PROSITE entry PS50021

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50021
Entry name [info]	CH
Accession [info]	PS50021
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 25-OCT-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50021
Associated ProRule [info]	PRU00044; PRU00300

Name and characterization of the entry

Description [info]

Calponin homology (CH) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=108;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=108;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0038266; R2=0.0069425; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1152; N_SCORE=10.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=648; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-20; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='M';  M=  -9, -32,  -3,  21, -24, -19,  -7, -30,  19,   3,  34,   6,  10,  13, -19,   7,   3, -29, -11, -64;
/M: SY='E';  M=   5,   7,  -4,  36, -24, -35, -44, -15, -14, -31,  -1,  12,   4,   7,   3,  24,  -8,   5, -81, -51;
/M: SY='Q';  M=   4, -74,  -5,  11, -66, -32, -29,  -9, -30,  10,  38, -24,  24,  42,  13,  16, -15, -15,  -9, -36;
/M: SY='E';  M= -37,  16,   2,  50, -52, -62,  -3, -23,  44, -18, -19, -43, -26,   8,  31,  -3, -36, -22,  13, -12;
/M: SY='E';  M=  -5, -76,  17,  48, -62, -41,  25, -65,  41, -59, -34,  15, -43,  31,  24,   3, -33, -54, -77,  -4;
/M: SY='E';  M=  13, -21,  28,  36, -71, -26, -63,  18, -13, -26, -33, -44, -12,  13, -16,  18,  28, -13, -81, -67;
/M: SY='L';  M=   1,  -7, -82, -75,  43, -80, -68,  15, -53,  64,  15, -77, -63, -55, -36, -60, -52, -11, -64,   8;
/M: SY='L';  M=  -3, -19, -75, -69, -52, -69, -68,  19,  -9,  51,   2, -69, -75, -23,   3, -51,  27,  28, -75,  -9;
/M: SY='R';  M=   7, -48,  16,  19, -30, -28, -18, -25,  20, -10, -60,  27, -68,  14,  35,   1,  17, -32, -79, -50;
/M: SY='W';  M= -74, -97, -97, -77,   4, -74, -17, -72, -43, -64, -71, -89, -79, -23, -73, -45, -84, -85, 172,  -6;
/M: SY='C';  M=  -7,  70, -56, -59, -15, -78, -74,  50, -72,  29,  40, -72, -78, -71, -39, -12, -40,  34, -78, -59;
/M: SY='N';  M= -61, -28, -28,  17, -30, -44, -37, -22,   2, -64, -30,  87, -70,  54,  32, -13, -31, -57, -82, -49;
/M: SY='S';  M=   6, -73,  22,  22, -31,  -4,   8, -55,  16, -58, -26,   9, -66,  25,  12,  28,  23, -42, -77,  -5;
/M: SY='H';  M= -36,  17, -66, -24,  17, -75,  64,   2,  14,  21,  -2, -34, -73,  36, -42, -22,   8,  17, -73,  -1;
/M: SY='L';  M= -30,  32, -14, -68, -26,  -7, -42,  -8, -23,  55, -32, -12, -33, -36, -59, -59,  42,  -3, -76, -16;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='E';  M=  25, -51, -11,  26, -72,  12,  -4, -44,  13, -11, -47,  -8,   8,  -7,   9,   9, -12,   8, -79, -67;
/M: SY='K';  M= -17, -18,   1,   8, -32,  21, -61, -15,  29,   2, -19,  25,  -1,  -2,  -5,  10,  -6, -25, -77, -29;
/M: SY='Y';  M=  15, -43,   8,  17, -18, -12, -11, -37,  -7, -14, -40,  -2,   0, -20,  18,   7, -15, -19, -65,  57;
