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PROSITE entry PS50038


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PURL: https://purl.expasy.org/prosite/signature/PS50038

Direct ScanProsite submission
General information about the entry

Entry name [info] FZ
Accession [info] PS50038
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50038
Associated ProRule [info] PRU00090

Name and characterization of the entry

Description [info] Frizzled (fz) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=122;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=117;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2697001; R2=0.0105200; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=8104.8271484; R2=10.7967176; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=688; H_SCORE=15533; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=498; H_SCORE=13482; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 111 in 108 different sequences
Number of true positive hits 111 in 108 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 9
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 92.50 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] P_Bucher
Feature key [info] DOMAIN
Feature description [info] FZ
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
108 sequences

CAM1_CAEEL  (G5EGK5), CBPZ_CHICK  (Q8QGP3), CBPZ_HUMAN  (Q66K79), 
» more

UniProtKB/Swiss-Prot
False negative sequences
9 sequences

FSLB_DICDI  (Q55CD6), FSLC_DICDI  (Q86J18), FSLD_DICDI  (Q55DT7), 
» more

UniProtKB/Swiss-Prot
'Partial' sequences
4 sequences

FZD3_CHICK  (Q9PTW3), FZD6_CHICK  (Q9PTW1), FZD8_CHICK  (Q9IA03), 
» more

PDB
[Detailed view]
70 PDB

1IJX; 1IJY; 2MAH; 3HKL; 4C79; 4C7A; 4F0A; 5BPB; 5BPQ; 5BQC; 5BQE; 5CL1;
» more