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PROSITE entry PS50052


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50052
Entry name [info] GUANYLATE_KINASE_2
Accession [info] PS50052
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00670
Associated ProRule [info] PRU00100

Name and characterization of the entry

Description [info] Guanylate kinase-like domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=178;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=173;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.8000000; R2=0.0117727; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6293.4550781; R2=12.5734768; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=655; H_SCORE=14529; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=485; H_SCORE=12392; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105; MM=1; M0=-4;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 451 in 451 different sequences
Number of true positive hits 432 in 432 different sequences
Number of 'unknown' hits 0
Number of false positive hits 19 in 19 different sequences
Number of false negative sequences 32
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 95.79 %
Recall (true positives / (true positives + false negatives)) 93.10 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] Guanylate kinase-like
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
432 sequences

A57_VACCC   (P21074), A57_VACCW   (Q01230), CAR14_HUMAN (Q9BXL6), 
» more

UniProtKB/Swiss-Prot
False negative sequences
32 sequences

CAR11_HUMAN (Q9BXL7), CAR11_MOUSE (Q8CIS0), PHNN_ACHXA  (E3HQ85), 
» more

UniProtKB/Swiss-Prot
False positive sequences
19 sequences

KAD_METAC   (Q8TRS3), KAD_STAAC   (Q5HDX9), KAD_STAAM   (P65201), 
» more

PDB
[Detailed view]
54 PDB

1EX6; 1EX7; 1GKY; 1JXM; 1JXO; 1KGD; 1KJW; 1LVG; 1S4Q; 1S96; 1Z8F; 1ZNW;
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