1J4X; 1M3G; 1MKP; 1OHC; 1OHD; 1OHE; 1R6H; 1RXD;
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