/M: SY='P';  M= -35, -33, -34, -22,   2,  30,   0,  -9, -20,   3, -30,  13,  51,  14,   7,  -4, -24, -31, -59,   7;
/I:         I=-14; MD=-34;
/M: SY='P';  M= -42,  19,  18, -28, -41,  15,  12, -24,  17, -14, -69,   9,  25, -17, -31,  -4, -23, -56,   8, -33; D=-14;
/I:         I=-14; MD=-34;
/M: SY='V';  M= -77, -18, -49, -62, -85, -49,   7,  -8,  10, -32, -73, -47,  26, -20, -18, -39, -50,  29,-101, -83; D=-14;
/I:         I=-14; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='N';  M= -23, -44,   9, -10, -80, -41, -26, -58, -18, -27, -54,  23,  -6,   6, -12,  22, -11, -57, -41, -82; D=-14;
/I:         I=-14; DM=-34;
/M: SY='I';  M= -30, -32, -30,  -9, -38, -48, -46,  50, -75, -21, -21, -64,   7, -47, -37, -57, -12,  49, -87, -69; D=-14;
/I:         I=-14; DM=-34;
/M: SY='T';  M= -38,  18,  10,  31, -35, -34,   8, -43,  16, -25, -62,  21, -13,  20,   8,  10,  46, -39, -81, -42;
/M: SY='N';  M= -35, -74,  65,  26, -80, -24,   4, -69,  -3, -80, -72,  76, -43,  -1, -28,  14, -24, -71, -90, -69;
/M: SY='F';  M= -52, -71, -12, -75,  83, -82, -68,  12, -75,  51, -17, -37, -82, -76, -75, -41, -35,  -2, -58, -30;
/M: SY='S';  M=   9, -33, -16,  17,  13, -34,  -9, -38,  -5, -19,   8, -29, -12,  11,   6,  27,  27, -25,   8,  19;
/M: SY='E';  M= -12, -73,  30,  42, -74, -52, -50, -51,  17, -25, -13, -15, -65,  39,   0,  28,  28,  -9, -81, -66;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='D';  M=   0,  -7,  74, -20, -36, -10, -61, -66, -44, -32, -71, -28, -70,   2, -56,  51, -22, -39,  11, -40; D=-38;
/I:         I=-38; DM=-97;
/M: SY='W';  M= -49,  19, -87, -79,  42, -52, -74,  12, -77,  64, -11, -81, -82, -74, -76, -75, -57, -10,  95, -44;
/M: SY='R';  M=   1,  34, -33, -29, -43, -33, -58, -62,  33, -61, -17, -28, -58,  18,  60,  42,  -2, -33, -76, -18;
/M: SY='D';  M= -53, -14,  95, -41, -81, -53, -53, -79, -40, -55, -75,  60, -68, -39, -61,  26,   0, -76, -96, -70;
/M: SY='G';  M= -19, -76, -64, -74, -82, 100, -70, -88, -69, -85, -74, -50, -48, -66, -76,  -9, -65, -81, -74, -57;
/M: SY='V';  M=  -2, -38, -73, -33, -38, -77,   3,  21, -15,  33,  12, -59, -75,  -7,  11, -59,  -3,  49,  -3,   4;
/M: SY='A';  M=  51, -18, -73, -67,   3, -51, -32,  20, -23,  20, -29, -29,  -3, -65, -14, -50, -34,  34, -73, -19;
/M: SY='L';  M= -67, -70, -83, -77,  49, -84, -49,  -1, -76,  72,  15, -79, -83, -50, -74, -74, -43,  -5, -61,  28;
/M: SY='C';  M=  24, 113, -72, -71, -24, -26, -25,  -6, -69,  16, -16,   9, -79, -31, -73,  -8, -28, -19, -83, -39;
/M: SY='Q';  M=  38, -74,   1,  25, -45, -59,  24, -46,  26, -30, -36,   6, -67,  60,   4, -26, -28, -43, -74,   2;
/M: SY='L';  M= -16, -69, -82, -75,  -6, -82, -19,  24, -75,  71,  -3, -78, -80, -54, -74, -71, -25,  29, -73, -54;
/M: SY='I';  M=  -4, -27, -83, -77,   8, -64, -72,  59, -75,  51,  43, -76, -78, -71, -75, -63, -43,  16, -70, -11;
