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PROSITE entry PS50026


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PURL: https://purl.expasy.org/prosite/signature/PS50026

Direct ScanProsite submission
General information about the entry

Entry name [info] EGF_3
Accession [info] PS50026
Entry type [info] MATRIX
Date [info] 01-OCT-2003 CREATED;
01-OCT-2003 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00021
Associated ProRule [info] PRU00076

Name and characterization of the entry

Description [info] EGF-like domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=38;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=38;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=5.6387091; R2=0.0023904; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1197; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=361; N_SCORE=6.5; MODE=1; TEXT='RR';
/DEFAULT: D=-60; I=-60; B0=-1500; B1=*; E0=-1500; E1=*; MI=-2358; MD=-2462; IM=-89; II=-312; DM=-70; DD=-138;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 3'900 in 873 different sequences
Number of true positive hits 3'898 in 871 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 260
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 99.95 %
Recall (true positives / (true positives + false negatives)) 93.75 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 45
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] N_Hulo
Feature key [info] DOMAIN
Feature description [info] EGF-like
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
871 sequences

ABCG1_ARTBC (D4AYW0), ADA11_HUMAN (O75078), ADA11_MOUSE (Q9R1V4), 
» more

UniProtKB/Swiss-Prot
False negative sequences
260 sequences

AD26A_MOUSE (Q9R158), ADA18_HUMAN (Q9Y3Q7), ADA20_HUMAN (O43506), 
» more

UniProtKB/Swiss-Prot
'Partial' sequences
4 sequences

FAXD_NOTSN  (P0CY52), HYAL_CONAQ  (I0CME8), NID1_RAT(P08460), 
» more

UniProtKB/Swiss-Prot
False positive sequences
2 sequences

IMPG1_HUMAN (Q17R60), TE92_HASHE  (P0CI15)

		
PDB
[Detailed view]
503 PDB

1A3P; 1APO; 1APQ; 1AUT; 1BF9; 1C5M; 1CCF; 1CQE; 1CVU; 1CX2; 1DAN; 1DDX;
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