/M: SY='H';  M= -59,  -1,  30,  40, -45, -32,  88, -69, -13, -56, -65,  76, -68,  -1, -54, -25, -56, -68, -38, -52;
/M: SY='Q';  M=   5,   8, -35, -33,  -7, -43,  11,  -9,  34, -18,  11,  -7, -70,  41,  24,   8, -12,  11, -35, -15;
/M: SY='I';  M= -39, -23, -80, -76,  27, -82,  25,  52, -74,  45, -31, -74, -79, -61, -73, -40, -43,  24, -34,  47;
/M: SY='R';  M=  17,  19,  18,   1,   3, -57,  -1, -50,   0, -23, -30, -16, -30,  23,  34,  16,   0, -18, -72,  18;
/M: SY='P';  M= -46, -85, -41, -25, -81,  12, -53, -70, -35, -47, -67, -20, 110,   8, -33, -28, -59, -24, -79, -77;
/M: SY='D';  M= -11, -21,  41,  33, -38,  35, -10, -54,  24, -57, -35,  10, -21,  12,   4,  -7, -36, -63, -11, -27;
/I:         I=-24; MD=-60;
/M: SY='W';  M=  -4,  -8, -25, -43,   9, -21,   0, -49,  10,  24,  -9, -21, -36,   0, -24,  29,  12,  -2,  40,   0; D=-24;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='V';  M= -44, -13, -47, -44,  41, -65, -65,  51, -55,  24,   5, -33, -31, -73, -49, -45, -57,  55, -71, -41;
/M: SY='D';  M= -17, -76,  59,  20, -67, -50,  -7, -58,   8, -37, -68,  43,  57, -30,  -6,   5,  -7, -68, -85, -70;
/M: SY='W';  M= -40, -52,   5,  18,  18, -45, -26, -37,  34,   7,  34, -43, -10, -22,  -6, -16, -40, -11,  70,  40;
/M: SY='K';  M=  -2, -74,  22,  10,  -8, -20,  21,  17,  28, -50, -59,  15,  -5, -19,  10,  14, -31,  -2, -76,  -4;
/M: SY='W';  M=   9, -11,  -3,  15, -49, -54,  31, -64,  36, -17, -25,  25, -30,  -9, -36,  26, -17,  -5,  71, -36;
/M: SY='L';  M= -23, -54, -48,  -7,   8, -10, -68,  21, -36,  41, -37,  -6, -52, -35,  -6,  -7, -41,  36,   7, -18;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='N';  M= -14,  23,  12,  16, -45, -25, -37, -71,  16, -52, -47,  58,   1,  15,  14,  24,  -1, -33, -79,  -2;
/M: SY='P';  M= -25, -34,   7,  -3,  -7, -29, -42, -17,  35, -16,  11,   2,  49,   6,  10,   8,   8, -39, -44, -26;
/I:         I=-9; MD=-22;
/M: SY='Q';  M= -33, -52,  -5, -23, -82, -24, -53,   2,  20, -70,  -7, -21,  23,  30,  -9,   4,   9, -16, -89, -56; D=-9;
/I:         I=-9; MD=-22;
/M: SY='P';  M=  -2, -40, -25, -18, -76, -45, -73,-100,  13, -94, -94,  -5,  32, -81, -34, -48, -19, -74,-106, -54; D=-9;
/I:         I=-9; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='S';  M= -42, -52, -61, -81, -44, -22, -77, -77, -78,   0,  26,  36, -70, -75, -62,  41,   7, -77, -98, -63; D=-9;
/I:         I=-9; DM=-22;
/M: SY='W';  M= -13, -89, -20,  18, -50, -81, -11, -57, -63, -30,  -2,  -6,  10,   8,  24, -13, -17, -28,  68, -31; D=-9;
/I:         I=-9; DM=-22;
/M: SY='F';  M=  -6, -81, -32,  10,  52, -80,  -6,  -5, -21, -26,  15, -32, -80,  -1,  20, -22, -28, -31,  33,   7; D=-9;
/I:         I=-9; DM=-22;
/M: SY='H';  M= -23, -75,  42,  24, -25, -44,  46, -45,  28,  -9, -16,  20, -40,  44, -13,   2, -36, -20, -81, -61;
/M: SY='C';  M=   8,  51, -25, -38, -31, -46,  13, -16,  48, -48,  33,  -3,   2,  27,  17,  -6, -48, -38, -72,  22;
/M: SY='M';  M= -43, -37, -61, -40,   7, -78, -30,  34,  11,  37,  45, -30, -74,  -7,  26, -25,  -9,  13, -72, -34;
/M: SY='E';  M= -13, -76,  37,  58, -52, -39,  38, -65,   9, -48, -51,  22, -65,  38, -10,  10, -29, -52, -78,   4;
/M: SY='N';  M= -51, -45, -33, -55, -73, -47, -32, -76, -17, -80, -68, 115, -73,   2,  10, -20, -49, -77, -87,   0;
/M: SY='I';  M=   9,  19, -77, -74,  15, -69, -42,  46, -72,  36, -25,  -2, -77, -58, -74, -58, -19,  38,  27,  -5;
/M: SY='N';  M= -13, -47,   0,  26, -74, -18, -15, -57,  34, -54, -32,  51, -66,  42,  17,  15,   7, -49, -79, -16;
/M: SY='N';  M= -27, -22, -30, -14, -16, -72,  18,  -2,  21,  30, -23,  36, -73,  28,   8, -35,  -8,  -6, -20,  23;
/M: SY='F';  M=  53,  18, -78, -72,  62, -58, -72,  13, -71,   6,  -3, -71, -76, -71, -73, -40, -57,  27,  -2, -21;
/M: SY='L';  M= -56, -44, -76, -39,  50, -81, -66,  22, -52,  58,  18, -12, -79,  21, -27, -69, -37,   3, -65, -25;
/M: SY='Q';  M= -18, -75,  35,  40, -77, -39,  -5, -73,  25, -35, -40,  22, -33,  50,  16,  21, -15, -39, -81, -56;
/M: SY='F';  M=  28, -42, -71, -48,  45,   1, -25,   4, -23,  -4,  14, -41, -73,   2, -54,   3,  -1,  24,  26,  -7;
/M: SY='C';  M=  52,  72, -76, -71,   2, -21, -72,  11, -71,  24,  18, -50, -75, -68, -73, -29, -56,  19, -76, -61;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='K';  M=  -4, -61,  23,  42, -76, -50,  12, -53,  46, -53, -65,  19, -66,  28,  44, -28, -16, -57, -32, -37;
/M: SY='E';  M=  -8, -75,  20,  46, -29, -36,  31, -41,  38, -46, -48, -14, -52,  -2,   8,  16, -18,  -7,  28, -16;
/M: SY='L';  M= -38, -33, -76, -34,  17, -59,  -7,  22, -24,  56,  49, -39, -77, -23,  -7, -60, -21, -13, -33,  25;
/M: SY='G';  M= -26, -75,   1, -54, -78,  81, -14, -80,  12, -31, -69,  24, -45,  -9, -26, -14, -55, -57, -77, -72;
/M: SY='C';  M= -27,  52, -45, -74,  13, -53, -25,  50, -72,  27,   8, -18, -51, -10, -59, -67, -58,  46, -74, -11;
/M: SY='P';  M= -44, -17,   9,   6, -52, -59,  20, -31,  31, -54, -64,  -1,  65,  22,  21,  15,  14, -46, -80, -67;
/I:         I=-16; MI=0; MD=-41; IM=0; DM=-41;
/M: SY='V';  M= -18,   3, -43, -15, -26, -38, -30,  -1, -33,   7, -20, -47, -19, -33, -83, -12, -13,   8, -37, -56; D=-16;
/I:         I=-16; DM=-41;
/M: SY='V';  M= -15,   0,  26,  -8,   3, -55, -13, -12,  19, -32, -25, -15,   9,  26,   7,  -6, -35,  29, -80, -38; D=-16;
/I:         I=-16; DM=-41;
/M: SY='L';  M= -43, -55,  -9, -43,   5,   5,  -2,   5, -11,  36,  35,  26, -26, -19, -16, -19, -15, -13, -35,  25;
/M: SY='F';  M= -31,   1, -34, -67,  64, -80, -72,  52, -54,  31,   6, -35,   8, -73, -60, -48, -26,   3,   0, -45;
/M: SY='D';  M= -19, -74,  44,  42, -54,   6,   0, -37, -43,  -8, -62,  -2, -21,  10, -17,  16,  23, -28,   5, -16;
/M: SY='P';  M=  36, -43, -65, -29, -58,  -2, -29, -16, -36, -12, -32, -16,  66, -62, -65,  17,  18,  15, -79, -69;
/M: SY='E';  M= -21, -56,  17,  63, -45, -41,  16, -54,  13, -55, -47,  15, -21,  25, -29,  30,  10, -28, -81, -66;
/M: SY='D';  M= -37, -79, 104,  21, -83, -36, -18, -51,  -6, -58, -12, -23, -66, -38, -32, -21, -50, -69, -94, -69;
/M: SY='I';  M= -55, -72, -83, -61, -26, -85, -31,  66, -75,  52,  48, -77, -44, -48, -75, -56, -59,  26, -74, -40;
/M: SY='V';  M=   0,   2, -18, -13,  18, -54,  -8,   7, -54,   0,   9, -11, -24, -27, -39, -16, -18,  54,  -8,  28;
/M: SY='E';  M=  -5, -75,  51,  51, -59, -57, -15, -44,  11, -28, -42,  19, -66,  12,  -3,  -4,  -1, -14, -78,   8;
/M: SY='G';  M= -14,  21, -18,   5, -46,  60, -17, -42,   0, -22,  11,  -5,  -3, -41,  -3, -26,  -5,   1, -78, -68;
/M: SY='N';  M= -15, -13,   5, -24, -50,  -7,  -1, -38,  47, -69, -36,  60,  -2,  -1,  22,  17, -18, -35, -81, -49;
/M: SY='P';  M= -27, -76,  26, -15, -21, -33, -16, -38,  -1,  -2,  -3,  42,  66,  -4,  -3, -10,  -9,  -9, -80, -66;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='K';  M= -45, -75, -35, -22, -10, -27,  31, -15,  54,   3,  17, -26,  23,  18,   8,  -4,   2, -13, -75, -40;
/M: SY='S';  M=  11, -19,   5,   0, -58, -11, -36, -29,  -6,  26,  32,  -5, -14, -21,   1,  36, -27, -11, -78, -54;
/M: SY='V';  M= -18, -43, -63,  10, -50, -74, -67,  45,   4, -26,  22,  29, -70,  -7, -35, -51,  30,  46, -36, -42;
/M: SY='L';  M= -36, -31, -81, -56, -19, -82, -69,  16, -73,  64,  59, -59, -79, -28, -64, -71, -41,  40, -73, -29;
/M: SY='T';  M=   5, -21, -11,   1, -55,  33,   2,   0, -13, -13,   3,   1, -68,  19, -10, -22,  41,  -8, -35, -46;
/M: SY='Y';  M= -59,  31, -73, -48,  40, -78, -59, -19, -17,  36,   2, -29, -79, -40,   9, -15,  -7,  13, -57,  66;
/M: SY='L';  M= -43,  20, -78, -51,   1, -81, -74,  40, -73,  47,  11, -47, -76, -71, -74, -39,  27,  45, -76, -56;
/M: SY='W';  M=  17, -73, -51, -20, -15, -61, -48,  -6, -53,  33,  -5, -53, -74,  12, -47,  14, -12,   8, 102,   8;
/M: SY='Q';  M=  12,  12, -61,  -7, -24, -54,  25, -51, -24,   2,  -8,  -3, -46,  68, -57,  23,  17, -42,  48,  19;
/M: SY='L';  M=  -2, -70, -80, -50,  28, -80, -15,  36, -63,  65,   5, -57, -79, -69, -53, -38, -41, -16, -24,  -5;
/M: SY='M';  M=  -4, -10, -74, -69,  34, -47, -34,  38,  11,  21,  47, -40, -35, -63, -19, -13, -49, -12, -34,  46;
/M: SY='K';  M= -20, -56,  -9,  -8, -40,  11,  24, -41,  29,  25, -37,  16, -70,  12,  26,   7, -17, -55,  19, -25;
/M: SY='H';  M=   6, -51, -55, -28,  12,   6,  46, -26,  22, -21,  -5, -32, -72, -47,  40,  -7, -13, -23,  42,  41;
/M: SY='F';  M= -17,  50, -63, -61,  65,  -7,  25, -31, -13,  -1, -11, -14, -78, -30, -23, -22,  -8, -37,  14,  57;
/M: SY='Q';  M=  30, -48,  -4,  23, -56, -43, -26, -35,   2,   0,  15, -11,  23,  45,   6,  -6, -10, -31, -10, -65;
/I:         E1=0; IE=-380; DE=-380;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	537 in 374 different sequences
Number of true positive hits	537 in 374 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	4
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist, P_Bucher
Feature key [info]	DOMAIN
Feature description [info]	Calponin-homology (CH)
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

374 sequences

ACTN1_BOVIN (Q3B7N2), ACTN1_CHICK (P05094), ACTN1_HUMAN (P12814),

ACTN1_MACFA (Q2PFV7), ACTN1_MOUSE (Q7TPR4), ACTN1_RAT   (Q9Z1P2), 
ACTN2_BOVIN (Q3ZC55), ACTN2_CHICK (P20111), ACTN2_HUMAN (P35609), 
ACTN2_MOUSE (Q9JI91), ACTN3_BOVIN (Q0III9), ACTN3_HUMAN (Q08043), 
ACTN3_MOUSE (O88990), ACTN4_BOVIN (A5D7D1), ACTN4_CHICK (Q90734), 
ACTN4_HUMAN (O43707), ACTN4_MOUSE (P57780), ACTN4_PONAB (Q5RCS6), 
ACTN4_RAT   (Q9QXQ0), ACTNA_DICDI (P05095), ACTNB_DICDI (O76329), 
ACTN_ANOGA  (Q7PKQ5), ACTN_DERFA  (L7UZ85), ACTN_DROME  (P18091), 
AIN1_SCHPO  (O13728), ANC1_CAEEL  (Q9N4M4), ARHG6_CHICK (Q5ZLR6), 
ARHG6_HUMAN (Q15052), ARHG6_MOUSE (Q8K4I3), ARHG6_RAT   (Q5XXR3), 
ARHG7_HUMAN (Q14155), ARHG7_MOUSE (Q9ES28), ASPM_AOTVO  (P62283), 
ASPM_BOVIN  (P62285), ASPM_CANLF  (P62286), ASPM_COLGU  (P62287), 
ASPM_FELCA  (P62288), ASPM_GORGO  (P62289), ASPM_HUMAN  (Q8IZT6), 
ASPM_HYLLA  (P62290), ASPM_MACFA  (P62291), ASPM_MACMU  (P62292), 
ASPM_MOUSE  (Q8CJ27), ASPM_PANTR  (P62293), ASPM_PONPY  (P62294), 
ASPM_SAIBB  (P62296), ASPM_SHEEP  (P62297), ASP_DROME   (Q9VC45), 
BIM1_YEAST  (P40013), CAM1B_DANRE (A5WUN7), CAMP1_HUMAN (Q5T5Y3), 
CAMP1_MOUSE (A2AHC3), CAMP1_RAT   (D3Z8E6), CAMP1_XENLA (Q6IRN6), 
CAMP2_HUMAN (Q08AD1), CAMP2_MOUSE (Q8C1B1), CAMP2_RAT   (D4AEC2), 
CAMP3_HUMAN (Q9P1Y5), CAMP3_MOUSE (Q80VC9), CDC24_YEAST (P11433), 
CFA47_HUMAN (Q6ZTR5), CFA47_MOUSE (A0A0G2JEB6), CHDP1_CAEEL (P91027), 
CLMN_HUMAN  (Q96JQ2), CLMN_MOUSE  (Q8C5W0), CNN1_BOVIN  (Q2HJ38), 
CNN1_CHICK  (P26932), CNN1_HUMAN  (P51911), CNN1_MELGA  (P37803), 
CNN1_MOUSE  (Q08091), CNN1_MUSPF  (Q9GK38), CNN1_PIG(Q08092), 
CNN1_RAT(Q08290), CNN1_SHEEP  (Q7YRL2), CNN2_BOVIN  (Q3SYU6), 
CNN2_HUMAN  (Q99439), CNN2_MOUSE  (Q08093), CNN2_PIG(Q08094), 
CNN2_PONAB  (Q5RFN6), CNN3_BOVIN  (Q32L92), CNN3_HUMAN  (Q15417), 
CNN3_MOUSE  (Q9DAW9), CNN3_RAT(P37397), CTXA_DICDI  (Q54HG2), 
CTXA_HETP5  (Q9Y0T4), CTXB_DICDI  (Q550R2), CTXB_HETP5  (Q9Y0T3), 
CYTSA_CANLF (Q2KNA0), CYTSA_CHICK (Q2KN97), CYTSA_DANRE (Q2KN93), 
CYTSA_HUMAN (Q69YQ0), CYTSA_MOUSE (Q2KN98), CYTSA_PANTR (Q2KNA1), 
CYTSA_RAT   (Q2KN99), CYTSA_TAKRU (Q2KN94), CYTSA_TETNG (Q2KN95), 
CYTSA_XENTR (Q2KN96), CYTSB_HUMAN (Q5M775), CYTSB_MOUSE (Q5SXY1), 
DAPLE_DANRE (A0A2R8QCI3), DAPLE_HUMAN (Q9P219), DAPLE_MOUSE (Q6VGS5), 
DAPLE_XENLA (P85120), DIXC1_HUMAN (Q155Q3), DIXC1_MOUSE (Q80Y83), 
DIXC1_RAT   (Q2VUH7), DMDA_DROME  (Q9VDW6), DMD_CAEEL   (Q9TW65), 
DMD_CANLF   (O97592), DMD_CHICK   (P11533), DMD_HUMAN   (P11532), 
DMD_MOUSE   (P11531), DMD_PIG (Q5GN48), DMD_RAT (P11530), 
DYST_HUMAN  (Q03001), DYST_MOUSE  (Q91ZU6), EB1A_ARATH  (Q7XJ60), 
EB1B_ARATH  (Q9FJJ5), EB1C_ARATH  (Q9FGQ6), EB1_DICDI   (Q8WQ86), 
EB1_GIAIC   (E2RU10), EH1L1_HUMAN (Q8N3D4), EH1L1_MOUSE (Q99MS7), 
EHBP1_HUMAN (Q8NDI1), EHBP1_MOUSE (Q69ZW3), FIMB1_ARATH (Q7G188), 
FIMB2_ARATH (O50064), FIMB3_ARATH (Q9FJ70), FIMB4_ARATH (Q9SJ84), 
FIMB5_ARATH (Q9FKI0), FIMB_DICDI  (P54680), FIMB_SCHPO  (O59945), 
FIMB_YEAST  (P32599), FLNA_DROME  (Q9VEN1), FLNA_HUMAN  (P21333), 
FLNA_MOUSE  (Q8BTM8), FLNB_HUMAN  (O75369), FLNB_MOUSE  (Q80X90), 
FLNC_HUMAN  (Q14315), FLNC_MOUSE  (Q8VHX6), FLNC_RAT(D3ZHA0), 
G2L2L_XENLA (A0A1L8HFX9), G2L2S_XENLA (A0A1L8H8C0), GA2L1_HUMAN (Q99501), 
GA2L1_MOUSE (Q8JZP9), GA2L2_HUMAN (Q8NHY3), GA2L2_MOUSE (Q5SSG4), 
GA2L2_RAT   (D3ZUE1), GA2L3_HUMAN (Q86XJ1), GA2L3_MOUSE (Q3UWW6), 
GA2PE_DROME (Q9W3Y4), GAS2_HUMAN  (O43903), GAS2_MOUSE  (P11862), 
GEFP_DICDI  (Q54TK8), GELA_DICDI  (P13466), GRDN_CAEEL  (F3Y5P4), 
GRDN_HUMAN  (Q3V6T2), GRDN_MOUSE  (Q5SNZ0), GXCB_DICDI  (Q55E26), 
GXCDD_DICDI (Q1ZXH8), HOOK1_CHICK (Q5ZJ27), HOOK1_DANRE (Q5TZ80), 
HOOK1_HUMAN (Q9UJC3), HOOK1_MOUSE (Q8BIL5), HOOK2_HUMAN (Q96ED9), 
HOOK2_MOUSE (Q7TMK6), HOOK2_XENLA (Q6NRB0), HOOK3_HUMAN (Q86VS8), 
HOOK3_MOUSE (Q8BUK6), HOOK3_XENLA (Q6GQ73), HOOK_AEDAE  (Q17AF4), 
HOOK_ANOGA  (Q7PWT9), HOOK_BRAFL  (B6MFW3), HOOK_CAEBR  (A8WUP2), 
HOOK_CAEEL  (Q23529), HOOK_CULQU  (B0WPU9), HOOK_DICDI  (Q54IK9), 
HOOK_DROAN  (B3MNR6), HOOK_DROER  (B3NL60), HOOK_DROGR  (B4JAL5), 
HOOK_DROME  (Q24185), HOOK_DROMO  (B4KE73), HOOK_DROPE  (B4G831), 
HOOK_DROPS  (Q29N92), HOOK_DROSE  (B4I5P7), HOOK_DROSI  (B4Q9E6), 
HOOK_DROVI  (O61493), HOOK_DROWI  (B4N1C2), HOOK_DROYA  (B4PAF2), 
IQG1_CANAL  (Q5AH02), IQG1_SCHPO  (O14188), IQG1_YEAST  (Q12280), 
IQGA1_HUMAN (P46940), IQGA1_MOUSE (Q9JKF1), IQGA2_HUMAN (Q13576), 
IQGA2_MOUSE (Q3UQ44), IQGA3_HUMAN (Q86VI3), KN14A_ORYSJ (B9EUM5), 
KN14C_ORYSJ (Q5JKW1), KN14D_ORYSJ (Q0E2L3), KN14F_ARATH (Q8W1Y3), 
KN14F_ORYSJ (Q10MN5), KN14G_ARATH (O81635), KN14H_ARATH (F4HZF0), 
KN14I_ARATH (F4IL57), KN14J_ARATH (B3H6Z8), KN14K_ARATH (F4JX00), 
KN14K_ORYSJ (B9FL70), KN14L_ARATH (F4J2M6), KN14P_ORYSJ (B9G8P1), 
KN14Q_ORYSJ (Q0IMS9), LIMC1_HUMAN (Q9UPQ0), LIMC1_MOUSE (Q3UH68), 
LIMC1_XENLA (Q3KQW7), LIMCH_DICDI (Q55GV9), LMO7_HUMAN  (Q8WWI1), 
LRCH1_FELCA (P41737), LRCH1_HUMAN (Q9Y2L9), LRCH1_MOUSE (P62046), 
LRCH2_HUMAN (Q5VUJ6), LRCH2_MOUSE (Q3UMG5), LRCH3_HUMAN (Q96II8), 
LRCH3_MOUSE (Q8BVU0), LRCH4_HUMAN (O75427), LRCH4_MOUSE (Q921G6), 
LRCH_DROME  (Q960C5), MACF1_HUMAN (Q9UPN3), MACF1_MOUSE (Q9QXZ0), 
MACF1_RAT   (D3ZHV2), MAL3_SCHPO  (Q10113), MARE1_BOVIN (Q3ZBD9), 
MARE1_CHICK (Q5ZLC7), MARE1_COTCO (Q6V291), MARE1_COTJA (Q66T82), 
MARE1_HUMAN (Q15691), MARE1_MOUSE (Q61166), MARE1_PONAB (Q5R7Z5), 
MARE1_RAT   (Q66HR2), MARE1_XENTR (Q6P848), MARE2_BOVIN (Q3SZP2), 
MARE2_CHICK (Q5ZKK1), MARE2_HUMAN (Q15555), MARE2_MOUSE (Q8R001), 
MARE2_PONAB (Q5R4I6), MARE2_RAT   (Q3B8Q0), MARE2_XENLA (Q7ZXP1), 
MARE3_HUMAN (Q9UPY8), MARE3_MOUSE (Q6PER3), MARE3_RAT   (Q5XIT1), 
MCA2B_DANRE (F1RA39), MCA3A_DANRE (F1QH17), MCA3B_DANRE (F1QWK4), 
MICA1_BOVIN (F1MH07), MICA1_DANRE (E7F9T0), MICA1_HUMAN (Q8TDZ2), 
MICA1_MOUSE (Q8VDP3), MICA1_RAT   (D3ZBP4), MICA2_BOVIN (F1MF74), 
MICA2_HUMAN (O94851), MICA2_MOUSE (Q8BML1), MICA2_RAT   (D4A1F2), 
MICA2_XENTR (F6QZ15), MICA3_BOVIN (G3MWR8), MICA3_HUMAN (Q7RTP6), 
MICA3_MOUSE (Q8CJ19), MICAL_DROME (Q86BA1), MILK1_BOVIN (E1BBG2), 
MILK1_HUMAN (Q8N3F8), MILK1_MOUSE (Q8BGT6), MILK1_RAT   (D3ZQL6), 
MILK2_HUMAN (Q8IY33), MILK2_MOUSE (Q3TN34), MILK2_RAT   (D3ZEN0), 
MP20_DROME  (P14318), MS300_DROME (M9MRD1), MYPH_ECHGR  (Q24799), 
NAV2_HUMAN  (Q8IVL1), NAV3_DANRE  (Q5TZ18), NAV3_HUMAN  (Q8IVL0), 
NAV3_MOUSE  (Q80TN7), PAKD_DICDI  (Q55DD4), PARVA_HUMAN (Q9NVD7), 
PARVA_MOUSE (Q9EPC1), PARVA_RAT   (Q9HB97), PARVB_HUMAN (Q9HBI1), 
PARVB_MOUSE (Q9ES46), PARVG_HUMAN (Q9HBI0), PARVG_MOUSE (Q9ERD8), 
PARV_CAEEL  (O16785), PLEC_CRIGR  (Q9JI55), PLEC_HUMAN  (Q15149), 
PLEC_MOUSE  (Q9QXS1), PLEC_RAT(P30427), PLSI_BOVIN  (A6H742), 
PLSI_CHICK  (P19179), PLSI_HUMAN  (Q14651), PLSI_MOUSE  (Q3V0K9), 
PLSL_DANRE  (Q6P698), PLSL_HUMAN  (P13796), PLSL_MOUSE  (Q61233), 
PLST_BOVIN  (A7E3Q8), PLST_CRIGR  (O88818), PLST_DANRE  (Q6DG81), 
PLST_HUMAN  (P13797), PLST_MOUSE  (Q99K51), PLST_RAT(Q63598), 
PTRN1_CAEEL (U4PAZ9), PTRO_DROME  (A1ZAU8), SCD1_SCHPO  (P40995), 
SCP1_YEAST  (Q08873), SICK_DROME  (Q9VIQ9), SMTL1_HUMAN (A8MU46), 
SMTL1_MOUSE (Q99LM3), SMTL2_BOVIN (Q2KI85), SMTL2_HUMAN (Q2TAL5), 
SMTL2_MOUSE (Q8CI12), SMTN_HUMAN  (P53814), SMTN_MOUSE  (Q921U8), 
SPAT4_HUMAN (Q8NEY3), SPAT4_MOUSE (Q8K3V1), SPAT4_PANTR (Q6DMN8), 
SPEF1_BOVIN (Q58DA1), SPEF1_HUMAN (Q9Y4P9), SPEF1_MOUSE (Q99JL1), 
SPEF1_XENLA (Q0IH24), SPEF2_HUMAN (Q9C093), SPEF2_MOUSE (Q8C9J3), 
SPEF2_PIG   (Q2IA00), SPEF2_RAT   (Q9R095), SPTB1_HUMAN (P11277), 
SPTB1_MOUSE (P15508), SPTB2_HUMAN (Q01082), SPTB2_MOUSE (Q62261), 
SPTCB_DROME (Q00963), SPTN2_HUMAN (O15020), SPTN2_RAT   (Q9QWN8), 
SPTN4_HUMAN (Q9H254), SPTN5_HUMAN (Q9NRC6), STG1_SCHPO  (O14185), 
SYNE1_HUMAN (Q8NF91), SYNE1_MOUSE (Q6ZWR6), SYNE2_HUMAN (Q8WXH0), 
SYNE2_MOUSE (Q6ZWQ0), TAGL2_BOVIN (Q5E9F5), TAGL2_HUMAN (P37802), 
TAGL2_MOUSE (Q9WVA4), TAGL2_RAT   (Q5XFX0), TAGL3_BOVIN (Q3ZBY2), 
TAGL3_HUMAN (Q9UI15), TAGL3_MACFA (Q4R5J4), TAGL3_MOUSE (Q9R1Q8), 
TAGL3_PONAB (Q5R6R2), TAGL3_RAT   (P37805), TAGL_BOVIN  (Q9TS87), 
TAGL_CHICK  (P19966), TAGL_HUMAN  (Q01995), TAGL_MOUSE  (P37804), 
TAGL_RAT(P31232), UNC53_CAEEL (Q7YSI9), UTRN_HUMAN  (P46939), 
UTRN_RAT(G3V7L1), VAV2_HUMAN  (P52735), VAV2_MOUSE  (Q60992), 
VAV3_HUMAN  (Q9UKW4), VAV3_MOUSE  (Q9R0C8), VAV_BOVIN   (Q08DN7), 
VAV_CAEEL   (Q45FX5), VAV_DROME   (Q9NHV9), VAV_HUMAN   (P15498), 
VAV_MOUSE   (P27870), VAV_RAT (P54100), Y2471_DICDI (Q75JP5), 
Y7875_DICDI (Q1ZXE2), YBX7_SCHPO  (Q10201)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

113 PDB

1AA2; 1AOA; 1BHD; 1BKR; 1DXX; 1H67; 1MB8; 1P2X; 1P5S; 1PA7; 1PXY; 1QAG;
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